Samuel N Breit

Samuel N Breit

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Samuel N Breit

Samuel N Breit

Publications by authors named "Samuel N Breit"

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MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury.

J Neurotrauma 2019 Aug 1. Epub 2019 Aug 1.

1St. Vincent's Centre for Applied Medical Research (AMR), St Vincent's Hospital and University of New South Wales (UNSW), Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1089/neu.2019.6421DOI Listing
August 2019

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.

Int J Obes (Lond) 2019 May 31. Epub 2019 May 31.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1038/s41366-019-0365-5DOI Listing
May 2019

Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes.

Curr Opin Support Palliat Care 2018 12;12(4):404-409

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW, Australia.

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http://Insights.ovid.com/crossref?an=01263393-900000000-9943
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http://dx.doi.org/10.1097/SPC.0000000000000384DOI Listing
December 2018

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.

Cell Metab 2018 09;28(3):353-368

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183046
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http://dx.doi.org/10.1016/j.cmet.2018.07.018DOI Listing
September 2018

Targeting Obesity and Cachexia: Identification of the GFRAL Receptor-MIC-1/GDF15 Pathway.

Trends Mol Med 2017 12 9;23(12):1065-1067. Epub 2017 Nov 9.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, 2010, Australia.

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http://dx.doi.org/10.1016/j.molmed.2017.10.005DOI Listing
December 2017

Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study.

Biochemistry 2016 07 29;55(27):3825-33. Epub 2016 Jun 29.

Department of Chemistry and Biomolecular Sciences, Macquarie University , Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1021/acs.biochem.6b00080DOI Listing
July 2016

CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.

Biol Open 2016 May 15;5(5):620-30. Epub 2016 May 15.

St Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia

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http://dx.doi.org/10.1242/bio.018119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874360PMC
May 2016

The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.

PLoS One 2015 13;10(4):e0123399. Epub 2015 Apr 13.

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395016PMC
March 2016

Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

PLoS One 2015 19;10(2):e0115189. Epub 2015 Feb 19.

St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335046PMC
January 2016

An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals.

Psychoneuroendocrinology 2015 Dec 29;62:80-8. Epub 2015 Jul 29.

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick, NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064530150085
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http://dx.doi.org/10.1016/j.psyneuen.2015.07.610DOI Listing
December 2015

CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: a smoking gun?

Biochim Biophys Acta 2014 Feb 1;1838(2):643-57. Epub 2013 Jun 1.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia; School of Physics, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2013.05.025DOI Listing
February 2014

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney Memory and Aging Study.

Aging Cell 2013 Oct 19;12(5):882-9. Epub 2013 Jul 19.

Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, 2010, Australia.

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http://dx.doi.org/10.1111/acel.12116DOI Listing
October 2013

Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis.

Cardiovasc Pathol 2012 Nov-Dec;21(6):499-505. Epub 2012 Mar 2.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.carpath.2012.02.003DOI Listing
May 2013

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.

J Cachexia Sarcopenia Muscle 2012 Dec 31;3(4):239-43. Epub 2012 Aug 31.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and UNSW, Sydney, NSW, 2010, Australia.

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http://doi.wiley.com/10.1007/s13539-012-0082-6
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http://dx.doi.org/10.1007/s13539-012-0082-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505580PMC
December 2012

Dendritic cells and multiple sclerosis: disease, tolerance and therapy.

Int J Mol Sci 2012 Dec 27;14(1):547-62. Epub 2012 Dec 27.

The Laboratory of Neuroinflammation, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney 2010, Australia.

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http://dx.doi.org/10.3390/ijms14010547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565281PMC
December 2012

Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer?

Cancer Epidemiol Biomarkers Prev 2012 Feb 5;21(2):337-46. Epub 2011 Dec 5.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Victoria St, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0786DOI Listing
February 2012

Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction.

Biochemistry 2011 Dec 18;50(50):10887-97. Epub 2011 Nov 18.

Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1021/bi2012564DOI Listing
December 2011

CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease.

J Neurosci 2011 Nov;31(48):17612-21

Laboratory of Neuroinflammation, Inflammation Research Program, St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney 2010, New South Wales, Australia.

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http://dx.doi.org/10.1523/JNEUROSCI.3449-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334319PMC
November 2011

The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

Growth Factors 2011 Oct 11;29(5):187-95. Epub 2011 Aug 11.

St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.3109/08977194.2011.607137DOI Listing
October 2011

Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4.

FEBS J 2011 May 30;278(10):1662-75. Epub 2011 Mar 30.

School of Physics, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08086.xDOI Listing
May 2011

GDF-15 contributes to proliferation and immune escape of malignant gliomas.

Clin Cancer Res 2010 Aug 9;16(15):3851-9. Epub 2010 Jun 9.

Laboratory of Molecular Neurooncology, Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0705DOI Listing
August 2010

The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.

J Interferon Cytokine Res 2010 Jun;30(6):389-97

St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1089/jir.2009.0052DOI Listing
June 2010

Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction.

