Samuel Antwi-Baffour - University of Ghana - Dr

Samuel Antwi-Baffour

University of Ghana

Dr

Accra | Ghana

Main Specialties: Allergy & Immunology, Blood Banking - Transfusion Medicine, Clinical & Laboratory Immunology, Hematology, Infectious Disease

Additional Specialties: Immunology and haematology

ORCID logohttps://orcid.org/0000-0002-7653-1129


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Samuel Antwi-Baffour - University of Ghana - Dr

Samuel Antwi-Baffour

Introduction

Dr. Samuel Antwi-Baffour is an Immunohaematologist and a Senior Lecturer with the School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana. He has worked as Specialist Biomedical Scientist in the United Kingdom for a number of years and is now in the forefront of Medical Laboratory Training in the country. He is a consultant to a number of Medical Laboratory Licensing and Training Institutions in Ghana and outside Ghana including the Allied Health Professions Council and NAPTEx. Dr. Antwi-
Baffour boast of a number teaching and practitioner experience and can be described as an accomplished Specialist Biomedical Scientist.

Primary Affiliation: University of Ghana - Accra , Ghana

Specialties:

Additional Specialties:

Research Interests:


View Samuel Antwi-Baffour’s Resume / CV

Education

London Metropolitan University
PhD
Immunology

Publications

26Publications

280Reads

4Profile Views

Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices.

Anemia 2019 19;2019:3179173. Epub 2019 Mar 19.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

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http://dx.doi.org/10.1155/2019/3179173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444271PMC
March 2019
3 Reads

Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana.

Lipids Health Dis 2018 Dec 13;17(1):283. Epub 2018 Dec 13.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
Publisher Site
http://dx.doi.org/10.1186/s12944-018-0926-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293632PMC
December 2018
12 Reads
2.219 Impact Factor

Plasma Levels of Cytokines (IL-10, IFN-γ and TNF-α) in Multidrug Resistant Tuberculosis and Drug Responsive Tuberculosis Patients in Ghana.

Diseases 2018 Dec 23;7(1). Epub 2018 Dec 23.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.

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http://www.mdpi.com/2079-9721/7/1/2
Publisher Site
http://dx.doi.org/10.3390/diseases7010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473728PMC
December 2018
13 Reads

Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children.

Malar J 2018 Nov 12;17(1):419. Epub 2018 Nov 12.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2569-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233557PMC
November 2018
31 Reads
3.109 Impact Factor

Proteomic analysis of microparticles isolated from malaria positive blood samples.

Proteome Sci 2016 24;15. Epub 2017 Mar 24.

Noguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.

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http://dx.doi.org/10.1186/s12953-017-0113-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366142PMC
March 2017
27 Reads
1.725 Impact Factor

The relative merits of therapies being developed to tackle inappropriate ('self'-directed) complement activation.

Auto Immun Highlights 2016 Dec 3;7(1). Epub 2016 Mar 3.

Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

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http://dx.doi.org/10.1007/s13317-016-0078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775539PMC
December 2016
22 Reads

Plasma Membrane- Derived Vesicles Shows Effects on the Induction of Differentiation of Promonocytes into Macrophages: A Possible Cancer Therapy

MOJ Immunol 4(4): 00135. DOI: 10.15406/moji.2016.04.00135

MOJ Immunology

Background: Acute promyelocytic leukaemia (APL) represents 5-15% of all adult leukaemias. One of the approaches to treat APL is differentiation therapy which works by inducing differentiation of leukaemic promonocytes into mature non-replicative cell types that eventually undergo apoptosis. Plasma Membrane-derived Vesicles, (PMVs) are a heterogeneous group of small, membrane-coated vesicles with phospholipid rich particles, membrane receptors as well as other proteins inherent in their parental cells. There is evidence that PMVs are involved in differentiation in the hematopoietic environment in the bone marrow which suggests a possible involvement in leukaemia myeloid development, and possibly monocytic haematopoiesis. This work aimed to show principally whether PMVs can initiate differentiation/stop proliferation in HL-60 cells (promonocytes) and cause their differentiation into macrophages. This way, PMVs can be considered for differentiation therapy.

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November 2016

A case-control study of prevalence of anemia among patients with type 2 diabetes.

J Med Case Rep 2016 May 4;10(1):110. Epub 2016 May 4.

Medical Affairs Directorate, Korle-bu Teaching Hospital, Accra, Ghana.

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http://dx.doi.org/10.1186/s13256-016-0889-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855820PMC
May 2016
10 Reads

Anemia in prospective blood donors deferred by the copper sulphate technique of hemoglobin estimation.

BMC Hematol 2015 22;15:15. Epub 2015 Oct 22.

