Samuel G Mackintosh

Samuel G Mackintosh

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Samuel G Mackintosh

Samuel G Mackintosh

Publications by authors named "Samuel G Mackintosh"

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DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.

Chem Commun (Camb) 2019 Apr;55(31):4467-4470

Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street (Slot 516), Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1039/c8cc10091hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459694PMC
April 2019

Proteomic characterization of the arsenic response locus in S. cerevisiae.

Epigenetics 2019 Feb 1;14(2):130-145. Epub 2019 Mar 1.

a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

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https://www.tandfonline.com/doi/full/10.1080/15592294.2019.1
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http://dx.doi.org/10.1080/15592294.2019.1580110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557609PMC
February 2019

Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.

J Proteome Res 2018 10 27;17(10):3384-3395. Epub 2018 Sep 27.

Department of Microbiology and Immunology , University of Arkansas for Medical Sciences , 4301 West Markham Street , Little Rock , Arkansas 72205 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209314PMC
October 2018

Oxidation resistance 1 is a novel senolytic target.

Aging Cell 2018 08 15;17(4):e12780. Epub 2018 May 15.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

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http://doi.wiley.com/10.1111/acel.12780
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http://dx.doi.org/10.1111/acel.12780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052462PMC
August 2018

Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1.

Clin Proteomics 2017 6;14:40. Epub 2017 Dec 6.

Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 845, Little Rock, AR 72205 USA.

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http://dx.doi.org/10.1186/s12014-017-9175-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717999PMC
December 2017

Indicators of responsiveness to immune checkpoint inhibitors.

Sci Rep 2017 04 11;7(1):807. Epub 2017 Apr 11.

Departments of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas, 72205, USA.

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http://dx.doi.org/10.1038/s41598-017-01000-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429745PMC
April 2017

1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.

Toxicology 2017 03 9;378:114-124. Epub 2017 Jan 9.

Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States; The Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319481PMC
March 2017

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

JCI Insight 2016 Oct 20;1(17):e86330. Epub 2016 Oct 20.

Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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http://dx.doi.org/10.1172/jci.insight.86330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070964PMC
October 2016

Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.

Cancer Biol Ther 2015 15;16(10):1557-65. Epub 2015 Jul 15.

e Department of Biochemistry & Molecular Biology; University of Arkansas for Medical Sciences; Little Rock , AR USA.

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http://dx.doi.org/10.1080/15384047.2015.1071740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846140PMC
September 2016

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.

J Biol Chem 2016 08 1;291(34):18041-57. Epub 2016 Jul 1.

From the Departments of Biochemistry and Molecular Biology and the Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 and

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http://dx.doi.org/10.1074/jbc.M116.718478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016190PMC
August 2016

PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.

Oncotarget 2016 Aug;7(31):48870-48886

McClellan Veterans Medical Center, Central Arkansas Veterans Healthcare Service, Little Rock, AR, USA.

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http://dx.doi.org/10.18632/oncotarget.10549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226477PMC
August 2016

Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.

Hypertension 2016 May 14;67(5):1006-13. Epub 2016 Mar 14.

From the Central Arkansas Veterans Healthcare System, Little Rock (S.A., F.M., X.W., R.J.S.R., J.L.M.); Department of Geriatrics (S.A., R.J.S.R.), Division of Cardiology (F.M., X.W., S.V.S.P., J.L.M.), and Department of Biochemistry and Molecular Biology (S.G.M., A.J.T., R.J.S.R.), University of Arkansas for Medical Sciences (UAMS), Little Rock; and Department of Cardiology, University of Rome "Tor Vergata", Rome, Italy (F.M., F.R.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833546PMC
May 2016

Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination.

Cancer Immunol Immunother 2016 May 15;65(5):563-73. Epub 2016 Mar 15.

Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 502, Little Rock, Arkansas, 72205, USA.

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http://dx.doi.org/10.1007/s00262-016-1821-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841729PMC
May 2016

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

Mol Cell 2016 05 28;62(4):558-71. Epub 2016 Apr 28.

Department of Epigenetics & Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA; Center for Cancer Epigenetics, Houston, TX 77030, USA; Program in Epigenetics and Molecular Carcinogenesis, Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765163001
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http://dx.doi.org/10.1016/j.molcel.2016.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874879PMC
May 2016

DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Nature 2016 Apr 30;532(7599):329-33. Epub 2016 Mar 30.

Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nature17640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977844PMC
April 2016

Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.

Mol Cell Proteomics 2016 Mar 30;15(3):765-75. Epub 2015 Nov 30.

From the ‡Department of Biochemistry and Molecular Biology, ‖Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205

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http://dx.doi.org/10.1074/mcp.M115.053363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813699PMC
March 2016

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.

J Virol 2016 02 18;90(3):1397-413. Epub 2015 Nov 18.

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas USA Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences, Little Rock, Arkansas USA

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http://dx.doi.org/10.1128/JVI.02022-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719591PMC
February 2016

A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates.

J Proteomics Bioinform 2016;9(Suppl 10). Epub 2015 Dec 28.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.4172/jpb.S10-005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780756PMC
December 2015

Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.

Chem Commun (Camb) 2015 Apr;51(33):7242-4

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 516, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1039/c5cc00742aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465349PMC
April 2015

Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions.

J Proteome Res 2015 Jan 9;14(1):434-46. Epub 2014 Dec 9.

Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia , 315 Riverbend Road, Athens, Georgia 30602, United States.

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http://dx.doi.org/10.1021/pr501174pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286206PMC
January 2015

The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.

Mol Cell Proteomics 2014 Nov 8;13(11):2896-910. Epub 2014 Aug 8.

From the ‡Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; §Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205;

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http://dx.doi.org/10.1074/mcp.M114.038174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223480PMC
November 2014

A CRISPR-based approach for proteomic analysis of a single genomic locus.

Epigenetics 2014 Sep 18;9(9):1207-11. Epub 2014 Jul 18.

University of Arkansas for Medical Sciences; Department of Biochemistry and Molecular Biology; Little Rock, AR USA.

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http://dx.doi.org/10.4161/epi.29919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169012PMC
September 2014

Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.

Elife 2014 Aug 26;3:e02996. Epub 2014 Aug 26.

Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, United States Center for Epigenetics, The Johns Hopkins University School of Medicine, Baltimore, United States

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141274PMC
http://dx.doi.org/10.7554/eLife.02996DOI Listing
August 2014

CD109 Overexpression in Pancreatic Cancer Identified by Cell-Surface Glycoprotein Capture.

J Proteomics Bioinform 2014;Suppl 10:S10003

Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences; Little Rock, Arkansas, USA.

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http://dx.doi.org/10.4172/jpb.S10-003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307595PMC
January 2014

A Proteomic Study of Human Merkel Cell Carcinoma.

J Proteomics Bioinform 2013 Nov;6:275-282

Department of Dermatology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.

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http://dx.doi.org/10.4172/jpb.1000291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181674PMC
November 2013

Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma.

J Proteomics Bioinform 2013 Mar;6(3):43-50

University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.4172/jpb.1000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748992PMC
March 2013

Analysis of Histone Exchange during Chromatin Purification.

J Integr OMICS 2011 Feb;1(1):61-65

University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.5584/jiomics.v1i1.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119864PMC
February 2011

Mapping the local protein interactome of the NuA3 histone acetyltransferase.

Protein Sci 2009 Sep;18(9):1987-97

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1002/pro.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777373PMC
September 2009

NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.

J Biol Chem 2009 Feb 16;284(8):4806-14. Epub 2008 Dec 16.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1074/jbc.M805540200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643493PMC
February 2009

DNA unwinding and protein displacement by superfamily 1 and superfamily 2 helicases.

Nucleic Acids Res 2006 25;34(15):4154-9. Epub 2006 Aug 25.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1093/nar/gkl501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1616963PMC
October 2006

Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus.

J Biol Chem 2006 Feb 22;281(6):3528-35. Epub 2005 Nov 22.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1074/jbc.M512100200DOI Listing
February 2006

Characterization of Staphylococcus aureus SarA binding sites.

J Bacteriol 2003 Aug;185(15):4410-7

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://jb.asm.org/content/185/15/4410.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165759PMC
http://dx.doi.org/10.1128/jb.185.15.4410-4417.2003DOI Listing
August 2003