Sandro Santagata

Sandro Santagata

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Sandro Santagata

Publications by authors named "Sandro Santagata"

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100Publications

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Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Nat Protoc 2019 Oct 18;14(10):2900-2930. Epub 2019 Sep 18.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41596-019-0206-yDOI Listing
October 2019

Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations.

Cancer 2019 Sep 17;125(17):2910-2914. Epub 2019 Jul 17.

Divisions of Neuro-Oncology and Hematology/Oncology, Departments of Neurology and Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.32197DOI Listing
September 2019

Correction to: An update on the CNS manifestations of neurofibromatosis type 2.

Acta Neuropathol 2019 Aug 20. Epub 2019 Aug 20.

Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Hale Building for Transformative Medicine, BTM8002P, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-019-02044-6DOI Listing
August 2019

Rapid MALDI mass spectrometry imaging for surgical pathology.

NPJ Precis Oncol 2019 4;3:17. Epub 2019 Jul 4.

2Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.

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http://dx.doi.org/10.1038/s41698-019-0089-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609678PMC
July 2019

An update on the CNS manifestations of neurofibromatosis type 2.

Acta Neuropathol 2019 Jun 4. Epub 2019 Jun 4.

Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Hale Building for Transformative Medicine, BTM8002P, 60 Fenwood Road, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-019-02029-5DOI Listing
June 2019

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.

Clin Cancer Res 2019 Jun 18. Epub 2019 Jun 18.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0596DOI Listing
June 2019

New molecular targets in meningiomas: the present and the future.

Curr Opin Neurol 2018 12;31(6):740-746

Divisions of Neuro-Oncology and Hematology/Oncology, Departments of Neurology and Medicine, Massachusetts General Hospital/Harvard Medical School.

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http://Insights.ovid.com/crossref?an=00019052-201812000-0001
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http://dx.doi.org/10.1097/WCO.0000000000000615DOI Listing
December 2018

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

J Natl Cancer Inst 2018 12;110(12):1328-1341

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1093/jnci/djy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292796PMC
December 2018

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

J Neurooncol 2018 Nov 20;140(2):269-279. Epub 2018 Aug 20.

Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Suite C5086, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s11060-018-2978-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244779PMC
November 2018

Updates in prognostic markers for gliomas.

Neuro Oncol 2018 11;20(suppl_7):vii17-vii26

Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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https://academic.oup.com/neuro-oncology/article/20/suppl_7/v
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http://dx.doi.org/10.1093/neuonc/noy158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225747PMC
November 2018

Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema.

J Neuropathol Exp Neurol 2018 10;77(10):877-882

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/jnen/nly064DOI Listing
October 2018

Integrating Genomics Into Neuro-Oncology Clinical Trials and Practice.

Am Soc Clin Oncol Educ Book 2018 May;38:148-157

From the Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; MacFeeters Hamilton Centre for Neuro-Oncology Research, University of Toronto, Toronto, ON, Canada; Ludwig Center at Harvard, Department of Pathology, Boston Children's Hospital, and Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_200989DOI Listing
May 2018

Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor.

Digit J Ophthalmol 2017 31;23(4):22-26. Epub 2017 Dec 31.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.5693/djo.02.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791626PMC
March 2018

A case of molecularly profiled extraneural medulloblastoma metastases in a child.

BMC Med Genet 2018 01 17;19(1):10. Epub 2018 Jan 17.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Harvard Institute of Medicine, HIM-921F, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12881-018-0526-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772742PMC
January 2018

BAP1 mutations in high-grade meningioma: implications for patient care.

Neuro Oncol 2017 Oct;19(11):1447-1456

Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts; Ludwig Center at Harvard, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737364PMC
October 2017

Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region.

Am J Surg Pathol 2017 Oct;41(10):1410-1421

*Department of Pathology, Brigham and Women's Hospital, Harvard Medical School ‡Department of Pathology, Boston Children's Hospital, Harvard Medical School Departments of §Medical Oncology ¶Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA †Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO ∥East Pathology and Neuropathology Center, East Hospital Group, University Hospital of Lyon Bron, France.

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http://dx.doi.org/10.1097/PAS.0000000000000903DOI Listing
October 2017

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

Cell Commun Signal 2017 09 18;15(1):34. Epub 2017 Sep 18.

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12964-017-0189-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604305PMC
September 2017

Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas.

J Neurosurg 2017 08 25;127(2):438-444. Epub 2016 Nov 25.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.3171/2016.8.JNS161076DOI Listing
August 2017

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors.

