Sangeeta Bhatia

Sangeeta Bhatia

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Sangeeta Bhatia

Publications by authors named "Sangeeta Bhatia"

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Real-time Epidemic Forecasting: Challenges and Opportunities.

Health Secur 2019 Jul/Aug;17(4):268-275

Britta Lassmann, MD, is Program Director, International Society for Infectious Diseases, Boston, MA.

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http://dx.doi.org/10.1089/hs.2019.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708259PMC
August 2020

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.

Cancer Res 2020 Apr 6;80(7):1461-1474. Epub 2020 Feb 6.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2578DOI Listing
April 2020

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.

Sci Transl Med 2020 Apr;12(537)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaw0262DOI Listing
April 2020

Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

Angew Chem Int Ed Engl 2020 Feb 7;59(7):2776-2783. Epub 2020 Jan 7.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201911762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002217PMC
February 2020

Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging.

ACS Synth Biol 2020 Feb 22;9(2):392-401. Epub 2020 Jan 22.

Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acssynbio.9b00416DOI Listing
February 2020

MERCAT: Visualising molecular epidemiology data combining genetic markers and drug resistance profiles.

Infect Genet Evol 2020 01 1;77:104043. Epub 2019 Nov 1.

School of Biotechnology & Biomolecular Sciences, and Evolution & Ecology Research Centre, University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2019.104043DOI Listing
January 2020

Targeting liver stage malaria with metformin.

JCI Insight 2019 Dec 19;4(24). Epub 2019 Dec 19.

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina Universidade de Lisboa, Lisboa, Portugal.

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http://dx.doi.org/10.1172/jci.insight.127441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975259PMC
December 2019

Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes.

Nanoscale 2019 Nov 31;11(44):21317-21323. Epub 2019 Oct 31.

Marble Center for Cancer Nanomedicine, Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139, USA and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA and Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c9nr01786kDOI Listing
November 2019

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring.

Nat Nanotechnol 2019 09 2;14(9):883-890. Epub 2019 Sep 2.

Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, UK.

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http://www.nature.com/articles/s41565-019-0527-6
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http://dx.doi.org/10.1038/s41565-019-0527-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045344PMC
September 2019

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer.

Oncotarget 2019 Sep 3;10(51):5349-5358. Epub 2019 Sep 3.

HMS Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.oncotarget.com/fulltext/27160
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http://dx.doi.org/10.18632/oncotarget.27160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731108PMC
September 2019

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Nat Commun 2019 07 19;10(1):3226. Epub 2019 Jul 19.

Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

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http://dx.doi.org/10.1038/s41467-019-11239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642103PMC
July 2019

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Gastroenterology 2019 05 12;156(6):1788-1804.e13. Epub 2019 Jan 12.

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Harvard Stem Cell Institute, Cambridge, Massachusetts; Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Divison of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532055PMC
May 2019

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

Cell Metab 2019 03;29(3):727-735.e3

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193006
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http://dx.doi.org/10.1016/j.cmet.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408324PMC
March 2019

Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.

Methods Mol Biol 2018 ;1787:41-52

Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-4939-7847-2_3DOI Listing
February 2019

Position and Content Paradigms in Genome Rearrangements: The Wild and Crazy World of Permutations in Genomics.

Bull Math Biol 2018 12 4;80(12):3227-3246. Epub 2018 Oct 4.

Centre for Research in Mathematics, Western Sydney University, Sydney, Australia.

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http://link.springer.com/10.1007/s11538-018-0514-3
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http://dx.doi.org/10.1007/s11538-018-0514-3DOI Listing
December 2018

Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.

EBioMedicine 2018 Dec 29;38:248-256. Epub 2018 Nov 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology Program, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183053
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http://dx.doi.org/10.1016/j.ebiom.2018.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306379PMC
December 2018

Classification of prostate cancer using a protease activity nanosensor library.

Proc Natl Acad Sci U S A 2018 09 20;115(36):8954-8959. Epub 2018 Aug 20.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1805337115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130343PMC
September 2018

The impact of coping strategies of cancer caregivers on psychophysiological outcomes: an integrative review.

Psychol Res Behav Manag 2018 24;11:207-215. Epub 2018 May 24.

Departamento de Psicologia, Centro de Investigação em Psicologia (CIP-UAL), Universidade Autónoma de Lisboa Luís de Camões, Lisboa, Portugal.

