Publications by authors named "Sandra E Dunn"

57Publications

The dawn of targeted therapies for triple negative breast cancer (TNBC): a snapshot of investigational drugs in phase I and II trials.

Expert Opin Investig Drugs 2020 Nov 17;29(11):1199-1208. Epub 2020 Sep 17.

Pre-clinical R&D, Phoenix Molecular Designs , Vancouver, BC, Canada.

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http://dx.doi.org/10.1080/13543784.2020.1818067DOI Listing
November 2020

RSK2: a promising therapeutic target for the treatment of triple-negative breast cancer.

Expert Opin Ther Targets 2020 01 27;24(1):1-5. Epub 2019 Dec 27.

Phoenix Molecular Designs, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1080/14728222.2020.1709824DOI Listing
January 2020

Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells.

J Pediatr Hematol Oncol 2019 08;41(6):e359-e370

Division of Pediatric Oncology, Alberta Children's Hospital, and POETIC Laboratory for Preclinical and Drug Discovery Studies, University of Calgary, Calgary, AB.

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http://dx.doi.org/10.1097/MPH.0000000000001416DOI Listing
August 2019

Y-box-binding protein 1 contributes to IL-7-mediated survival signaling in B-cell precursor acute lymphoblastic leukemia.

Oncol Lett 2017 Jan 28;13(1):497-505. Epub 2016 Nov 28.

Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.3892/ol.2016.5437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244896PMC
January 2017

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.

Oncotarget 2015 Nov;6(35):38239-56

Molecular Pathology, Vall d'Hebron Research Institute (VHIR), Universidad Autonoma of Barcelona, Barcelona, Spain.

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http://www.oncotarget.com/fulltext/5664
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http://dx.doi.org/10.18632/oncotarget.5664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741996PMC
November 2015

Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.

Stem Cells 2015 Apr;33(4):1042-6

Experimental Medicine Program, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/stem.1956
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http://dx.doi.org/10.1002/stem.1956DOI Listing
April 2015

YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.

Stem Cells 2014 Jun;32(6):1437-50

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Experimental Medicine Program, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/stem.1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321723PMC
June 2014

Deep sequencing identifies IDH1 R132S mutation in adult medulloblastoma.

J Clin Oncol 2015 Feb 10;33(6):e27-31. Epub 2014 Mar 10.

University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1200/JCO.2013.49.4864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517370PMC
February 2015

Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities.

Cell Commun Signal 2013 Aug 27;11:63. Epub 2013 Aug 27.

Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany.

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http://dx.doi.org/10.1186/1478-811X-11-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766096PMC
August 2013

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.

Cancer Res 2013 Nov 9;73(22):6734-44. Epub 2013 Sep 9.

Authors' Affiliations: Department of Pediatrics; Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine; Division of Pediatric Neurosurgery, Department of Surgery, BC Children's Hospital, University of British Columbia; Department of Pathology and Laboratory Medicine, Centre for Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia; Division of Neurosurgery, Department of Surgery, Faculty of Health Sciences, McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton; The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario; Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada; and Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4331DOI Listing
November 2013

Overcoming resistance to Sonic Hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.

Pediatr Blood Cancer 2014 Jan 12;61(1):107-15. Epub 2013 Aug 12.

Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/pbc.24675DOI Listing
January 2014

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress.

Nat Commun 2013 ;4:2189

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncomms3189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740589PMC
January 2014

YB-1: oncoprotein, prognostic marker and therapeutic target?

Biochem J 2013 Jan;449(1):11-23

Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1042/BJ20121323DOI Listing
January 2013

Medulloblastoma stem cells: modeling tumor heterogeneity.

Cancer Lett 2013 Sep 14;338(1):23-31. Epub 2012 Jul 14.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8S 4K1.

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http://dx.doi.org/10.1016/j.canlet.2012.07.010DOI Listing
September 2013

Medulloblastoma stem cells: where development and cancer cross pathways.

Pediatr Res 2012 Apr 8;71(4 Pt 2):516-22. Epub 2012 Feb 8.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/pr.2011.62DOI Listing
April 2012

Stem cells in brain tumour development and therapy- two-sides of the same coin.

Can J Neurol Sci 2012 Mar;39(2):145-56

Department of Pediatrics, Experimental Medicine and Medical Genetics, Child and Family Research Institute, University of British Columbia, BC, Canada.

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http://dx.doi.org/10.1017/s0317167100013159DOI Listing
March 2012

Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.

Breast Cancer Res 2012 Feb 6;14(1):R22. Epub 2012 Feb 6.

Laboratory for Oncogenomic Research, Departments of Pediatrics, Experimental Medicine, and Medical Genetics, Child and Family Research Institute, University of British Columbia, 950 W, 28th Ave, Vancouver, British Columbia, V5Z 4H4, Canada.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/bcr3107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496140PMC
February 2012

YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention.

