Sandra Liekens

Sandra Liekens

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Sandra Liekens

Publications by authors named "Sandra Liekens"

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Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity.

Biochem J 2019 Jul 1. Epub 2019 Jul 1.

Laboratory of Immunobiology, Rega Institute for Medical Research, Leuven, Leuven, Belgium

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http://dx.doi.org/10.1042/BCJ20180382DOI Listing
July 2019

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.

J Gen Virol 2019 Apr 14;100(4):583-601. Epub 2019 Feb 14.

1​Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1099/jgv.0.001235DOI Listing
April 2019

CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.

Exp Cell Res 2018 Nov 2;372(2):168-177. Epub 2018 Oct 2.

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, University of Leuven (KU Leuven), Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S00144827183043
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http://dx.doi.org/10.1016/j.yexcr.2018.09.023DOI Listing
November 2018

HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis.

Biochem Pharmacol 2018 09 21;155:305-315. Epub 2018 Jul 21.

Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, University of Leuven (KU Leuven), Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952183027
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http://dx.doi.org/10.1016/j.bcp.2018.07.011DOI Listing
September 2018

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.

Eur J Med Chem 2018 Sep 29;157:248-267. Epub 2018 Jul 29.

Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.062DOI Listing
September 2018

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

Steroids 2018 08 18;136:47-55. Epub 2018 May 18.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2018.05.002DOI Listing
August 2018

Modulation of BACE1 Activity by Chemically Modified Aptamers.

Chembiochem 2018 04 19;19(7):754-763. Epub 2018 Feb 19.

Univ Evry, CNRS-UMR8030-Laboratoire iSSB, CEA, DRF, IG, Genoscope, Université Paris-Saclay, 5 rue Henri Desbruères, Évry, 91030, France.

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http://dx.doi.org/10.1002/cbic.201700461DOI Listing
April 2018

Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents.

Eur J Med Chem 2018 Mar 9;147:183-193. Epub 2018 Feb 9.

Depart. de Q. Orgánica, Univ. de Valencia, E-46100 Burjassot, Valencia, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2018.01.058DOI Listing
March 2018

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Eur J Med Chem 2018 Mar 10;148:337-348. Epub 2018 Feb 10.

Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.02.019DOI Listing
March 2018

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.

J Biol Chem 2018 02 13;293(7):2534-2545. Epub 2017 Dec 13.

From the Department of Cellular and Molecular Medicine, Laboratory of Structural Neurobiology, Faculty of Medicine, KU Leuven, 3000 Leuven, Belgium,

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http://dx.doi.org/10.1074/jbc.M117.815316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818190PMC
February 2018

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity.

Eur J Med Chem 2018 Feb 5;145:425-430. Epub 2018 Jan 5.

Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia 4, I-80126, Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.005DOI Listing
February 2018

Relative distribution and biological characterization of CXCL4L1 isoforms in platelets from healthy donors.

Biochem Pharmacol 2017 12 30;145:123-131. Epub 2017 Aug 30.

KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.020DOI Listing
December 2017

Tumor angiogenesis revisited: Regulators and clinical implications.

Med Res Rev 2017 11 23;37(6):1231-1274. Epub 2017 Jun 23.

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1002/med.21452DOI Listing
November 2017

Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens.

Steroids 2017 08 15;124:54-59. Epub 2017 Jun 15.

School of Pharmacy, Department of Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2017.06.001DOI Listing
August 2017

Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.

Biochem Pharmacol 2017 07 6;136:51-61. Epub 2017 Apr 6.

Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland; School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland.

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http://dx.doi.org/10.1016/j.bcp.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557014PMC
July 2017

Synthesis and anticancer activity of novel aza-artemisinin derivatives.

Bioorg Med Chem 2017 07 30;25(14):3671-3676. Epub 2017 Apr 30.

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173053
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http://dx.doi.org/10.1016/j.bmc.2017.04.041DOI Listing
July 2017

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

Biochem Pharmacol 2017 05 18;132:92-101. Epub 2017 Mar 18.

KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952173013
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http://dx.doi.org/10.1016/j.bcp.2017.03.009DOI Listing
May 2017

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes.

