Sameer Agnihotri

Sameer Agnihotri

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Sameer Agnihotri

Publications by authors named "Sameer Agnihotri"

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Tackling 1q+ PFA ependymomas.

Authors:
Sameer Agnihotri

Neuro Oncol 2019 Dec;21(12):1489

Brain Tumor Research Center, John G. Rangos Research Center, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1093/neuonc/noz194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917405PMC
December 2019

Clinical Utility of GlioSeq Next-Generation Sequencing Test in Pediatric and Young Adult Patients With Brain Tumors.

J Neuropathol Exp Neurol 2019 Jun 10. Epub 2019 Jun 10.

Division of Molecular & Genomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1093/jnen/nlz055DOI Listing
June 2019

A functional genomics approach to identify pathways of drug resistance in medulloblastoma.

Acta Neuropathol Commun 2018 12 27;6(1):146. Epub 2018 Dec 27.

Department of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1186/s40478-018-0652-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307130PMC
December 2018

Erratum: Targeting Metabolic Remodeling in Glioblastoma Multiforme.

Oncotarget 2018 10 5;9(78):34855. Epub 2018 Oct 5.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1L7.

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http://www.oncotarget.com/fulltext/26219
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http://dx.doi.org/10.18632/oncotarget.26219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205170PMC
October 2018

Molecular Signatures for Tumor Classification: An Analysis of The Cancer Genome Atlas Data.

J Mol Diagn 2017 11 1;19(6):881-891. Epub 2017 Sep 1.

Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.008DOI Listing
November 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Mol Cell 2017 Mar;65(6):999-1013.e7

Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426642PMC
March 2017

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Cancer Res 2016 08 20;76(16):4708-19. Epub 2016 Jun 20.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada. RS McLaughlin, Professor and Chairman, University of Toronto, Toronto, Ontario, Canada. Department of Surgery, Hospital for Sick Children, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3079DOI Listing
August 2016

A role for activated Cdc42 in glioblastoma multiforme invasion.

Oncotarget 2016 08;7(35):56958-56975

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, M5G 0A4, Canada.

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http://dx.doi.org/10.18632/oncotarget.10925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302965PMC
August 2016

Epithelial Cell Transforming 2 and Aurora Kinase B Modulate Formation of Stress Granule-Containing Transcripts from Diverse Cellular Pathways in Astrocytoma Cells.

Am J Pathol 2016 06 20;186(6):1674-87. Epub 2016 Apr 20.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.02.013DOI Listing
June 2016

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions.

Neuro Oncol 2016 Feb 14;18(2):160-72. Epub 2015 Jul 14.

MacFeeters-Hamilton Brain Tumor Centre, Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada (S.A., G.Z.); Department of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Canada (G.Z).

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http://dx.doi.org/10.1093/neuonc/nov125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724176PMC
February 2016

Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma.

Mol Cancer Ther 2015 Nov 8;14(11):2560-8. Epub 2015 Sep 8.

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0282DOI Listing
November 2015

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

Clin Cancer Res 2015 Aug 8;21(16):3750-8. Epub 2015 May 8.

Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537825PMC
August 2015

A role for matrix remodelling proteins in invasive and malignant meningiomas.

Neuropathol Appl Neurobiol 2015 Feb;41(2):e16-28

Labatt's Brain Tumor Research Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/nan.12166DOI Listing
February 2015

Serum lactate as a potential biomarker of malignancy in primary adult brain tumours.

J Clin Neurosci 2015 Jan 27;22(1):144-8. Epub 2014 Aug 27.

Division of Neurosurgery, Department of Surgery, University Health Network, Toronto Western Hospital, 399 Bathurst Street, West Wing 4-439, M5T 2S8 Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2014.06.005DOI Listing
January 2015

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

Cancer Res 2015 Jan 12;75(1):134-46. Epub 2014 Nov 12.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Canada. Division of Neurosurgery, Hospital for Sick Children, Toronto, Canada. Department of Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3629DOI Listing
January 2015

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastoma.

Neurosurg Focus 2014 Dec;37(6):E13

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children;

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http://dx.doi.org/10.3171/2014.9.FOCUS14505DOI Listing
December 2014

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Cancer Discov 2014 Oct 6;4(10):1198-213. Epub 2014 Aug 6.

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada. Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184920PMC
October 2014

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway.

Oncotarget 2014 Oct;5(19):9382-95

Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada. Department of Surgery, University of Toronto, Toronto ON, Canada.

