Sanford D Markowitz

Sanford D Markowitz

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Sanford D Markowitz

Publications by authors named "Sanford D Markowitz"

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Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH.

Cancer Epidemiol Biomarkers Prev 2018 07 16;27(7):728-736. Epub 2018 May 16.

Department of Surgery, Division of Surgical Oncology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519921PMC
July 2018

Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing.

Dig Dis Sci 2018 06 7;63(6):1449-1453. Epub 2018 Mar 7.

Department of Family Medicine and Community Health, Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44016, USA.

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http://dx.doi.org/10.1007/s10620-018-5001-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960589PMC
June 2018

Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2).

Neoplasia 2017 Oct 5;19(10):805-816. Epub 2017 Sep 5.

Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587890PMC
October 2017

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.

Proc Natl Acad Sci U S A 2017 08 17;114(31):E6427-E6436. Epub 2017 Jul 17.

The Cecil H. and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1704945114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547630PMC
August 2017

Cancer bypasses the lymph nodes.

Science 2017 07;357(6346):35-36

Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aan8299
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http://dx.doi.org/10.1126/science.aan8299DOI Listing
July 2017

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.

J Med Chem 2017 05 25;60(9):3979-4001. Epub 2017 Apr 25.

Department of Biochemistry, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580352PMC
May 2017

Prostaglandin E Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.

Gastroenterology 2017 02 15;152(3):616-630. Epub 2016 Nov 15.

Biomedical Research Center, Asan Institute for Life Sciences, Seoul, South Korea; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285392PMC
February 2017

Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.

J Natl Cancer Inst 2016 12 31;108(12). Epub 2016 Aug 31.

Department of Genetics and Genome Sciences (ZW), Department of Family Medicine (LL, ZC), Division of Hematology and Oncology, Department of Medicine (SDM), Department of Epidemiology and Biostatistics (JBS), Department of Pathology (JW), Case Comprehensive Cancer Center (ZW, LL, KG, JBS, YSP, SDM, JW), Case Western Reserve University and Case Medical Center (LL, SDM, JW), Cleveland, OH

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http://dx.doi.org/10.1093/jnci/djw164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241897PMC
December 2016

Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

JAMA Oncol 2016 Oct;2(10):1333-1339

Division of Gastroenterology and Liver Disease, Department of Medicine, Case Medical Center, Cleveland, Ohio6Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063702PMC
http://dx.doi.org/10.1001/jamaoncol.2016.2054DOI Listing
October 2016

ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.

Genome Med 2015 20;7:69. Epub 2015 Jul 20.

Division of General Medical Sciences-Oncology, Case Western Reserve University, Cleveland, OH 44106 USA ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 USA ; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 USA ; Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106 USA.

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http://dx.doi.org/10.1186/s13073-015-0192-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534088PMC
May 2016

Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Cancer Epidemiol Biomarkers Prev 2016 05 29;25(5):727-35. Epub 2016 Feb 29.

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Division of Gastroenterology and Hepatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873373PMC
May 2016

Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.

Cancer Epidemiol Biomarkers Prev 2015 Dec 6;24(12):1890-7. Epub 2015 Nov 6.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670566PMC
December 2015

Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Proc Natl Acad Sci U S A 2015 Jun 4;112(22):E2853. Epub 2015 May 4.

Case Comprehensive Cancer Center, and Department of Medicine, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; Department of Pathology.

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http://dx.doi.org/10.1073/pnas.1505059112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460466PMC
June 2015

IL-33 activates tumor stroma to promote intestinal polyposis.

Proc Natl Acad Sci U S A 2015 May 27;112(19):E2487-96. Epub 2015 Apr 27.

Department of Molecular and Human Genetics, Dan L. Duncan Cancer Center, and Texas Medical Center Digestive Diseases Center, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1422445112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434739PMC
May 2015

The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening.

Dig Dis Sci 2015 Mar 10;60(3):762-72. Epub 2014 Dec 10.

Clinical Research Division, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue N., D4-100, Seattle, WA, 98109, USA,

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http://dx.doi.org/10.1007/s10620-014-3444-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779895PMC
March 2015

Novel recurrently mutated genes in African American colon cancers.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1149-54. Epub 2015 Jan 12.

Case Comprehensive Cancer Center, and Department of Medicine, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; Department of Pathology.

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http://dx.doi.org/10.1073/pnas.1417064112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313860PMC
January 2015

GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers.

PLoS One 2014 30;9(1):e87966. Epub 2014 Jan 30.

Case Comprehensive Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, Ohio, United States of America ; Division of General Medical Sciences-Oncology, Case Western Reserve University and Case Medical Center, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087966PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907576PMC
September 2014

Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.

J Immunol 2014 Sep 23;193(5):2127-34. Epub 2014 Jul 23.

Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106;

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http://dx.doi.org/10.4049/jimmunol.1400857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784709PMC
September 2014

Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.

Gastroenterology 2014 Aug 30;147(2):418-29.e8. Epub 2014 Apr 30.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington School of Medicine, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107146PMC
August 2014

Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.

Cancer Prev Res (Phila) 2014 Aug 16;7(8):805-12. Epub 2014 May 16.

Division of Hematology and Oncology, Departments of Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine; University Hospitals Case Medical Center, Cleveland, Ohio;

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125515PMC
August 2014

Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.

PLoS One 2013 22;8(5):e64122. Epub 2013 May 22.

Department of Family Medicine and Community Health, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064122PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661460PMC
April 2014

Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).

Sci Transl Med 2014 Apr;6(233):233re2

Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030641PMC
April 2014

NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.