Eur J Med Chem 2017 May 23;132:219-235. Epub 2017 Mar 23.

KU Leuven, Rega Institute for Medical Research, Herestraat 49, Postbus 1043, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.044DOI Listing
May 2017

A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage.

ChemMedChem 2017 05 3;12(10):760-769. Epub 2017 May 3.

Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technologies, University of Ferrara, via L. Borsari 46, 44121, Ferrara, Italy.

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http://dx.doi.org/10.1002/cmdc.201700137DOI Listing
May 2017

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes.

Org Biomol Chem 2017 May;15(18):3892-3900

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1039/c7ob00707hDOI Listing
May 2017

Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides.

Arch Pharm (Weinheim) 2017 Apr 17;350(3-4). Epub 2017 Mar 17.

Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.

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http://dx.doi.org/10.1002/ardp.201700023DOI Listing
April 2017

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.

J Med Chem 2016 10 27;59(19):8685-8711. Epub 2016 Jun 27.

Rega Institute for Medical Research, KU Leuven , B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00463DOI Listing
October 2016

Bioluminescent avian pathogenic Escherichia coli for monitoring colibacillosis in experimentally infected chickens.

Vet J 2016 Oct 20;216:87-92. Epub 2016 Jul 20.

Department of Biosystems, Division of Gene Technology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, Leuven 3000, Belgium.

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http://dx.doi.org/10.1016/j.tvjl.2016.07.011DOI Listing
October 2016

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models.

PLoS Pathog 2016 Sep 23;12(9):e1005851. Epub 2016 Sep 23.

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada), Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035034PMC
http://dx.doi.org/10.1371/journal.ppat.1005851DOI Listing
September 2016

Metal-Free Route for the Synthesis of 4-Acyl-1,2,3-Triazoles from Readily Available Building Blocks.

Chemistry 2016 Jul 10;22(29):9966-70. Epub 2016 Jun 10.

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.

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http://dx.doi.org/10.1002/chem.201601928DOI Listing
July 2016

A single-step acid catalyzed reaction for rapid assembly of NH-1,2,3-triazoles.

Chem Commun (Camb) 2016 Jul 29;52(59):9236-9. Epub 2016 Jun 29.

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1039/c6cc03744eDOI Listing
July 2016

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.

Molecules 2016 Apr 30;21(5). Epub 2016 Apr 30.

KU Leuven-University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven B-3000, Belgium.

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http://dx.doi.org/10.3390/molecules21050579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273944PMC
April 2016

A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones.

Chem Commun (Camb) 2016 Feb;52(14):2885-8

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

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http://dx.doi.org/10.1039/c5cc08347hDOI Listing
February 2016

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus.

Biochem Pharmacol 2016 Jan 10;100:73-85. Epub 2015 Nov 10.

KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.11.001DOI Listing
January 2016

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.

J Med Chem 2015 Oct 9;58(20):8110-27. Epub 2015 Oct 9.

Department of Medical Microbiology and Immunology, University of Alberta , 6-020 Katz Group Centre, Edmonton, Alberta T6G 2E1, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893804PMC
October 2015

Mycoplasmas and cancer: focus on nucleoside metabolism.

EXCLI J 2014 27;13:300-22. Epub 2014 Mar 27.

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x - bus 1030, B-3000 Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464442PMC
September 2015

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds.

Eur J Med Chem 2015 Aug 25;101:205-17. Epub 2015 Jun 25.

Department of Biochemistry, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2015.06.042DOI Listing
August 2015

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs.

FEBS Open Bio 2015 3;5:634-9. Epub 2015 Aug 3.

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x - bus 1030, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.fob.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541722PMC
August 2015

Antiviral Activity of Synthetic Aminopyrrolic Carbohydrate Binding Agents: Targeting the Glycans of Viral gp120 to Inhibit HIV Entry.

Chemistry 2015 Jul 1;21(28):10089-93. Epub 2015 Jun 1.

Istituto di Metodologie Chimiche (IMC), Consiglio Nazionale delle Ricerche (CNR), Dipartimento di Chimica, Polo Scientifico e Tecnologico, 50019 Sesto Fiorentino, Firenze (Italy).

