Dr. Sandra Orsulic, Ph.D. - Massachusetts General Hospital

Dr. Sandra Orsulic

Ph.D.

Massachusetts General Hospital

United States

Dr. Sandra Orsulic, Ph.D. - Massachusetts General Hospital

Dr. Sandra Orsulic

Ph.D.

Introduction

Primary Affiliation: Massachusetts General Hospital - United States

Publications

50Publications

1905Reads

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1675PubMed Central Citations

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Authors:
Antoinette Hollestelle Frederieke H van der Baan Andrew Berchuck Sharon E Johnatty Katja K Aben Bjarni A Agnarsson Kristiina Aittomäki Elisa Alducci Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Antonis C Antoniou Carmel Apicella Volker Arndt Norbert Arnold Banu K Arun Brita Arver Alan Ashworth Laura Baglietto Rosemary Balleine Elisa V Bandera Daniel Barrowdale Yukie T Bean Lars Beckmann Matthias W Beckmann Javier Benitez Andreas Berger Raanan Berger Benoit Beuselinck Maria Bisogna Line Bjorge Carl Blomqvist Natalia V Bogdanova Anders Bojesen Stig E Bojesen Manjeet K Bolla Bernardo Bonanni Judith S Brand Hiltrud Brauch Hermann Brenner Louise Brinton Angela Brooks-Wilson Fiona Bruinsma Joan Brunet Thomas Brüning Agnieszka Budzilowska Clareann H Bunker Barbara Burwinkel Ralf Butzow Saundra S Buys Maria A Caligo Ian Campbell Jonathan Carter Jenny Chang-Claude Stephen J Chanock Kathleen B M Claes J Margriet Collée Linda S Cook Fergus J Couch Angela Cox Daniel Cramer Simon S Cross Julie M Cunningham Cezary Cybulski Kamila Czene Francesca Damiola Agnieszka Dansonka-Mieszkowska Hatef Darabi Miguel de la Hoya Anna deFazio Joseph Dennis Peter Devilee Ed M Dicks Orland Diez Jennifer A Doherty Susan M Domchek Cecilia M Dorfling Thilo Dörk Isabel Dos Santos Silva Andreas du Bois Martine Dumont Alison M Dunning Mercedes Duran Douglas F Easton Diana Eccles Robert P Edwards Hans Ehrencrona Bent Ejlertsen Arif B Ekici Steve D Ellis Christoph Engel Mikael Eriksson Peter A Fasching Lidia Feliubadalo Jonine Figueroa Dieter Flesch-Janys Olivia Fletcher Annette Fontaine Stefano Fortuzzi Florentia Fostira Brooke L Fridley Tara Friebel Eitan Friedman Grace Friel Debra Frost Judy Garber Montserrat García-Closas Simon A Gayther Aleksandra Gentry-Maharaj Anne-Marie Gerdes Graham G Giles Rosalind Glasspool Gord Glendon Andrew K Godwin Marc T Goodman Martin Gore Mark H Greene Mervi Grip Jacek Gronwald Daphne Gschwantler Kaulich Pascal Guénel Starr R Guzman Lothar Haeberle Christopher A Haiman Per Hall Sandra L Halverson Ute Hamann Thomas V O Hansen Philipp Harter Jaana M Hartikainen Sue Healey Alexander Hein Florian Heitz Brian E Henderson Josef Herzog Michelle A T Hildebrandt Claus K Høgdall Estrid Høgdall Frans B L Hogervorst John L Hopper Keith Humphreys Tomasz Huzarski Evgeny N Imyanitov Claudine Isaacs Anna Jakubowska Ramunas Janavicius Katarzyna Jaworska Allan Jensen Uffe Birk Jensen Nichola Johnson Arja Jukkola-Vuorinen Maria Kabisch Beth Y Karlan Vesa Kataja Noah Kauff Linda E Kelemen Michael J Kerin Lambertus A Kiemeney Susanne K Kjaer Julia A Knight Jacoba P Knol-Bout Irene Konstantopoulou Veli-Matti Kosma Camilla Krakstad Vessela Kristensen Karoline B Kuchenbaecker Jolanta Kupryjanczyk Yael Laitman Diether Lambrechts Sandrina Lambrechts Melissa C Larson Adriana Lasa Pierre Laurent-Puig Conxi Lazaro Nhu D Le Loic Le Marchand Arto Leminen Jenny Lester Douglas A Levine Jingmei Li Dong Liang Annika Lindblom Noralane Lindor Jolanta Lissowska Jirong Long Karen H Lu Jan Lubinski Lene Lundvall Galina Lurie Phuong L Mai Arto Mannermaa Sara Margolin Frederique Mariette Frederik Marme John W M Martens Leon F A G Massuger Christine Maugard Sylvie Mazoyer Lesley McGuffog Valerie McGuire Catriona McLean Iain McNeish Alfons Meindl Florence Menegaux Primitiva Menéndez Janusz Menkiszak Usha Menon Arjen R Mensenkamp Nicola Miller Roger L Milne Francesmary Modugno Marco Montagna Kirsten B Moysich Heiko Müller Anna Marie Mulligan Taru A Muranen Steven A Narod Katherine L Nathanson Roberta B Ness Susan L Neuhausen Heli Nevanlinna Patrick Neven Finn C Nielsen Sune F Nielsen Børge G Nordestgaard Robert L Nussbaum Kunle Odunsi Kenneth Offit Edith Olah Olufunmilayo I Olopade Janet E Olson Sara H Olson Jan C Oosterwijk Irene Orlow Nick Orr Sandra Orsulic Ana Osorio Laura Ottini James Paul Celeste L Pearce Inge Sokilde Pedersen Bernard Peissel Tanja Pejovic Liisa M Pelttari Jo Perkins Jenny Permuth-Wey Paolo Peterlongo Julian Peto Catherine M Phelan Kelly-Anne Phillips Marion Piedmonte Malcolm C Pike Radka Platte Joanna Plisiecka-Halasa Elizabeth M Poole Bruce Poppe Katri Pylkäs Paolo Radice Susan J Ramus Timothy R Rebbeck Malcolm W R Reed Gad Rennert Harvey A Risch Mark Robson Gustavo C Rodriguez Atocha Romero Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo Runnebaum Ritu Salani Helga B Salvesen Elinor J Sawyer Joellen M Schildkraut Marjanka K Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Michael G Schrauder Fredrick Schumacher Ira Schwaab Giulietta Scuvera Thomas A Sellers Gianluca Severi Caroline M Seynaeve Mitul Shah Martha Shrubsole Nadeem Siddiqui Weiva Sieh Jacques Simard Christian F Singer Olga M Sinilnikova Dominiek Smeets Christof Sohn Maria Soller Honglin Song Penny Soucy Melissa C Southey Christa Stegmaier Dominique Stoppa-Lyonnet Lara Sucheston Anthony Swerdlow Ingvild L Tangen Muy-Kheng Tea Manuel R Teixeira Kathryn L Terry Mary Beth Terry Mads Thomassen Pamela J Thompson Laima Tihomirova Marc Tischkowitz Amanda Ewart Toland Rob A E M Tollenaar Ian Tomlinson Diana Torres Thérèse Truong Helen Tsimiklis Nadine Tung Shelley S Tworoger Jonathan P Tyrer Celine M Vachon Laura J Van 't Veer Anne M van Altena C J Van Asperen David van den Berg Ans M W van den Ouweland Helena C van Doorn Els Van Nieuwenhuysen Elizabeth J van Rensburg Ignace Vergote Senno Verhoef Robert A Vierkant Joseph Vijai Allison F Vitonis Anna von Wachenfeldt Christine Walsh Qin Wang Shan Wang-Gohrke Barbara Wappenschmidt Maren Weischer Jeffrey N Weitzel Caroline Weltens Nicolas Wentzensen Alice S Whittemore Lynne R Wilkens Robert Winqvist Anna H Wu Xifeng Wu Hannah P Yang Daniela Zaffaroni M Pilar Zamora Wei Zheng Argyrios Ziogas Georgia Chenevix-Trench Paul D P Pharoah Matti A Rookus Maartje J Hooning Ellen L Goode

Gynecol Oncol 2016 05 2;141(2):386-401. Epub 2015 May 2.

Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.ygyno.2015.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630206PMC
May 2016
71 Reads
1 Citation
3.774 Impact Factor

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.

Authors:
Ganna Chornokur Hui-Yi Lin Jonathan P Tyrer Kate Lawrenson Joe Dennis Ernest K Amankwah Xiaotao Qu Ya-Yu Tsai Heather S L Jim Zhihua Chen Ann Y Chen Jennifer Permuth-Wey Katja K H Aben Hoda Anton-Culver Natalia Antonenkova Fiona Bruinsma Elisa V Bandera Yukie T Bean Matthias W Beckmann Maria Bisogna Line Bjorge Natalia Bogdanova Louise A Brinton Angela Brooks-Wilson Clareann H Bunker Ralf Butzow Ian G Campbell Karen Carty Jenny Chang-Claude Linda S Cook Daniel W Cramer Julie M Cunningham Cezary Cybulski Agnieszka Dansonka-Mieszkowska Andreas du Bois Evelyn Despierre Ed Dicks Jennifer A Doherty Thilo Dörk Matthias Dürst Douglas F Easton Diana M Eccles Robert P Edwards Arif B Ekici Peter A Fasching Brooke L Fridley Yu-Tang Gao Aleksandra Gentry-Maharaj Graham G Giles Rosalind Glasspool Marc T Goodman Jacek Gronwald Patricia Harrington Philipp Harter Alexander Hein Florian Heitz Michelle A T Hildebrandt Peter Hillemanns Claus K Hogdall Estrid Hogdall Satoyo Hosono Anna Jakubowska Allan Jensen Bu-Tian Ji Beth Y Karlan Linda E Kelemen Mellissa Kellar Lambertus A Kiemeney Camilla Krakstad Susanne K Kjaer Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Nhu D Le Alice W Lee Shashi Lele Arto Leminen Jenny Lester Douglas A Levine Dong Liang Boon Kiong Lim Jolanta Lissowska Karen Lu Jan Lubinski Lene Lundvall Leon F A G Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Iain McNeish Usha Menon Roger L Milne Francesmary Modugno Kirsten B Moysich Roberta B Ness Heli Nevanlinna Ursula Eilber Kunle Odunsi Sara H Olson Irene Orlow Sandra Orsulic Rachel Palmieri Weber James Paul Celeste L Pearce Tanja Pejovic Liisa M Pelttari Malcolm C Pike Elizabeth M Poole Harvey A Risch Barry Rosen Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Eva Schernhammer Ira Schwaab Xiao-Ou Shu Yurii B Shvetsov Nadeem Siddiqui Weiva Sieh Honglin Song Melissa C Southey Beata Spiewankiewicz Lara Sucheston Soo-Hwang Teo Kathryn L Terry Pamela J Thompson Lotte Thomsen Ingvild L Tangen Shelley S Tworoger Anne M van Altena Robert A Vierkant Ignace Vergote Christine S Walsh Shan Wang-Gohrke Nicolas Wentzensen Alice S Whittemore Kristine G Wicklund Lynne R Wilkens Anna H Wu Xifeng Wu Yin-Ling Woo Hannah Yang Wei Zheng Argyrios Ziogas Hanis N Hasmad Andrew Berchuck Edwin S Iversen Joellen M Schildkraut Susan J Ramus Ellen L Goode Alvaro N A Monteiro Simon A Gayther Steven A Narod Paul D P Pharoah Thomas A Sellers Catherine M Phelan

PLoS One 2015 19;10(6):e0128106. Epub 2015 Jun 19.

Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.

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http://eprints.soton.ac.uk/382464/1/__userfiles.soton.ac.uk_
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http://dx.plos.org/10.1371/journal.pone.0128106
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128106PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474865PMC
April 2016
157 Reads
6 Citations
3.234 Impact Factor

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.

Authors:
Sharon E Johnatty Jonathan P Tyrer Siddhartha Kar Jonathan Beesley Yi Lu Bo Gao Peter A Fasching Alexander Hein Arif B Ekici Matthias W Beckmann Diether Lambrechts Els Van Nieuwenhuysen Ignace Vergote Sandrina Lambrechts Mary Anne Rossing Jennifer A Doherty Jenny Chang-Claude Francesmary Modugno Roberta B Ness Kirsten B Moysich Douglas A Levine Lambertus A Kiemeney Leon F A G Massuger Jacek Gronwald Jan Lubiński Anna Jakubowska Cezary Cybulski Louise Brinton Jolanta Lissowska Nicolas Wentzensen Honglin Song Valerie Rhenius Ian Campbell Diana Eccles Weiva Sieh Alice S Whittemore Valerie McGuire Joseph H Rothstein Rebecca Sutphen Hoda Anton-Culver Argyrios Ziogas Simon A Gayther Aleksandra Gentry-Maharaj Usha Menon Susan J Ramus Celeste L Pearce Malcolm C Pike Daniel O Stram Anna H Wu Jolanta Kupryjanczyk Agnieszka Dansonka-Mieszkowska Iwona K Rzepecka Beata Spiewankiewicz Marc T Goodman Lynne R Wilkens Michael E Carney Pamela J Thompson Florian Heitz Andreas du Bois Ira Schwaab Philipp Harter Jacobus Pisterer Peter Hillemanns Beth Y Karlan Christine Walsh Jenny Lester Sandra Orsulic Stacey J Winham Madalene Earp Melissa C Larson Zachary C Fogarty Estrid Høgdall Allan Jensen Susanne Kruger Kjaer Brooke L Fridley Julie M Cunningham Robert A Vierkant Joellen M Schildkraut Edwin S Iversen Kathryn L Terry Daniel W Cramer Elisa V Bandera Irene Orlow Tanja Pejovic Yukie Bean Claus Høgdall Lene Lundvall Ian McNeish James Paul Karen Carty Nadeem Siddiqui Rosalind Glasspool Thomas Sellers Catherine Kennedy Yoke-Eng Chiew Andrew Berchuck Stuart MacGregor Paul D P Pharoah Ellen L Goode Anna deFazio Penelope M Webb Georgia Chenevix-Trench