Biochemistry 2010 Jun;49(25):5278-89

Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

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http://dx.doi.org/10.1021/bi100111cDOI Listing
June 2010

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Genesis 2010 Feb;48(2):127-36

St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/dvg.20590DOI Listing
February 2010

Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane.

Eur Biophys J 2009 Dec 23;39(1):129-38. Epub 2009 Apr 23.

Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia.

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http://dx.doi.org/10.1007/s00249-009-0450-0DOI Listing
December 2009

Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome.

Int J Cancer 2009 Dec;125(11):2624-30

Department of Neurosurgery, Laboratory of Brain Tumor Biology and Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/ijc.24639DOI Listing
December 2009

Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer.

Clin Cancer Res 2009 Nov 20;15(21):6658-64. Epub 2009 Oct 20.

Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-3126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557964PMC
November 2009

Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss.

Prostate 2009 May;69(6):652-61

Division of Hematology-Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-3300, USA.

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http://dx.doi.org/10.1002/pros.20913DOI Listing
May 2009

Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity.

J Invest Dermatol 2009 Feb 28;129(2):383-91. Epub 2008 Aug 28.

Melanoma Genomics Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/jid.2008.270DOI Listing
February 2009

Blockade of chloride intracellular ion channel 1 stimulates Abeta phagocytosis.

J Neurosci Res 2008 Aug;86(11):2488-98

Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1002/jnr.21693DOI Listing
August 2008

Structure of the Janus protein human CLIC2.

J Mol Biol 2007 Nov 20;374(3):719-31. Epub 2007 Sep 20.

Biota Structural Biology Laboratory, St. Vincent's Institute, Fitzroy, Victoria 3065, Australia.

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http://dx.doi.org/10.1016/j.jmb.2007.09.041DOI Listing
November 2007

Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction.

Arthritis Rheum 2007 Mar;56(3):753-64

St. Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/art.22410DOI Listing
March 2007

Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases.

Cancer Epidemiol Biomarkers Prev 2007 Mar;16(3):532-7

Department of Medicine, Division of Hematology-Oncology, University of Alabama at Birmingham, WTI T558, 1824 6th Avenue South, Birmingham, AL 35294-3300, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0841DOI Listing
March 2007

Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer.

Cancer Res 2006 May;66(10):4983-6

Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4067DOI Listing
May 2006

GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

Circ Res 2006 Feb 5;98(3):342-50. Epub 2006 Jan 5.

Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1161/01.RES.0000202804.84885.d0DOI Listing
February 2006

Transforming growth factor-beta1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system.

Cancer Immunol Immunother 2005 Sep 18;54(9):898-906. Epub 2005 Mar 18.

Dermatology Research Unit, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, University of Sydney, Blackburn Building, D06, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s00262-004-0652-3DOI Listing
September 2005

Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin.

Am J Physiol Endocrinol Metab 2005 Sep 12;289(3):E419-28. Epub 2005 Apr 12.

Department of Hematology, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1152/ajpendo.00512.2004DOI Listing
September 2005

The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.

J Biol Chem 2004 Mar 12;279(10):9298-305. Epub 2003 Nov 12.

Initiative for Biomolecular Structure, School of Physics, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.M308444200DOI Listing
March 2004

Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage.

Lancet 2004 Jan;363(9403):129-30

Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton 3168, Victoria, Australia.

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http://dx.doi.org/10.1016/S0140-6736(03)15265-8DOI Listing
January 2004

Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation.

J Biol Chem 2003 Oct 5;278(43):42136-48. Epub 2003 Aug 5.

School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1074/jbc.M212824200DOI Listing
October 2003

Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation.

Mol Cancer Ther 2003 Oct;2(10):1023-9

Discovery Oncology, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA.

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October 2003

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes.

Mol Hum Reprod 2003 Sep;9(9):535-40

Liggins Institute, Department of Pharmacology, University of Aukland Faculty of Medical and Health Sciences, Aukland, New Zealand.

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http://dx.doi.org/10.1093/molehr/gag068DOI Listing
September 2003

Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.

Cancer Res 2003 Aug;63(16):5034-40

Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Victoria Street, Sydney, NSW 2010, Australia.

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August 2003

MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

Clin Cancer Res 2003 Jul;9(7):2642-50

Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney NSW, Australia.

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July 2003

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.

Oncogene 2002 Jun;21(27):4212-9

Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hosptial Lausanne, 1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/sj.onc.1205610DOI Listing
June 2002

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study.

Lancet 2002 Jun;359(9324):2159-63

Centre for Immunology, St Vincent's Hospital and University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/S0140-6736(02)09093-1DOI Listing
June 2002

Activation of macrophage promatrix metalloproteinase-9 by lipopolysaccharide-associated proteinases.

J Immunol 2002 Mar;168(5):2449-55

Kanematsu Laboratories, Sydney Cancer Center, Royal Prince Alfred Hospital, University of Sydney, Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia.

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http://dx.doi.org/10.4049/jimmunol.168.5.2449DOI Listing
March 2002