Sam Afkhami

Sam Afkhami

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Sam Afkhami

Sam Afkhami

Publications by authors named "Sam Afkhami"

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14Publications

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Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells.

Front Immunol 2019 6;10:2075. Epub 2019 Sep 6.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3389/fimmu.2019.02075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747041PMC
September 2019

Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.

Int J Pharm 2019 Apr 28;561:66-73. Epub 2019 Feb 28.

Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.035DOI Listing
April 2019

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.

Cell 2018 11 25;175(6):1634-1650.e17. Epub 2018 Oct 25.

McMaster Immunology Research Centre, M. G. DeGroote Institute for Infectious Disease Research, & Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.09.042DOI Listing
November 2018

New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity.

Trends Immunol 2018 05 9;39(5):419-433. Epub 2018 Feb 9.

McMaster Immunology Research Centre, McMaster University, Hamilton, ONT, Canada; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ONT, Canada; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ONT, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.01.006DOI Listing
May 2018

CD11b Dendritic Cell-Mediated Anti- Th1 Activation Is Counterregulated by CD103 Dendritic Cells via IL-10.

J Immunol 2018 03 26;200(5):1746-1760. Epub 2018 Jan 26.

McMaster Immunology Research Centre, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada; and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4K1, Canada

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http://dx.doi.org/10.4049/jimmunol.1701109DOI Listing
March 2018

CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway.

J Immunol 2017 10 21;199(7):2555-2569. Epub 2017 Aug 21.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario L8S 4K1, Canada;

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http://dx.doi.org/10.4049/jimmunol.1700382DOI Listing
October 2017

Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis.

Sci Rep 2017 08 25;7(1):9525. Epub 2017 Aug 25.

McMaster Immunology Research Centre, Department of Pathology & Molecular Medicine, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-017-09909-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573413PMC
August 2017

Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo.

Vaccine 2017 05 21;35(22):2916-2924. Epub 2017 Apr 21.

McMaster Immunology Research Centre and Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.04.026DOI Listing
May 2017

Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens.

Mol Ther Methods Clin Dev 2016 27;3:16030. Epub 2016 Apr 27.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University , Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mtm.2016.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847555PMC
May 2016

Role of B Cells in Mucosal Vaccine-Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis.

J Immunol 2015 Sep 12;195(6):2900-7. Epub 2015 Aug 12.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

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http://dx.doi.org/10.4049/jimmunol.1500981DOI Listing
September 2015

Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments.

Eur Respir Rev 2015 Jun;24(136):356-60

McMaster Immunology Research Centre, M. G. DeGroote Institute for Infectious Disease Research, and Dept of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada

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http://err.ersjournals.com/cgi/doi/10.1183/16000617.00002515
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http://dx.doi.org/10.1183/16000617.00002515DOI Listing
June 2015