Endocrinology 2017 07;158(7):2284-2291

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/en.2016-1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505210PMC
July 2017

Treatment of brain metastases in the modern genomic era.

Pharmacol Ther 2017 02 20;170:64-72. Epub 2016 Oct 20.

Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.10.011DOI Listing
February 2017

Fatal Eastern Equine Encephalitis in a Patient on Maintenance Rituximab: A Case Report.

Open Forum Infect Dis 2017 12;4(1):ofx021. Epub 2017 Feb 12.

Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/ofid/ofx021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414020PMC
February 2017

Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes.

Mod Pathol 2016 12 26;29(12):1446-1459. Epub 2016 Aug 26.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/modpathol.2016.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442446PMC
December 2016

Potential evolution of neurosurgical treatment paradigms for craniopharyngioma based on genomic and transcriptomic characteristics.

Neurosurg Focus 2016 Dec;41(6):E3

Pediatric Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado; and.

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http://dx.doi.org/10.3171/2016.9.FOCUS16308DOI Listing
December 2016

Susan Lindquist (1949-2016).

Science 2016 Nov;354(6315):974

Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.aal3609DOI Listing
November 2016

Genomic landscape of intracranial meningiomas.

J Neurosurg 2016 09 15;125(3):525-35. Epub 2016 Jan 15.

Department of Neurosurgery, Brigham and Women's Hospital;

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http://dx.doi.org/10.3171/2015.6.JNS15591DOI Listing
September 2016

Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

Cancer Res 2016 06 12;76(12):3451-62. Epub 2016 Apr 12.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911248PMC
June 2016

Checkpoint inhibition in meningiomas.

Immunotherapy 2016 06;8(6):721-31

Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.2217/imt-2016-0017DOI Listing
June 2016

: meningioma.

Neurooncol Pract 2016 Jun 13;3(2):120-134. Epub 2016 Jan 13.

Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA (S.E.F.); Department of Radiology, Mayo Clinic, Rochester, MN, USA (D.R.J., T.J.K.); Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (F.G.B.); Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (P.K.B.); Department of Neurology and Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA (J.L.C.); Department of Neurology, Karl Landsteiner University Clinic, St Pölten, Austria (S.O.); Department of Internal Medicine, Medical University, Vienna, CCC, Austria (M.P.); Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA (A.R.); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (S.S.); Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA (P.V.T.).

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http://dx.doi.org/10.1093/nop/npv063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668267PMC
June 2016

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.

Neuro Oncol 2016 05 28;18(5):649-55. Epub 2016 Jan 28.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (M.A., P.H.M., R.B., M.L.L., S.H.R., R.D.F., K.L.L., A.H.L., S.S.); Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia (M.A.); King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia (M.A.); Harvard Medical School, Boston, Massachusetts (M.A., A.A.A., D.D.-S., P.K.B., D.A.R., P.Y.W., O.A.-M., S.H.R., R.D.F., K.L.L., A.H.L., B.M.A., I.F.D., R.B., S.S.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., O.A.-M., I.F.D.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A., B.M.A.); Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (P.K.A.); Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (D.D.-S.); Center for Cancer Genomic Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts (A.R.T., P.V.H.); Department of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts (P.K.B.); Center of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R., P.Y.W, R.B.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (K.L.L., R.B.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (S.S.).

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http://dx.doi.org/10.1093/neuonc/nov316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827048PMC
May 2016

Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy.

J Clin Oncol 2016 Apr 4;34(10):e87-9. Epub 2014 Aug 4.

Harvard Medical School; and Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.51.1766DOI Listing
April 2016

ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma.

Eur J Endocrinol 2016 Apr 12;174(4):R139-44. Epub 2015 Nov 12.

Division of Neuro-OncologyMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USADepartment of Cancer BiologyDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USADepartment of PathologyBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USADepartment of PathologyBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Division of Neuro-OncologyMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USADepartment of Cancer BiologyDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USADepartment of PathologyBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USADepartment of PathologyBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Division of Neuro-OncologyMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USADepartment of Cancer BiologyDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USADepartment of PathologyBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USADepartment of PathologyBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

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http://dx.doi.org/10.1530/EJE-15-0957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876601PMC
April 2016

Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours.

J Pathol 2016 Mar;238(4):584-97

Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364032PMC
March 2016

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma.

