Samuel F Bakhoum

Samuel F Bakhoum

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Samuel F Bakhoum

Samuel F Bakhoum

Publications by authors named "Samuel F Bakhoum"

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Expanding the Role of STING in Cellular Homeostasis and Transformation.

Trends Cancer 2019 Apr 23;5(4):195-197. Epub 2019 Feb 23.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.02.001DOI Listing
April 2019

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Cell 2018 09;174(6):1347-1360

Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136429PMC
September 2018

A Markov chain for numerical chromosomal instability in clonally expanding populations.

PLoS Comput Biol 2018 09 11;14(9):e1006447. Epub 2018 Sep 11.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://dx.plos.org/10.1371/journal.pcbi.1006447
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http://dx.doi.org/10.1371/journal.pcbi.1006447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150543PMC
September 2018

SnapShot: CGAS-STING Signaling.

Cell 2018 03;173(1):276-276.e1

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183029
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http://dx.doi.org/10.1016/j.cell.2018.03.015DOI Listing
March 2018

Cancer Evolution: No Room for Negative Selection.

Cell 2017 11;171(5):987-989

Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Division of Hematology and Medical Oncology, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; New York Genome Center, New York, NY 10013, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.039DOI Listing
November 2017

Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution.

Cold Spring Harb Perspect Med 2017 Jun 1;7(6). Epub 2017 Jun 1.

Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065.

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http://dx.doi.org/10.1101/cshperspect.a029611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453382PMC
June 2017

Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.

Trends Cancer 2017 03 28;3(3):225-234. Epub 2017 Feb 28.

Institute of Molecular Oncology, Section for Cellular Oncology, Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center, University of Göttingen, D-37077 Goettingen, Germany.

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http://dx.doi.org/10.1016/j.trecan.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518619PMC
March 2017

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.

Cell Rep 2015 Aug 23;12(5):809-20. Epub 2015 Jul 23.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.065DOI Listing
August 2015

Numerical chromosomal instability mediates susceptibility to radiation treatment.

Nat Commun 2015 Jan 21;6:5990. Epub 2015 Jan 21.

1] Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA [2] Norris-Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1038/ncomms6990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516720PMC
January 2015

DNA-damage response during mitosis induces whole-chromosome missegregation.

Cancer Discov 2014 Nov 8;4(11):1281-9. Epub 2014 Aug 8.

Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221427PMC
November 2014

A predictive model of complications after spine surgery: the National Surgical Quality Improvement Program (NSQIP) 2005-2010.

Spine J 2014 Jul 4;14(7):1247-55. Epub 2013 Oct 4.

Department of Neurosurgery, Portsmouth Hospital, 333 Borthwick Ave., Portsmouth, NH 03801, USA.

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http://dx.doi.org/10.1016/j.spinee.2013.08.009DOI Listing
July 2014

Chromosomal instability, aneuploidy, and cancer.

Front Oncol 2014 19;4:161. Epub 2014 Jun 19.

Cancer Research UK London Research Institute , London , UK ; University College London Cancer Institute , London , UK.

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http://dx.doi.org/10.3389/fonc.2014.00161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062911PMC
July 2014

Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy.

Cancer 2014 Jun 6;120(11):1733-42. Epub 2014 Mar 6.

Section of Radiation Oncology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Dartmouth College, Lebanon, New Hampshire.

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http://dx.doi.org/10.1002/cncr.28656DOI Listing
June 2014

The mitotic origin of chromosomal instability.

Curr Biol 2014 Feb;24(4):R148-9

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA; Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970164PMC
February 2014

Outcome prediction in intracranial tumor surgery: the National Surgical Quality Improvement Program 2005-2010.

J Neurooncol 2013 May 24;113(1):57-64. Epub 2013 Feb 24.

Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.1007/s11060-013-1089-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617728PMC
May 2013

A risk factor-based predictive model of outcomes in carotid endarterectomy: the National Surgical Quality Improvement Program 2005-2010.

Stroke 2013 Apr 14;44(4):1085-1090. Epub 2013 Feb 14.

Section of Neurosurgery (K.B., A.D.), Department of Medicine (T.A.M.), and Section of Vascular Surgery (P.G.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Geisel School of Medicine at Dartmouth (S.F.B.), Hanover, NH; and Section of Vascular Surgery, State University of New York at Stony Brook, Stony Brook, NY (N.L.).

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http://dx.doi.org/10.1161/STROKEAHA.111.674358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279219PMC
April 2013

Chromosomal instability and cancer: a complex relationship with therapeutic potential.

J Clin Invest 2012 Apr 2;122(4):1138-43. Epub 2012 Apr 2.

Department of Biochemistry and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1172/JCI59954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314464PMC
April 2012

Kinetochores and disease: keeping microtubule dynamics in check!

Curr Opin Cell Biol 2012 Feb 21;24(1):64-70. Epub 2011 Dec 21.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.ceb.2011.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294090PMC
February 2012

Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.

Clin Cancer Res 2011 Dec;17(24):7704-11

Department of Biochemistry; The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244806PMC
December 2011

Mechanisms of chromosomal instability.

Curr Biol 2010 Mar;20(6):R285-95

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.cub.2010.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781365PMC
March 2010

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

Curr Biol 2009 Dec 29;19(22):1937-42. Epub 2009 Oct 29.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.cub.2009.09.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787757PMC
December 2009

Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells.

Curr Biol 2009 Dec;19(24):2108-13

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.cub.2009.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805786PMC
December 2009

Cancer: CINful centrosomes.

Curr Biol 2009 Aug;19(15):R642-5

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.cub.2009.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880930PMC
August 2009

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.

Nat Cell Biol 2009 Jan 7;11(1):27-35. Epub 2008 Dec 7.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://www.nature.com/articles/ncb1809
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http://dx.doi.org/10.1038/ncb1809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614462PMC
January 2009

Ion-induced nucleation in solution: promotion of solute nucleation in charged levitated droplets.

J Am Chem Soc 2007 Sep 24;129(37):11364-77. Epub 2007 Aug 24.

Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.

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http://dx.doi.org/10.1021/ja067094iDOI Listing
September 2007

The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

Mol Biol Cell 2007 Aug 30;18(8):2970-9. Epub 2007 May 30.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1091/mbc.e07-02-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949365PMC
August 2007

Convergent evolution of clamp-like binding sites in diverse chaperones.

Nat Struct Mol Biol 2006 Oct;13(10):865-70

Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada.

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http://dx.doi.org/10.1038/nsmb1153DOI Listing
October 2006

Bench-to-bedside solution to funding problems.

Authors:
Samuel F Bakhoum

Nature 2006 Oct;443(7111):506

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http://dx.doi.org/10.1038/443506bDOI Listing
October 2006

Archiving and absolute quantitation of solutes separated by single charged droplet coulomb explosion.

Anal Chem 2005 Jun;77(11):3461-5

Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A1S6, Canada.

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http://dx.doi.org/10.1021/ac048113eDOI Listing
June 2005

Study of chemistry in droplets with net charge before and after Coulomb explosion: ion-induced nucleation in solution and implications for ion production in an electrospray.

Anal Chem 2005 May;77(10):3189-97

Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

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http://dx.doi.org/10.1021/ac048536gDOI Listing
May 2005

Promotion of alpha-cyano-4-hydroxycinnamic acid and peptide cocrystallization within levitated droplets with net charge.

J Am Soc Mass Spectrom 2005 Feb;16(2):254-62

Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jasms.2004.11.006DOI Listing
February 2005