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http://dx.doi.org/10.1002/chem.201501030DOI Listing
July 2015

CXCR3 ligands in disease and therapy.

Cytokine Growth Factor Rev 2015 Jun 22;26(3):311-27. Epub 2014 Nov 22.

Laboratory of Molecular Immunology, University of Leuven (KU Leuven), Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cytogfr.2014.11.009DOI Listing
June 2015

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.

Proc Natl Acad Sci U S A 2015 Mar 2;112(11):3475-80. Epub 2015 Mar 2.

Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8020;

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http://dx.doi.org/10.1073/pnas.1420233112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371953PMC
March 2015

Endothelial dysfunction in dengue virus pathology.

Rev Med Virol 2015 Jan 27;25(1):50-67. Epub 2014 Nov 27.

KU Leuven, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1002/rmv.1818DOI Listing
January 2015

Hairpin oligonucleotides forming G-quadruplexes: new aptamers with anti-HIV activity.

Eur J Med Chem 2015 Jan 14;89:51-8. Epub 2014 Oct 14.

Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia 4, I-80126 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.10.030DOI Listing
January 2015

Structure-activity relationship of tumor-selective 5-substituted 2-amino-3-carboxymethylthiophene derivatives.

ChemMedChem 2014 Dec 18;9(12):2744-53. Epub 2014 Sep 18.

Department of Chemistry, KU Leuven, 3001Heverlee (Belgium).

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http://dx.doi.org/10.1002/cmdc.201402274DOI Listing
December 2014

Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.

PLoS Biol 2014 Dec 2;12(12):e1002011. Epub 2014 Dec 2.

MRC-Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251836PMC
December 2014

Synthesis and antiproliferative activity of 6-phenylaminopurines.

Eur J Med Chem 2014 Nov 30;87:421-8. Epub 2014 Sep 30.

Instituto de Química Médica (IQM-CSIC), c/Juan de la Cierva 3, E-28006 Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234140092
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http://dx.doi.org/10.1016/j.ejmech.2014.09.093DOI Listing
November 2014

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

J Antimicrob Chemother 2014 Oct 12;69(10):2878-80. Epub 2014 Jun 12.

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x-bus 1030, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/jac/dku201DOI Listing
October 2014

Antiproliferative novel isoxazoles: modeling, virtual screening, synthesis, and bioactivity evaluation.

Eur J Med Chem 2014 Jun 4;81:139-49. Epub 2014 May 4.

Agricultural University of Athens, Chemistry Laboratory, Iera Odos 75, Athens 11855, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234140042
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http://dx.doi.org/10.1016/j.ejmech.2014.05.011DOI Listing
June 2014

Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine.

J Biol Chem 2014 May 25;289(19):13054-65. Epub 2014 Mar 25.

From the Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x-bus 1030, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M114.558924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036319PMC
May 2014

Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.

J Med Chem 2014 May 9;57(10):3924-38. Epub 2014 May 9.

Instituto de Química Médica (IQM-CSIC) , Juan de la Cierva 3, E-28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jm401939gDOI Listing
May 2014

Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs.

Mol Pharmacol 2013 Dec 25;84(6):865-75. Epub 2013 Sep 25.

Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.113.088625DOI Listing
December 2013

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis.

Eur J Med Chem 2012 Dec 8;58:160-70. Epub 2012 Oct 8.

University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, SI - 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.ejmech.2012.10.001DOI Listing
December 2012

Novel pyrazole and indazole derivatives: synthesis and evaluation of their anti-proliferative and anti-angiogenic activities.

Arch Pharm (Weinheim) 2012 Oct 18;345(10):804-11. Epub 2012 Jun 18.

Chemistry Laboratory, Agricultural University of Athens, Athens, Greece.

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http://doi.wiley.com/10.1002/ardp.201200057
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http://dx.doi.org/10.1002/ardp.201200057DOI Listing
October 2012

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

Biochem J 2012 Jul;445(1):113-23

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x - bus 1030, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1042/BJ20112225DOI Listing
July 2012

Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative.