Neuro Oncol 2016 Feb 30;18(2):269-74. Epub 2015 Aug 30.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (A.A.A., M.C.H., N.D.A., B.M.A.); Department of Pathology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (M.A., K.L.L., A.H.L., S.S.); Department of Neurosurgery, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (W.L.B., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (E.Q.L., L.N., M.L.R., A.D.N., D.A.R., P.Y.W., R.B.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/neuonc/nov177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724184PMC
February 2016

Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

J Natl Cancer Inst 2016 Feb 23;108(2). Epub 2015 Oct 23.

Department of Medicine (PKB, RS), Department of Neurology (PKB, CMG), Department of Neurosurgery (GMS, PJ, BN, DPC, WTC, FGB), Department of Surgical Oncology (DTF), Department of Pathology (GG, DNL), Cancer Center (PKB, CMG, NN, DNL), Department of Radiology (JR) Massachusetts General Hospital, Harvard Medical School, Boston, MA; Broad Institute (ATW, GG), Department of Pathology, (MA, SS) and Department of Neurosurgery, Brigham and Women's Hospital (IFD), Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (DJP).

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http://dx.doi.org/10.1093/jnci/djv310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862417PMC
February 2016

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.

Neuro Oncol 2015 Nov 29;17(11):1486-96. Epub 2015 Mar 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts (G.B., P.B., B.R.P., S.E.S., B.T., R.F.-L., C.S., R.S., R.B.); Broad Institute, Cambridge, Massachusetts (G.B., P.B., B.R.P., S.E.S., B.T., R.F.-L., T.G., R.B.); Pediatric Neuro-Oncology Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts (P.B., L.C.G., M.W.K.); Liver Cancer Program, Tisch Cancer Institute, Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York (Y.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.R., S.S., P.Y.W., A.H.L., K.L.L., J.A.C.); Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.R., L.R., B.R., C.L.M., K.L.L.); Department of Neurosurgery, Acibadem University Medical Center, Istanbul, Turkey (M.O.); Department of Pathology, Acibadem University Medical Center, Istanbul, Turkey (A.S.); Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts (L.C.G.); Departement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France (J.G.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.).

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http://dx.doi.org/10.1093/neuonc/nov045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648300PMC
November 2015

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

Neuro Oncol 2015 Oct 9;17(10):1344-55. Epub 2015 Mar 9.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.H.R., L.A.R., S.H., D.K., Y.J.K., K.L.L.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.E.S., L.B., M.B., D.A.R., E.Q.L., M.L.R., A.D.N., L.N., S.R., L.M.D., D.C.L., P.K., B.J.R., P.Y.W., R.B., K.L.L.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., E.B.C, O.A.-M., M.D.J., A.J.G., I.F.D., E.A.C.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Harvard Radiation Oncology Program, Boston, Massachusetts (A.R.); Kravis Center for Molecular Oncology & Department of Epidemiology and Biostatistics, Memorial Sloan- Kettering Cancer Center, New York, New York (N.S.); Broad Institute, Cambridge, Massachusetts (R.B.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., A.D., J.B.C., M.A., S.S., R.D.F., N.I.L., A.H.L., K.L.L.)

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http://dx.doi.org/10.1093/neuonc/nov015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578577PMC
October 2015

Intraoperative Magnetic Resonance Imaging in Intracranial Glioma Resection: A Single-Center, Retrospective Blinded Volumetric Study.

World Neurosurg 2015 Aug 1;84(2):528-36. Epub 2015 May 1.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.wneu.2015.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532608PMC
August 2015

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9978-83. Epub 2015 Jul 27.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

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http://www.pnas.org/content/112/32/9978.full.pdf
Web Search
http://www.pnas.org/lookup/doi/10.1073/pnas.1423101112
Publisher Site
http://dx.doi.org/10.1073/pnas.1423101112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538649PMC
August 2015

ARID1A and TERT promoter mutations in dedifferentiated meningioma.

Cancer Genet 2015 Jun 18;208(6):345-50. Epub 2015 Mar 18.

Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882906PMC
June 2015

Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia.

Mod Pathol 2015 Apr 21;28(4):596-606. Epub 2014 Nov 21.

1] Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/modpathol2014150
Publisher Site
http://dx.doi.org/10.1038/modpathol.2014.150DOI Listing
April 2015

Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making.

Int J Mass Spectrom 2015 Feb;377:690-698

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 ; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 ; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115.

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http://linkinghub.elsevier.com/retrieve/pii/S138738061400250
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http://dx.doi.org/10.1016/j.ijms.2014.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379512PMC
February 2015

Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy.

