Publications by authors named "Sanaz Soltani"

13 Publications

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Careful data extraction in meta-analysis: the case of maternal caffeine intake during pregnancy and low-birth weight, childhood overweight, and obesity.

Int J Obes (Lond) 2021 Feb 1. Epub 2021 Feb 1.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1038/s41366-021-00746-0DOI Listing
February 2021

Adherence to Dietary Approaches to Stop Hypertension Eating Plan and Prevalence of Irritable Bowel Syndrome in Adults.

J Neurogastroenterol Motil 2021 Jan;27(1):78-86

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background/aims: Despite huge evidence on the link between adherence to dietary approaches to stop hypertension (DASH) eating pattern and several metabolic abnormalities, the association of this diet with irritable bowel syndrome (IBS) has not been investigated so far. We aim to examine the association between adherence to the DASH diet and prevalence of IBS symptoms and subtypes in adults.

Methods: This cross-sectional study was done among 3362 adult people in Isfahan, Iran. Usual dietary intakes were assessed using a validated 106-item dish-based semi-quantitative food frequency questionnaire. To investigate participants' adherence to DASH-style diet, we created DASH score based on 8 main foods and nutrients emphasized or minimized in the DASH diet. Participants were classified into 3 categories according to their DASH-style diet scores. A validated modified Persian version of the Rome III questionnaire was applied for assessment of IBS.

Results: Totally, 22.2% of study participants were affected by IBS. After adjustment for potential confounding factors, we found that participants in the highest tertile of DASH score had lower odds of IBS (OR, 0.65; 95% CI, 0.50-0.83) compared with those in the lowest tertile. The same findings were also reached for IBS with constipation (OR for the highest vs the lowest tertile of DASH-style diet = 0.56; 95% CI, 0.38-0.85). No significant association was seen between adherence to DASH-style diet and IBS with diarrhea (OR, 1.31; 95% CI, 0.83-2.06).

Conclusions: We found a significant inverse association between adherence to DASH dietary pattern and odds of IBS and IBS with constipation. Further prospective studies are required to confirm these findings.
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http://dx.doi.org/10.5056/jnm20007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786080PMC
January 2021

Inflammatory potential of the diet and risk of sarcopenia and its components.

Nutr J 2020 11 28;19(1):129. Epub 2020 Nov 28.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.

Background: Despite a large body of evidence on the link between dietary inflammatory index (DII) and several chronic conditions, limited data are available about the association of DII and sarcopenia. This study aimed to examine the relationship between inflammatory potential of the diet (as measured by DII) and sarcopenia and its components among community-dwelling elderly population.

Methods: This population-based cross-sectional study was performed in 2011 among 300 elderly people (150 men and 150 women) aged ≥55 years, who were selected using cluster random sampling method. Dietary assessment was done using a pre-tested food frequency questionnaire. Energy-adjusted DII was calculated based on earlier studies. Sarcopenia and its components were determined based on the European Working Group on Sarcopenia (EWGSOP) definition.

Results: Mean age of study participants was 66.7 ± 7.7 y. Subjects in the highest tertile of DII score (i.e. those with a more pro-inflammatory diet) were more likely to be older (P = 0.02). The prevalence of sarcopenia (P = 0.016) and low muscle mass (P = 0.041) was significantly higher among subjects in the top tertile compared with those in the bottom tertile of DII. After adjustment for potential confounders, those with the highest DII were 2.18 times (95% CI: 1.01-4.74) more likely to have sarcopenia than those with the lowest DII. With regard to components of sarcopenia, subjects in the top tertile of DII had not significantly greater odds of low muscle mass (OR: 1.38; 95% CI: 0.72-2.63), abnormal handgrip strength (OR: 0.97; 95% CI: 0.49-1.89), and abnormal gait speed (OR: 1.61; 95% CI: 0.84-3.08) than those in the bottom tertile.

Conclusions: In conclusion, a diet with more pro-inflammatory potential was associated with a greater odds of sarcopenia. Further studies are required to confirm these findings.
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http://dx.doi.org/10.1186/s12937-020-00649-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700703PMC
November 2020

Association of dietary approaches to stop hypertension eating style and risk of sarcopenia.

Sci Rep 2020 11 9;10(1):19339. Epub 2020 Nov 9.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.

