Publications by authors named "Samuel C Dudley"

100Publications

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

J Biol Chem 2020 Dec;295(52):18148-18159

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

J Biol Chem 2020 Dec 22;295(52):18148-18159. Epub 2020 Oct 22.

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA

View Article and Find Full Text PDF
December 2020

Association of Life's Simple 7 with Atrial Fibrillation Burden (From the Atherosclerosis Risk in Communities Study).

Am J Cardiol 2020 12 28;137:31-38. Epub 2020 Sep 28.

Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.

View Article and Find Full Text PDF
December 2020

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease.

Antioxidants (Basel) 2020 Sep 23;9(10). Epub 2020 Sep 23.

Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA.

View Article and Find Full Text PDF
September 2020

Serum magnesium and burden of atrial and ventricular arrhythmias: The Atherosclerosis Risk in Communities (ARIC) Study.

J Electrocardiol 2020 Sep - Oct;62:20-25. Epub 2020 Jul 22.

Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.

View Article and Find Full Text PDF
July 2020

Evidence for Inflammation as a Driver of Atrial Fibrillation.

Front Cardiovasc Med 2020 29;7:62. Epub 2020 Apr 29.

Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, MN, United States.

View Article and Find Full Text PDF
April 2020

Metabolic regulation of endothelial SK channels and human coronary microvascular function.

Int J Cardiol 2020 08 12;312:1-9. Epub 2020 Mar 12.

Division of Cardiothoracic Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, United States of America. Electronic address:

View Article and Find Full Text PDF
August 2020

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Authors:
Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K Hedman Jemma B Wilk Michael P Morley Mark D Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G Aragam Johan Ärnlöv Joshua D Backman Mary L Biggs Heather L Bloom Jeffrey Brandimarto Michael R Brown Leonard Buckbinder David J Carey Daniel I Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P Cook Graciela E Delgado Spiros Denaxas Alexander S Doney Marcus Dörr Samuel C Dudley Michael E Dunn Gunnar Engström Tõnu Esko Stephan B Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S Gottdiener Stefan Gross Daníel F Guðbjartsson Rebecca Gutmann Christopher M Haggerty Pim van der Harst Craig L Hyde Erik Ingelsson J Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M Lindgren Barry London Luca A Lotta Ruth C Lovering Jian'an Luan Patrik Magnusson Anubha Mahajan Kenneth B Margulies Winfried März Olle Melander Ify R Mordi Thomas Morgan Andrew D Morris Andrew P Morris Alanna C Morrison Michael W Nagle Christopher P Nelson Alexander Niessner Teemu Niiranen Michelle L O'Donoghue Anjali T Owens Colin N A Palmer Helen M Parry Markus Perola Eliana Portilla-Fernandez Bruce M Psaty Kenneth M Rice Paul M Ridker Simon P R Romaine Jerome I Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A Shalaby Diane T Smelser Nicholas L Smith Steen Stender David J Stott Per Svensson Mari-Liis Tammesoo Kent D Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A Voors Xiaosong Wang Nicholas J Wareham Dawn Waterworth Peter E Weeke Raul Weiss Kerri L Wiggins Heming Xing Laura M Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J Samani John J V McMurray Jian Yang Peter M Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A Lubitz Naveed Sattar Michael V Holmes Thomas P Cappola Folkert W Asselbergs Aroon D Hingorani Karoline Kuchenbaecker Patrick T Ellinor Chim C Lang Kari Stefansson J Gustav Smith Ramachandran S Vasan Daniel I Swerdlow R Thomas Lumbers

Nat Commun 2020 01 9;11(1):163. Epub 2020 Jan 9.

British Heart Foundation Research Accelerator, University College London, London, UK.

View Article and Find Full Text PDF
January 2020

Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling.

Free Radic Biol Med 2019 09 26;141:291-298. Epub 2019 Jun 26.

Lillehei Heart Institute and Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. Electronic address:

View Article and Find Full Text PDF
September 2019

Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, Minnesota.

View Article and Find Full Text PDF
January 2019

The role of the unfolded protein response in arrhythmias.