Clin Cancer Res 2015 Dec 7;21(23):5264-76. Epub 2015 Jul 7.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624261PMC
December 2015
68 Reads
7 Citations
8.722 Impact Factor

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Authors:
Siddhartha P Kar Jonathan P Tyrer Qiyuan Li Kate Lawrenson Katja K H Aben Hoda Anton-Culver Natalia Antonenkova Georgia Chenevix-Trench Helen Baker Elisa V Bandera Yukie T Bean Matthias W Beckmann Andrew Berchuck Maria Bisogna Line Bjørge Natalia Bogdanova Louise Brinton Angela Brooks-Wilson Ralf Butzow Ian Campbell Karen Carty Jenny Chang-Claude Yian Ann Chen Zhihua Chen Linda S Cook Daniel Cramer Julie M Cunningham Cezary Cybulski Agnieszka Dansonka-Mieszkowska Joe Dennis Ed Dicks Jennifer A Doherty Thilo Dörk Andreas du Bois Matthias Dürst Diana Eccles Douglas F Easton Robert P Edwards Arif B Ekici Peter A Fasching Brooke L Fridley Yu-Tang Gao Aleksandra Gentry-Maharaj Graham G Giles Rosalind Glasspool Ellen L Goode Marc T Goodman Jacek Grownwald Patricia Harrington Philipp Harter Alexander Hein Florian Heitz Michelle A T Hildebrandt Peter Hillemanns Estrid Hogdall Claus K Hogdall Satoyo Hosono Edwin S Iversen Anna Jakubowska James Paul Allan Jensen Bu-Tian Ji Beth Y Karlan Susanne K Kjaer Linda E Kelemen Melissa Kellar Joseph Kelley Lambertus A Kiemeney Camilla Krakstad Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Nhu D Le Alice W Lee Shashi Lele Arto Leminen Jenny Lester Douglas A Levine Dong Liang Jolanta Lissowska Karen Lu Jan Lubinski Lene Lundvall Leon Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Iain A McNeish Usha Menon Francesmary Modugno Kirsten B Moysich Steven A Narod Lotte Nedergaard Roberta B Ness Heli Nevanlinna Kunle Odunsi Sara H Olson Irene Orlow Sandra Orsulic Rachel Palmieri Weber Celeste Leigh Pearce Tanja Pejovic Liisa M Pelttari Jennifer Permuth-Wey Catherine M Phelan Malcolm C Pike Elizabeth M Poole Susan J Ramus Harvey A Risch Barry Rosen Mary Anne Rossing Joseph H Rothstein Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Joellen M Schildkraut Ira Schwaab Xiao-Ou Shu Yurii B Shvetsov Nadeem Siddiqui Weiva Sieh Honglin Song Melissa C Southey Lara E Sucheston-Campbell Ingvild L Tangen Soo-Hwang Teo Kathryn L Terry Pamela J Thompson Agnieszka Timorek Ya-Yu Tsai Shelley S Tworoger Anne M van Altena Els Van Nieuwenhuysen Ignace Vergote Robert A Vierkant Shan Wang-Gohrke Christine Walsh Nicolas Wentzensen Alice S Whittemore Kristine G Wicklund Lynne R Wilkens Yin-Ling Woo Xifeng Wu Anna Wu Hannah Yang Wei Zheng Argyrios Ziogas Thomas A Sellers Alvaro N A Monteiro Matthew L Freedman Simon A Gayther Paul D P Pharoah

Cancer Epidemiol Biomarkers Prev 2015 Oct 24;24(10):1574-84. Epub 2015 Jul 24.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592449PMC
October 2015
103 Reads
7 Citations
4.125 Impact Factor

Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.

Cancer Immunol Res 2015 Sep 8;3(9):1030-41. Epub 2015 Jun 8.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0073DOI Listing
September 2015
50 Reads
19 Citations

Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy.

J Cancer Res Clin Oncol 2015 Aug 30;141(8):1363-9. Epub 2014 Dec 30.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA,

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http://dx.doi.org/10.1007/s00432-014-1904-zDOI Listing
August 2015
8 Reads
2 Citations
3.081 Impact Factor

The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancer.

Biochem Biophys Res Commun 2015 Aug 3;463(4):551-6. Epub 2015 Jun 3.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.05.083DOI Listing
August 2015
75 Reads
16 Citations
2.300 Impact Factor

Reduced expression and growth inhibitory activity of the aging suppressor klotho in epithelial ovarian cancer.

Cancer Lett 2015 Jul 28;362(2):149-57. Epub 2015 Mar 28.

Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.035DOI Listing
July 2015
37 Reads
6 Citations
5.621 Impact Factor

ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.

Carcinogenesis 2015 Jul 29;36(7):739-47. Epub 2015 Apr 29.

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA and

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http://dx.doi.org/10.1093/carcin/bgv059DOI Listing
July 2015
7 Reads
5 Citations
5.334 Impact Factor

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.

Authors:
Sophie Blein Claire Bardel Vincent Danjean Lesley McGuffog Sue Healey Daniel Barrowdale Andrew Lee Joe Dennis Karoline B Kuchenbaecker Penny Soucy Mary Beth Terry Wendy K Chung David E Goldgar Saundra S Buys Ramunas Janavicius Laima Tihomirova Nadine Tung Cecilia M Dorfling Elizabeth J van Rensburg Susan L Neuhausen Yuan Chun Ding Anne-Marie Gerdes Bent Ejlertsen Finn C Nielsen Thomas Vo Hansen Ana Osorio Javier Benitez Raquel Andrés Conejero Ena Segota Jeffrey N Weitzel Margo Thelander Paolo Peterlongo Paolo Radice Valeria Pensotti Riccardo Dolcetti Bernardo Bonanni Bernard Peissel Daniela Zaffaroni Giulietta Scuvera Siranoush Manoukian Liliana Varesco Gabriele L Capone Laura Papi Laura Ottini Drakoulis Yannoukakos Irene Konstantopoulou Judy Garber Ute Hamann Alan Donaldson Angela Brady Carole Brewer Claire Foo D Gareth Evans Debra Frost Diana Eccles Fiona Douglas Jackie Cook Julian Adlard Julian Barwell Lisa Walker Louise Izatt Lucy E Side M John Kennedy Marc Tischkowitz Mark T Rogers Mary E Porteous Patrick J Morrison Radka Platte Ros Eeles Rosemarie Davidson Shirley Hodgson Trevor Cole Andrew K Godwin Claudine Isaacs Kathleen Claes Kim De Leeneer Alfons Meindl Andrea Gehrig Barbara Wappenschmidt Christian Sutter Christoph Engel Dieter Niederacher Doris Steinemann Hansjoerg Plendl Karin Kast Kerstin Rhiem Nina Ditsch Norbert Arnold Raymonda Varon-Mateeva Rita K Schmutzler Sabine Preisler-Adams Nadja Bogdanova Markov Shan Wang-Gohrke Antoine de Pauw Cédrick Lefol Christine Lasset Dominique Leroux Etienne Rouleau Francesca Damiola Hélène Dreyfus Laure Barjhoux Lisa Golmard Nancy Uhrhammer Valérie Bonadona Valérie Sornin Yves-Jean Bignon Jonathan Carter Linda Van Le Marion Piedmonte Paul A DiSilvestro Miguel de la Hoya Trinidad Caldes Heli Nevanlinna Kristiina Aittomäki Agnes Jager Ans Mw van den Ouweland Carolien M Kets Cora M Aalfs Flora E van Leeuwen Frans Bl Hogervorst Hanne Ej Meijers-Heijboer Jan C Oosterwijk Kees Ep van Roozendaal Matti A Rookus Peter Devilee Rob B van der Luijt Edith Olah Orland Diez Alex Teulé Conxi Lazaro Ignacio Blanco Jesús Del Valle Anna Jakubowska Grzegorz Sukiennicki Jacek Gronwald Jan Lubinski Katarzyna Durda Katarzyna Jaworska-Bieniek Bjarni A Agnarsson Christine Maugard Alberto Amadori Marco Montagna Manuel R Teixeira Amanda B Spurdle William Foulkes Curtis Olswold Noralane M Lindor Vernon S Pankratz Csilla I Szabo Anne Lincoln Lauren Jacobs Marina Corines Mark Robson Joseph Vijai Andreas Berger Anneliese Fink-Retter Christian F Singer Christine Rappaport Daphne Geschwantler Kaulich Georg Pfeiler Muy-Kheng Tea Mark H Greene Phuong L Mai Gad Rennert Evgeny N Imyanitov Anna Marie Mulligan Gord Glendon Irene L Andrulis Sandrine Tchatchou Amanda Ewart Toland Inge Sokilde Pedersen Mads Thomassen Torben A Kruse Uffe Birk Jensen Maria A Caligo Eitan Friedman Jamal Zidan Yael Laitman Annika Lindblom Beatrice Melin Brita Arver Niklas Loman Richard Rosenquist Olufunmilayo I Olopade Robert L Nussbaum Susan J Ramus Katherine L Nathanson Susan M Domchek Timothy R Rebbeck Banu K Arun Gillian Mitchell Beth Y Karlan Jenny Lester Sandra Orsulic Dominique Stoppa-Lyonnet Gilles Thomas Jacques Simard Fergus J Couch Kenneth Offit Douglas F Easton Georgia Chenevix-Trench Antonis C Antoniou Sylvie Mazoyer Catherine M Phelan Olga M Sinilnikova David G Cox

