Samuel G Mackintosh

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street (slot 516), Little Rock, AR 72205-7199, USA.

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August 2020

Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome.

Authors:

Xien Yu Chua Theresa Mensah Timothy Aballo Samuel G Mackintosh Ricky D Edmondson Arthur R Salomon

Mol Cell Proteomics 2020 04 18;19(4):730-743. Epub 2020 Feb 18.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island

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April 2020

Accurate and Sensitive Quantitation of the Dynamic Heat Shock Proteome Using Tandem Mass Tags.

Authors:

Aaron J Storey Rebecca E Hardman Stephanie D Byrum Samuel G Mackintosh Rick D Edmondson Wayne P Wahls Alan J Tackett Jeffrey A Lewis

J Proteome Res 2020 03 19;19(3):1183-1195. Epub 2020 Feb 19.

Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, United States.

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March 2020

Respiratory defects in the KO mouse model of osteogenesis imperfecta.

Authors:

Milena Dimori Melissa E Heard-Lipsmeyer Stephanie D Byrum Samuel G Mackintosh Richard C Kurten John L Carroll Roy Morello

Am J Physiol Lung Cell Mol Physiol 2020 04 5;318(4):L592-L605. Epub 2020 Feb 5.

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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April 2020

Exploiting Correlations between Protein Abundance and the Functional Status of and To Identify Virulence Factors of Potential Importance in the Pathogenesis of Osteomyelitis.

Authors:

Aura M Ramirez Stephanie D Byrum Karen E Beenken Charity Washam Rick D Edmondson Samuel G Mackintosh Horace J Spencer Alan J Tackett Mark S Smeltzer

ACS Infect Dis 2020 02 26;6(2):237-249. Epub 2019 Nov 26.

Department of Microbiology and Immunology, College of Medicine , University of Arkansas for Medical Sciences , 4301 W. Markham Street, Slot 511 , Little Rock , Arkansas 72205 , United States.

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February 2020

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.

Authors:

Joel H Vazquez Melissa M Clemens Felicia D Allard Eric U Yee Stefanie Kennon-McGill Samuel G Mackintosh Hartmut Jaeschke Michael D Hambuchen Mitchell R McGill

Toxicol Sci 2020 02;173(2):244-254

Department of Pharmacology and Toxicology.

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February 2020

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.

Blood 2019 10 5;134(14):1176-1189. Epub 2019 Aug 5.

Lineberger Comprehensive Cancer Center and.

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October 2019

Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.

Authors:

Chad E Cragle Melanie C MacNicol Stephanie D Byrum Linda L Hardy Samuel G Mackintosh William A Richardson Nicola K Gray Gwen V Childs Alan J Tackett Angus M MacNicol

J Biol Chem 2019 07 31;294(28):10969-10986. Epub 2019 May 31.

From the Department of Neurobiology and Developmental Sciences,

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July 2019

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.

Sci Transl Med 2019 05;11(491)

Department of Lymphoma and Myeloma, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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May 2019

Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.

Authors:

Edgar Garcia-Rill Alan J Tackett Stephanie D Byrum Renny S Lan Samuel G Mackintosh James R Hyde Veronica Bisagno Francisco J Urbano

Brain Sci 2019 Mar 18;9(3). Epub 2019 Mar 18.

IFIBYNE, CONICET, Universidad de Buenos Aires, Buenos Aires C1113, Argentina.

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March 2019

DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.

Authors:

Jun Gao Alicia K Byrd Boris L Zybailov John C Marecki Michael J Guderyon Andrea D Edwards Shubeena Chib Kirk L West Zachary J Waldrip Samuel G Mackintosh Zhaofeng Gao Andrea A Putnam Eckhard Jankowsky Kevin D Raney

Chem Commun (Camb) 2019 Apr;55(31):4467-4470

Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street (Slot 516), Little Rock, Arkansas 72205, USA.

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April 2019

Proteomic characterization of the arsenic response locus in S. cerevisiae.

Authors:

Kirk L West Stephanie D Byrum Samuel G Mackintosh Rick D Edmondson Sean D Taverna Alan J Tackett

Epigenetics 2019 02 1;14(2):130-145. Epub 2019 Mar 1.

a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

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February 2019

Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats.

Authors:

Boris L Zybailov Galina V Glazko Yasir Rahmatallah Dmitri S Andreyev Taylor McElroy Oleg Karaduta Stephanie D Byrum Lisa Orr Alan J Tackett Samuel G Mackintosh Ricky D Edmondson Dorothy A Kieffer R J Martin Sean H Adams Nosratola D Vaziri John M Arthur

PLoS One 2019 30;14(1):e0199274. Epub 2019 Jan 30.

Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America.

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September 2019

Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma.

Authors:

Bradley D Shields Brian Koss Erin M Taylor Aaron J Storey Kirk L West Stephanie D Byrum Samuel G Mackintosh Rick Edmondson Fade Mahmoud Sara C Shalin Alan J Tackett

Cancer Res 2019 03 23;79(6):1113-1123. Epub 2019 Jan 23.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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March 2019

Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.

