Samuel Leung

Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Center for Gynaecologic Oncology, Netherlands Cancer Institute and Amsterdam University Medical Center, 1066, CX, Amsterdam, the Netherlands.

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December 2020

Molecular characterization of invasive and in situ squamous neoplasia of the vulva and implications for morphologic diagnosis and outcome.

Authors:

Basile Tessier-Cloutier Jennifer Pors Emily Thompson Julie Ho Leah Prentice Melissa McConechy Rosalia Aguirre-Hernandez Ruth Miller Samuel Leung Lily Proctor Jessica N McAlpine David G Huntsman C Blake Gilks Lynn N Hoang

Mod Pathol 2021 02 13;34(2):508-518. Epub 2020 Aug 13.

Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.

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February 2021

Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma.

Clin Cancer Res 2020 Oct 31;26(20):5400-5410. Epub 2020 Jul 31.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.

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October 2020

Single cell transcriptomes of normal endometrial derived organoids uncover novel cell type markers and cryptic differentiation of primary tumours.

J Pathol 2020 10 22;252(2):201-214. Epub 2020 Aug 22.

Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada.

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October 2020

Differential expression and prognostic relevance of autophagy-related markers ATG4B, GABARAP, and LC3B in breast cancer.

Authors:

Svetlana Bortnik Basile Tessier-Cloutier Samuel Leung Jing Xu Karama Asleh Samantha Burugu Jamie Magrill Kendall Greening Fatemeh Derakhshan Stephen Yip Tony Ng Karen A Gelmon Torsten O Nielsen Sharon M Gorski

Breast Cancer Res Treat 2020 Oct 20;183(3):525-547. Epub 2020 Jul 20.

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.

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October 2020

Correction to: Mismatch repair protein loss in breast cancer: clinicopathological associations in a large British Columbia cohort.

Authors:

Angela S Cheng Samuel C Y Leung Dongxia Gao Samantha Burugu Meenakshi Anurag Matthew J Ellis Torsten O Nielsen

Breast Cancer Res Treat 2020 08;182(3):765

Genetic Pathology Evaluation Centre and University of British Columbia, Vancouver, BC, Canada.

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August 2020

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.

Authors:

Filipe Correia Martins Dominique-Laurent Couturier Anna Paterson Anthony N Karnezis Christine Chow Tayyebeh M Nazeran Adekunle Odunsi Aleksandra Gentry-Maharaj Aleksandra Vrvilo Alexander Hein Aline Talhouk Ana Osorio Andreas D Hartkopf Angela Brooks-Wilson Anna DeFazio Anna Fischer Arndt Hartmann Brenda Y Hernandez Bryan M McCauley Chloe Karpinskyj Christiani B de Sousa Claus Høgdall Daniel G Tiezzi Esther Herpel Florin Andrei Taran Francesmary Modugno Gary Keeney Gregg Nelson Helen Steed Honglin Song Hugh Luk Javier Benitez Jennifer Alsop Jennifer M Koziak Jenny Lester Joseph H Rothstein Jurandyr M de Andrade Lene Lundvall Luis Paz-Ares Luis Robles-Díaz Lynne R Wilkens Maria J Garcia Maria P Intermaggio Marie-Lyne Alcaraz Mary A Brett Matthias W Beckmann Mercedes Jimenez-Linan Michael Anglesio Michael E Carney Michael Schneider Nadia Traficante Nadja Pejovic Naveena Singh Nhu Le Peter Sinn Prafull Ghatage Ramona Erber Robert Edwards Robert Vierkant Roberta B Ness Samuel Leung Sandra Orsulic Sara Y Brucker Scott H Kaufmann Sian Fereday Simon Gayther Stacey J Winham Stefan Kommoss Tanja Pejovic Teri A Longacre Valerie McGuire Valerie Rhenius Weiva Sieh Yurii B Shvetsov Alice S Whittemore Annette Staebler Beth Y Karlan Cristina Rodriguez-Antona David D Bowtell Ellen L Goode Estrid Høgdall Francisco J Candido Dos Reis Jacek Gronwald Jenny Chang-Claude Kirsten B Moysich Linda E Kelemen Linda S Cook Marc T Goodman Peter A Fasching Robin Crawford Suha Deen Usha Menon David G Huntsman Martin Köbel Susan J Ramus Paul D P Pharoah James D Brenton

Br J Cancer 2020 Sep 18;123(5):793-802. Epub 2020 Jun 18.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, England.

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September 2020

Phospho-Ser-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer.

Authors:

Cuige Zhu Anna Rogers Karama Asleh Jennifer Won Dongxia Gao Samuel Leung Shan Li Kiran R Vij Jian Zhu Jason M Held Zhongsheng You Torsten O Nielsen Jieya Shao

Cell Rep 2020 06;31(10):107745

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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June 2020

FGFR2c Mesenchymal Isoform Expression Is Associated with Poor Prognosis and Further Refines Risk Stratification within Endometrial Cancer Molecular Subtypes.