Breast Cancer Res 2015 Apr 25;17:61. Epub 2015 Apr 25.

INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

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http://dx.doi.org/10.1186/s13058-015-0567-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478717PMC
April 2015
112 Reads
3 Citations

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Authors:
Alice W Lee Jonathan P Tyrer Jennifer A Doherty Douglas A Stram Jolanta Kupryjanczyk Agnieszka Dansonka-Mieszkowska Joanna Plisiecka-Halasa Beata Spiewankiewicz Emily J Myers Georgia Chenevix-Trench Peter A Fasching Matthias W Beckmann Arif B Ekici Alexander Hein Ignace Vergote Els Van Nieuwenhuysen Diether Lambrechts Kristine G Wicklund Ursula Eilber Shan Wang-Gohrke Jenny Chang-Claude Anja Rudolph Lara Sucheston-Campbell Kunle Odunsi Kirsten B Moysich Yurii B Shvetsov Pamela J Thompson Marc T Goodman Lynne R Wilkens Thilo Dörk Peter Hillemanns Matthias Dürst Ingo B Runnebaum Natalia Bogdanova Liisa M Pelttari Heli Nevanlinna Arto Leminen Robert P Edwards Joseph L Kelley Philipp Harter Ira Schwaab Florian Heitz Andreas du Bois Sandra Orsulic Jenny Lester Christine Walsh Beth Y Karlan Estrid Hogdall Susanne K Kjaer Allan Jensen Robert A Vierkant Julie M Cunningham Ellen L Goode Brooke L Fridley Melissa C Southey Graham G Giles Fiona Bruinsma Xifeng Wu Michelle A T Hildebrandt Karen Lu Dong Liang Maria Bisogna Douglas A Levine Rachel Palmieri Weber Joellen M Schildkraut Edwin S Iversen Andrew Berchuck Kathryn L Terry Daniel W Cramer Shelley S Tworoger Elizabeth M Poole Sara H Olson Irene Orlow Elisa V Bandera Line Bjorge Ingvild L Tangen Helga B Salvesen Camilla Krakstad Leon F A G Massuger Lambertus A Kiemeney Katja K H Aben Anne M van Altena Yukie Bean Tanja Pejovic Melissa Kellar Nhu D Le Linda S Cook Linda E Kelemen Angela Brooks-Wilson Jan Lubinski Jacek Gronwald Cezary Cybulski Anna Jakubowska Nicolas Wentzensen Louise A Brinton Jolanta Lissowska Hannah Yang Lotte Nedergaard Lene Lundvall Claus Hogdall Honglin Song Ian G Campbell Diana Eccles Rosalind Glasspool Nadeem Siddiqui Karen Carty James Paul Iain A McNeish Weiva Sieh Valerie McGuire Joseph H Rothstein Alice S Whittemore John R McLaughlin Harvey A Risch Catherine M Phelan Hoda Anton-Culver Argyrios Ziogas Usha Menon Susan J Ramus Aleksandra Gentry-Maharaj Patricia Harrington Malcolm C Pike Francesmary Modugno Mary Anne Rossing Roberta B Ness Paul D P Pharoah Daniel O Stram Anna H Wu Celeste Leigh Pearce

Gynecol Oncol 2015 Mar 17;136(3):542-8. Epub 2014 Dec 17.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2014.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892108PMC
March 2015
66 Reads
3 Citations
3.774 Impact Factor

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism.

Cancer Metab 2014 15;2:21. Epub 2014 Dec 15.

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.

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http://dx.doi.org/10.1186/2049-3002-2-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322794PMC
February 2015
28 Reads
25 Citations

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.