Channels (Austin) 2018 ;12(1):335-345

a Division of Cardiology, Department of Medicine, The Lillehei Heart Institute , University of Minnesota at Twin Cities , Minneapolis , USA.

View Article and Find Full Text PDF
August 2019

Functional cardiac Na channels are expressed in human melanoma cells.

Oncol Lett 2018 Aug 31;16(2):1689-1695. Epub 2018 May 31.

Department of Biology, Providence College, Providence, RI 02918, USA.

View Article and Find Full Text PDF
August 2018

Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes.

PLoS One 2018 12;13(7):e0200448. Epub 2018 Jul 12.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, United States of America.

View Article and Find Full Text PDF
January 2019

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

View Article and Find Full Text PDF
June 2018

RNA Binding Protein, HuR, Regulates Expression Through Stabilizing MEF2C transcription factor mRNA.

J Am Heart Assoc 2018 04 20;7(9). Epub 2018 Apr 20.

Department of Cardiology, Warren Alpert School of Medicine at Brown University, Providence, RI

View Article and Find Full Text PDF
April 2018

Mitochondrial Ca Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy.

J Am Heart Assoc 2018 04 7;7(8). Epub 2018 Apr 7.

Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN

View Article and Find Full Text PDF
April 2018

Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

J Mol Cell Cardiol 2018 04 21;117:62-71. Epub 2018 Feb 21.

Division of Cardiology, Dept. of Medicine, the Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, United States. Electronic address:

View Article and Find Full Text PDF
April 2018

HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure.

Heart Rhythm 2018 07 16;15(7):1072-1080. Epub 2018 Feb 16.

Department of Cardiology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island; The Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota. Electronic address:

View Article and Find Full Text PDF
July 2018

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy.

Int J Cardiol 2017 Dec 7;249:282-286. Epub 2017 Sep 7.

Department of Cardiology, Warren Alpert School of Medicine at Brown University, Providence, RI, United States. Electronic address:

View Article and Find Full Text PDF
December 2017

SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.

Cardiovasc Res 2017 03;113(3):343-353

Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 1 Hoppin Street, Providence, RI, 02903-4141, USA.

View Article and Find Full Text PDF
March 2017

Role of protein kinase C in metabolic regulation of the cardiac Na channel.

Heart Rhythm 2017 03 15;14(3):440-447. Epub 2016 Dec 15.

Division of Cardiology, Department of Medicine, The Warren Alpert Medical School of Brown University, Lifespan Cardiovascular Institute, Providence, Rhode Island; Providence VA Medical Center, Providence, Rhode Island. Electronic address:

View Article and Find Full Text PDF
March 2017

Obstructive Sleep Apnea and Circulating Potassium Channel Levels.

J Am Heart Assoc 2016 08 19;5(8). Epub 2016 Aug 19.

Lifespan Cardiovascular Institute, Brown University, Providence, RI The Providence VA, Providence, RI

View Article and Find Full Text PDF
August 2016

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction.

J Am Heart Assoc 2016 05 5;5(5). Epub 2016 May 5.

Cardiovascular Research Center, Lifespan Rhode Island Hospital, Providence, RI The Warren Alpert Medical School, Brown University, Providence, RI Providence Veterans Affairs Medical Center, Providence, RI

View Article and Find Full Text PDF
May 2016

Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias.

Int J Mol Sci 2015 Dec 31;17(1). Epub 2015 Dec 31.

The Warren Alpert Medical School of Brown University, Lifespan Cardiovascular Institute, the Providence VA Medical Center, 593 Eddy Street, APC814, Providence, RI 02903, USA.

View Article and Find Full Text PDF
December 2015

Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction.

Biomed Res Int 2015 4;2015:825027. Epub 2015 Oct 4.

Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.

View Article and Find Full Text PDF
August 2016

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Europace 2016 Sep 25;18(9):1383-90. Epub 2015 Oct 25.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Halsted 565, Baltimore, MD 21287, USA

View Article and Find Full Text PDF
September 2016

Mechanisms of sudden cardiac death: oxidants and metabolism.