The association between habitual intake of the "dietary approaches to stop hypertension" (DASH) eating plan and sarcopenia has received limited attention. The present study aimed to investigate the association between adherence to DASH dietary pattern and sarcopenia and its components including muscle mass, muscle strength, and muscle performance among community-dwelling older adults population. This population-based cross-sectional study was performed in 2011 among 300 older people (150 men and 150 women) aged ≥ 55 years, who were selected using cluster random sampling method. Dietary intake of study participants were examined by the use of a Block-format 117-item food frequency questionnaire (FFQ). The DASH score was constructed based on eight main foods and nutrients emphasized or minimized in the DASH diet. All components of sarcopenia was measured using standard protocols and sarcopenia was defined based on both former and new European Working Group on Sarcopenia in Older People (EWGSOP) guidelines. Mean age and BMI of study participants were 66.7 ± 7.7 years and 27.3 ± 4.2 kg/m, respectively. Totally, 31 individuals meet the criteria of EWGSOP2-sarcopenia. We found no significant association between adherence to the DASH diet and EWGSOP2-sarcopenia either before (OR 1.08; 95% CI 0.45-2.54) or after adjustment for potential confounders (OR 1.04; 95% CI 0.39-2.75). The same findings were obtained in the gender-stratified analyses (men: OR 2.29; 95% CI 0.39-13.29 and women: 0.75; 95% CI 0.23-2.45). In conclusion, we found that adherence to the DASH-style diet was not significantly associated with odds of sarcopenia. Future prospective studies are required to confirm these findings.
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http://dx.doi.org/10.1038/s41598-020-76452-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652878PMC
November 2020

The association between dietary glycemic index and load and risk of gestational diabetes mellitus: A prospective study.

Diabetes Res Clin Pract 2020 Dec 25;170:108469. Epub 2020 Sep 25.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Aims: This study aimed to investigate the association between dietary GI and GL and risk of GDM in a group of pregnant women in Iran.

Methods: A number of 812 pregnant women were recruited in their first trimester in a prospective study. A validated 117-item semi-quantitative food frequency questionnaire was used to assess usual dietary intakes of participants at study baseline. Dietary GI and GL were calculated based on earlier publications. GDM was diagnosed based on the results of a fasting plasma glucose concentration and a 50-g, 1-h oral glucose tolerance test at 24-28 weeks of gestation. Cox proportional hazards model was used to compute relative risks (RRs) and 95% confidence intervals (CI) for GDM.

Results: Mean ± SD of age and BMI of study participants was 29.4 ± 4.84 y and 25.14 ± 4.08 kg/m, respectively at study baseline. Mean ± SD of dietary GI was 58 ± 7 and that of dietary GL was 176 ± 42. Overall, 28.4% (n = 231) of study population developed GDM at weeks 24-28 of pregnancy. After adjustment for potential confounding variables, we found that women in the highest tertile of dietary GL were 43% more likely to develop GDM than those in the lowest tertile (95% CI: 1.01, 2.00; P-trend = 0.03). However, no significant association was seen between dietary GI (RR for the highest tertile compared to the lowest: 0.85; 95% CI: 0.61, 1.20; P-trend = 0.37), and risk of GDM.

Conclusions: We found that women with the highest dietary GL were at a greater risk of developing GDM during pregnancy. No significant association was seen between dietary GI and risk of GDM.
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http://dx.doi.org/10.1016/j.diabres.2020.108469DOI Listing
December 2020

A case-control study on dietary calcium intake and risk of glioma.

Eur J Cancer Prev 2020 Sep 17. Epub 2020 Sep 17.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran.

Limited evidence exists regarding the association between dietary calcium intake and risk of glioma. The objective of this study was to determine the relationship between dietary calcium intake and risk of glioma in Iranian adults. In this hospital-based case-control study, we enrolled 128 newly-diagnosed cases of glioma and 256 age- and sex-matched controls. Patients with pathologically confirmed glioma (without any other cancers) were selected. Dietary intakes of study participants were collected through a validated 126-item food-frequency questionnaire. Dietary calcium intake was computed from dairy products in the questionnaire. Participants were categorized into quartiles of dietary calcium intake. Binary logistic regression was used to examine the association between dietary calcium intake and glioma. Higher dietary intake of calcium was associated with younger age, long duration of cell phone use, and frequent canned foods intake. After taking age, sex, and energy intake into account, participants with the greatest dietary calcium intake had 84% lower odds of glioma than those with the lowest intake [odds ratio (OR): 0.16; 95% confidence interval (CI), 0.07-0.37]. Further adjustment for other potential confounders including nutrient intakes did not significantly alter the association (OR: 0.22; 95% CI, 0.08-0.64). Even after additional adjustment for BMI, we found a significant inverse association between dietary calcium intake and odds of glioma (OR: 0.23; 95% CI, 0.08-0.65). We found an inverse protective association between high dietary calcium intake and odds of glioma. Further prospective cohort studies are needed to confirm these findings.
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http://dx.doi.org/10.1097/CEJ.0000000000000629DOI Listing
September 2020

Adherence to the MIND diet in relation to glioma: a case-control study.