Authors:
Karoline B Kuchenbaecker Susan J Ramus Jonathan Tyrer Andrew Lee Howard C Shen Jonathan Beesley Kate Lawrenson Lesley McGuffog Sue Healey Janet M Lee Tassja J Spindler Yvonne G Lin Tanja Pejovic Yukie Bean Qiyuan Li Simon Coetzee Dennis Hazelett Alexander Miron Melissa Southey Mary Beth Terry David E Goldgar Saundra S Buys Ramunas Janavicius Cecilia M Dorfling Elizabeth J van Rensburg Susan L Neuhausen Yuan Chun Ding Thomas V O Hansen Lars Jønson Anne-Marie Gerdes Bent Ejlertsen Daniel Barrowdale Joe Dennis Javier Benitez Ana Osorio Maria Jose Garcia Ian Komenaka Jeffrey N Weitzel Pamela Ganschow Paolo Peterlongo Loris Bernard Alessandra Viel Bernardo Bonanni Bernard Peissel Siranoush Manoukian Paolo Radice Laura Papi Laura Ottini Florentia Fostira Irene Konstantopoulou Judy Garber Debra Frost Jo Perkins Radka Platte Steve Ellis Andrew K Godwin Rita Katharina Schmutzler Alfons Meindl Christoph Engel Christian Sutter Olga M Sinilnikova Francesca Damiola Sylvie Mazoyer Dominique Stoppa-Lyonnet Kathleen Claes Kim De Leeneer Judy Kirk Gustavo C Rodriguez Marion Piedmonte David M O'Malley Miguel de la Hoya Trinidad Caldes Kristiina Aittomäki Heli Nevanlinna J Margriet Collée Matti A Rookus Jan C Oosterwijk Laima Tihomirova Nadine Tung Ute Hamann Claudine Isaccs Marc Tischkowitz Evgeny N Imyanitov Maria A Caligo Ian G Campbell Frans B L Hogervorst Edith Olah Orland Diez Ignacio Blanco Joan Brunet Conxi Lazaro Miquel Angel Pujana Anna Jakubowska Jacek Gronwald Jan Lubinski Grzegorz Sukiennicki Rosa B Barkardottir Marie Plante Jacques Simard Penny Soucy Marco Montagna Silvia Tognazzo Manuel R Teixeira Vernon S Pankratz Xianshu Wang Noralane Lindor Csilla I Szabo Noah Kauff Joseph Vijai Carol A Aghajanian Georg Pfeiler Andreas Berger Christian F Singer Muy-Kheng Tea Catherine M Phelan Mark H Greene Phuong L Mai Gad Rennert Anna Marie Mulligan Sandrine Tchatchou Irene L Andrulis Gord Glendon Amanda Ewart Toland Uffe Birk Jensen Torben A Kruse Mads Thomassen Anders Bojesen Jamal Zidan Eitan Friedman Yael Laitman Maria Soller Annelie Liljegren Brita Arver Zakaria Einbeigi Marie Stenmark-Askmalm Olufunmilayo I Olopade Robert L Nussbaum Timothy R Rebbeck Katherine L Nathanson Susan M Domchek Karen H Lu Beth Y Karlan Christine Walsh Jenny Lester Alexander Hein Arif B Ekici Matthias W Beckmann Peter A Fasching Diether Lambrechts Els Van Nieuwenhuysen Ignace Vergote Sandrina Lambrechts Ed Dicks Jennifer A Doherty Kristine G Wicklund Mary Anne Rossing Anja Rudolph Jenny Chang-Claude Shan Wang-Gohrke Ursula Eilber Kirsten B Moysich Kunle Odunsi Lara Sucheston Shashi Lele Lynne R Wilkens Marc T Goodman Pamela J Thompson Yurii B Shvetsov Ingo B Runnebaum Matthias Dürst Peter Hillemanns Thilo Dörk Natalia Antonenkova Natalia Bogdanova Arto Leminen Liisa M Pelttari Ralf Butzow Francesmary Modugno Joseph L Kelley Robert P Edwards Roberta B Ness Andreas du Bois Florian Heitz Ira Schwaab Philipp Harter Keitaro Matsuo Satoyo Hosono Sandra Orsulic Allan Jensen Susanne Kruger Kjaer Estrid Hogdall Hanis Nazihah Hasmad Mat Adenan Noor Azmi Soo-Hwang Teo Yin-Ling Woo Brooke L Fridley Ellen L Goode Julie M Cunningham Robert A Vierkant Fiona Bruinsma Graham G Giles Dong Liang Michelle A T Hildebrandt Xifeng Wu Douglas A Levine Maria Bisogna Andrew Berchuck Edwin S Iversen Joellen M Schildkraut Patrick Concannon Rachel Palmieri Weber Daniel W Cramer Kathryn L Terry Elizabeth M Poole Shelley S Tworoger Elisa V Bandera Irene Orlow Sara H Olson Camilla Krakstad Helga B Salvesen Ingvild L Tangen Line Bjorge Anne M van Altena Katja K H Aben Lambertus A Kiemeney Leon F A G Massuger Melissa Kellar Angela Brooks-Wilson Linda E Kelemen Linda S Cook Nhu D Le Cezary Cybulski Hannah Yang Jolanta Lissowska Louise A Brinton Nicolas Wentzensen Claus Hogdall Lene Lundvall Lotte Nedergaard Helen Baker Honglin Song Diana Eccles Ian McNeish James Paul Karen Carty Nadeem Siddiqui Rosalind Glasspool Alice S Whittemore Joseph H Rothstein Valerie McGuire Weiva Sieh Bu-Tian Ji Wei Zheng Xiao-Ou Shu Yu-Tang Gao Barry Rosen Harvey A Risch John R McLaughlin Steven A Narod Alvaro N Monteiro Ann Chen Hui-Yi Lin Jenny Permuth-Wey Thomas A Sellers Ya-Yu Tsai Zhihua Chen Argyrios Ziogas Hoda Anton-Culver Aleksandra Gentry-Maharaj Usha Menon Patricia Harrington Alice W Lee Anna H Wu Celeste L Pearce Gerry Coetzee Malcolm C Pike Agnieszka Dansonka-Mieszkowska Agnieszka Timorek Iwona K Rzepecka Jolanta Kupryjanczyk Matt Freedman Houtan Noushmehr Douglas F Easton Kenneth Offit Fergus J Couch Simon Gayther Paul P Pharoah Antonis C Antoniou Georgia Chenevix-Trench

Nat Genet 2015 Feb 12;47(2):164-71. Epub 2015 Jan 12.

Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445140PMC
February 2015
202 Reads
63 Citations
29.352 Impact Factor

Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS.

Oncotarget 2015 Jan;6(2):696-714

Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.18632/oncotarget.2673DOI Listing
January 2015
14 Reads
19 Citations
6.360 Impact Factor

Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Authors:
Paolo Peterlongo Jenny Chang-Claude Kirsten B Moysich Anja Rudolph Rita K Schmutzler Jacques Simard Penny Soucy Rosalind A Eeles Douglas F Easton Ute Hamann Stefan Wilkening Bowang Chen Matti A Rookus Marjanka K Schmidt Frederieke H van der Baan Amanda B Spurdle Logan C Walker Felicity Lose Ana-Teresa Maia Marco Montagna Laura Matricardi Jan Lubinski Anna Jakubowska Encarna B Gómez Garcia Olufunmilayo I Olopade Robert L Nussbaum Katherine L Nathanson Susan M Domchek Timothy R Rebbeck Banu K Arun Beth Y Karlan Sandra Orsulic Jenny Lester Wendy K Chung Alex Miron Melissa C Southey David E Goldgar Saundra S Buys Ramunas Janavicius Cecilia M Dorfling Elizabeth J van Rensburg Yuan Chun Ding Susan L Neuhausen Thomas V O Hansen Anne-Marie Gerdes Bent Ejlertsen Lars Jønson Ana Osorio Cristina Martínez-Bouzas Javier Benitez Edye E Conway Kathleen R Blazer Jeffrey N Weitzel Siranoush Manoukian Bernard Peissel Daniela Zaffaroni Giulietta Scuvera Monica Barile Filomena Ficarazzi Frederique Mariette Stefano Fortuzzi Alessandra Viel Giuseppe Giannini Laura Papi Aline Martayan Maria Grazia Tibiletti Paolo Radice Athanassios Vratimos Florentia Fostira Judy E Garber Alan Donaldson Carole Brewer Claire Foo D Gareth R Evans Debra Frost Diana Eccles Angela Brady Jackie Cook Marc Tischkowitz Julian Adlard Julian Barwell Lisa Walker Louise Izatt Lucy E Side M John Kennedy Mark T Rogers Mary E Porteous Patrick J Morrison Radka Platte Rosemarie Davidson Shirley V Hodgson Steve Ellis Trevor Cole Andrew K Godwin Kathleen Claes Tom Van Maerken Alfons Meindl Andrea Gehrig Christian Sutter Christoph Engel Dieter Niederacher Doris Steinemann Hansjoerg Plendl Karin Kast Kerstin Rhiem Nina Ditsch Norbert Arnold Raymonda Varon-Mateeva Barbara Wappenschmidt Shan Wang-Gohrke Brigitte Bressac-de Paillerets Bruno Buecher Capucine Delnatte Claude Houdayer Dominique Stoppa-Lyonnet Francesca Damiola Isabelle Coupier Laure Barjhoux Laurence Venat-Bouvet Lisa Golmard Nadia Boutry-Kryza Olga M Sinilnikova Olivier Caron Pascal Pujol Sylvie Mazoyer Muriel Belotti Marion Piedmonte Michael L Friedlander Gustavo C Rodriguez Larry J Copeland Miguel de la Hoya Pedro Perez Segura Heli Nevanlinna Kristiina Aittomäki Theo A M van Os Hanne E J Meijers-Heijboer Annemarie H van der Hout Maaike P G Vreeswijk Nicoline Hoogerbrugge Margreet G E M Ausems Helena C van Doorn J Margriet Collée Edith Olah Orland Diez Ignacio Blanco Conxi Lazaro Joan Brunet Lidia Feliubadalo Cezary Cybulski Jacek Gronwald Katarzyna Durda Katarzyna Jaworska-Bieniek Grzegorz Sukiennicki Adalgeir Arason Jocelyne Chiquette Manuel R Teixeira Curtis Olswold Fergus J Couch Noralane M Lindor Xianshu Wang Csilla I Szabo Kenneth Offit Marina Corines Lauren Jacobs Mark E Robson Liying Zhang Vijai Joseph Andreas Berger Christian F Singer Christine Rappaport Daphne Geschwantler Kaulich Georg Pfeiler Muy-Kheng M Tea Catherine M Phelan Mark H Greene Phuong L Mai Gad Rennert Anna Marie Mulligan Gord Glendon Sandrine Tchatchou Irene L Andrulis Amanda Ewart Toland Anders Bojesen Inge Sokilde Pedersen Mads Thomassen Uffe Birk Jensen Yael Laitman Johanna Rantala Anna von Wachenfeldt Hans Ehrencrona Marie Stenmark Askmalm Åke Borg Karoline B Kuchenbaecker Lesley McGuffog Daniel Barrowdale Sue Healey Andrew Lee Paul D P Pharoah Georgia Chenevix-Trench Antonis C Antoniou Eitan Friedman

Cancer Epidemiol Biomarkers Prev 2015 Jan 21;24(1):308-16. Epub 2014 Oct 21.

Sheba Medical Center, Tel Aviv, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294951PMC
January 2015
130 Reads
7 Citations
4.125 Impact Factor

Ten-gene biomarker panel: a new hope for ovarian cancer?

Biomark Med 2014 ;8(4):523-6

Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330556PMC
December 2014
1 Read
1 Citation
2.860 Impact Factor

FOXC1 is a critical mediator of EGFR function in human basal-like breast cancer.

Ann Surg Oncol 2014 Dec 15;21 Suppl 4:S758-66. Epub 2014 Aug 15.

Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1245/s10434-014-3980-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237705PMC
December 2014
33 Reads
17 Citations
3.930 Impact Factor

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.

Authors:
Linda E Kelemen Kathryn L Terry Marc T Goodman Penelope M Webb Elisa V Bandera Valerie McGuire Mary Anne Rossing Qinggang Wang Ed Dicks Jonathan P Tyrer Honglin Song Jolanta Kupryjanczyk Agnieszka Dansonka-Mieszkowska Joanna Plisiecka-Halasa Agnieszka Timorek Usha Menon Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Steven A Narod Harvey A Risch John R McLaughlin Nadeem Siddiqui Rosalind Glasspool James Paul Karen Carty Jacek Gronwald Jan Lubiński Anna Jakubowska Cezary Cybulski Lambertus A Kiemeney Leon F A G Massuger Anne M van Altena Katja K H Aben Sara H Olson Irene Orlow Daniel W Cramer Douglas A Levine Maria Bisogna Graham G Giles Melissa C Southey Fiona Bruinsma Susanne K Kjaer Estrid Høgdall Allan Jensen Claus K Høgdall Lene Lundvall Svend-Aage Engelholm Florian Heitz Andreas du Bois Philipp Harter Ira Schwaab Ralf Butzow Heli Nevanlinna Liisa M Pelttari Arto Leminen Pamela J Thompson Galina Lurie Lynne R Wilkens Diether Lambrechts Els Van Nieuwenhuysen Sandrina Lambrechts Ignace Vergote Jonathan Beesley Peter A Fasching Matthias W Beckmann Alexander Hein Arif B Ekici Jennifer A Doherty Anna H Wu Celeste L Pearce Malcolm C Pike Daniel Stram Jenny Chang-Claude Anja Rudolph Thilo Dörk Matthias Dürst Peter Hillemanns Ingo B Runnebaum Natalia Bogdanova Natalia Antonenkova Kunle Odunsi Robert P Edwards Joseph L Kelley Francesmary Modugno Roberta B Ness Beth Y Karlan Christine Walsh Jenny Lester Sandra Orsulic Brooke L Fridley Robert A Vierkant Julie M Cunningham Xifeng Wu Karen Lu Dong Liang Michelle A T Hildebrandt Rachel Palmieri Weber Edwin S Iversen Shelley S Tworoger Elizabeth M Poole Helga B Salvesen Camilla Krakstad Line Bjorge Ingvild L Tangen Tanja Pejovic Yukie Bean Melissa Kellar Nicolas Wentzensen Louise A Brinton Jolanta Lissowska Montserrat Garcia-Closas Ian G Campbell Diana Eccles Alice S Whittemore Weiva Sieh Joseph H Rothstein Hoda Anton-Culver Argyrios Ziogas Catherine M Phelan Kirsten B Moysich Ellen L Goode Joellen M Schildkraut Andrew Berchuck Paul D P Pharoah Thomas A Sellers Angela Brooks-Wilson Linda S Cook Nhu D Le

Mol Nutr Food Res 2014 Oct 28;58(10):2023-35. Epub 2014 Jul 28.

Departments of Medical Genetics and Oncology, University of Calgary, Calgary, AB, Canada*

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http://dx.doi.org/10.1002/mnfr.201400068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197821PMC
October 2014
68 Reads
3 Citations
4.603 Impact Factor

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

J Natl Cancer Inst 2014 Jul 23;106(7). Epub 2014 Jun 23.

