Biography

Dr Keating's research interests include the characterisation of changes and events that underlie the development and progression of vascular complications associated with diabetes including epigenetic mechanisms of metabolic memory.

Exploring the role of the Set7 lysine methyltransferase in gene regulation in the vascular endothelium, Dr Keating's doctoral thesis examining gene networks provided strong preliminary data and framework for the characterisation of epigenetics relevant to diabetic vascular disease. Comprehensive reviews of epigenetic changes implicated in vascular complications demonstrate his extensive background knowledge, appreciation for current and unmet challenges in the field, as well as an ability to identify important areas of discovery. Dr Keating's recognition as an emerging researcher is reflected by journal invitations that include an authoritative review article in a special issue on epigenetics in Circulation Research (Epigenetics and metabolism, Circ Res 2015 116(4):715-36).

In 2015 Dr Keating was awarded an Australian Endeavour Research Fellowship, allowing him to pursue further research training focused on the profiling of DNA methylation in blood cells (monocytes) as well as kidney epithelial cells for 6 months (May – November 2015) in the clinical FinnDiane laboratory led by Professor Per-Henrik Groop at the Folkhälsan Research Institute in Helsinki, Finland.

In addition to experimental work, his skills in written communication are recognised by leading roles in the preparation and editing of manuscripts for publication. This is complemented by strong interests in effective oral and visual communication of basic and clinical science as well as scientific education.

Primary Affiliation: Radboud University Nijmegen Medical Centre - Nijmegen, Gelderland , Netherlands

Specialties: epigenetics, vascular endothelium, heart disease, diabetes, atherosclerosis

Publications


Epigenetic Changes in Diabetes and Cardiovascular Risk.
Circ Res 2016 May;118(11):1706-22
From the Epigenetics in Human Health and Disease Laboratory (S.T.K., A.E.-O.) and Epigenomics Profiling Facility (A.E.-O.), Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.P.); Department of Pathology, The University of Melbourne, Victoria, Australia (A.E.-O.); and Central Clinical School, Department of Medicine, Monash University, Victoria, Australia (A.E.-O.).

Epigenetics and metabolism.
Circ Res 2015 Feb;116(4):715-36
From the Epigenetics in Human Health and Disease Laboratory (S.T.K., A.E.-O.) and Epigenomics Profiling Facility (S.T.K., A.E.-O.), Baker IDI Heart & Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia; Department of Pathology, The University of Melbourne, Victoria, Australia (A.E.-O.); and Central Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia (A.E.-O.).

Non-referenced genome assembly from epigenomic short-read data.
Epigenetics 2014 Oct;9(10):1329-38
a Epigenetics in Human Health and Disease Laboratory ; Baker IDI Heart and Diabetes Institute ; The Alfred Medical Research and Education Precinct ; Melbourne , Victoria , Australia ;

Vascular histone deacetylation by pharmacological HDAC inhibition.
Genome Res 2014 Aug 14;24(8):1271-84. Epub 2014 Apr 14.
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia; Faculty of Medicine, Monash University, Victoria 3800, Australia

Endothelial transcriptome in response to pharmacological methyltransferase inhibition.
ChemMedChem 2014 Aug 21;9(8):1755-62. Epub 2014 May 21.
Epigenetics in Human Health & Disease Laboratory, Baker IDI Heart & Diabetes Institute, The Alfred Medical Research & Education Precinct, Melbourne, Victoria 3004 (Australia); Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria 3800 (Australia).

Chromatin modifications remodel cardiac gene expression.
Cardiovasc Res 2014 Jul 8;103(1):7-16. Epub 2014 May 8.
Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia Central Clinical School, Faculty of Medicine, Monash University, Victoria, Australia Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia

Interplay of chromatin modifications and non-coding RNAs in the heart.
Epigenetics 2014 Jan 10;9(1):101-12. Epub 2013 Oct 10.
Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Epigenomics Profiling Facility; Baker IDI Heart and Diabetes Institute; The Alfred Medical Research and Education Precinct; Melbourne, VIC Australia; Department of Pathology; The University of Melbourne; Melbourne, VIC Australia; Faculty of Medicine; Monash University; Melbourne, VIC Australia.

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