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http://dx.doi.org/10.2147/PRBM.S164946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973462PMC
May 2018

Personalized RNA Medicine for Pancreatic Cancer.

Clin Cancer Res 2018 04 12;24(7):1734-1747. Epub 2018 Jan 12.

Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2733DOI Listing
April 2018

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Cell Host Microbe 2018 Mar 22;23(3):395-406.e4. Epub 2018 Feb 22.

Harvard-MIT Department of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MA 02142, USA; Broad Institute, Boston, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Boston, MA 02142, USA; Department of Medicine, Brigham and Women's Hospital Boston, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.01.002DOI Listing
March 2018

Engineered Livers for Infectious Diseases.

Cell Mol Gastroenterol Hepatol 2018 22;5(2):131-144. Epub 2017 Nov 22.

Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756057PMC
November 2017

Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas.

Sci Rep 2017 10 10;7(1):12922. Epub 2017 Oct 10.

Eaton Peabody Laboratories, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-13032-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635039PMC
October 2017

Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.

Adv Mater 2017 Sep 12;29(35). Epub 2017 Jul 12.

Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Harvard-MIT Division of Health Sciences and Technology, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/adma.201701527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765747PMC
September 2017

Ultrasensitive tumour-penetrating nanosensors of protease activity.

Nat Biomed Eng 2017 10;1. Epub 2017 Apr 10.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1038/s41551-017-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621765PMC
April 2017

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers.

Sci Rep 2017 03 31;7:45424. Epub 2017 Mar 31.

Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/srep45424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374446PMC
March 2017

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Int J Parasitol 2016 10 25;46(11):679-83. Epub 2016 Jul 25.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpara.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028309PMC
October 2016

Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Nano Lett 2016 Oct 13;16(10):6303-6310. Epub 2016 Sep 13.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.nanolett.6b02670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344125PMC
October 2016

High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.

J Biomol Screen 2016 Oct 4;21(9):897-911. Epub 2016 Aug 4.

Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA The Broad Institute of MIT and Harvard, Cambridge, MA, USA Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA Howard Hughes Medical Institute, Chevy Chase, MD, USA

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http://dx.doi.org/10.1177/1087057116660277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352718PMC
October 2016

Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide-siRNA Nanocomplexes.

Bioconjug Chem 2016 10 16;27(10):2323-2331. Epub 2016 Sep 16.

Koch Institute for Integrative Cancer Research, MIT , 500 Main Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410868PMC
October 2016

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Adv Mater 2016 Sep 6;28(36):7962-7969. Epub 2016 Jul 6.

Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093-0358, USA.

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http://dx.doi.org/10.1002/adma.201600634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274592PMC
September 2016

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Angew Chem Int Ed Engl 2016 09 24;55(40):12440-4. Epub 2016 Aug 24.

Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/anie.201606123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864249PMC
September 2016

Host AMPK Is a Modulator of Plasmodium Liver Infection.

Cell Rep 2016 09 25;16(10):2539-2545. Epub 2016 Aug 25.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014760PMC
September 2016

Porous silicon-graphene oxide core-shell nanoparticles for targeted delivery of siRNA to the injured brain.

Nanoscale Horiz 2016 Sep 14;1(5):407-414. Epub 2016 Jun 14.

Department of Chemistry, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1039/C6NH00082GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935492PMC
September 2016

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

ACS Nano 2016 08 21;10(8):7926-33. Epub 2016 Jul 21.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.6b03858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896006PMC
August 2016

Synchronized cycles of bacterial lysis for in vivo delivery.

Nature 2016 08 20;536(7614):81-85. Epub 2016 Jul 20.

Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048415PMC
http://dx.doi.org/10.1038/nature18930DOI Listing
August 2016

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Virology 2016 07 27;494:236-47. Epub 2016 Apr 27.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366982PMC
July 2016

Engineering a perfusable 3D human liver platform from iPS cells.

Lab Chip 2016 07;16(14):2644-53

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA and Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139, USA and Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

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http://xlink.rsc.org/?DOI=C6LC00598E
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http://dx.doi.org/10.1039/c6lc00598eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318999PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Sustained-release synthetic biomarkers for monitoring thrombosis and inflammation using point-of-care compatible readouts.

Adv Funct Mater 2016 May 22;26(17):2919-2928. Epub 2016 Mar 22.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1002/adfm.201505142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914179PMC
May 2016

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Methods 2016 Mar 11;96:6-11. Epub 2015 Dec 11.