Nutr Neurosci 2020 Aug 25:1-8. Epub 2020 Aug 25.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

: Although some components of MIND diet have been shown to have favorable association with glioma, no information exist about the potential link between adherence to the whole MIND diet and risk of glioma. This study was conducted to examine the association between adherence to MIND diet and risk of glioma in a group of Iranian adults. : In this hospital-based case-control study, 128 newly diagnosed glioma cases and 256 age- and sex-matched controls were included. Dietary intakes of study participants were assessed using a validated 126-item semi-quantitative FFQ. The MIND diet score was computed based on participants' dietary intakes obtained from FFQ. Conditional logistic regression models were used to examine the association between the MIND diet score and glioma. : After controlling for age, sex and energy intake, individuals with the greatest adherence to the MIND diet were less likely to have glioma compared with those with the lowest adherence; such that those in the top tertile were 47% less likely to have glioma than those in the bottom tertile (OR: 0.53; 95% CI: 0.30-0.94). Further adjustment for other potential confounders strengthened the association (OR for the highest tertile vs. the lowest: OR: 0.37; 95% CI: 0.18-0.79). Additional controlling for BMI did not influence the association significantly (OR: 0.39; 95% CI: 0.18-0.84). : In conclusion, we found that adherence to the MIND diet might be inversely associated with odds of glioma in this case-control study. Further studies are required to confirm these findings.
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http://dx.doi.org/10.1080/1028415X.2020.1809876DOI Listing
August 2020

A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer.

Oncologist 2020 12 24;25(12):1013-e1824. Epub 2020 Jun 24.

Women's Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Lessons Learned: Monotherapy with prexasertib demonstrated modest activity in BRCA wild-type, recurrent triple-negative breast cancer, highlighting the unmet need for combination treatment strategies. Neutropenia, anemia, and thrombocytopenia are common with the use of prexasertib but are manageable with supportive care measures. Prophylactic use of granulocyte colony stimulating factor should be considered to avoid dose reductions or treatment delays. Pharmacodynamic studies showed prexasertib treatment induced DNA damage in peripheral immune cells.

Background: Cell cycle checkpoint kinase 1 (CHK1) is a major G2/M cell cycle regulator in tumors with p53 dysfunction, such as triple-negative breast cancer (TNBC). We hypothesized the second-generation CHK1 inhibitor, prexasertib, would yield clinical activity in sporadic TNBC.

Methods: This single arm, phase II trial evaluated prexasertib at 105 mg/m IV every 2 weeks in patients with metastatic/recurrent TNBC. The primary endpoint was overall response rate (ORR).

Results: All nine patients enrolled were germline BRCA wild-type (BRCAwt) and had at least one prior treatment. One partial response (PR) was observed (ORR of 11.1%). Four patients experienced stable disease. The median progression-free survival (PFS) was 86 days (range 17 to 159 days). Grade 3/4 treatment-related adverse events included afebrile neutropenia (n = 8; 88.9%), anemia (n = 3; 33.3%), and thrombocytopenia (n = 1; 11.1%). Pharmacodynamic studies showed prexasertib treatment induced DNA damage in peripheral immune cells and demonstrated a decrease in activated/reinvigorated CD8 T cells; however, the one patient with a PR showed evidence of T-cell recovery.

Conclusion: Prexasertib monotherapy had modest clinical efficacy in BRCAwt TNBC. Further studies of prexasertib in combination with other agents are needed.
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http://dx.doi.org/10.1634/theoncologist.2020-0491DOI Listing
December 2020

Association between Adherence to "Dietary Approaches to Stop Hypertension" Eating Plan and Breast Cancer.