Affiliations of authors: Children's Cancer Institute Australia, Randwick, Australia (ELH, AJR, RTW, CF, MDN, MH, MJH); Department of Gynaecological Oncology and Westmead Institute for Cancer Research (BG, CE, AOCSG, AdF), Crown Princess Mary Cancer Centre and Westmead Institute for Cancer Research (PH) University of Sydney at the Westmead Millennium Institute, Westmead Hospital, Sydney, Australia; Queensland Institute of Medical Research, Brisbane, Australia (YL, JB, SEJ, XC, AOCSG, GC-T, SM); Peter MacCallum Cancer Centre, Melbourne, Australia (JG, AOCSG, DDB); Vesalius Research Center, VIB, Leuven, Belgium (DL); Department of Oncology, University of Leuven and University Hospitals Leuven, Leuven, Belgium (ED, SL, IV); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA (BK, JL, SO, CW); Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany (PF, MWB, AH); University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA (PF); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan (ABE, KM, SH); Department of Gynecology (TN), and Department of Pathology and Molecular Diagnostics (YY), Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan; Department of Obstetrics and Gynecology (TP, YB), and Knight Cancer Institute (TP, YB), Oregon Health & Science University, Portland, OR; Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany (FH); Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany (FH); De

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http://dx.doi.org/10.1093/jnci/dju149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110473PMC
July 2014
37 Reads
23 Citations
12.583 Impact Factor

The immunomodulatory effects of pegylated liposomal doxorubicin are amplified in BRCA1--deficient ovarian tumors and can be exploited to improve treatment response in a mouse model.

Gynecol Oncol 2014 Jun 27;133(3):584-90. Epub 2014 Mar 27.

Division of Gynecologic Oncology, University of New Mexico Cancer Center, 1201 Camino de Salud NE, 1 University of New Mexico, Albuquerque, NM 87106, USA.

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June 2014
4 Reads
4 Citations
3.774 Impact Factor

A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer.

Clin Cancer Res 2014 Feb 11;20(3):711-23. Epub 2013 Nov 11.

Authors' Affiliations: Women's Cancer Program, Department of Medicine, Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Institute; Department of Pathology and Laboratory Medicine; Graduate Program in Biomedical Sciences and Translational Medicine, Cedars-Sinai Medical Center; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles; and John Wayne Cancer Institute, Saint John's Hospital, Santa Monica, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946428PMC
February 2014
11 Reads
73 Citations
8.722 Impact Factor

POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

Gynecol Oncol 2014 Feb 22;132(2):334-42. Epub 2013 Dec 22.

Division of Hematology/Oncology and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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February 2014
24 Reads
10 Citations
3.774 Impact Factor

Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo.

Cancer Lett 2013 Oct 18;339(2):237-46. Epub 2013 Jun 18.

Vincent Center for Reproductive Biology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.

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October 2013
28 Reads
9 Citations
5.621 Impact Factor

Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.

Authors:
Fergus J Couch Xianshu Wang Lesley McGuffog Andrew Lee Curtis Olswold Karoline B Kuchenbaecker Penny Soucy Zachary Fredericksen Daniel Barrowdale Joe Dennis Mia M Gaudet Ed Dicks Matthew Kosel Sue Healey Olga M Sinilnikova Adam Lee François Bacot Daniel Vincent Frans B L Hogervorst Susan Peock Dominique Stoppa-Lyonnet Anna Jakubowska Paolo Radice Rita Katharina Schmutzler Susan M Domchek Marion Piedmonte Christian F Singer Eitan Friedman Mads Thomassen Thomas V O Hansen Susan L Neuhausen Csilla I Szabo Ignacio Blanco Mark H Greene Beth Y Karlan Judy Garber Catherine M Phelan Jeffrey N Weitzel Marco Montagna Edith Olah Irene L Andrulis Andrew K Godwin Drakoulis Yannoukakos David E Goldgar Trinidad Caldes Heli Nevanlinna Ana Osorio Mary Beth Terry Mary B Daly Elizabeth J van Rensburg Ute Hamann Susan J Ramus Amanda Ewart Toland Maria A Caligo Olufunmilayo I Olopade Nadine Tung Kathleen Claes Mary S Beattie Melissa C Southey Evgeny N Imyanitov Marc Tischkowitz Ramunas Janavicius Esther M John Ava Kwong Orland Diez Judith Balmaña Rosa B Barkardottir Banu K Arun Gad Rennert Soo-Hwang Teo Patricia A Ganz Ian Campbell Annemarie H van der Hout Carolien H M van Deurzen Caroline Seynaeve Encarna B Gómez Garcia Flora E van Leeuwen Hanne E J Meijers-Heijboer Johannes J P Gille Margreet G E M Ausems Marinus J Blok Marjolijn J L Ligtenberg Matti A Rookus Peter Devilee Senno Verhoef Theo A M van Os Juul T Wijnen Debra Frost Steve Ellis Elena Fineberg Radka Platte D Gareth Evans Louise Izatt Rosalind A Eeles Julian Adlard Diana M Eccles Jackie Cook Carole Brewer Fiona Douglas Shirley Hodgson Patrick J Morrison Lucy E Side Alan Donaldson Catherine Houghton Mark T Rogers Huw Dorkins Jacqueline Eason Helen Gregory Emma McCann Alex Murray Alain Calender Agnès Hardouin Pascaline Berthet Capucine Delnatte Catherine Nogues Christine Lasset Claude Houdayer Dominique Leroux Etienne Rouleau Fabienne Prieur Francesca Damiola Hagay Sobol Isabelle Coupier Laurence Venat-Bouvet Laurent Castera Marion Gauthier-Villars Mélanie Léoné Pascal Pujol Sylvie Mazoyer Yves-Jean Bignon Elżbieta Złowocka-Perłowska Jacek Gronwald Jan Lubinski Katarzyna Durda Katarzyna Jaworska Tomasz Huzarski Amanda B Spurdle Alessandra Viel Bernard Peissel Bernardo Bonanni Giulia Melloni Laura Ottini Laura Papi Liliana Varesco Maria Grazia Tibiletti Paolo Peterlongo Sara Volorio Siranoush Manoukian Valeria Pensotti Norbert Arnold Christoph Engel Helmut Deissler Dorothea Gadzicki Andrea Gehrig Karin Kast Kerstin Rhiem Alfons Meindl Dieter Niederacher Nina Ditsch Hansjoerg Plendl Sabine Preisler-Adams Stefanie Engert Christian Sutter Raymonda Varon-Mateeva Barbara Wappenschmidt Bernhard H F Weber Brita Arver Marie Stenmark-Askmalm Niklas Loman Richard Rosenquist Zakaria Einbeigi Katherine L Nathanson Timothy R Rebbeck Stephanie V Blank David E Cohn Gustavo C Rodriguez Laurie Small Michael Friedlander Victoria L Bae-Jump Anneliese Fink-Retter Christine Rappaport Daphne Gschwantler-Kaulich Georg Pfeiler Muy-Kheng Tea Noralane M Lindor Bella Kaufman Shani Shimon Paluch Yael Laitman Anne-Bine Skytte Anne-Marie Gerdes Inge Sokilde Pedersen Sanne Traasdahl Moeller Torben A Kruse Uffe Birk Jensen Joseph Vijai Kara Sarrel Mark Robson Noah Kauff Anna Marie Mulligan Gord Glendon Hilmi Ozcelik Bent Ejlertsen Finn C Nielsen Lars Jønson Mette K Andersen Yuan Chun Ding Linda Steele Lenka Foretova Alex Teulé Conxi Lazaro Joan Brunet Miquel Angel Pujana Phuong L Mai Jennifer T Loud Christine Walsh Jenny Lester Sandra Orsulic Steven A Narod Josef Herzog Sharon R Sand Silvia Tognazzo Simona Agata Tibor Vaszko Joellen Weaver Alexandra V Stavropoulou Saundra S Buys Atocha Romero Miguel de la Hoya Kristiina Aittomäki Taru A Muranen Mercedes Duran Wendy K Chung Adriana Lasa Cecilia M Dorfling Alexander Miron Javier Benitez Leigha Senter Dezheng Huo Salina B Chan Anna P Sokolenko Jocelyne Chiquette Laima Tihomirova Tara M Friebel Bjarni A Agnarsson Karen H Lu Flavio Lejbkowicz Paul A James Per Hall Alison M Dunning Daniel Tessier Julie Cunningham Susan L Slager Chen Wang Steven Hart Kristen Stevens Jacques Simard Tomi Pastinen Vernon S Pankratz Kenneth Offit Douglas F Easton Georgia Chenevix-Trench Antonis C Antoniou