College of Agriculture and Natural Sciences, School of Biological Sciences, Department of Molecular Biology and Biotechnology, University of Cape Coast, Cape Coast, Ghana.

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http://bmchematol.biomedcentral.com/articles/10.1186/s12878-
Publisher Site
http://dx.doi.org/10.1186/s12878-015-0035-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618942PMC
October 2015
16 Reads

Prevalence of hemoglobin S trait among blood donors: a cross-sectional study.

BMC Res Notes 2015 Oct 19;8:583. Epub 2015 Oct 19.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

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http://dx.doi.org/10.1186/s13104-015-1583-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617725PMC
October 2015
14 Reads

Storage of Blood for Transfusion in Domestic Refrigerators: Any Immune Consequences?

Open Access Library Journal, 2, e1909. doi.org/10.4236/oalib.1101909.

Open Access Library Journal

Background: Blood storage particularly for transfusion is a common practice among Medical Laboratory Scientists. However, haemolysis of blood during storage is inevitable but the degree of occurrence is largely dependent on the mode of storage, which has not been fully investigated. Aim: The aim of this study was to measure and compare the extent of haemolysis in blood for transfusion stored in domestic and medical laboratory refrigerators. 

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October 2015

Understanding the biosynthesis of platelets-derived extracellular vesicles.

Immun Inflamm Dis 2015 Sep 16;3(3):133-40. Epub 2015 Jun 16.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana 143, Korle-Bu, Accra, Ghana.

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http://dx.doi.org/10.1002/iid3.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578515PMC
September 2015
13 Reads

Prolonged Storage of Red Blood Cells for Transfusion in Citrate Phosphate Dextrose Adenine-1 Affects Their Viability.

Open Access Library Journal, 2, 1-7. doi: 10.4236/oalib.1101908.

Open Access Library Journal

Abstract

Most donor blood units for transfusion purposes are stored in Citrate Phosphate Dextrose Adenine-1 (CPDA-1) at blood-banks until used. Despite improvements made in blood storage attempts, CPDA-1 may still cause morphological and degenerative changes in red blood cells (RBCs) if storage is prolonged. The purpose of the study was to assess the viability of RBCs through characteristic changes resulting from prolonged storage in CPDA-1. A total of fifteen whole blood stored in CPDA-1 were analyzed for changes in erythrocytes morphology, Packed Cell Volume (PCV) and osmotic fragility in a seven day interval over a thirty-five day period. On day 1 (control), samples were analyzed within 6 hours of collection, and subsequently taken to the blood bank to be stored and re-analyzed from days 7 to 35. Mean Cell Fragility (MCF) which is suggestive of RBC membrane instability showed changes that were statistically significant between days 1 and 35. Morphological changes observed over the storage period included spherocytosis, echinocytosis, and marked sphero-echinocytosis with increased rouleaux formation. PCV value decreased marginally over the period. The author concluded that donor blood units stored for longer periods may result in RBC defects, affecting their viability and consequently interfere with expected therapeutic outcomes. Keywords Blood, Transfusion, Membrane, Red Blood Cells, Morphological, CPDA-1

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September 2015

Molecular characterisation of plasma membrane-derived vesicles.

J Biomed Sci 2015 Aug 11;22:68. Epub 2015 Aug 11.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143,, Korle-Bu, Accra, Ghana.

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http://www.jbiomedsci.com/content/22/1/68
Publisher Site
http://dx.doi.org/10.1186/s12929-015-0174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532247PMC
August 2015
3 Reads
2.736 Impact Factor

Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population.

Clin Diabetes Endocrinol 2015 20;1. Epub 2015 Aug 20.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Korle-bu, Accra, Ghana.

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http://dx.doi.org/10.1186/s40842-015-0008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471723PMC
August 2015

Biological Functions of Plasma Membrane-Derived Extracellular Vesicles and Their Role in Diseases

Journal of Cells, Conscientia Beam, vol. 1(2), pages 33-42.

Journal of Cells

Abstract

Plasma Membrane-derived Extracellular Vesicles (PMEVs) are membrane-coated vesicles of diameter 0.1 to 1.5µm, carrying various proteins inherent in their parental cells. PMEVs are released when cells undergo activation/apoptosis via blebbing and shedding and have a function in intercellular communication. Exposition of phosphatidylserine (PS) on the outer membrane leaflet that mark them as a biologically distinct entity could also explain a role for PMEVs in phagocytosis and thrombosis. The purpose of this review is to outline and discuss some of the functions of PMEVs in detail to throw more light on its biological effects as more research delve into emerging therapies targeting the microvesicle communication system. The role of PMEVs as a differentiation agent and therefore its possible use in differentiation therapy is discussed. In some experiments, the myeloid differentiating agents all trans retinoic acid (ATRA), phorbol 12-myristate 13-acetate (PMA) and histamine, which inhibit promonocyte proliferation, induced an intracellular Ca2+-mediated PMEV release from HL-60 promonocytes. These PMEVs caused HL-60 cells to enter G0/G1 cell cycle arrest and induce terminal monocyte-to-macrophage differentiation through TGF-β1 mediation.  The review also discusses the relationship between PMEVs and diseases where it is known that patients with certain inflammatory diseases show increased PMEV levels in the plasma. The review conclude on the fact that PMEVs have a lot of biological functions that are beneficial to the physiological functions in humans and therefore more work is required to elucidate their composition and the mechanisms involved in exertion of their effects.