The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766037PMC
March 2016

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

ACS Nano 2015 Dec 13;9(12):11708-17. Epub 2015 Nov 13.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.5b05946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588683PMC
December 2015

Algebraic double cut and join : A group-theoretic approach to the operator on multichromosomal genomes.

J Math Biol 2015 Nov 11;71(5):1149-78. Epub 2014 Dec 11.

Centre for Research in Mathematics, University of Western Sydney, Penrith, NSW, 2751, Australia.

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http://dx.doi.org/10.1007/s00285-014-0852-1DOI Listing
November 2015

Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Proc Natl Acad Sci U S A 2015 Nov 23;112(47):14460-6. Epub 2015 Nov 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1508522112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664363PMC
November 2015

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.

J Biomed Mater Res A 2015 Oct 30;103(10):3331-8. Epub 2015 Apr 30.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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https://pdfs.semanticscholar.org/2c2c/b058b2f48cefcaca3d1bfa
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https://lmrt.mit.edu/sites/default/files/Stevens_JBMR-A_2015
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http://doi.wiley.com/10.1002/jbm.a.35478
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http://dx.doi.org/10.1002/jbm.a.35478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890565PMC
October 2015

Mathematical framework for activity-based cancer biomarkers.

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):12627-32. Epub 2015 Sep 28.

Institute for Medical Engineering and Science, Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Chevy Chase, MD 20815

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http://dx.doi.org/10.1073/pnas.1506925112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611621PMC
October 2015

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Cancer Res 2015 Aug 29;75(16):3255-67. Epub 2015 Jun 29.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Cambridge, Massachusetts. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts. Broad Institute, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833008PMC
August 2015

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.

Sci Rep 2015 Jun 2;5:10833. Epub 2015 Jun 2.

1] Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [2] Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA [3] Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [4] Broad Institute, Cambridge, MA 02139, USA [5] Howard Hughes Medical Institute, Cambridge, MA 02139, USA [6] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep10833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649911PMC
June 2015

Patterning vascular networks in vivo for tissue engineering applications.

Tissue Eng Part C Methods 2015 May 18;21(5):509-17. Epub 2015 Feb 18.

1 Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ten.TEC.2014.0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410304PMC
May 2015

Programmable probiotics for detection of cancer in urine.

Sci Transl Med 2015 May;7(289):289ra84

Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electrical Engineering and Computer Science and David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa3519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511399PMC
May 2015

Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro.

Stem Cell Reports 2015 Mar 7;4(3):348-59. Epub 2015 Feb 7.

Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Koch Institute, and Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375936PMC
March 2015

Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.

Cancer Discov 2015 Feb 24;5(2):168-81. Epub 2014 Nov 24.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Cambridge, Massachusetts. Division of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-13-0760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367955PMC
February 2015

In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.

Eukaryot Cell 2015 Jan 21;14(1):96-103. Epub 2014 Nov 21.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

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http://dx.doi.org/10.1128/EC.00166-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279013PMC
January 2015

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Annu Rev Virol 2014 Nov;1:475-499

Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Cambridge, Massachusetts 02139.

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http://dx.doi.org/10.1146/annurev-virology-031413-085437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398347PMC
November 2014

Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

J Am Chem Soc 2014 Oct 23;136(39):13709-14. Epub 2014 Sep 23.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Building 76-453, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ja505676hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183649PMC
October 2014

Drug-induced amplification of nanoparticle targeting to tumors.

Nano Today 2014 Oct 23;9(5):550-559. Epub 2014 Sep 23.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1016/j.nantod.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935498PMC
October 2014

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.

Trends Biotechnol 2014 Sep 30;32(9):448-55. Epub 2014 Jul 30.

Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2014.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295824PMC
September 2014

Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.

ACS Nano 2014 Sep 19;8(9):8776-85. Epub 2014 Aug 19.

Department of Chemical Engineering and ‡Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn501129qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174090PMC
September 2014

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.

Proc Natl Acad Sci U S A 2014 Sep 11;111(38):13948-53. Epub 2014 Sep 11.

Koch Institute for Integrative Cancer Research, Departments of Materials Science and Engineering, Biological Engineering,

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http://dx.doi.org/10.1073/pnas.1400821111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183329PMC
September 2014

Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues.

Tissue Eng Part A 2014 Aug 28;20(15-16):2200-12. Epub 2014 Apr 28.

1 Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts.

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http://dx.doi.org/10.1089/ten.tea.2013.0667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137334PMC
August 2014

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.

