Samuel Lessard

Samuel Lessard

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Samuel Lessard

Samuel Lessard

Publications by authors named "Samuel Lessard"

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11Publications

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14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.

Authors:
Samuel Lessard Mélissa Beaudoin Stuart H Orkin Daniel E Bauer Guillaume Lettre

Hum Mol Genet 2018 04;27(8):1411-1420

Montreal Heart Institute, Montréal, QC H1T 1C8, Canada.

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http://dx.doi.org/10.1093/hmg/ddy051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251675PMC
April 2018

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.

Authors:
Laura M Raffield Jacob C Ulirsch Rakhi P Naik Samuel Lessard Robert E Handsaker Deepti Jain Hyun M Kang Nathan Pankratz Paul L Auer Erik L Bao Joshua D Smith Leslie A Lange Ethan M Lange Yun Li Timothy A Thornton Bessie A Young Goncalo R Abecasis Cathy C Laurie Deborah A Nickerson Steven A McCarroll Adolfo Correa James G Wilson Guillaume Lettre Vijay G Sankaran Alex P Reiner

PLoS Genet 2018 03 28;14(3):e1007293. Epub 2018 Mar 28.

Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891078PMC
March 2018

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

Authors:
Samuel Lessard Laurent Francioli Jessica Alfoldi Jean-Claude Tardif Patrick T Ellinor Daniel G MacArthur Guillaume Lettre Stuart H Orkin Matthew C Canver

Proc Natl Acad Sci U S A 2017 12 11;114(52):E11257-E11266. Epub 2017 Dec 11.

Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1714640114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748207PMC
December 2017

Frameshift indels introduced by genome editing can lead to in-frame exon skipping.

Authors:
Simon Lalonde Oliver A Stone Samuel Lessard Adam Lavertu Jessica Desjardins Mélissa Beaudoin Manuel Rivas Didier Y R Stainier Guillaume Lettre

PLoS One 2017 1;12(6):e0178700. Epub 2017 Jun 1.

Montreal Heart Institute, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178700PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453576PMC
September 2017

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.

Authors:
Samuel Lessard Emily Stern Gatof Mélissa Beaudoin Patrick G Schupp Falak Sher Adnan Ali Sukhpal Prehar Ryo Kurita Yukio Nakamura Esther Baena Jonathan Ledoux Delvac Oceandy Daniel E Bauer Guillaume Lettre

J Clin Invest 2017 Aug 17;127(8):3065-3074. Epub 2017 Jul 17.

Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1172/JCI94378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531409PMC
August 2017

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Authors:
Matthew C Canver Samuel Lessard Luca Pinello Yuxuan Wu Yann Ilboudo Emily N Stern Austen J Needleman Frédéric Galactéros Carlo Brugnara Abdullah Kutlar Colin McKenzie Marvin Reid Diane D Chen Partha Pratim Das Mitchel A Cole Jing Zeng Ryo Kurita Yukio Nakamura Guo-Cheng Yuan Guillaume Lettre Daniel E Bauer Stuart H Orkin

Nat Genet 2017 Apr 20;49(4):625-634. Epub 2017 Feb 20.

Division of Hematology/Oncology, Boston Children's Hospital; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Harvard Stem Cell Institute; and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374001PMC
April 2017

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients.

Authors:
Albert Nguyen Maya Mamarbachi Valérie Turcot Samuel Lessard Carol Yu Xiaoyan Luo Julie Lalongé Doug Hayami Mathieu Gayda Martin Juneau Nathalie Thorin-Trescases Guillaume Lettre Anil Nigam Eric Thorin

PLoS One 2016 21;11(4):e0153920. Epub 2016 Apr 21.

Montreal Heart Institute, Research Center, Université de Montréal, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153920PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839636PMC
March 2017

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.