Authors:

Asmerom T Sengal Ann-Marie Patch Cameron E Snell Deborah S Smith Samuel C Y Leung Aline Talhouk Elizabeth D Williams Jessica N McAlpine Pamela M Pollock

Clin Cancer Res 2020 Sep 15;26(17):4569-4580. Epub 2020 May 15.

Queensland University of Technology, School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, located at the Translational Research Institute, PA Hospital Campus, 37 Kent St Woolloongabba, Brisbane, Queensland, Australia.

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September 2020

Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type.

Clin Cancer Res 2020 Aug 14;26(16):4402-4413. Epub 2020 May 14.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

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August 2020

Proteomic analysis of transitional cell carcinoma-like variant of tubo-ovarian high-grade serous carcinoma.

Hum Pathol 2020 07 29;101:40-52. Epub 2020 Apr 29.

Institute of Pathology, Medizin Campus Bodensee, Friedrichshafen, Germany. Electronic address:

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July 2020

Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.

Authors:

Mayanne M T Zhu Samantha Burugu Dongxia Gao Jamie Yu Zuzana Kos Samuel Leung Basil A Horst Torsten O Nielsen

Mod Pathol 2020 09 29;33(9):1753-1763. Epub 2020 Apr 29.

Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada.

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September 2020

Molecular subtypes of clear cell carcinoma of the endometrium: Opportunities for prognostic and predictive stratification.

Authors:

Soyoun Rachel Kim Basile Tessier Cloutier Samuel Leung Dawn Cochrane Heidi Britton Annick Pina Claudine Storness-Bliss David Farnell Leo Huang Kathryn Shum Amy Lum Janine Senz Cheng-Han Lee C Blake Gilks Lien Hoang Jessica N McAlpine

Gynecol Oncol 2020 07 21;158(1):3-11. Epub 2020 Apr 21.

Department of Obstetrics and Gynecology, Division of Gynecology Oncology, University of British Columbia, Vancouver, BC, Canada; BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

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July 2020

Association of human papilloma virus status and response to radiotherapy in vulvar squamous cell carcinoma.

Authors:

Lily Proctor Lien Hoang Jocelyn Moore Emily Thompson Samuel Leung Divya Natesan Junzo Chino Blake Gilks Jessica N McAlpine

Int J Gynecol Cancer 2020 01 25;30(1):100-106. Epub 2019 Nov 25.

Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada

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January 2020

Mismatch repair protein loss in breast cancer: clinicopathological associations in a large British Columbia cohort.

Authors:

Angela S Cheng Samuel C Y Leung Dongxia Gao Samantha Burugu Meenakshi Anurag Matthew J Ellis Torsten O Nielsen

Breast Cancer Res Treat 2020 Jan 14;179(1):3-10. Epub 2019 Sep 14.

Genetic Pathology Evaluation Centre and University of British Columbia, Vancouver, BC, Canada.

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January 2020

Expression of L1 retrotransposon open reading frame protein 1 in gynecologic cancers.

Authors:

Zhouchunyang Xia Dawn R Cochrane Basile Tessier-Cloutier Samuel Leung Anthony N Karnezis Angela S Cheng David A Farnell Jamie Magrill Dietmar Schmidt Stefan Kommoss Felix K F Kommoss Friederich Kommoss Jessica N McAlpine C Blake Gilks Martin Koebel Joseph T Rabban David G Huntsman

Hum Pathol 2019 10 18;92:39-47. Epub 2019 Jun 18.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1L3, Canada; Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada. Electronic address:

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October 2019

Use of Immunohistochemical Markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to Distinguish Endometrial Clear Cell Carcinoma From Its Morphologic Mimics Including Arias-Stella Reaction.

Authors:

Jennifer X Ji Dawn R Cochrane Basile Tessier-Cloutier Samuel Leung Angela S Cheng Christine Chow Blake Gilks David G Huntsman Lynn N Hoang

Int J Gynecol Pathol 2020 Jul;39(4):344-353

Department of Pathology and Laboratory Medicine, University of British Columbia (J.X.J., B.T.-C, B.G., D.G.H., L.N.H.) Department of Molecular Oncology, British Columbia Cancer Research Centre (D.R.C.) Genetic Pathology Evaluation Centre (S.L., A.S.C., C.C.) Department of Pathology, Vancouver General Hospital (B.G., L.N.H.), Vancouver, British Columbia, Canada.

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July 2020

Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration.

Histopathology 2019 Aug 8;75(2):225-235. Epub 2019 Jul 8.

The Institute of Cancer Research, London, UK.

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August 2019

Molecular classification defines outcomes and opportunities in young women with endometrial carcinoma.

Authors:

Heidi Britton Leo Huang Amy Lum Samuel Leung Kathryn Shum Mruganka Kale Angela Burleigh Janine Senz Winnie Yang Melissa McConechy Stefan Kommoss Sara Brucker Aline Talhouk C Blake Gilks Jessica N McAlpine

Gynecol Oncol 2019 06 25;153(3):487-495. Epub 2019 Mar 25.

Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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June 2019