Sandra Gemma

Sandra Gemma

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Sandra Gemma

Sandra Gemma

Publications by authors named "Sandra Gemma"

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Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.

J Med Chem 2020 Jan 27;63(1):23-39. Epub 2019 Aug 27.

Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022 , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00924DOI Listing
January 2020

Screening and Phenotypical Characterization of Histone Deacetylase 8 (HDAC8) Inhibitors as Multistage Antischistosomal Agents.

ACS Infect Dis 2020 Jan 12;6(1):100-113. Epub 2019 Nov 12.

Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.

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http://dx.doi.org/10.1021/acsinfecdis.9b00224DOI Listing
January 2020

Telomerase-based cancer therapeutics: a review on their clinical trials.

Curr Top Med Chem 2020 Jan 1. Epub 2020 Jan 1.

University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100 Siena. Italy.

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http://dx.doi.org/10.2174/1568026620666200102104930DOI Listing
January 2020

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas.

Med Res Rev 2019 Nov 19. Epub 2019 Nov 19.

Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1002/med.21646DOI Listing
November 2019

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.

Molecules 2019 Nov 29;24(23). Epub 2019 Nov 29.

Department of Biotechnology (DoE 2018-2022), Chemistry and Pharmacy (DoE 2018-2022), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.3390/molecules24234373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930672PMC
November 2019

Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors.

Drug Discov Today 2019 07 25;24(7):1370-1388. Epub 2019 May 25.

University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100 Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.05.015DOI Listing
July 2019

Dietary polyphenols rutin, taxifolin and quercetin related compounds target Leishmania amazonensis arginase.

Food Funct 2019 Jun;10(6):3172-3180

Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Avenida Duque de Caxias Norte, 225, 13635-900 Pirassununga, SP, Brazil.

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http://dx.doi.org/10.1039/c9fo00265kDOI Listing
June 2019

A light in the dark: state of the art and perspectives in optogenetics and optopharmacology for restoring vision.

Future Med Chem 2019 03 25;11(5):463-487. Epub 2019 Mar 25.

Department of Biotechnology, Chemistry & Pharmacy, Department of Excellence 2018-2022, University of Siena, Via A. Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.4155/fmc-2018-0315DOI Listing
March 2019

Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase.

Chem Biol Drug Des 2019 02 10;93(2):139-146. Epub 2018 Oct 10.

Universidade Anhembi Morumbi, São Paulo, Brazil.

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http://dx.doi.org/10.1111/cbdd.13391DOI Listing
February 2019

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Eur J Med Chem 2019 Jan 3;162:290-320. Epub 2018 Nov 3.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I-53100, Siena, Italy; Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131, Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183095
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http://dx.doi.org/10.1016/j.ejmech.2018.11.004DOI Listing
January 2019

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

ChemMedChem 2018 10 30;13(19):2090-2103. Epub 2018 Aug 30.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy (DoE 2018-2020), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.201800397DOI Listing
October 2018

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Eur J Med Chem 2018 Sep 31;157:127-138. Epub 2018 Jul 31.

European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.069DOI Listing
September 2018

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Eur J Med Chem 2018 Apr 10;150:698-718. Epub 2018 Mar 10.

Department of Biotechnology, Chemistry and Pharmacy, Dipartimento di Eccellenza 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902032PMC
April 2018

Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.

ChemMedChem 2017 12 29;12(24):2074-2085. Epub 2017 Nov 29.

European Research Centre for Drug Discovery and Development, NatSynDrugs and Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.201700551DOI Listing
December 2017

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.

Eur J Med Chem 2017 Sep 9;138:438-457. Epub 2017 Jun 9.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università degli Studi di Siena via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2017.06.017DOI Listing
September 2017

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

Eur J Med Chem 2017 Jul 24;135:479-490. Epub 2017 Apr 24.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università di Siena via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2017.04.057DOI Listing
July 2017

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.

J Enzyme Inhib Med Chem 2016 28;31(sup1):98-109. Epub 2016 Apr 28.

a European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena , Siena , Italy.

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http://dx.doi.org/10.3109/14756366.2016.1172575DOI Listing
February 2017

Identification of novel fluorescent probes preventing PrP replication in prion diseases.

Eur J Med Chem 2017 Feb 1;127:859-873. Epub 2016 Nov 1.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2016.10.064DOI Listing
February 2017

Computational Tool for Fast Evaluation of ERG K Channel Affinity.

Front Chem 2017 23;5. Epub 2017 Feb 23.

European Research Centre for Drug Discovery (NatSynDrugs), University of SienaSiena, Italy.

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http://dx.doi.org/10.3389/fchem.2017.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408157PMC
February 2017

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.

Front Neurosci 2016 5;10:451. Epub 2016 Oct 5.

European Research Centre for Drug Discovery and Development and Department of Biotechnology, Chemistry and Pharmacy, University of Siena Siena, Italy.

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http://dx.doi.org/10.3389/fnins.2016.00451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050208PMC
October 2016

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.

Future Med Chem 2016 09 24;8(13):1573-87. Epub 2016 Aug 24.

European Research Centre for Drug Discovery & Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.4155/fmc-2016-0068DOI Listing
September 2016

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.

J Nat Prod 2016 05 20;79(5):1459-63. Epub 2016 Apr 20.

Department of Veterinary Medicine, Universidade de São Paulo , Avenida Duque de Caxias Norte, 225, 13635-900 Pirassununga, SP, Brazil.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00875DOI Listing
May 2016

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors.