Nutr Cancer 2021 25;73(3):433-441. Epub 2020 Apr 25.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Despite the favorable association of components of "dietary approaches to stop hypertension (DASH)" diet and breast cancer (BC), limited data are available linking the whole DASH diet to BC. The aim of the present study was to examine the association between adherence to DASH eating plan and odds of BC in Iranian women. This population-based case-control study was conducted among women aged ≥30 years, who were residing in Isfahan, Iran. Cases were 350 patients with newly diagnosed stage I-IV breast cancer, for whom in-situ or invasive status of BC was confirmed by physical examination and mammography. Controls were 700 age-matched apparently healthy individuals who were randomly selected from general population. Dietary data were collected using a validated 106-item Willett-format semi-quantitative dish-based food frequency questionnaire. To investigate participants' adherence to DASH diet, we created DASH scores based on foods and nutrients emphasized or minimized in the DASH diet. After controlling for potential confounders, individuals in the highest quartile of the DASH diet score had 85% lower odds of breast cancer than women in the bottom quartile (OR: 0.15; 95% CIs: 0.09-0.24). Stratified analysis by menopausal status revealed such association in postmenopausal women (OR: 0.11; 95% CI: 0.06-0.19), but not in premenopausal women (OR: 0.60; 95% CI: 0.14-2.59). In addition, when stratified by BMI status, we found statistically significant inverse association between adherence to the DASH eating pattern and odds of breast cancer among normal-weight (OR for comparing extreme quartiles: 0.13; 95% CI: 0.07-0.24; -trend < 0.001) and obese women (0.13; 0.05-0.34; -trend < 0.001). In conclusion, our findings indicated an inverse association between adherence to the DASH eating plan and odds of breast cancer among Iranian women. Further, prospective studies are required to confirm our findings.
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http://dx.doi.org/10.1080/01635581.2020.1756354DOI Listing
April 2020

Food Item Avoidance of Patients with Irritable Bowel Syndrome Compared with Healthy People.

Arch Iran Med 2019 07 1;22(7):369-375. Epub 2019 Jul 1.

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: To construct a dietary guideline for patients with irritable bowel syndrome (IBS), data about foods these people exclude from their diet to improve their symptoms are necessary. This study was designed to assess the prevalence of food exclusions as well as the reasons for such exclusions in a large group of IBS patients.

Methods: In this cross-sectional study, data on 3846 Iranian adults, 828 of whom were patients with IBS, working in 50 different health centers were examined. A 106-item self-administered Dish-based Semi-quantitative Food Frequency Questionnaire (DSFFQ) which was designed and validated specifically for Iranian adults was used for assessing dietary intake. IBS was assessed using a modified Persian version of the Rome III questionnaire.

Results: The whole prevalence of IBS was 21.5% (n = 828) in the total population (23.9% in women and 18.6% in men). Mean age of patients with IBS was 36.26 ± 7.91 years and for subjects without IBS, it was 36.52 ± 8.12 years. IBS patients had a greater probability to avoid consumption of ketchup (90% vs 33%, P = 0.005), Dough (100% vs 1%, P = 0.003), Gaz (50% vs. 1%, P = 0.035), grapes (33% vs. 7%, P = 0.034), fresh berries (56% vs. 14%, P = 0.036) and butter (100% vs. 60%, P = 0.02) due to gastrointestinal (GI) symptoms compared with healthy individuals. Although, the exclusion of plum (1% vs. 26%, P = 0.006), pickles (39% vs. 67%, P = 0.004), lemon juice (21% vs 35%, P = 0.027), egg (5% vs. 25%, P = 0.011), fresh fig (19% vs. 44%, P = 0.038) and cake (25% vs. 100%, P = 0.028) due to GI symptoms in IBS patients were lower than non-IBS participants.

Conclusion: The present study showed that IBS patients were more likely to avoid consumption of ketchup, Dough, Gaz, grapes, fresh berries and butter due to GI symptoms compared with healthy individuals. Further studies are required to confirm these findings.
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July 2019

General and abdominal obesity in relation to the prevalence of irritable bowel syndrome.

Neurogastroenterol Motil 2019 04 18;31(4):e13549. Epub 2019 Jan 18.

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Earlier studies on the obesity-IBS association have mostly been reported from Western nations, and limited data are available in this regard from developing countries. This study was performed to examine the association of general and abdominal obesity with Irritable bowel syndrome (IBS) in a Middle Eastern population.

Methods: In this cross-sectional study, 4763 Iranian adults participated. Data on self-reported anthropometric measurements were collected, and BMI was calculated. Overweight and obesity were defined as 25 ≤ BMI < 30 and BMI ≥ 30 kg/m , respectively. Also, we used WC measurements to define the three categories of normal (<94 cm in men <80 cm in women), abdominal overweight (94 ≤ WC < 102 in men and 80 ≤ WC < 88 in women), and abdominal obesity (WC ≥ 102 cm in men and WC ≥ 88 cm in women). Assessment of different GI symptoms including those related to IBS was done using a validated Persian version of the Rome III questionnaire. IBS was defined as the presence of recurrent abdominal pain or discomfort at least sometimes in the last 3 months associated with 2 or more of the following features: improvement with defecation, pain onset associated with a change in frequency of stool, and pain onset associated with a change in form (appearance) of stool.

