Publications by authors named "Sanda Alexandrescu"

44Publications

Loss of H3K27me3 and nuclear expression of TLE1 in primary intracranial sarcoma, DICER1-mutant.

Histopathology 2020 Jul 21. Epub 2020 Jul 21.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.1111/his.14217DOI Listing
July 2020

A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood.

Eur J Med Genet 2020 Sep 8;63(9):104002. Epub 2020 Jul 8.

Robert's Program for Sudden Unexpected Death in Pediatrics, Boston Children's Hospital, USA; Department of Pediatrics, Harvard Medical School, USA; Division of General Pediatrics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2020.104002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469702PMC
September 2020

Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience.

J Neurooncol 2020 Aug 5;149(1):113-122. Epub 2020 Jul 5.

Dana Farber/Boston Children's Cancer and Blood Disorder Center, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11060-020-03578-6DOI Listing
August 2020

Embryonal Tumors of the Central Nervous System: An Update.

Surg Pathol Clin 2020 Jun 7;13(2):235-247. Epub 2020 Apr 7.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.path.2020.01.003DOI Listing
June 2020

An Update on Pediatric Gliomas.

Surg Pathol Clin 2020 Jun;13(2):217-233

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Bader 104, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.path.2020.02.005DOI Listing
June 2020

Mechanisms and therapeutic implications of hypermutation in gliomas.

Nature 2020 04 15;580(7804):517-523. Epub 2020 Apr 15.

Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2209-9DOI Listing
April 2020

Somatic mutations in intracranial arteriovenous malformations.

PLoS One 2019 31;14(12):e0226852. Epub 2019 Dec 31.

Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226852PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938308PMC
April 2020

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.

Cancer Cell 2019 11 17;36(5):528-544.e10. Epub 2019 Oct 17.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.09.005DOI Listing
November 2019

Characterization of molecular signatures of supratentorial ependymomas.

Mod Pathol 2020 01 2;33(1):47-56. Epub 2019 Aug 2.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41379-019-0329-2DOI Listing
January 2020

Pediatric CNS-isolated hemophagocytic lymphohistiocytosis.

Neurol Neuroimmunol Neuroinflamm 2019 05 8;6(3):e560. Epub 2019 Apr 8.

Department of Neurology (L.A.B., M.J.R., M.P.G.), Boston Children's Hospital; Dana-Farber/Boston Children's Cancer and Blood Disorders Center (H.L., A.L.K., L.E.L., B.A.D., C.N.D.); Department of Rheumatology (L.A.H., R.P.S.), Boston Children's Hospital; Department of Pathology (I.H.S002E, S.A.), Boston Children's Hospital, Boston, MA; Undiagnosed Diseases Program (A.S., J.M., W.A.G.), National Human Genome Research Institute; Neuroimmunological Diseases Section (B.B.), Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases; Laboratory of Clinical Immunology and Microbiology (A.P.H., S.M.H.), National Institute of Allergy and Infectious Diseases, Bethesda, MD; and Division of Hematology, Oncology (M.L.A.), and Marrow and Blood Cell Transplantation, Children's Hospital at Montefiore, Bronx, NY.

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http://dx.doi.org/10.1212/NXI.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467688PMC
May 2019

An update on the central nervous system manifestations of DICER1 syndrome.

Acta Neuropathol 2020 04 5;139(4):689-701. Epub 2019 Apr 5.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Bader 104, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00401-019-01997-yDOI Listing
April 2020

Recurrent EP300-BCOR Fusions in Pediatric Gliomas With Distinct Clinicopathologic Features.

J Neuropathol Exp Neurol 2019 04;78(4):305-314

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

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https://academic.oup.com/jnen/advance-article/doi/10.1093/jn
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http://dx.doi.org/10.1093/jnen/nlz011DOI Listing
April 2019

Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System.

J Neuropathol Exp Neurol 2018 12;77(12):1079-1084

Departments of Pathology, Boston Children's Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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https://academic.oup.com/jnen/advance-article/doi/10.1093/jn
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http://dx.doi.org/10.1093/jnen/nly094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658858PMC
December 2018

Expanding the spectrum of pediatric NTRK-rearranged fibroblastic tumors to the central nervous system: A case report with RBPMS-NTRK3 fusion.

Neuropathology 2018 Dec 6;38(6):624-630. Epub 2018 Sep 6.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1111/neup.12513
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http://dx.doi.org/10.1111/neup.12513DOI Listing
December 2018

PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours.