Biochem Pharmacol 2012 May 16;83(10):1358-63. Epub 2012 Feb 16.

Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bcp.2012.02.005DOI Listing
May 2012

Angiogenic activity of hepatitis B and C viruses.

Antivir Chem Chemother 2012 Jan 17;22(4):159-70. Epub 2012 Jan 17.

Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3851/IMP1987DOI Listing
January 2012

Viruses as key regulators of angiogenesis.

Rev Med Virol 2011 May;21(3):181-200

Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1002/rmv.688DOI Listing
May 2011

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

Eur J Med Chem 2011 Apr 22;46(4):993-1005. Epub 2011 Jan 22.

Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, University of Thessaly, 26 Ploutonos Str, 41221 Larissa, Greece.

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http://dx.doi.org/10.1016/j.ejmech.2011.01.005DOI Listing
April 2011

Novel pyrazole derivatives: synthesis and evaluation of anti-angiogenic activity.

Bioorg Med Chem 2010 Jun 20;18(12):4338-50. Epub 2010 May 20.

Chemistry Laboratory, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.

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http://dx.doi.org/10.1016/j.bmc.2010.04.076DOI Listing
June 2010

The dual role of thymidine phosphorylase in cancer development and chemotherapy.

Med Res Rev 2009 Nov;29(6):903-53

Rega Institute for Medical Research, KULeuven, Leuven, Belgium.

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http://www3.uah.es/farmamol/Public/PDF_files_FGago/MRR2009_T
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http://doi.wiley.com/10.1002/med.20159
Publisher Site
http://dx.doi.org/10.1002/med.20159DOI Listing
November 2009

Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes.

Lancet Oncol 2009 Jun;10(6):628-35

Rega Institute for Medical Research, K U Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(09)70037-3DOI Listing
June 2009

The cytostatic activity of pyrimidine nucleosides is strongly modulated by Mycoplasma hyorhinis infection: Implications for cancer therapy.

Biochem Pharmacol 2008 Jul 4;76(2):188-97. Epub 2008 May 4.

Rega Institute for Medical Research, K.U. Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bcp.2008.04.019DOI Listing
July 2008

Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy.

Biochem Pharmacol 2007 Dec 16;74(11):1555-67. Epub 2007 May 16.

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bcp.2007.05.008DOI Listing
December 2007

Heparin-mimicking sulfonic acid polymers as multitarget inhibitors of human immunodeficiency virus type 1 Tat and gp120 proteins.

Antimicrob Agents Chemother 2007 Jul 23;51(7):2337-45. Epub 2007 Apr 23.

General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1128/AAC.01362-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913280PMC
July 2007

The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells.

Mol Pharmacol 2007 Mar 7;71(3):695-703. Epub 2006 Dec 7.

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.106.026559DOI Listing
March 2007

Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR4.

Biochem Biophys Res Commun 2006 Sep 17;348(1):192-9. Epub 2006 Jul 17.

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2006.07.030DOI Listing
September 2006

5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.

J Med Chem 2006 Sep;49(18):5562-70

Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, E-28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jm0605379DOI Listing
September 2006

5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.

Mol Pharmacol 2006 Aug 4;70(2):501-9. Epub 2006 May 4.

Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.105.021188DOI Listing
August 2006

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

Mol Pharmacol 2006 Jun 23;69(6):1891-6. Epub 2006 Mar 23.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1124/mol.106.023002DOI Listing
June 2006

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Mini Rev Med Chem 2005 Dec;5(12):1113-23

Instituto de Química Médica (CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain.

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December 2005

Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies.

Cytometry A 2004 Oct;61(2):178-88

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/cyto.a.20070DOI Listing
October 2004

The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action.

J Biol Chem 2004 Jul 3;279(28):29598-605. Epub 2004 May 3.

Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M402602200DOI Listing
July 2004

The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.

Biochemistry 2002 May;41(20):6517-24

Rega Institute for Medical Research, K. U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/bi0255930DOI Listing
May 2002

Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase.

FEBS Lett 2002 Jan;510(1-2):83-8

Rega Institute for Medical Research, Minderbroedersstraat 10, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/s0014-5793(01)03233-1DOI Listing
January 2002