Proc Natl Acad Sci U S A 2014 Aug 4;111(33):12193-8. Epub 2014 Aug 4.

Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1412631111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143014PMC
August 2014

Microfluidic organs-on-chips.

Nat Biotechnol 2014 Aug;32(8):760-72

1] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts, USA. [2] Vascular Biology Program, Departments of Pathology &Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nbt.2989
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http://dx.doi.org/10.1038/nbt.2989DOI Listing
August 2014

Cell and tissue engineering for liver disease.

Sci Transl Med 2014 Jul;6(245):245sr2

Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, and McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374645PMC
July 2014

A Macro-to-Micro Interface for the Control of Cellular Organization.

J Microelectromech Syst 2014 Apr;23(2):391-397

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; the Howard Hughes Medical Institute, Cambridge, MA 02139, USA; and the Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ( ).

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http://dx.doi.org/10.1109/JMEMS.2013.2278813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495972PMC
April 2014

Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.

Proc Natl Acad Sci U S A 2014 Mar 24;111(10):3671-6. Epub 2014 Feb 24.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.1314651111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956200PMC
March 2014

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.

Dis Model Mech 2014 Feb 28;7(2):215-24. Epub 2013 Nov 28.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.013490
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http://dx.doi.org/10.1242/dmm.013490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917242PMC
February 2014

Weighing nanoparticles in solution at the attogram scale.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1310-5. Epub 2014 Jan 13.

Departments of Biological Engineering, Materials Science and Engineering, Electrical Engineering and Computer Science, and Mechanical Engineering, Koch Institute for Integrative Cancer Research, Computational and Systems Biology Initiative, Harvard-MIT Health Sciences and Technology, Institute for Medical Engineering and Science, and Microsystems Technology Laboratories, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.1318602111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910582PMC
January 2014

A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.

Nano Today 2013 Dec;8(6):566-576

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Division of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA ; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.nantod.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084751PMC
December 2013

Nanotechnology: emerging tools for biology and medicine.

Genes Dev 2013 Nov;27(22):2397-408

Center for Biomedical Engineering, School of Engineering.

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http://dx.doi.org/10.1101/gad.226837.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841729PMC
November 2013

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.

ACS Nano 2013 Oct 12;7(10):9001-9. Epub 2013 Sep 12.

Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nn403550cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807694PMC
October 2013

Nanoparticle amplification photothermal unveiling of cryptic collagen binding sites.

J Mater Chem B 2013 Oct 14;1(39):5235-5240. Epub 2013 Jun 14.

Harvard-MIT Division of Health Sciences and Technology , 77 Massachusetts Ave. 76-453 , Cambridge , MA 02139 , USA . Email:

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http://dx.doi.org/10.1039/c3tb20619jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809612PMC
October 2013

Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.

ACS Nano 2013 Sep 20;7(9):8089-97. Epub 2013 Aug 20.

Koch Institute for Integrative Cancer Research, ¶Health Sciences and Technology, and #Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology , Cambridge, Massachusetts, United States.

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http://dx.doi.org/10.1021/nn4033757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788585PMC
September 2013

Identification of small molecules for human hepatocyte expansion and iPS differentiation.

Nat Chem Biol 2013 Aug 2;9(8):514-20. Epub 2013 Jun 2.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720805PMC
August 2013

Measuring growth and gene expression dynamics of tumor-targeted S. typhimurium bacteria.

J Vis Exp 2013 Jul 6(77):e50540. Epub 2013 Jul 6.

Health Sciences and Technology, Massachusetts Institute of Technology.

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http://dx.doi.org/10.3791/50540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731438PMC
July 2013

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.

Cell Host Microbe 2013 Jul;14(1):104-15

Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.chom.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780791PMC
July 2013

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.

Lab Chip 2013 May 5;13(10):1969-78. Epub 2013 Apr 5.

Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1039/c3lc41300dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812960PMC
May 2013

Geometric control of vascular networks to enhance engineered tissue integration and function.

Proc Natl Acad Sci U S A 2013 May 22;110(19):7586-91. Epub 2013 Apr 22.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1217796110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651499PMC
May 2013

Mitochondrial localization and the persistent migration of epithelial cancer cells.

Biophys J 2013 May;104(9):2077-88

Harvard-MIT Division of Health-Science Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.bpj.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647149PMC
May 2013

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.

Nat Biotechnol 2013 Jan 16;31(1):63-70. Epub 2012 Dec 16.

Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542405PMC
January 2013