Oncotarget 2011 May;2(5):401-6

Laboratory of Oncogenomic Research, Departments of Pediatrics and Experimental Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248184PMC
http://dx.doi.org/10.18632/oncotarget.276DOI Listing
May 2011

The promise and challenges of targeting RSK for the treatment of cancer.

Expert Opin Ther Targets 2011 Jan;15(1):1-4

University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1517/14728222.2011.537656DOI Listing
January 2011

Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.

PLoS One 2010 Sep 10;5(9). Epub 2010 Sep 10.

Laboratory for Oncogenomic Research, Child and Family Research Institute, The Prostate Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937023PMC
September 2010

Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer.

Expert Rev Mol Med 2010 Jul 26;12:e22. Epub 2010 Jul 26.

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1017/S1462399410001535DOI Listing
July 2010

Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase.

Mol Cancer Ther 2009 Dec;8(12):3276-84

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia, Canada V5Z 4H4.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-09
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http://dx.doi.org/10.1158/1535-7163.MCT-09-0478DOI Listing
December 2009

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

Cancer Res 2008 Dec;68(24):10238-46

Department of Pediatrics, Laboratory for Oncogenomic Research, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2755DOI Listing
December 2008

Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.

Breast Cancer Res 2008 27;10(6):R99. Epub 2008 Nov 27.

Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/bcr2202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656895PMC
April 2009

Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.

Cancer Res 2008 Nov;68(21):8661-6

Department of Pediatrics and Experimental Medicine, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1082DOI Listing
November 2008

Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes.

Breast Cancer Res 2008 16;10(5):R86. Epub 2008 Oct 16.

Laboratory for Oncogenomic Research, Departments of Pediatrics and Experimental Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1186/bcr2156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614522PMC
February 2009

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.

J Cell Sci 2008 Mar 12;121(Pt 5):664-74. Epub 2008 Feb 12.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.013029
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http://dx.doi.org/10.1242/jcs.013029DOI Listing
March 2008

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK).

Transl Oncogenomics 2007 23;2:85-97. Epub 2007 Jul 23.

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634623PMC
May 2013

YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression.

Transl Oncogenomics 2007 11;2:49-65. Epub 2007 May 11.

Laboratory for Oncogenomic Research, Departments of Pediatrics, Experimental Medicine and Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634714PMC
May 2013

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.

Mol Pharmacol 2006 Nov 3;70(5):1534-41. Epub 2006 Aug 3.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, 336 Parks Hall, The Ohio State University, 500 West 12th Avenue, Columbus, 43210-1291, USA.

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http://dx.doi.org/10.1124/mol.106.023911DOI Listing
November 2006

Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2.

Cancer Res 2006 May;66(9):4872-9

Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3561DOI Listing
May 2006

Celecoxib inhibits urokinase-type plasminogen activator (uPA) production in MDA-MB-231 breast cancer cells.

Breast Cancer Res Treat 2005 Nov;94(1):47-52

Department of Pediatrics, British Columbia Institute for Children's and Women's Health, Vancouver, BC, Canada.

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http://link.springer.com/10.1007/s10549-005-6941-5
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http://dx.doi.org/10.1007/s10549-005-6941-5DOI Listing
November 2005

Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.

Breast Cancer Res 2005 1;7(5):R796-807. Epub 2005 Aug 1.

British Columbia Research Institute for Children's and Women's Health, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1186/bcr1294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242152PMC
February 2006

Role of IGF-1R in mediating breast cancer invasion and metastasis.

Breast Dis 2003 ;17:41-7

Department of Pediatrics, BC Research Institute for Children's and Women's Health, University of British Columbia, Vancouver BC V6R 2T6, Canada.

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http://dx.doi.org/10.3233/bd-2003-17105DOI Listing
March 2005

Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma.

Clin Cancer Res 2004 Sep;10(18 Pt 1):6143-51

Genetic Pathology Evaluation Centre of the Department of Pathology, and Prostate Research Centre of Vancouver General Hospital, British Columbia Cancer Agency and University of British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0429DOI Listing
September 2004

Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin.

Cancer Res 2004 Jan;64(1):286-91

British Columbia Research Institute for Children's and Women's Health, Department of Pediatrics, Laboratory for Oncogenomic Research, University of British Columbia, Vancouver British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.can-03-1242DOI Listing
January 2004

Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.

Recent Prog Horm Res 2003 ;58:325-42

Physiologie de la Reproduction et des Comportements, Unite Mixte de Recherches 6073, Institut National de la Recherche Agronomique-Centre National de la Recherche Scientifique, Université F. Rabelais, Tours 37380 Nouzilly, France.

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http://dx.doi.org/10.1210/rp.58.1.325DOI Listing
July 2003