Publications by authors named "Samuel M Cohen"

100Publications

Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.

Toxicol Lett 2021 Jan 8;336:32-38. Epub 2020 Nov 8.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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January 2021

Urinary crystal formation and urothelial effects of pyroxasulfone administered to male rats.

Toxicol Mech Methods 2020 Nov 4;30(9):656-671. Epub 2020 Sep 4.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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November 2020

Relevance of mouse lung tumors to human risk assessment.

J Toxicol Environ Health B Crit Rev 2020 07 25;23(5):214-241. Epub 2020 May 25.

Exponent Inc ., Alexandria, VA, USA.

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July 2020

An Interesting and Productive Research and Clinical Career.

Authors:
Samuel M Cohen

Int J Toxicol 2020 May/Jun;39(3):182-188. Epub 2020 Apr 7.

The 2020 Mildred S. Christian Career Achievement Award Winner, Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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April 2020

Cell proliferation analysis is a reliable predictor of lack of carcinogenicity: Case study using the pyrethroid imiprothrin on lung tumorigenesis in mice.

Regul Toxicol Pharmacol 2020 Jun 27;113:104646. Epub 2020 Mar 27.

Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan. Electronic address:

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June 2020

An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action.

Toxicol Sci 2020 05;175(1):50-63

Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd, Konohana-ku, Osaka 554-8558, Japan.

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May 2020

Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo.

Toxicology 2020 01 1;429:152325. Epub 2019 Nov 1.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.

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January 2020

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO).

Food Chem Toxicol 2019 Nov 29;133:110793. Epub 2019 Aug 29.

Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA. Electronic address:

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November 2019

Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach.

Crit Rev Toxicol 2019 01 1;49(1):36-84. Epub 2019 Apr 1.

Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center , Omaha , NE , USA.

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January 2019

Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice.

Regul Toxicol Pharmacol 2019 Jul 21;105:1-14. Epub 2019 Mar 21.

Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Omaha, NE, 68198-3135, USA.

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July 2019

Editorial.

Regul Toxicol Pharmacol 2019 02;101:A1-A2

Laboratory of Drug Metabolism and Pharmacokinetics Showa Pharmaceutical University Machida, Tokyo, Japan. Electronic address:

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February 2019

Chemical carcinogenicity revisited 1: A unified theory of carcinogenicity based on contemporary knowledge.

Regul Toxicol Pharmacol 2019 Apr 8;103:86-92. Epub 2019 Jan 8.

Parker Doe LLP, Carpenter Court, Maple Road, Bramhall, Stockport, Cheshire, SK7 2DH, UK. Electronic address:

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April 2019

Duration of unilateral auditory deprivation is associated with reduced speech perception after cochlear implantation: A single-sided deafness study.

Cochlear Implants Int 2019 03 28;20(2):51-56. Epub 2018 Nov 28.

a Department of Otolaryngology , New York University School of Medicine , New York , NY , USA.

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March 2019

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Food Chem Toxicol 2019 Feb 24;124:192-218. Epub 2018 Nov 24.

Scientific Secretary to the FEMA Expert Panel, 1101 17th Street, NW Suite 700, Washington, DC, 20036, USA. Electronic address:

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February 2019

Crystalluria and Chronic Kidney Disease.

Authors:
Samuel M Cohen

Toxicol Pathol 2018 12 1;46(8):949-955. Epub 2018 Oct 1.

1 Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2018

The safety evaluation of food flavouring substances: the role of metabolic studies.

Toxicol Res (Camb) 2018 Jul 28;7(4):618-646. Epub 2018 Mar 28.

Flavor and Extract Manufacturers Association , 1101 17th Street , NW Suite 700 , Washington , DC 20036 , USA . Email: ; ; Tel: +1 (202)293-5800.

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July 2018

Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary.

Authors:
Samuel M Cohen

Toxicol Res (Camb) 2018 Jul 23;7(4):565-575. Epub 2018 Jan 23.

Havlik-Wall Professor of Oncology , Department of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , NE 68198-3135 , USA . Email:

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July 2018

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory.

Nat Commun 2018 06 22;9(1):2451. Epub 2018 Jun 22.

Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.