Expert Rev Anticancer Ther 2014 Dec 27;14(12):1385-9. Epub 2014 Sep 27.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1586/14737140.2014.956096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688891PMC
December 2014

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

Proc Natl Acad Sci U S A 2014 Dec 8;111(51):18297-302. Epub 2014 Dec 8.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142; and Howard Hughes Medical Institute, Cambridge, MA 02142

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http://dx.doi.org/10.1073/pnas.1421323111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280614PMC
December 2014

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma.

Neuro Oncol 2014 Nov 2;16(11):1547-53. Epub 2014 Jun 2.

Harvard Radiation Oncology Program, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A.); Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (N.D.A., B.M.A.); Department of Biostatistics, Dana-Farber Cancer Institute, Boston, Massachusetts (P.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C., A.J.G., M.D.J., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (P.Y.W., D.A.R., E.Q.L., L.N., M.L.R., R.B.); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (S.E.W.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., S.S., M.A.).

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http://dx.doi.org/10.1093/neuonc/nou098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201070PMC
November 2014

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.

Proc Natl Acad Sci U S A 2014 Jul 30;111(30):11121-6. Epub 2014 Jun 30.

Department of Cancer Biology, Harvard Medical School and Dana-Farber Cancer Institute, Boston, MA 02115;Neurosurgery, andRadiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121790PMC
July 2014

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Cell 2014 Jul;158(3):564-78

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249939PMC
July 2014

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.

Proteomics 2014 May 17;14(10):1152-7. Epub 2014 Apr 17.

Department of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, MA, USA; Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA; Department of Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA.

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http://dx.doi.org/10.1002/pmic.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507715PMC
May 2014

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02.

Neuro Oncol 2014 Apr 26;16(4):567-78. Epub 2014 Jan 26.

Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (P.Y.W., A.D.N., J.D.); Department of Neurosurgery, University of California, San Francisco, San Francisco, California (S.M.C., K.R.L., M.D.P.); University of Texas Health Science Center, San Antonio, Texas (J.G.K.); Division of Neuro-Oncology, Department of Neurology, University of California, Los Angeles, Los Angeles, California (T.F.C.); University of Wisconsin, Madison Wisconsin (H.I.R., M.P.M.); Neurooncology Program, Division of Hematology/Oncology, University of Pittsburgh Medical Center Cancer Pavilion, Pittsburgh, Pennsylvania (F.S.L.); Division of Neuro-Oncology, MD Anderson Cancer Center, Houston, Texas (M.R.G., M.D.G., W.K.A.Y., K.D.A.); Center for Molecular Oncologic Pathology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (S.S., A.H.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.S., A.H.L., K.L.L.); Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland (J.D.*, J.J.W.).

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http://dx.doi.org/10.1093/neuonc/not247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956354PMC
April 2014

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.

J Med Chem 2014 Apr 25;57(7):2851-63. Epub 2014 Mar 25.

SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona , 250 East Valencia Road, Tucson, Arizona 85706, United States.

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http://dx.doi.org/10.1021/jm401279nDOI Listing
April 2014

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Nat Genet 2014 Feb 12;46(2):161-5. Epub 2014 Jan 12.

1] Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA. [4] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.2868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982316PMC
February 2014

Mass spectrometry imaging as a tool for surgical decision-making.

J Mass Spectrom 2013 Nov;48(11):1178-87

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1002/jms.3295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957233PMC
November 2013

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.

J Clin Invest 2012 Oct 4;122(10):3742-54. Epub 2012 Sep 4.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

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http://www.jci.org/articles/view/62727
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http://dx.doi.org/10.1172/JCI62727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461912PMC
October 2012

Relapsing tumefactive lesion in an adult with medulloblastoma previously treated with chemoradiotherapy and stem cell transplant.

Pathol Oncol Res 2012 Apr 28;18(2):539-43. Epub 2011 Sep 28.

Department of Neurosciences, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1007/s12253-011-9464-xDOI Listing
April 2012

Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

ACS Chem Biol 2012 Feb 30;7(2):340-9. Epub 2011 Nov 30.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291478PMC
February 2012

Classifying human brain tumors by lipid imaging with mass spectrometry.

Cancer Res 2012 Feb 2;72(3):645-54. Epub 2011 Dec 2.

Department of Chemistry and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271168PMC
February 2012

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Proc Natl Acad Sci U S A 2011 Nov 31;108(45):18378-83. Epub 2011 Oct 31.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1115031108
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http://dx.doi.org/10.1073/pnas.1115031108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215027PMC
November 2011