J Mol Graph Model 2016 Mar 19;64:121-130. Epub 2016 Jan 19.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.jmgm.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276822PMC
March 2016

Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents.

Bioorg Med Chem Lett 2015 Nov 5;25(22):5412-8. Epub 2015 Sep 5.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2015.09.007DOI Listing
November 2015

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.

Eur J Med Chem 2015 Sep 8;102:648-60. Epub 2015 Aug 8.

Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Cagliari, Cittadella Universitaria, s.p. 8, Km 0.700, I-09042 Monserrato, Cagliari, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2015.08.009DOI Listing
September 2015

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Sci Rep 2015 May 7;5:9705. Epub 2015 May 7.

1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena [2] Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1038/srep09705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423475PMC
May 2015

HCV-targeted antivirals: current status and future challenges.

Curr Pharm Des 2014 ;20(21):3445-64

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università di Siena, via Aldo Moro 2, 53100, Siena (Italy).

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http://dx.doi.org/10.2174/13816128113199990630DOI Listing
March 2015

A stereoselective approach to peptidomimetic BACE1 inhibitors.

Eur J Med Chem 2013 6;70:233-47. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.09.056DOI Listing
September 2014

Rational design of the first difluorostatone-based PfSUB1 inhibitors.

Bioorg Med Chem Lett 2014 Aug 23;24(15):3582-6. Epub 2014 May 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2014.05.044DOI Listing
August 2014

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

CNS Neurosci Ther 2014 Jul;20(7):624-32

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/cns.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493034PMC
July 2014

The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.

Curr Top Med Chem 2013 ;13(15):1787-807

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034716PMC
http://dx.doi.org/10.2174/15680266113139990137DOI Listing
March 2014

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.

ACS Med Chem Lett 2013 Dec 6;4(12):1178-82. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy ; European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/ml4002908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027481PMC
December 2013

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Eur J Med Chem 2013 May 8;63:85-94. Epub 2013 Feb 8.

Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.01.044DOI Listing
May 2013

Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.

Bioorg Med Chem Lett 2013 Jan 14;23(1):85-9. Epub 2012 Nov 14.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.011DOI Listing
January 2013

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.

Bioorg Med Chem Lett 2013 Jan 22;23(2):492-5. Epub 2012 Nov 22.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.035DOI Listing
January 2013

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

J Med Chem 2012 Aug 26;55(15):6898-915. Epub 2012 Jul 26.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm300689cDOI Listing
August 2012

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Bioorg Med Chem Lett 2012 Aug 23;22(16):5317-21. Epub 2012 Jun 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.023DOI Listing
August 2012

A straightforward approach for engineering efficacy and selectivity at GPCRs.

J Med Chem 2012 Aug 18;55(15):6687-8. Epub 2012 Jul 18.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm301017vDOI Listing
August 2012

Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate.

Malar J 2011 Dec 1;10:348. Epub 2011 Dec 1.

European Research Centre for Drug Discovery and Development, Department of Pharmaceutical and Applied Chemistry, University of Siena, Italy.

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http://dx.doi.org/10.1186/1475-2875-10-348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260111PMC
December 2011

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.

J Med Chem 2011 Aug 29;54(16):5949-53. Epub 2011 Jul 29.

European Research Centre for Drug Discovery and Development (NatSynDrugs), 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm200686dDOI Listing
August 2011

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.

Org Biomol Chem 2011 Jul 1;9(14):5137-48. Epub 2011 Jun 1.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro, 53100, Siena, Italy.

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http://dx.doi.org/10.1039/c1ob05288hDOI Listing
July 2011

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.

Bioorg Med Chem Lett 2011 May 6;21(9):2776-9. Epub 2010 Sep 6.

European Research Centre for Drug Discovery and Development, Università di Siena, via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.002DOI Listing
May 2011

Malaria chemotherapy: recent advances in drug development.

Recent Pat Antiinfect Drug Discov 2010 Nov;5(3):195-225

Department of Pharmaceutical and Applied Chemistry, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/157489110793348776DOI Listing
November 2010

The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.

Curr Top Med Chem 2010 ;10(5):504-26

Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università di Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.2174/156802610791111560DOI Listing
September 2010

Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues.

J Org Chem 2010 Apr;75(7):2333-40

Dipartimento Farmaco Chimico Tecnologico (DFCT), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jo1001559DOI Listing
April 2010

Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.

Bioorg Med Chem Lett 2010 Feb 5;20(3):1241-6. Epub 2009 Dec 5.

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, United States.

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http://dx.doi.org/10.1016/j.bmcl.2009.11.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179850PMC
February 2010

An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.

J Org Chem 2008 Nov 10;73(21):8458-68. Epub 2008 Oct 10.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Banchi di Sotto 55, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jo8015456DOI Listing
November 2008

Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.

Bioorg Med Chem Lett 2008 Oct 26;18(19):5213-6. Epub 2008 Aug 26.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.076DOI Listing
October 2008

beta-Secretase as a therapeutic target for Alzheimer's disease.

Neurotherapeutics 2008 Jul;5(3):399-408

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1016/j.nurt.2008.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963069PMC
July 2008

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.

J Med Chem 2007 Feb 31;50(4):595-8. Epub 2007 Jan 31.

Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universita' di Siena, via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm061429pDOI Listing
February 2007