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June 2018

Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN).

Toxicol Pathol 2018 04 4;46(3):266-272. Epub 2018 Mar 4.

1 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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April 2018

Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis.

Toxicology 2018 04 6;398-399:31-40. Epub 2018 Mar 6.

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan.

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April 2018

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice.

J Pharmacol Exp Ther 2018 05 23;365(2):272-280. Epub 2018 Feb 23.

Department of Pharmacology and Experimental Neuroscience (J.M.M., D.A.C., M.G.B., R.S.D., A.A.B.W., W.W., E.M., T.K., P.S.J., H.E.G., S.G., L.Y.P.), Developmental Neuroscience, Munroe Meyer Institute for Genetics and Rehabilitation (C.B.G.), Department of Pharmaceutical Sciences (Z.L.), Mouse Genome Engineering Core Facility, Vice Chancellor for Research Office (R.M.Q., D.W.H., C.B.G.), and Department of Pathology and Microbiology (S.M.C.), University of Nebraska Medical Center, Omaha, Nebraska

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May 2018

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food.

Food Chem Toxicol 2018 Mar 31;113:171-178. Epub 2018 Jan 31.

Scientific Secretary to the FEMA Expert Panel, 1101 17th Street, NW Suite 700, Washington, DC, 20036, USA. Electronic address:

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March 2018

Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer.

Nanomedicine 2018 04 9;14(3):769-780. Epub 2018 Jan 9.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE. Electronic address:

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April 2018

Effect of polyhexamethylene biguanide on rat liver.

Toxicol Lett 2018 Mar 2;285:94-103. Epub 2018 Jan 2.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States; Havlik-Wall Professor of Oncology, United States. Electronic address:

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March 2018

Letter to the editor, re: Lynch et al., 2017.

Authors:
Samuel M Cohen

Environ Int 2018 02 10;111:316. Epub 2017 Nov 10.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, United States. Electronic address:

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February 2018

Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite.

Toxicol Rep 2017 14;4:32-38. Epub 2016 Dec 14.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

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December 2016

Tuning polypeptide-based micellar carrier for efficient combination therapy of ErbB2-positive breast cancer.

J Control Release 2017 10 11;264:276-287. Epub 2017 Sep 11.

Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address:

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October 2017

Inorganic arsenic: A non-genotoxic carcinogen.

J Environ Sci (China) 2016 Nov 17;49:28-37. Epub 2016 May 17.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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November 2016

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Food Chem Toxicol 2017 Jan 9;99:40-59. Epub 2016 Nov 9.

Flavor and Extract Manufacturers Association, 1101 17th Street, NW Suite 700, Washington, DC, 20036, USA. Electronic address:

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January 2017

Response to Druwe and Burgoon, 2016 Letter to the Editor in Archives of Toxicology.

Arch Toxicol 2017 02 9;91(2):999-1000. Epub 2016 Nov 9.

University of Nebraska Medical Center, Omaha, NE, USA.

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February 2017

Critical role of toxicologic pathology in a short-term screen for carcinogenicity.

J Toxicol Pathol 2016 Oct 23;29(4):215-227. Epub 2016 May 23.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Omaha, NE 68198-3135, USA.

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October 2016

Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale.

Nutr Cancer 2016 Nov-Dec;68(8):1247-1261. Epub 2016 Sep 21.

f Department of Pathology , New York Medical College , Valhalla , New York , USA.

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December 2017

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results.

Food Chem Toxicol 2016 Dec 20;98(Pt B):201-209. Epub 2016 Oct 20.

Flavor and Extract Manufacturers Association, 1101 17th Street, NW Suite 700, Washington, DC 20036, USA. Electronic address:

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December 2016

Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite.

Chem Res Toxicol 2016 09 8;29(9):1480-7. Epub 2016 Aug 8.

Analytical and Environmental Toxicology Division, Department of Laboratory Medicine and Pathology, University of Alberta , Edmonton, Alberta T6G 2G3, Canada.

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September 2016

Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons.

Neuron 2016 04 31;90(2):292-307. Epub 2016 Mar 31.

Department of Neuroscience and Physiology and NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address:

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April 2016

Suggestive evidence for the induction of colonic aberrant crypts in mice fed sodium nitrite.