PLoS Genet 2013 27;9(3):e1003212. Epub 2013 Mar 27.

Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609646PMC
June 2013
119 Reads
88 Citations

Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer.

Cancer 2012 Feb 12;118(3):689-97. Epub 2011 Jul 12.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Women's Cancer Research Institute, Los Angeles, California 90048, USA.

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February 2012
25 Reads
9 Citations
4.890 Impact Factor

Mouse models of cancer.

Annu Rev Pathol 2011 ;6:95-119

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1146/annurev.pathol.3.121806.154244DOI Listing
April 2011
11 Reads
73 Citations
18.750 Impact Factor

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):745-50. Epub 2010 Dec 27.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1016538108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021044PMC
January 2011
11 Reads
28 Citations
9.810 Impact Factor

Fluvastatin and cisplatin demonstrate synergistic cytotoxicity in epithelial ovarian cancer cells.

Gynecol Oncol 2010 Dec 15;119(3):549-56. Epub 2010 Sep 15.

Women's Cancer Research Institute and Division of Gynecologic Oncology, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.ygyno.2010.08.017DOI Listing
December 2010
55 Reads
12 Citations
3.774 Impact Factor

Hippo pathway effector Yap is an ovarian cancer oncogene.

Cancer Res 2010 Nov 14;70(21):8517-25. Epub 2010 Oct 14.

Department of Molecular and Human Genetics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970655PMC
November 2010
7 Reads
78 Citations
9.330 Impact Factor

BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.

Cancer Res 2010 Sep 31;70(18):7155-65. Epub 2010 Aug 31.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940979PMC
September 2010
30 Reads
18 Citations
9.330 Impact Factor

Whole ovary immunohistochemistry for monitoring cell proliferation and ovulatory wound repair in the mouse.

Reprod Biol Endocrinol 2010 Aug 16;8:98. Epub 2010 Aug 16.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929235PMC
August 2010
12 Reads
5 Citations
2.410 Impact Factor

Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers.

PLoS One 2010 Apr 21;5(4):e10277. Epub 2010 Apr 21.

Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858084PMC
April 2010
11 Reads
159 Citations
3.234 Impact Factor

A role for BRCA1 in uterine leiomyosarcoma.

Cancer Res 2009 Nov 20;69(21):8231-5. Epub 2009 Oct 20.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783882PMC
November 2009
5 Reads
26 Citations
9.330 Impact Factor

MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse.

Differentiation 2008 Dec 2;76(10):1081-92. Epub 2008 Jul 2.

Department of Molecular Genetics, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.

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http://dx.doi.org/10.1111/j.1432-0436.2008.00295.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593124PMC
December 2008
6 Reads
23 Citations
3.440 Impact Factor

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model.

Int J Cancer 2008 Nov;123(9):2041-7

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.

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http://dx.doi.org/10.1002/ijc.23726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653430PMC
November 2008
6 Reads
12 Citations
5.085 Impact Factor

Mechanisms of Cables 1 gene inactivation in human ovarian cancer development.

Cancer Biol Ther 2008 Feb 15;7(2):180-88. Epub 2007 Nov 15.

Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachussetts 02114, USA.

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http://dx.doi.org/10.4161/cbt.7.2.5253DOI Listing
February 2008
3 Reads
9 Citations
3.072 Impact Factor

HOXB13 promotes ovarian cancer progression.

Proc Natl Acad Sci U S A 2007 Oct 17;104(43):17093-8. Epub 2007 Oct 17.

Molecular Pathology Research Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0707938104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040435PMC
October 2007
2 Reads
40 Citations
9.810 Impact Factor

Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer.

Cancer Res 2007 Jun;67(11):5285-92

Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0828DOI Listing
June 2007
1 Read
17 Citations
9.330 Impact Factor

Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells.

Mol Cancer Ther 2007 Jan;6(1):334-45

Department of Microbiology and Immunology, New York Medical College, Room 331, Basic Sciences Building, Grasslands Reservation, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584019PMC
January 2007
1 Read
23 Citations
5.683 Impact Factor

A mouse model for the molecular characterization of brca1-associated ovarian carcinoma.

Cancer Res 2006 Sep;66(18):8949-53

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802660PMC
September 2006
40 Reads
40 Citations
9.330 Impact Factor

Models of ovarian cancer metastasis: Murine models.

Drug Discov Today Dis Models 2006 Jun;3(2):149-154

Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY7, Charlestown, MA 02129, United States.

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http://dx.doi.org/10.1016/j.ddmod.2006.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662599PMC
June 2006
10 Reads
9 Citations

Modeling resistance to pathway-targeted therapy in ovarian cancer.

Cell Cycle 2005 Aug 25;4(8):1004-6. Epub 2005 Aug 25.

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268865PMC
http://dx.doi.org/10.4161/cc.4.8.1869DOI Listing
August 2005
4 Reads
6 Citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.

Nature 2005 Aug 3;436(7054):1186-90. Epub 2005 Jul 3.

Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720-3200, USA.

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http://dx.doi.org/10.1038/nature03884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352168PMC
August 2005
16 Reads
386 Citations
42.351 Impact Factor

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.

Proc Natl Acad Sci U S A 2005 May 28;102(19):6936-41. Epub 2005 Apr 28.

Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0502256102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087513PMC
May 2005
62 Reads
28 Citations
9.810 Impact Factor

Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.

Cancer Res 2005 May;65(9):3735-44

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584020PMC
May 2005
1 Read
39 Citations
9.330 Impact Factor

An RCAS-TVA-based approach to designer mouse models.

Authors:
Sandra Orsulic

Mamm Genome 2002 Oct;13(10):543-7

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1007/s00335-002-4003-4DOI Listing
October 2002
5 Reads
32 Citations
3.070 Impact Factor

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.

Cancer Cell 2002 Feb;1(1):53-62

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267863PMC
February 2002
1 Read
105 Citations
23.523 Impact Factor