Circ Res 2015 Jun;116(12):1937-55

From the Department of Pharmacology (K.-C.Y.) and Division of Cardiology, Department of Internal Medicine (K.-C.Y.), National Taiwan University Hospital, Taipei, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.W.K., J.C.M.); and Lifespan Cardiovascular Institute, the Providence VA Medical Center, and Brown University, RI (S.C.D.).

View Article and Find Full Text PDF
June 2015

Diastolic dysfunction.

Circ J 2015 5;79(3):470-7. Epub 2015 Feb 5.

Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University.

View Article and Find Full Text PDF
November 2015

A Circulating Biomarker Risk-Prediction Model Correlates with CHADS-2 Risk Score in Chronic Atrial Fibrillation.

IJC Metab Endocr 2015 Mar;6:24-26

Lifespan Cardiovascular Institute and the Warren Alpert Medical School of Brown University, Providence, RI.

View Article and Find Full Text PDF
March 2015

Nitroglycerin tolerance in caveolin-1 deficient mice.

PLoS One 2014 26;9(8):e104101. Epub 2014 Aug 26.

Department of Medicine-Section of Cardiology, University of Illinois at Chicago, Chicago, Illinois, United States of America; Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, United States of America.

View Article and Find Full Text PDF
May 2015

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.

Circ Arrhythm Electrophysiol 2014 Aug 13;7(4):701-10. Epub 2014 Jul 13.

From the Lifespan Cardiovascular Research Center, Department of Medicine, Warren Alpert School of Medicine, Brown University, Providence Veterans Administration Medical Center, RI (K.-C.Y., C.A.R., A.X., H.L., S.C.D.); Department of Medicine (K.-C.Y., C.A.R.), Department of Pharmacology (M.M., M.G.B., R.D.M.), and Department of Anesthesiology (F.R.B., R.D.M.), University of Illinois at Chicago; and Department of Anesthesiology, VA San Diego Healthcare Systems, University of California (H.H.P.).

View Article and Find Full Text PDF
August 2014

Cardiac sodium channel mutations: why so many phenotypes?

Nat Rev Cardiol 2014 Oct 24;11(10):607-15. Epub 2014 Jun 24.

Warren Alpert Medical School, Brown University, 593 Eddy Street, APC730, Providence, RI 02903, USA.

View Article and Find Full Text PDF
October 2014

Targeting the unfolded protein response in heart diseases.

Expert Opin Ther Targets 2014 Jul 28;18(7):719-23. Epub 2014 May 28.

Brown University, Lifespan Cardiovascular Institute, The Providence VA Medical Center , Providence, RI , USA.

View Article and Find Full Text PDF
July 2014

Mitochondria and arrhythmias.

Free Radic Biol Med 2014 Jun 5;71:351-361. Epub 2014 Apr 5.

Lifespan Cardiovascular Institute, Providence VA Medical Center, and Brown University, Providence, RI 02903, USA. Electronic address:

View Article and Find Full Text PDF
June 2014

Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.

J Am Coll Cardiol 2014 Jun 2;63(21):2261-9. Epub 2014 Apr 2.

Section of Cardiology and the Jesse Brown VAMC, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

View Article and Find Full Text PDF
June 2014

New diagnostic and therapeutic possibilities for diastolic heart failure.

R I Med J (2013) 2014 Feb 3;97(2):35-7. Epub 2014 Feb 3.

Chief of Cardiology, The Miriam and Rhode Island Hospitals and Brown University; Director, Lifespan Cardiovascular Institute; and the Ruth and Paul Levinger Professor of Cardiology, The Warren Alpert Medical School of Brown University.

View Article and Find Full Text PDF
February 2014

c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction.

J Am Coll Cardiol 2014 Mar 8;63(9):928-34. Epub 2014 Jan 8.

Lifespan Cardiovascular Institute, the Warren Alpert School of Medicine of Brown University, and the Providence Veterans Administration Medical Center, Providence. Rhode Island. Electronic address:

View Article and Find Full Text PDF
March 2014

Unfolded protein response regulates cardiac sodium current in systolic human heart failure.

Circ Arrhythm Electrophysiol 2013 Oct 13;6(5):1018-24. Epub 2013 Sep 13.

