Sang Myun Park

Sang Myun Park

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Sang Myun Park

Sang Myun Park

Publications by authors named "Sang Myun Park"

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Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

Acta Neuropathol Commun 2019 May 2;7(1):68. Epub 2019 May 2.

Department of Pharmacology, and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.

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http://dx.doi.org/10.1186/s40478-019-0716-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498585PMC
May 2019

A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D synthase expression.

Neurobiol Dis 2019 Apr 4;127:482-491. Epub 2019 Apr 4.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Department of Pharmacology, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea; Department of Brain Science, Ajou University School of Medicine, Worldcup-ro 164, Suwon 16499, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.003DOI Listing
April 2019

Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.

Exp Neurobiol 2018 Oct 31;27(5):377-386. Epub 2018 Oct 31.

Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.5607/en.2018.27.
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http://dx.doi.org/10.5607/en.2018.27.5.377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221840PMC
October 2018

A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis.

Glia 2018 02 6;66(2):445-458. Epub 2017 Nov 6.

Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Suwon, Kyunggi-do, 16499, Korea.

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http://dx.doi.org/10.1002/glia.23258DOI Listing
February 2018

DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.

Proc Natl Acad Sci U S A 2018 02 31;115(7):1629-1634. Epub 2018 Jan 31.

Department of Pharmacology, Ajou University School of Medicine, 16499 Suwon, Korea;

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http://dx.doi.org/10.1073/pnas.1708754115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816138PMC
February 2018

Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.

Cell Rep 2018 01;22(1):136-148

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea; BK21 Plus Program, Department of Biological Sciences, Ajou University School of Medicine, Suwon, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.009DOI Listing
January 2018

Hopping from One Cell to Another: Huntington's Disease Propagates.

Authors:
Sang Myun Park

Exp Neurobiol 2017 Dec 22;26(6):319-320. Epub 2017 Dec 22.

Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.

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http://dx.doi.org/10.5607/en.2017.26.6.319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746496PMC
December 2017

Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson's disease.

Neuroreport 2017 Mar;28(5):242-249

aSchool of Life Sciences bBK21 Plus KNU Creative BioResearch Group cInstitute of Life Science and Biotechnology dDepartment of Biochemistry and Cell Biology, School of Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program eBrain Science and Engineering Institute, Kyungpook National University fDepartment of Brain-Cognitive Science, Daegu-Gyeongbuk Institute of Science and Technology, Daegu gDepartment of Pharmacology hChronic Inflammatory Disease Research Center iBK21 Plus Program, Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea.

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http://dx.doi.org/10.1097/WNR.0000000000000740DOI Listing
March 2017

LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2.

Exp Neurobiol 2016 Oct 26;25(5):269-276. Epub 2016 Oct 26.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.; Department of Brain Science, Ajou University School of Medicine, Suwon 16499, Korea.; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.

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http://dx.doi.org/10.5607/en.2016.25.5.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081473PMC
October 2016

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.

Sci Rep 2016 06 27;6:28823. Epub 2016 Jun 27.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1038/srep28823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922019PMC
June 2016

P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma.

J Cell Mol Med 2016 Feb 27;20(2):333-41. Epub 2015 Nov 27.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1111/jcmm.12727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727565PMC
February 2016

Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.

Mol Neurodegener 2015 Dec 1;10:63. Epub 2015 Dec 1.

Department of Pharmacology, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, 16499, Korea.

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http://dx.doi.org/10.1186/s13024-015-0060-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666086PMC
December 2015

FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis.

Neurobiol Dis 2015 Nov 3;83:90-9. Epub 2015 Sep 3.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea; Neuroscience graduate program, Department of Biological Sciences, Ajou University School of Medicine, Suwon, Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.08.025DOI Listing
November 2015

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Nat Commun 2015 Sep 14;6:8255. Epub 2015 Sep 14.

Department of Biomedical Sciences, Neuroscience Graduate Program, Ajou University School of Medicine, Suwon, Gyeonggi-do 443-380, Korea.

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http://dx.doi.org/10.1038/ncomms9255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647842PMC
September 2015

MAP kinase phosphatase-1 expression is regulated by 15-deoxy-Δ12,14-prostaglandin J2 via a HuR-dependent post-transcriptional mechanism.

Biochim Biophys Acta 2015 Jun 22;1849(6):612-25. Epub 2015 Mar 22.

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2015.03.004DOI Listing
June 2015

Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury.

Proc Natl Acad Sci U S A 2014 Jul 23;111(27):9911-6. Epub 2014 Jun 23.

Department of Pharmacology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and

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http://dx.doi.org/10.1073/pnas.1402261111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103370PMC
July 2014

The association between airflow obstruction and radiologic change by tuberculosis.

J Thorac Dis 2014 May;6(5):471-6

Division of Pulmonology, Allergy & Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Seoul, Republic of Korea.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2014.04.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014992PMC
May 2014

The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex.

Neuroreport 2014 Jan;25(1):18-22

aDepartment of Pharmacology bNeuroscience Graduate Program, Graduate School of Biomedical Sciences cChronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, South Korea.

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http://dx.doi.org/10.1097/WNR.0000000000000022DOI Listing
January 2014

Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease.

