Sang-Hoon Sin - Dept. Microbiology & Immunology / University of North Carolina at Chapel Hill - Research Assistant Professor

Sang-Hoon Sin

Dept. Microbiology & Immunology / University of North Carolina at Chapel Hill

Research Assistant Professor

Chapel Hill, NC | United States

Main Specialties: Biology, Oncology

Additional Specialties: KSHV

ORCID logohttps://orcid.org/0000-0002-6503-4960

Sang-Hoon Sin - Dept. Microbiology & Immunology / University of North Carolina at Chapel Hill - Research Assistant Professor

Sang-Hoon Sin

Introduction

Primary Affiliation: Dept. Microbiology & Immunology / University of North Carolina at Chapel Hill - Chapel Hill, NC , United States

Specialties:

Additional Specialties:

Research Interests:

Education

Jul 1999 - Jul 2004
North Carolina State University
PhD
plant pathology

Experience

Oct 2013
University of North Carolina at Chapel Hill
Research Assistant Professor
Microbiology & Immunology

Publications

19Publications

348Reads

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Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections.

J Virol 2018 10 12;92(19). Epub 2018 Sep 12.

Department of Microbiology and Immunology, Programs in Global Oncology and Virology, Lineberger Comprehensive Cancer Center and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.01138-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146794PMC
October 2018
29 Reads
4.440 Impact Factor

Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.

Oncotarget 2016 09;7(39):63504-63513

Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.

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http://dx.doi.org/10.18632/oncotarget.11531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325380PMC
September 2016
8 Reads
6.360 Impact Factor

Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation.

J Virol 2016 02 9;90(4):2150-4. Epub 2015 Dec 9.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.02456-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734016PMC
February 2016
14 Reads
4.440 Impact Factor

Animal models of tumorigenic herpesviruses--an update.

Curr Opin Virol 2015 Oct;14:145-50

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1016/j.coviro.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628858PMC
October 2015
7 Reads
6.300 Impact Factor

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice.

PLoS Pathog 2015 Sep 1;11(9):e1005135. Epub 2015 Sep 1.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556645PMC
September 2015
11 Reads

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.

PLoS Pathog 2013 18;9(7):e1003484. Epub 2013 Jul 18.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715412PMC
February 2014
117 Reads

Latency locus complements MicroRNA 155 deficiency in vivo.

J Virol 2013 Nov 21;87(21):11908-11. Epub 2013 Aug 21.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/JVI.01620-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807310PMC
November 2013
12 Reads
4.440 Impact Factor

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.

PLoS Pathog 2012 29;8(11):e1003048. Epub 2012 Nov 29.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510261PMC
April 2013
41 Reads

Viral latency locus augments B-cell response in vivo to induce chronic marginal zone enlargement, plasma cell hyperplasia, and lymphoma.

Blood 2013 Apr 30;121(15):2952-63. Epub 2013 Jan 30.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1182/blood-2012-03-415620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624941PMC
April 2013
8 Reads
10.452 Impact Factor

mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis.

Cancer Res 2013 Apr 4;73(7):2235-46. Epub 2013 Feb 4.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618543PMC
April 2013
13 Reads
9.330 Impact Factor

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.

Virology 2012 Nov 24;433(1):220-5. Epub 2012 Aug 24.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1016/j.virol.2012.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505605PMC
November 2012
22 Reads
3.321 Impact Factor

Nuclear factor kappa B pathway associated biomarkers in AIDS defining malignancies.

Int J Cancer 2012 Jun 29;130(11):2728-33. Epub 2011 Aug 29.

The Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1002/ijc.26302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265660PMC
June 2012
23 Reads
5.085 Impact Factor

Cytokine homologs of human gammaherpesviruses.

J Interferon Cytokine Res 2012 Feb 5;32(2):53-9. Epub 2011 Dec 5.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA.

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http://dx.doi.org/10.1089/jir.2011.0083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275093PMC
February 2012
4 Reads
2.000 Impact Factor

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

Blood 2011 Aug 17;118(7):e32-9. Epub 2011 Jun 17.

Curriculum in Genetics and Molecular Biology, UNC Lineberger Comprehensive Cancer Center, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1182/blood-2010-12-323659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158728PMC
August 2011
5 Reads
10.452 Impact Factor

The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo.

J Virol 2010 Oct 4;84(20):10653-60. Epub 2010 Aug 4.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, CB#7290, 715 Mary Ellen Jones Bldg, Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1128/JVI.00848-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950586PMC
October 2010
8 Reads
4.440 Impact Factor

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.

Blood 2010 Jun 18;115(22):4455-63. Epub 2010 Mar 18.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1182/blood-2009-10-251082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881502PMC
June 2010
7 Reads
10.452 Impact Factor

Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling.

Blood 2007 Mar 2;109(5):2165-73. Epub 2006 Nov 2.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599-7290, USA.

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http://dx.doi.org/10.1182/blood-2006-06-028092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801055PMC
March 2007
9 Reads
10.452 Impact Factor

Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.

J Virol 2007 Feb 22;81(4):1912-22. Epub 2006 Nov 22.

Lineberger Comprehensive Cancer Center, Center for AIDS Research and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1128/JVI.01757-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797584PMC
February 2007
4 Reads
4.440 Impact Factor

Viral genetic determinants for thrips transmission of Tomato spotted wilt virus.

Proc Natl Acad Sci U S A 2005 Apr 7;102(14):5168-73. Epub 2005 Mar 7.

Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695, USA.

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http://dx.doi.org/10.1073/pnas.0407354102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552972PMC
April 2005
6 Reads
9.810 Impact Factor