Lifespan Cardiovascular Research Center, the Warren Alpert School of Medicine, Brown University and Providence Veterans Administration Medical Center, Providence, RI.

View Article and Find Full Text PDF
October 2013

Oxidative stress and atrial fibrillation: finding a missing piece to the puzzle.

Circulation 2013 Oct 12;128(16):1724-6. Epub 2013 Sep 12.

Lifespan Cardiovascular Institute, the Warren Alpert School of Medicine, Brown University, and the Providence Veterans Administration Medical Center, Providence, RI.

View Article and Find Full Text PDF
October 2013

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.

Circ Arrhythm Electrophysiol 2013 Jun 4;6(3):623-31. Epub 2013 Apr 4.

Section of Cardiology and Center for Cardiovascular Research, University of Illinois at Chicago, IL, USA.

View Article and Find Full Text PDF
June 2013

Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties.

J Mol Cell Cardiol 2013 Mar 14;56:44-54. Epub 2012 Dec 14.

Department of Medicine, Section of Cardiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

View Article and Find Full Text PDF
March 2013

Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy.

J Mol Cell Cardiol 2013 Jan 1;54:25-34. Epub 2012 Nov 1.

Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
January 2013

RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.

Trends Cardiovasc Med 2013 Jan 31;23(1):5-8. Epub 2012 Aug 31.

Section of Cardiology, Department of Medicine, University of Illinois at Chicago and the Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
January 2013

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation.

Front Physiol 2012 6;3:311. Epub 2012 Aug 6.

Section of Cardiology, Center for Cardiovascular Research, University of Illinois at Chicago Chicago, IL, USA.

View Article and Find Full Text PDF
October 2012

Association of low plasma adiponectin with early diastolic dysfunction.

Congest Heart Fail 2012 Jul-Aug;18(4):187-91. Epub 2012 Jan 9.

Section of Cardiology, University of Illinois at Chicago, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
December 2012

Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation.

Clin Chim Acta 2012 Dec 8;414:1-6. Epub 2012 Jun 8.

Clinical Biomarkers Laboratory, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States.

View Article and Find Full Text PDF
December 2012

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

J Am Coll Cardiol 2011 Nov;58(22):2332-9

Section of Cardiology and Center for Cardiovascular Research, University of Illinois at Chicago, 840 S.Wood Street, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
November 2011

Metabolic stress, reactive oxygen species, and arrhythmia.

J Mol Cell Cardiol 2012 Feb 25;52(2):454-63. Epub 2011 Sep 25.

Section of Cardiology, University of Illinois at Chicago, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
February 2012

Use of human embryonic stem cell derived-mesenchymal cells for cardiac repair.

Biotechnol Bioeng 2012 Jan 2;109(1):274-83. Epub 2011 Sep 2.

University of Illinois at Chicago/Jesse Brown VA Medical Center, 840 S. Wood Street, MC715, Chicago, Illinois 60612, USA.

View Article and Find Full Text PDF
January 2012

Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse.

Am J Physiol Heart Circ Physiol 2011 Sep 1;301(3):H824-31. Epub 2011 Jul 1.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine/Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA.

View Article and Find Full Text PDF
September 2011

Ion channelopathies: a tapped-out mine?

Authors:
Samuel C Dudley

Am J Physiol Heart Circ Physiol 2011 Mar 30;300(3):H716-7. Epub 2010 Dec 30.

View Article and Find Full Text PDF
March 2011

Statin therapy for the prevention of atrial fibrillation trial (SToP AF trial).

J Cardiovasc Electrophysiol 2011 Apr 13;22(4):414-9. Epub 2010 Oct 13.

Section of Cardiology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

View Article and Find Full Text PDF
April 2011

Atrial fibrillation: the emerging role of inflammation and oxidative stress.

Cardiovasc Hematol Disord Drug Targets 2010 Dec;10(4):262-8

University of Illinois at Chicago, 60612, USA.

View Article and Find Full Text PDF
December 2010

Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel.

Circ Res 2010 Oct 19;107(8):967-74. Epub 2010 Aug 19.