Authors:

Stephanie D Byrum Allister J Loughran Karen E Beenken Lisa M Orr Aaron J Storey Samuel G Mackintosh Ricky D Edmondson Alan J Tackett Mark S Smeltzer

J Proteome Res 2018 10 27;17(10):3384-3395. Epub 2018 Sep 27.

Department of Microbiology and Immunology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States.

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October 2018

Oxidation resistance 1 is a novel senolytic target.

Authors:

Xin Zhang Suping Zhang Xingui Liu Yingying Wang Jianhui Chang Xuan Zhang Samuel G Mackintosh Alan J Tackett Yonghan He Dongwen Lv Remi-Martin Laberge Judith Campisi Jianrong Wang Guangrong Zheng Daohong Zhou

Aging Cell 2018 08 15;17(4):e12780. Epub 2018 May 15.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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August 2018

Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1.

Authors:

Emily R Holthoff Stephanie D Byrum Samuel G Mackintosh Thomas Kelly Alan J Tackett Charles M Quick Steven R Post

Clin Proteomics 2017 6;14:40. Epub 2017 Dec 6.

Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 845, Little Rock, AR 72205 USA.

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December 2017

Indicators of responsiveness to immune checkpoint inhibitors.

Authors:

Bradley D Shields Fade Mahmoud Erin M Taylor Stephanie D Byrum Deepanwita Sengupta Brian Koss Giulia Baldini Seth Ransom Kyle Cline Samuel G Mackintosh Ricky D Edmondson Sara Shalin Alan J Tackett

Sci Rep 2017 04 11;7(1):807. Epub 2017 Apr 11.

Departments of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas, 72205, USA.

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April 2017

Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection.

Authors:

Stephanie D Byrum Marie S Burdine Lisa Orr Samuel G Mackintosh Simon Authier Mylene Pouliot Martin Hauer-Jensen Alan J Tackett

PLoS One 2017 28;12(3):e0174771. Epub 2017 Mar 28.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

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August 2017

KDM5 lysine demethylases are involved in maintenance of 3'UTR length.

Authors:

Lauren P Blair Zongzhi Liu Ramon Lorenzo D Labitigan Lizhen Wu Dinghai Zheng Zheng Xia Erica L Pearson Fathima I Nazeer Jian Cao Sabine M Lang Rachel J Rines Samuel G Mackintosh Claire L Moore Wei Li Bin Tian Alan J Tackett Qin Yan

Sci Adv 2016 Nov 18;2(11):e1501662. Epub 2016 Nov 18.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.

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November 2016

1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.

Authors:

Jessica H Hartman Grover P Miller Andres A Caro Stephanie D Byrum Lisa M Orr Samuel G Mackintosh Alan J Tackett Lee Ann MacMillan-Crow Lance M Hallberg Bill T Ameredes Gunnar Boysen

Toxicology 2017 03 9;378:114-124. Epub 2017 Jan 9.

Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States; The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Electronic address:

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March 2017

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in .

Authors:

Srinivas Ayyadevara Meenakshisundaram Balasubramaniam Pooja Suri Samuel G Mackintosh Alan J Tackett Dennis H Sullivan Robert J Shmookler Reis Richard A Dennis

Aging (Albany NY) 2016 12;8(12):3486-3497

Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA.

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December 2016

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

Authors:

Toshifumi Fujiwara Shiqiao Ye Thiago Castro-Gomes Caylin G Winchell Norma W Andrews Daniel E Voth Kottayil I Varughese Samuel G Mackintosh Yunfeng Feng Nathan Pavlos Takashi Nakamura Stavros C Manolagas Haibo Zhao

JCI Insight 2016 Oct 20;1(17):e86330. Epub 2016 Oct 20.

Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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October 2016

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.

Authors:

Rong Chu Sarah E Alford Katherine Hart Anisha Kothari Samuel G Mackintosh Matthew R Kovak Timothy C Chambers

Oncotarget 2016 Nov;7(48):78958-78970

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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November 2016

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.

Authors:

Srinivas Ayyadevara Meenakshisundaram Balasubramaniam Paul A Parcon Steven W Barger W Sue T Griffin Ramani Alla Alan J Tackett Samuel G Mackintosh Emanuel Petricoin Weidong Zhou Robert J Shmookler Reis

Aging Cell 2016 10 23;15(5):924-39. Epub 2016 Jul 23.

McClellan Veterans Medical Center, Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA.

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October 2016

PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.

Authors:

Srinivas Ayyadevara Meenakshisundaram Balasubramaniam Jay Johnson Ramani Alla Samuel G Mackintosh Robert J Shmookler Reis

Oncotarget 2016 Aug;7(31):48870-48886

McClellan Veterans Medical Center, Central Arkansas Veterans Healthcare Service, Little Rock, AR, USA.

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August 2016

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.

Authors:

Alicia K Byrd Boris L Zybailov Leena Maddukuri Jun Gao John C Marecki Mihir Jaiswal Matthew R Bell Wezley C Griffin Megan R Reed Shubeena Chib Samuel G Mackintosh Angus M MacNicol Giulia Baldini Robert L Eoff Kevin D Raney

J Biol Chem 2016 08 1;291(34):18041-57. Epub 2016 Jul 1.

From the Departments of Biochemistry and Molecular Biology and the Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 and

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August 2016

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