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http://www.oncotarget.com/fulltext/2412
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253441PMC
http://dx.doi.org/10.18632/oncotarget.2412DOI Listing
October 2014

GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity.

Neuro Oncol 2014 Sep 18;16(9):1167-75. Epub 2014 Mar 18.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (A.V., S.K.S., S.A., S.J., K.B., G.Z.); Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada (G.Z.); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (K.D.A.).

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http://dx.doi.org/10.1093/neuonc/nou035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136895PMC
September 2014

The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas.

Endocr Relat Cancer 2014 Aug;21(4):R331-44

Institute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, CanadaInstitute of Medical ScienceDepartment of Medical BiophysicsUniversity of Toronto, Toronto, Ontario, CanadaDivision of NeurosurgeryToronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8Ontario Cancer InstitutePrincess Margaret Hospital, Toronto, Ontario, CanadaEndocrine Oncology Site GroupPrincess Margaret Hospital, Toronto, Ontario, CanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1530/ERC-14-0188DOI Listing
August 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.

Glia 2013 Nov 30;61(11):1862-72. Epub 2013 Aug 30.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1002/glia.22563
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http://dx.doi.org/10.1002/glia.22563DOI Listing
November 2013

Differential transformation capacity of neuro-glial progenitors during development.

Proc Natl Acad Sci U S A 2013 Aug 13;110(35):14378-83. Epub 2013 Aug 13.

The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 1L7.

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http://dx.doi.org/10.1073/pnas.1303504110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761617PMC
August 2013

A novel high-resolution in vivo imaging technique to study the dynamic response of intracranial structures to tumor growth and therapeutics.

J Vis Exp 2013 Jun 16(76):e50363. Epub 2013 Jun 16.

Brain Tumor Research Centre, Hospital for Sick Children, Toronto Medical Discovery Tower.

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http://dx.doi.org/10.3791/50363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727480PMC
June 2013

Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development.

Brain Pathol 2013 Mar 11;23(2):178-91. Epub 2012 Oct 11.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00631.xDOI Listing
March 2013

The role of drebrin in glioma migration and invasion.

Exp Cell Res 2013 Feb 29;319(4):517-28. Epub 2012 Nov 29.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00144827120045
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http://dx.doi.org/10.1016/j.yexcr.2012.11.008DOI Listing
February 2013

Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies.

Arch Immunol Ther Exp (Warsz) 2013 Feb 7;61(1):25-41. Epub 2012 Dec 7.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Tower, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00005-012-0203-0DOI Listing
February 2013

Investigation of the in vitro therapeutic efficacy of nilotinib in immortalized human NF2-null vestibular schwannoma cells.

PLoS One 2012 20;7(6):e39412. Epub 2012 Jun 20.

Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039412PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379978PMC
November 2012

Overexpression of CD99 Increases the Migration and Invasiveness of Human Malignant Glioma Cells.

Genes Cancer 2012 Sep;3(9-10):535-49

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada ; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (R.O.K.).

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http://dx.doi.org/10.1177/1947601912473603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591096PMC
September 2012

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.

Neurobiol Dis 2011 Oct 25;44(1):84-91. Epub 2011 Jun 25.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, 11-401E, 101 College Street, East Tower, Ontario, Canada, M5G 1L7.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961110020
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http://dx.doi.org/10.1016/j.nbd.2011.06.007DOI Listing
October 2011

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.

J Exp Med 2011 Apr 4;208(4):689-702. Epub 2011 Apr 4.

The Arthur and Sonia Labatt's Brain Tumor Research Centre, The Hospital for Sick Children's Research Institute, Toronto Western Hospital, University of Toronto, Toronto M5A 2N4, Ontario, Canada.

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http://dx.doi.org/10.1084/jem.20102099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135351PMC
April 2011

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

J Exp Med 2011 Feb 17;208(2):313-26. Epub 2011 Jan 17.

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://www.jem.org/lookup/doi/10.1084/jem.20101470
Publisher Site
http://dx.doi.org/10.1084/jem.20101470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039857PMC
February 2011

Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas.

Neuro Oncol 2011 Jan 12;13(1):42-50. Epub 2010 Nov 12.

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Cell Biology, Suite 1503, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.1093/neuonc/noq145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018916PMC
January 2011

Targeting metabolic remodeling in glioblastoma multiforme.

Oncotarget 2010 11;1(7):552-62

The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.18632/oncotarget.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035636PMC
November 2010