Prion 2013 Mar-Apr;7(2):121-6. Epub 2012 Nov 15.

Department of Pharmacology, Neuroscience Graduate Program, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, South Korea.

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http://dx.doi.org/10.4161/pri.22850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609117PMC
December 2013

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1.

Neurobiol Dis 2013 Dec 20;60:1-10. Epub 2013 Aug 20.

Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; National Research Lab of Brain Inflammation, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Republic of Korea; Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.nbd.2013.08.007DOI Listing
December 2013

Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.

J Biol Chem 2012 Jul 22;287(30):24862-72. Epub 2012 May 22.

Department of Pharmacology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1074/jbc.M112.348128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408156PMC
July 2012

Role of vitamin D-binding protein in isocyanate-induced occupational asthma.

Exp Mol Med 2012 May;44(5):319-29

Department of Pharmacology and Chronic Inflammatory, Disease Research Center, Ajou University School of Medicine, Suwon 443-721, Korea.

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http://dx.doi.org/10.3858/emm.2012.44.5.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366325PMC
May 2012

Fibrillar superstructure formation of hemoglobin A and its conductive, photodynamic and photovoltaic effects.

Acta Biomater 2010 Dec 1;6(12):4689-97. Epub 2010 Jul 1.

School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul 151-744, Republic of Korea.

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http://dx.doi.org/10.1016/j.actbio.2010.06.023DOI Listing
December 2010

Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.

J Biol Chem 2010 Jul 6;285(28):21416-25. Epub 2010 May 6.

Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1074/jbc.M110.103499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898423PMC
July 2010

Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma.

J Clin Immunol 2009 Nov 27;29(6):786-94. Epub 2009 Jun 27.

Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1007/s10875-009-9314-8DOI Listing
November 2009

Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.

Mol Cell 2009 Sep;35(6):806-17

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1016/j.molcel.2009.07.021DOI Listing
September 2009

Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.

J Leukoc Biol 2009 Aug 30;86(2):349-59. Epub 2009 Apr 30.

Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1189/jlb.1008659DOI Listing
August 2009

On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft.

J Neurochem 2009 Jul 5;110(1):400-11. Epub 2009 May 5.

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06150.xDOI Listing
July 2009

Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes.

Free Radic Biol Med 2009 Jun 5;46(12):1694-702. Epub 2009 Apr 5.

Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.03.026DOI Listing
June 2009

Identification of the amino acid sequence motif of alpha-synuclein responsible for macrophage activation.

Biochem Biophys Res Commun 2009 Mar 8;381(1):39-43. Epub 2009 Feb 8.

Department of Microbiology and Brain Korea 21 Projects For Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-gu, Seoul 120-752, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2009.02.002DOI Listing
March 2009

GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro.

Brain Res 2008 Dec 7;1244:13-23. Epub 2008 Oct 7.

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Republic of Korea.

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http://dx.doi.org/10.1016/j.brainres.2008.09.072DOI Listing
December 2008

The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1.

J Immunol 2008 Dec;181(12):8642-9

Department of Pharmacology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.4049/jimmunol.181.12.8642DOI Listing
December 2008

Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.

Glia 2008 Aug;56(11):1215-23

Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.1002/glia.20691DOI Listing
August 2008

A soluble and heat-resistant form of hantavirus nucleocapsid protein for the serodiagnosis of HFRS.

J Virol Methods 2008 Jan 10;147(1):1-9. Epub 2007 Sep 10.

Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Republic of Korea.

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http://dx.doi.org/10.1016/j.jviromet.2007.08.001DOI Listing
January 2008

Effects of novel peptides derived from the acidic tail of synuclein (ATS) on the aggregation and stability of fusion proteins.

Protein Eng Des Sel 2004 Mar 5;17(3):251-60. Epub 2004 Apr 5.

Department of Microbiology and Brain Korea 21 Project of Medical Sciences, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-gu, Seoul 120-752, Korea.

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http://dx.doi.org/10.1093/protein/gzh029DOI Listing
March 2004

Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets.

Blood 2002 Oct;100(7):2506-14

Department of Microbiology and Brain Korea 21 Project of Medical Sciences, Department of Clinical Pathology, and Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood.V100.7.250
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http://dx.doi.org/10.1182/blood.V100.7.2506DOI Listing
October 2002

Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells.

J Immunol 2002 Oct;169(7):3726-35

Department of Microbiology and Brain, Korea 21 Project of Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4049/jimmunol.169.7.3726DOI Listing
October 2002

Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of alpha-synuclein, a molecular chaperone.

J Biol Chem 2002 Aug 24;277(32):28512-20. Epub 2002 May 24.

Department of Microbiology and Brain Korea 21 Project of Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Korea.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111971200
Publisher Site
http://dx.doi.org/10.1074/jbc.M111971200DOI Listing
August 2002

Stress-induced aggregation profiles of GST-alpha-synuclein fusion proteins: role of the C-terminal acidic tail of alpha-synuclein in protein thermosolubility and stability.

Biochemistry 2002 Mar;41(12):4137-46

Department of Microbiology and Brain Korea 21 Project of Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.

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March 2002