Authors:
Nathalie Chami Ming-Huei Chen Andrew J Slater John D Eicher Evangelos Evangelou Salman M Tajuddin Latisha Love-Gregory Tim Kacprowski Ursula M Schick Akihiro Nomura Ayush Giri Samuel Lessard Jennifer A Brody Claudia Schurmann Nathan Pankratz Lisa R Yanek Ani Manichaikul Raha Pazoki Evelin Mihailov W David Hill Laura M Raffield Amber Burt Traci M Bartz Diane M Becker Lewis C Becker Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Michelle L O'Donoghue David R Crosslin Simon de Denus Marie-Pierre Dubé Paul Elliott Gunnar Engström Michele K Evans James S Floyd Myriam Fornage He Gao Andreas Greinacher Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Jussi Hernesniemi Heather M Highland Joel N Hirschhorn Albert Hofman Marguerite R Irvin Mika Kähönen Ethan Lange Lenore J Launer Terho Lehtimäki Jin Li David C M Liewald Allan Linneberg Yongmei Liu Yingchang Lu Leo-Pekka Lyytikäinen Reedik Mägi Rasika A Mathias Olle Melander Andres Metspalu Nina Mononen Mike A Nalls Deborah A Nickerson Kjell Nikus Chris J O'Donnell Marju Orho-Melander Oluf Pedersen Astrid Petersmann Linda Polfus Bruce M Psaty Olli T Raitakari Emma Raitoharju Melissa Richard Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Frank Schmidt Albert Vernon Smith John M Starr Kent D Taylor Alexander Teumer Betina H Thuesen Eric S Torstenson Russell P Tracy Ioanna Tzoulaki Neil A Zakai Caterina Vacchi-Suzzi Cornelia M van Duijn Frank J A van Rooij Mary Cushman Ian J Deary Digna R Velez Edwards Anne-Claire Vergnaud Lars Wallentin Dawn M Waterworth Harvey D White James G Wilson Alan B Zonderman Sekar Kathiresan Niels Grarup Tõnu Esko Ruth J F Loos Leslie A Lange Nauder Faraday Nada A Abumrad Todd L Edwards Santhi K Ganesh Paul L Auer Andrew D Johnson Alexander P Reiner Guillaume Lettre

Am J Hum Genet 2016 Jul 23;99(1):8-21. Epub 2016 Jun 23.

Department of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada; Montreal Heart Institute, Montréal, QC H1T 1C8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005438PMC
July 2016

Testing the role of predicted gene knockouts in human anthropometric trait variation.

Authors:
Samuel Lessard Alisa K Manning Cécile Low-Kam Paul L Auer Ayush Giri Mariaelisa Graff Claudia Schurmann Hanieh Yaghootkar Jian'an Luan Tonu Esko Tugce Karaderi Erwin P Bottinger Yingchang Lu Chris Carlson Mark Caulfield Marie-Pierre Dubé Rebecca D Jackson Charles Kooperberg Barbara McKnight Ian Mongrain Ulrike Peters Alex P Reiner David Rhainds Nona Sotoodehnia Joel N Hirschhorn Robert A Scott Patricia B Munroe Timothy M Frayling Ruth J F Loos Kari E North Todd L Edwards Jean-Claude Tardif Cecilia M Lindgren Guillaume Lettre

Hum Mol Genet 2016 05 21;25(10):2082-2092. Epub 2016 Feb 21.

Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada Faculté de Médecine, Université de Montréal, Montréal, Québec H3T 1J4, Canada

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http://dx.doi.org/10.1093/hmg/ddw055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062577PMC
May 2016

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.

Authors:
Samuel Lessard Mélissa Beaudoin Karim Benkirane Guillaume Lettre

Genome Med 2015 20;7(1). Epub 2015 Jan 20.

Montreal Heart Institute, 5000 Bélanger Street, Montréal, Québec H1T 1C8 Canada ; Faculté de Médecine, Université de Montréal, 2900 Boul. Édouard-Montpetit, Montréal, Québec H3T 1J4 Canada.

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http://genomemedicine.com/content/7/1/1
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http://dx.doi.org/10.1186/s13073-014-0122-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298057PMC
January 2015

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Authors:
Daniel E Bauer Sophia C Kamran Samuel Lessard Jian Xu Yuko Fujiwara Carrie Lin Zhen Shao Matthew C Canver Elenoe C Smith Luca Pinello Peter J Sabo Jeff Vierstra Richard A Voit Guo-Cheng Yuan Matthew H Porteus John A Stamatoyannopoulos Guillaume Lettre Stuart H Orkin

Science 2013 Oct;342(6155):253-7

Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1242088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018826PMC
October 2013