PLoS Genet 2013 11;9(7):e1003552. Epub 2013 Jul 11.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.

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http://dx.doi.org/10.1371/journal.pgen.1003552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708790PMC
January 2014

Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention.

Dig Dis Sci 2013 Sep 27;58(9):2615-22. Epub 2013 Apr 27.

Department of Medicine, Case Western Reserve University and Case Medical Center, 10900 Euclid Ave., Wolstein Research Building, Rm 3-128, Cleveland, OH 44106-7285, USA.

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http://dx.doi.org/10.1007/s10620-013-2670-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769508PMC
September 2013

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Cancer Cell 2013 May 2;23(5):583-93. Epub 2013 May 2.

Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671608PMC
May 2013

Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.

J Biol Chem 2011 Apr 24;286(16):14493-507. Epub 2011 Feb 24.

Department of Pediatrics (W. A. Bernbaum Center for Cystic Fibrosis Research), Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M111.218701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077648PMC
April 2011

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Nature 2010 Mar 3;464(7288):610-4. Epub 2010 Mar 3.

The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1038/nature08802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176451PMC
March 2010

Molecular origins of cancer: Molecular basis of colorectal cancer.

N Engl J Med 2009 Dec;361(25):2449-60

Department of Medicine and Ireland Cancer Center, Case Western Reserve University School of Medicine and Case Medical Center, Cleveland, USA.

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http://dx.doi.org/10.1056/NEJMra0804588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843693PMC
December 2009

Sensitive digital quantification of DNA methylation in clinical samples.

Nat Biotechnol 2009 Sep 16;27(9):858-63. Epub 2009 Aug 16.

The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nbt.1559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847606PMC
September 2009

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers.

Genes Chromosomes Cancer 2008 Nov;47(11):939-46

Department of Medicine and Ireland Cancer Center, Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1002/gcc.20596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739997PMC
November 2008

Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.

Cancer Res 2008 Aug;68(15):6118-26

Department of Molecular Biology and Microbiology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106-7285, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614906PMC
August 2008

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

Proc Natl Acad Sci U S A 2008 Aug 21;105(34):12411-6. Epub 2008 Aug 21.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0805685105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518831PMC
August 2008

The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.

Int J Cancer 2008 Jul;123(1):14-21

Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA.

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http://dx.doi.org/10.1002/ijc.23608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777657PMC
July 2008

Colorectal neoplasia goes with the flow: prostaglandin transport and termination.

Cancer Prev Res (Phila) 2008 Jul 19;1(2):77-9. Epub 2008 Mar 19.

Department of Medicine and Ireland Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533154PMC
July 2008

Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study.

Am J Hum Genet 2008 Mar 28;82(3):723-36. Epub 2008 Feb 28.

Department of Epidemiology and Biostatistics, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.ajhg.2008.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427227PMC
March 2008

Comparative lesion sequencing provides insights into tumor evolution.

Proc Natl Acad Sci U S A 2008 Mar 12;105(11):4283-8. Epub 2008 Mar 12.

The Ludwig Center for Cancer Genetics and Therapeutics, Department of Biostatistics, Howard Hughes Medical Institute, and Sidney Kimmel Cancer Center at The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0712345105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393770PMC
March 2008

Clinical trial resources on the internet must be designed to reach underrepresented minorities.

Cancer J 2006 Nov-Dec;12(6):475-81

Fox Chase Virtua Health Cancer Treatment Center, Voorhies, New Jersey 08043, USA.

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October 2007

An improved method for staining cell colonies in clonogenic assays.

Cytotechnology 2007 Jun 12;54(2):85-8. Epub 2007 Jun 12.

Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, 2103 Cornell road, Wolstein Research Building- 3rd Floor, Mailstop 3101, Cleveland, OH, 44106, USA,

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http://dx.doi.org/10.1007/s10616-007-9083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267497PMC
June 2007

Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

Cancer Epidemiol Biomarkers Prev 2007 May;16(5):892-4

Department of Epidemiology, University Hospitals of Cleveland/Case Western Reserve University and Howard Hughes Medical Institute, and Cleveland, Ohio, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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May 2007

Aspirin and colon cancer--targeting prevention?

N Engl J Med 2007 May;356(21):2195-8

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http://www.nejm.org/doi/abs/10.1056/NEJMe078044
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May 2007

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.

J Cell Biol 2006 Dec 27;175(5):703-8. Epub 2006 Nov 27.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200606145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064669PMC
December 2006

Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers.

Clin Cancer Res 2006 Jan;12(2):454-9

Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0919DOI Listing
January 2006

Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.

J Natl Cancer Inst 2005 Aug;97(15):1124-32

Department of Medicine, Ireland Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA.

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http://academic.oup.com/jnci/article/97/15/1124/2521303/Dete
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August 2005

Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.

Clin Cancer Res 2005 Feb;11(3):1203-9

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA.

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February 2005

C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.

Int J Cancer 2004 Aug;111(1):72-5

Department of Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.

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http://doi.wiley.com/10.1002/ijc.20235
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August 2004

The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.

J Physiol 2004 Jun 16;557(Pt 3):719-31. Epub 2004 Apr 16.

Groupe d'etude des protéines membranaires, Pavillon Paul-G-Desmarais, Université de Montréal, QC, Canada.

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June 2004

Three classes of genes mutated in colorectal cancers with chromosomal instability.

Cancer Res 2004 May;64(9):2998-3001

Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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May 2004

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.

Nat Genet 2004 Apr 14;36(4):417-22. Epub 2004 Mar 14.

Division of Tumor Biology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, Maryland 21231, USA.

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April 2004