Publications by authors named "Samuel Olusoji Olusi"

2 Publications

  • Page 1 of 1

The predictive value of CD38 positive hepatic stellate cell count for assessing disease activity and fibrosis in patients with chronic hepatitis.

Acta Histochem 2009 1;111(6):520-30. Epub 2008 Oct 1.

Department of Pathology, Faculty of Medicine, Health Science Centre, Kuwait University, P.O. Box. 24923, 13110 Safat, Kuwait.

The activation of hepatic stellate cells (HSCs) is a critical event in hepatic fibrosis. The objectives of this study were to find out if cluster of differentiation 38 (CD38) can be demonstrated immunohistochemically on HSCs in liver biopsies from patients with chronic liver disease and if CD38 immunopositive HSC count is correlated with METAVIR inflammatory and fibrosis scores. Immunohistochemical labelling for CD38 was performed on 100 liver biopsies from patients with chronic liver disease. The CD38 immunopositive HSCs were identified and counted. The CD38 immunopositive HSC count was found to be associated with both the METAVIR score and the fibrosis scores. The CD38 immunopositive HSC count was able to discriminate between no fibrosis and stages 2, 3 or 4 fibrosis, but could not discriminate between no fibrosis and stage 1 fibrosis. Using receiver operating characteristic (ROC) curves, a cut-off point of 10 HSCs per 10 high power field (hpf), or 25 per 100 hepatocytes, is 80% sensitive and 70% specific for predicting fibrosis. The specificity rose to 100% in patients with hepatitis C viral (HCV) infection. We conclude that CD38 positive HSCs can be demonstrated immunohistochemically and that the count is highly predictive of moderate to severe hepatic fibrosis.
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http://dx.doi.org/10.1016/j.acthis.2008.04.008DOI Listing
February 2010

Baseline population survey data on the prevalence of risk factors for coronary artery disease among Kuwaitis aged 15 years and older.

Ann Saudi Med 2003 May-Jul;23(3-4):162-6

Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

Background: There are no baseline population survey data on the prevalence of risk factors for coronary artery disease (CAD) among normal, healthy Kuwaiti women upon which future interventional studies can be based.

Subjects And Methods: We collected data on the prevalence of excessive weight, obesity, diabetes mellitus, dyslipidemia, current smoking and physical inactivity for 7,609 apparently healthy Kuwaitis aged 15 years and older by means of a household survey. Using a structured questionnaire, we collected demographic data from the respondents, measured their body weight and height, and collected blood samples for measurement of glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, and apolipoproteins A1 and B.

Results: The prevalence of obesity among adult Kuwaitis was 23.5%. It was higher among women (30.0%) than among men (17.5%). The combined prevalence of obesity and excessive weight in the population was 58% (63.4% among women and 53% among men). Diabetes mellitus and hypercholesterolemia were slightly higher in women than in men (21.8 vs 17.7 and 36.6 vs 30.2% respectively) while hypertriglyceridemia and low HDL-C were higher in men than in women (44.1 vs 33.8 and 52.2 vs 21.8% respectively). The prevalence of smoking was significantly higher in men (31.7%) than in women (1.4%), while the prevalence of physical inactivity was higher in women (71.4%) than in men (50.6%).

Conclusion: We conclude that Kuwaiti women, like men, have high risk factors for CAD and should receive equal attention in future programs to prevent CAD death among Kuwaitis.
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http://dx.doi.org/10.5144/0256-4947.2003.162DOI Listing
June 2007