Nutr Cancer 2016 23;68(1):105-12. Epub 2015 Dec 23.

a Eppley Institute for Research in Cancer, University of Nebraska Medical Center , Omaha , Nebraska , USA.

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December 2016

Targeted delivery of platinum-taxane combination therapy in ovarian cancer.

J Control Release 2015 Dec 14;220(Pt B):651-9. Epub 2015 Sep 14.

Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. Electronic address:

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December 2015

Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.

Biochem Biophys Res Commun 2015 Apr;460(1):88-99

NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address:

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April 2015

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells.

Toxicol Rep 2015 21;2:833-837. Epub 2015 May 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135, USA.

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May 2015

Response to: NMDA hypofunction attenuates driver inputs in higher order thalamic nuclei: An alternative view.

Schizophr Res 2015 Aug 5;166(1-3):343-4. Epub 2015 May 5.

NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA; Department of Psychiatry, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address:

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August 2015

Polypeptide-based nanogels co-encapsulating a synergistic combination of doxorubicin with 17-AAG show potent anti-tumor activity in ErbB2-driven breast cancer models.

J Control Release 2015 Jun 3;208:59-66. Epub 2015 Feb 3.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, United States. Electronic address:

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June 2015

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia.

Schizophr Res 2015 Sep 9;167(1-3):98-107. Epub 2015 Jan 9.

NYU Neuroscience Institute, Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA; Department of Psychiatry, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA. Electronic address:

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September 2015

γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.

Cell 2014 Oct;159(2):281-94

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address:

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October 2014

Orally administered nicotine induces urothelial hyperplasia in rats and mice.

Toxicology 2014 Jan 19;315:49-54. Epub 2013 Nov 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA; Havlik-Wall Professor of Oncology. Electronic address:

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January 2014

Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches.

Toxicology 2013 Dec 27;314(2-3):238-46. Epub 2013 Oct 27.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM), Department of Pathology, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address:

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December 2013

Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic.

Toxicol Sci 2014 Jan 4;137(1):36-46. Epub 2013 Oct 4.

* Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135;

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January 2014

Pathogenesis of human hemangiosarcomas and hemangiomas.

Hum Pathol 2013 Oct;44(10):2302-11

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.

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October 2013

Evaluation of the carcinogenicity of inorganic arsenic.

Crit Rev Toxicol 2013 Oct;43(9):711-52

Department of Pathology and Microbiology, University of Nebraska Medical Center , Omaha, NE , USA .

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October 2013

Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells.

Toxicology 2013 Oct 19;312:18-29. Epub 2013 Jul 19.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA. Electronic address:

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October 2013

Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide.

Toxicol Sci 2013 Aug 6;134(2):271-5. Epub 2013 Jun 6.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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August 2013

Arsenic speciation in the blood of arsenite-treated F344 rats.

Chem Res Toxicol 2013 Jun 4;26(6):952-62. Epub 2013 Jun 4.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

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June 2013

Time course of urothelial changes in rats and mice orally administered arsenite.

Toxicol Pathol 2014 Jul 20;42(5):855-62. Epub 2013 May 20.

Department of Pathology and Microbiology and the Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

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July 2014

Biodegradable hybrid polymer micelles for combination drug therapy in ovarian cancer.

J Control Release 2013 Nov 9;171(3):339-48. Epub 2013 May 9.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha 68198-5830, USA.

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November 2013

Diuron-induced rat bladder epithelial cytotoxicity.

Toxicol Sci 2012 Dec 24;130(2):281-8. Epub 2012 Aug 24.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.

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December 2012

Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles.

Chemother Res Pract 2012 15;2012:905796. Epub 2012 Jul 15.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-5830, USA.

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August 2012

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.

Int J Nanomedicine 2012 8;7:2557-71. Epub 2012 Jun 8.

Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-5830, USA.

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January 2013

Evaluation of the male reproductive toxicity of gallium arsenide.

Regul Toxicol Pharmacol 2012 Oct 21;64(1):77-86. Epub 2012 Jun 21.

REACh ChemConsult GmbH Dresden, Germany.

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October 2012