Publications by authors named "Sandra Gilchrist"

2 Publications

  • Page 1 of 1

An NMR-based metabolomics study on sea anemones () with atrazine exposure.

Mol Omics 2021 Dec 6;17(6):1012-1020. Epub 2021 Dec 6.

Department of Chemistry, North Carolina A&T State University, Greensboro, NC, USA.

Sea anemones have been recommended as critical bioindicators for marine environmental stressors; however, the understanding of the biological effects in response to sublethal pollutant exposure is still limited. In this study, NMR-based metabolomics was performed to investigate the effects of atrazine on with concentrations ranging from 3 to 90 ppb. As a result, the metabolic profiling of was significantly affected after 70 ppb treatment while a partial perturbation was observed as early as 3 ppb treatment. Glutamate was significantly changed at low atrazine concentrations with increased upregulation in concentrated atrazine experiments which is a potential biomarker for exposed to atrazine stressors. The TCA intermediates succinate and malate as well as the TCA cycle-related metabolites such as alanine, glycine, and taurine downregulated after atrazine treatment which also indicated the lower energy supply of In summary, our study demonstrated that significant metabolic level perturbation could be detected at low atrazine concentrations before a physical change could be observed, and glutamate or the nitrogen metabolism may be the initial target for sea anemones by atrazine. The study may provide pioneering results for using to predict the impacts of exposure to atrazine toxin in marine systems.
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http://dx.doi.org/10.1039/d1mo00223fDOI Listing
December 2021

Aquatic invertebrate protein sources for long-duration space travel.

Life Sci Space Res (Amst) 2021 Feb 24;28:1-10. Epub 2020 Oct 24.

NASA, Kennedy Space Center, FL. Electronic address:

During the summer of 2020, NASA returned to launching astronauts to the International Space Station (ISS) from American soil. By 2024, NASA's mission is to return to the Moon, and by 2028 create a sustainable presence. Long duration missions come with obstacles, especially when trying to create a sustainable environment in a location where "living off the land" is impossible. Some resources on the Moon can be recovered or resupplied; however, many resources such as those needed for sustaining life must be recycled or grown to support humans. To achieve sustainability, food and water must be grown and recycled using elements found within the habitat. NASA's current work focuses on food resupply and growing plants as supplemental nutrient content. This paper examines the possibility for using aquaculture systems to purify water while growing nutrient-rich species as food sources, which aquatic food sources would be ideal for a habitat environment, and which species might provide an ideal test case for future studies aboard ISS. The aquatic species should be rapidly grown with high protein content and low launch mass requirements. Although there are numerous challenges and unknown technology gaps for maintaining aquaculture systems in reduced gravity environments, the benefit of employing such systems would be of great advantage towards creating a sustainable presence beyond Earth's orbit for sustainable aquaculture.
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http://dx.doi.org/10.1016/j.lssr.2020.10.002DOI Listing
February 2021
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