Histopathology 2018 Sep 4;73(3):483-491. Epub 2018 Jul 4.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.13648DOI Listing
September 2018

Focal cerebral β-amyloid angiopathy: A distinct clinicopathologic presentation.

Neurol Clin Pract 2017 Oct;7(5):444-448

Memory and Aging Center (EK, GN, GT, BLM, GDR, LTG) and Multiple Sclerosis and Neuroinflammation Center (SJP, JMG), Department of Neurology, and Department of Pathology and Laboratory Medicine (SA), University of California San Francisco; Neurological Institute of Athens (EK), Greece; and Department of Pathology (LTG), University of São Paulo Medical School, Brazil. S.A. is currently affiliated with Boston Children's Hospital, MA.

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http://dx.doi.org/10.1212/CPJ.0000000000000354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874474PMC
October 2017

Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

Am J Pathol 2018 06 13;188(6):1334-1344. Epub 2018 Mar 13.

Department of Pathology, Boston Children's Hospital, Boston, Massachusetts; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971223PMC
June 2018

A novel GIT2-BRAF fusion in pilocytic astrocytoma.

Diagn Pathol 2017 Nov 15;12(1):82. Epub 2017 Nov 15.

Department of Pathology, Boston Children's Hospital, 300 Longwood Ave, Bader, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s13000-017-0669-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688665PMC
November 2017

Neurenteric cyst at the dorsal craniocervical junction in a child: Case report.

J Clin Neurosci 2018 Feb 11;48:86-89. Epub 2017 Nov 11.

Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2017.10.014DOI Listing
February 2018

Mycoplasma hominis Empyema in an 18-Year-old Stem Cell and Lung Transplant Recipient: Case Report and Review of the Literature.

J Pediatric Infect Dis Soc 2017 Nov;6(4):e173-e176

Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/jpids/pix049DOI Listing
November 2017

Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation.

Pediatr Dev Pathol 2017 Mar-Apr;20(2):105-111. Epub 2017 Jan 26.

1 Department of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://journals.sagepub.com/doi/10.1177/1093526616683881
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http://dx.doi.org/10.1177/1093526616683881DOI Listing
April 2019

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome.

Pediatr Neurol 2017 02 21;67:59-63. Epub 2016 Oct 21.

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303551PMC
February 2017

CNS intravascular large cell lymphoma in a patient with autoimmune hemolytic anemia.

Neuropathology 2015 Apr 6;35(2):170-4. Epub 2014 Nov 6.

Department of Pathology, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1111/neup.12175DOI Listing
April 2015

Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia.

N Engl J Med 2014 Mar;370(12):1131-7

From the Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London (S.S., P.S., V.A., K.H.), and the Departments of Paediatric Endocrinology (S.S., P.S., V.A., K.H.) and Histopathology (D.P., M.A.), Great Ormond Street Hospital for Children, London, and the Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter (S.F., S.E.) - all in the United Kingdom; the Department of Pathology, University of California, San Francisco, San Francisco (S.A.); and the Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston (N.T., R.E.B.).

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http://dx.doi.org/10.1056/NEJMoa1310967DOI Listing
March 2014

Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: an institutional experience.

Int J Clin Exp Pathol 2013 15;6(12):2955-61. Epub 2013 Nov 15.

Department of Pathology, University of California at San Francisco CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843278PMC
August 2014

Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis.

Int J Clin Exp Pathol 2012 29;5(6):503-11. Epub 2012 Jul 29.

Department of Pathology, University of Texas at Houston-Health Science Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430113PMC
January 2013

Acute promyelocytic leukemia as a cause of intracoronary drug-eluting-stent thrombosis.

Tex Heart Inst J 2012 ;39(3):416-9

Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368467PMC
October 2012

Neuron precursor features of spindle cell oncocytoma of adenohypophysis.

Ann Clin Lab Sci 2012 ;42(2):123-9

Department of Pathology and Laboratory Medicine, University of Texas-Houston, School of Medicine, Houston, TX 77030, USA.

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September 2012

Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications.

Int J Clin Exp Pathol 2010 Aug 8;3(7):691-705. Epub 2010 Aug 8.

Department of Pathology and Laboratory Medicine, University of Texas Health Science Center-Medical School at Houston, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933389PMC
August 2010

Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis.

J Am Soc Nephrol 2008 Jun 12;19(6):1168-76. Epub 2008 Mar 12.

Department of Pathology, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1681/ASN.2007050607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396930PMC
June 2008