Key Results: Irritable bowel syndrome was more prevalent among individuals with abdominal obesity compared with normal subjects (23.8% vs 19%). Neither in crude nor in adjusted models, we found any significant association between overweight and obesity and IBS [for overweight: OR: 0.95, 95% CI: 0.66-1.36 and for obesity: OR: 1.06, 95% CI: 0.85-1.31]. We observed a significant positive association between abdominally overweight and IBS in crude model (OR: 1.31, 95% CI: 1.09-1.60); however, this association became non-significant after adjustment for potential confounders (OR: 1.09, 95% CI: 0.82-1.44). Across BMI categories, neither in crude nor in adjusted models, we did not find any significant association between overweight (OR: 0.89, 95% CI: 0.62-1.27), obesity (OR: 1.05, 95% CI: 0.58-1.87), and abdominal pain severity. Abdominal overweight (OR: 0.96, 95% CI: 0.65-1.40) and obesity (OR: 1.61, 95% CI: 0.67-1.63) were not associated with abdominal pain severity.

Conclusions And Inferences: It is concluded that general or abdominal obesity was not associated with odds of IBS. Future longitudinal studies are needed to clarify the association between obesity and IBS.
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http://dx.doi.org/10.1111/nmo.13549DOI Listing
April 2019

Analysis of breast cancer in young women in the Department of Defense (DOD) database.

Breast Cancer Res Treat 2018 Apr 15;168(2):501-511. Epub 2017 Dec 15.

Women's Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

Purpose: Breast tumors from young women under the age of 40 account for approximately 7% of cases and have a poor prognosis independent of established prognostic factors. We evaluated the patient population served by the Military Health System, where a disproportionate number of breast cancer cases in young women are seen and treated in a single universal coverage healthcare system.

Methods: The Military Health System Repository and the DoD Central Registration databases were used to identify female breast cancer patients diagnosed or treated at military treatment facilities from 1998 to 2007.

Results: 10,066 women were diagnosed with invasive breast cancer at DoD facilities from 1998 to 2007, of which 11.3% (1139), 23.4% (2355) and 65.2% (6572) were < 40, 40-49 and > 50 years old (yo), respectively, at diagnosis. 53% in the < 40 yo cohort were white, 25% were African American (AA) and 8% were Hispanic, with 14% undisclosed. Breast cancer in women diagnosed < 40 yo was more high grade (p < 0.0001), Stage II (p < 0.0001) and ER negative (p < 0.0001). There was a higher rate of bilateral mastectomies among the women < 40 compared to those 40-49 and > 50 (18.4% vs. 9.1% and 5.0%, respectively). Independent of disease stage, chemotherapy was given more frequently to < 40 yo (90.43%) and 40-49 yo (81.44%) than ≥ 50 yo (53.71%). The 10-year overall survival of younger women was similar to the ≥ 50 yo cohort. Outcomes in the African American and Hispanic subpopulations were comparable to the overall cohort.

Conclusion: Younger women had a similar overall survival rate to older women despite receiving more aggressive treatment.
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http://dx.doi.org/10.1007/s10549-017-4615-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301053PMC
April 2018

Comparison of Serum LP-PLA2 Level and some Nutritional Factors between Well-Controlled and Poorly-Controlled Diabetic Patients.

Acta Med Iran 2015 Nov;53(11):690-6

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is produced by inflammatory cells, bound to LDL and other lipoproteins, and hydrolyzes oxidized phospholipids in LDL. Type 2 diabetes is the most common form of diabetes some investigations show the association of lipoprotein-associated phospholipase A2 mass and activity with the incidence of cardiovascular disease (CVD) in populations with high prevalences of insulin resistance and diabetes. This study is a cross-sectional descriptive and analytic study on 80 individuals with diabetes referring to the Tehran Diabetes Association. Patients divided into two groups (well-controlled and poorly controlled) based on their HbA1C. Personal information, anthropometric assessments (including height, weight, waist circumference and hip circumference) and semi-quantitative 147 items FFQ was used and vein blood samples were taken. After plasma separation, blood sample used for FBS, HbA1c and LP-PLA2 measurement. The independent sample T test was used for comparing means. Data analyses showed a significant difference between weight and WHR (waist to hip ratio) means in two studied groups, also there was a statistically significant difference in food intake (Energy, carbohydrate, protein, micronutrients percent and some of the micronutrients). FBS, HbA1C and LP-PLA2 means showed statistically significant difference (P<0/001) between two groups. This study showed LP-PLA2 is elevated in poorly-controlled patients compared to well-controlled diabetic patients, which may suggest some nutritional factors contributing to the regulation of this enzyme.
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November 2015