Sandra Ryeom

Sandra Ryeom

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Sandra Ryeom

Sandra Ryeom

Publications by authors named "Sandra Ryeom"

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KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem-Like Cells and Promotes Metastasis.

Mol Cancer Res 2019 09 19;17(9):1945-1957. Epub 2019 Jun 19.

Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726517PMC
September 2019

Testicular endothelial cells promote self-renewal of spermatogonial stem cells in rats†.

Biol Reprod 2019 Aug;101(2):360-367

Department of Animal Science and Technology, Chung-Ang University, Anseong, Republic of Korea.

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https://academic.oup.com/biolreprod/article/101/2/360/551399
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http://dx.doi.org/10.1093/biolre/ioz105DOI Listing
August 2019

Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype.

Cancer Res 2019 Aug 12;79(15):3928-3939. Epub 2019 Jun 12.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679769PMC
August 2019

Testicular endothelial cells are a critical population in the germline stem cell niche.

Nat Commun 2018 10 22;9(1):4379. Epub 2018 Oct 22.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-018-06881-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197186PMC
October 2018

Detection of Oncogene-Induced Senescence In Vivo.

Methods Mol Biol 2017 ;1534:185-198

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Room 752 BRB II/III, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-6670-7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449035PMC
January 2018

E-cadherin and K-ras: implications of a newly developed model of gastric cancer.

Oncoscience 2017 Nov 28;4(11-12):162-163. Epub 2017 Nov 28.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncoscience.379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769975PMC
November 2017

Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression.

Cancer Res 2017 10 31;77(19):5349-5359. Epub 2017 Jul 31.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626624PMC
October 2017

Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.

Mol Cancer Res 2017 08 1;15(8):1106-1116. Epub 2017 May 1.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540756PMC
August 2017

Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.

Oncotarget 2016 10;7(40):65429-65440

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.18632/oncotarget.11748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323166PMC
October 2016

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.

PLoS Genet 2015 Jun 23;11(6):e1005212. Epub 2015 Jun 23.

Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477940PMC
June 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma.

Sci Rep 2015 Jun 30;5:11781. Epub 2015 Jun 30.

Deparment of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA 19104.

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http://dx.doi.org/10.1038/srep11781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485314PMC
June 2015

Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species.

Mol Cancer Res 2014 Nov 9;12(11):1663-76. Epub 2014 Jul 9.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233164PMC
November 2014

Concomitant low-dose doxorubicin treatment and exercise.

Am J Physiol Regul Integr Comp Physiol 2014 Sep 9;307(6):R685-92. Epub 2014 Jul 9.

School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1152/ajpregu.00082.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166763PMC
September 2014

Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.

Cancer Res 2014 Apr 3;74(8):2171-81. Epub 2014 Mar 3.

Authors' Affiliations: Department of Cancer Biology, Abramson Family Cancer Research Institute; Department of Microbiology, Institute for Immunology, Perelman School of Medicine; Department of Pathobiology, Veterinary School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Children's Hospital, Boston, Massachusetts; and Department of Molecular and Cellular Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061618PMC
April 2014

Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Cell 2014 Jan;156(3):440-55

Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140000
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http://dx.doi.org/10.1016/j.cell.2013.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951122PMC
January 2014

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.

Blood 2013 Apr 27;121(16):3205-15. Epub 2013 Feb 27.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2012-04-421172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630833PMC
April 2013

Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials.

Curr Angiogenes 2012 Sep;1(3):169-179

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA ; Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069862PMC
http://dx.doi.org/10.2174/2211552811201030169DOI Listing
September 2012

The cautionary tale of side effects of chronic Notch1 inhibition.

Authors:
Sandra W Ryeom

J Clin Invest 2011 Feb 25;121(2):508-9. Epub 2011 Jan 25.

Department of Cancer Biology, University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, 311 BRB, 421 Curie Boulevard, Philadelphia, Pennsylvania 19106, USA.

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http://dx.doi.org/10.1172/JCI45976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026750PMC
February 2011

Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment.

Cancer Res 2010 Nov 26;70(21):8357-67. Epub 2010 Oct 26.

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970713PMC
November 2010

Regional control of tumor growth.

Mol Cancer Res 2010 Sep 24;8(9):1198-206. Epub 2010 Aug 24.

Vascular Biology Program and Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044487PMC
September 2010

Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.

Blood 2010 Jun 19;115(22):4605-13. Epub 2010 Jan 19.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-09-242065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881490PMC
June 2010

Role of endogenous angiogenesis inhibitors in Down syndrome.

J Craniofac Surg 2009 Mar;20 Suppl 1:595-6

Vascular Biology Program, Department of Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/scs.0b013e3181927f47DOI Listing
March 2009

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.

Cancer Cell 2008 May;13(5):420-31

Vascular Biology Program, Department of Surgery, Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.02.018DOI Listing
May 2008

Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.

Clin Cancer Res 2008 Mar;14(5):1529-39

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4126DOI Listing
March 2008

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium.

Mol Cancer Ther 2008 Feb 1;7(2):418-24. Epub 2008 Feb 1.

Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0568DOI Listing
February 2008

TORC1 is essential for NF1-associated malignancies.

Curr Biol 2008 Jan 27;18(1):56-62. Epub 2007 Dec 27.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Ludwig Center at Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2007.11.066DOI Listing
January 2008

Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.

J Surg Res 2007 Sep 5;142(1):129-36. Epub 2007 Jul 5.

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.jss.2006.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995402PMC
September 2007

Endothelial progenitor cells contribute to accelerated liver regeneration.

J Pediatr Surg 2007 Jul;42(7):1190-8

Vascular Biology Program, Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jpedsurg.2007.02.034DOI Listing
July 2007

Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression.

J Surg Res 2006 Oct;135(2):282-90

Department of Surgery, Massachusetts General Hospital, Division of Surgical Oncology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jss.2006.01.023DOI Listing
October 2006

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.

Proc Natl Acad Sci U S A 2006 Oct 20;103(44):16266-71. Epub 2006 Oct 20.

Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, CCSR Building, Room 1120, 269 Campus Drive, Stanford, CA 94305-5151, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0608017103
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http://dx.doi.org/10.1073/pnas.0608017103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637571PMC
October 2006

Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A.

Cancer Res 2005 Jul;65(13):5881-9

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4078DOI Listing
July 2005

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin.

Nat Immunol 2003 Sep 17;4(9):874-81. Epub 2003 Aug 17.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ni966DOI Listing
September 2003