Jr, Section of Cardiology, University of Illinois at Chicago/Jesse Brown VA Medical Center, 840 S Wood St, MC715, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
October 2010

Statins Decrease Oxidative Stress and ICD Therapies.

Cardiol Res Pract 2010 25;2010:253803. Epub 2010 Mar 25.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article and Find Full Text PDF
July 2011

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction.

Circulation 2010 Feb 18;121(4):519-28. Epub 2010 Jan 18.

Department of Medicine (Division of Cardiology), Emory University School of Medicine, Atlanta, GA, USA.

View Article and Find Full Text PDF
February 2010

Cardiac Na+ current regulation by pyridine nucleotides.

Circ Res 2009 Oct 10;105(8):737-45. Epub 2009 Sep 10.

Division in Cardiology, University of Illinois at Chicago and the Jesse Brown Veteran Affairs Medical Center, Chicago, IL 60612, USA.

View Article and Find Full Text PDF
October 2009

Lost in translation: what is limiting cardiomyoplasty and can tissue engineering help?

Curr Stem Cell Res Ther 2009 Sep;4(3):210-23

Georgia Institute of Technology, Atlanta, GA 30332, USA.

View Article and Find Full Text PDF
September 2009

Redox regulation, NF-kappaB, and atrial fibrillation.

Antioxid Redox Signal 2009 Sep;11(9):2265-77

Section of Cardiology, University of Illinois at Chicago, and the Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA.

View Article and Find Full Text PDF
September 2009

The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias.

Heart Rhythm 2008 Jun 4;5(6 Suppl):S12-7. Epub 2008 Mar 4.

Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, USA.

View Article and Find Full Text PDF
June 2008

Sudden death in myotonic dystrophy.

N Engl J Med 2008 Oct;359(15):1628; author reply 1328-9

View Article and Find Full Text PDF
October 2008

The tail of the cardiac sodium channel.

Channels (Austin) 2008 May-Jun;2(3):161-2. Epub 2008 May 24.

Section of Cardiology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

View Article and Find Full Text PDF
October 2010

Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.

Channels (Austin) 2007 Sep-Oct;1(5):344-52. Epub 2007 Oct 3.

Department of Medicine, Providence Veterans Affairs Medical Center/Brown University, Providence, Rhode Island 02904, USA.

View Article and Find Full Text PDF
November 2008

NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II.

Am J Physiol Cell Physiol 2008 Jan 21;294(1):C372-9. Epub 2007 Nov 21.

Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, USA.

View Article and Find Full Text PDF
January 2008

Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

Biophys J 2007 Dec 24;93(12):4209-24. Epub 2007 Aug 24.

Center for Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.

View Article and Find Full Text PDF
December 2007

Oxidative stress markers are associated with persistent atrial fibrillation.

Clin Chem 2007 Sep 28;53(9):1652-7. Epub 2007 Jun 28.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

View Article and Find Full Text PDF
September 2007

A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling.

Stem Cells 2007 Sep 24;25(9):2350-7. Epub 2007 May 24.

Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.

View Article and Find Full Text PDF
September 2007

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

Am J Physiol Heart Circ Physiol 2007 Jul 2;293(1):H182-92. Epub 2007 Mar 2.

Division of Cardiology, Atlanta VA Medical Center, 1670 Clairmont Road, Atlanta, GA 30033, USA.

View Article and Find Full Text PDF
July 2007

A sodium channel pore mutation causing Brugada syndrome.

Heart Rhythm 2007 Jan 28;4(1):46-53. Epub 2006 Sep 28.

Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA.

View Article and Find Full Text PDF
January 2007

A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias.

J Mol Cell Cardiol 2006 Oct 17;41(4):698-705. Epub 2006 Aug 17.

Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, and Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA.

View Article and Find Full Text PDF
October 2006

Early determinants of H2O2-induced endothelial dysfunction.

Free Radic Biol Med 2006 Sep 3;41(5):810-7. Epub 2006 Jun 3.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA.

View Article and Find Full Text PDF
September 2006

Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Methods Mol Biol 2006 ;330:221-31

Division of Cardiology Atlanta, Emory University, Decatur, GA, USA.

View Article and Find Full Text PDF
August 2006