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June 2015

Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9.

Biochem Biophys Res Commun 2015 May 24;460(3):589-95. Epub 2015 Mar 24.

Cellular and Molecular Immunology Research Centre, London Metropolitan University, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X150052
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http://dx.doi.org/10.1016/j.bbrc.2015.03.074DOI Listing
May 2015
7 Reads
2.297 Impact Factor

Effects of Blood Lead Levels on Haematological Indices of Fuel Station Attendants.

Advances in Biochemistry & Biotechnology, 1 (1) 1 – 11.

Advances in Biochemistry & Biotechnology

Background: Occupational exposure to lead has been reported to have a toxic effect on multiple body systems, including haematological and gastrointestinal systems. Those who work directly in petroleum industries (such as fuel station attendants) are likely to be affected. Aim: The aim of this study was to investigate for haematological alterations that may be due to lead exposure in apparently healthy fuel station attendants. 

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January 2015

Pain, range of motion and activity level as correlates of dynamic balance among elderly people with musculoskeletal disorder.

Ghana Med J 2014 Dec;48(4):214-8

Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Legon, Ghana.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335435PMC
December 2014

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance.

Biochem Biophys Res Commun 2014 Oct 6;453(3):619-24. Epub 2014 Oct 6.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.09.132DOI Listing
October 2014
13 Reads
2.297 Impact Factor

Blood/plasma secretome and microvesicles.

Biochim Biophys Acta 2013 Nov 13;1834(11):2317-25. Epub 2013 Apr 13.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2013.04.005DOI Listing
November 2013
23 Reads

Microvesicles in health and disease.

Arch Immunol Ther Exp (Warsz) 2012 Apr 4;60(2):107-21. Epub 2012 Feb 4.

Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.

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http://dx.doi.org/10.1007/s00005-012-0165-2DOI Listing
April 2012
13 Reads
3.176 Impact Factor

A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma.

J Immunol Methods 2011 Aug 30;371(1-2):143-51. Epub 2011 Jun 30.

Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences, London Metropolitan University, London, UK.

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http://dx.doi.org/10.1016/j.jim.2011.06.024DOI Listing
August 2011
24 Reads
2.005 Impact Factor

Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells.

J Immunol 2010 Nov 4;185(9):5236-46. Epub 2010 Oct 4.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, Faculty of Life Sciences, London Metropolitan University, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1001656DOI Listing
November 2010
12 Reads
4.922 Impact Factor

Red cell PMVs, plasma membrane-derived vesicles calling out for standards.

Biochem Biophys Res Commun 2010 Sep 30;399(4):465-9. Epub 2010 Jul 30.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, Faculty of Life Sciences, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.

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http://dx.doi.org/10.1016/j.bbrc.2010.07.095DOI Listing
September 2010
18 Reads
2.297 Impact Factor

Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells--possible role in SLE.

Biochem Biophys Res Commun 2010 Jul 23;398(2):278-83. Epub 2010 Jun 23.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, Faculty of Life Sciences, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK.

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http://dx.doi.org/10.1016/j.bbrc.2010.06.079DOI Listing
July 2010
6 Reads
2.297 Impact Factor

Top co-authors

Ransford Kyeremeh
Ransford Kyeremeh

School of Biomedical and Allied Health Sciences

9
Sigrun Lange
Sigrun Lange

Institute for Experimental Pathology

8
Jonathan Kofi Adjei
Jonathan Kofi Adjei

School of Biomedical and Allied Health Sciences

7
Dan Stratton
Dan Stratton

London Metropolitan University

7
Jameel M Inal
Jameel M Inal

London Metropolitan University

4
Sharad Kholia
Sharad Kholia

London Metropolitan University

4
Ephraim A Ansa-Addo
Ephraim A Ansa-Addo

London Metropolitan University

4
Jameel Inal
Jameel Inal

London Metropolitan University

4
George Kpentey
George Kpentey

University of Ghana

3
Samireh Jorfi
Samireh Jorfi

London Metropolitan University

3