Publications by authors named "Salvatore Siena"

100Publications

The Evolutionary Landscape of Treatment for Mutant Metastatic Colorectal Cancer.

Authors:
Gianluca Mauri Erica Bonazzina Alessio Amatu Federica Tosi Katia Bencardino Viviana Gori Daniela Massihnia Tiziana Cipani Francesco Spina Silvia Ghezzi Salvatore Siena Andrea Sartore-Bianchi

Cancers (Basel) 2021 Jan 4;13(1). Epub 2021 Jan 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy.

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January 2021

Impact of inter-reader contouring variability on textural radiomics of colorectal liver metastases.

Authors:
Francesco Rizzetto Francesca Calderoni Cristina De Mattia Arianna Defeudis Valentina Giannini Simone Mazzetti Lorenzo Vassallo Silvia Ghezzi Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena Daniele Regge Alberto Torresin Angelo Vanzulli

Eur Radiol Exp 2020 11 10;4(1):62. Epub 2020 Nov 10.

Department of Radiology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

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November 2020

Haematopoietic stem cell transplantation in adult soft-tissue sarcoma: an analysis from the European Society for Blood and Marrow Transplantation.

Authors:
Christoph E Heilig Manuela Badoglio Myriam Labopin Stefan Fröhling Simona Secondino Jürgen Heinz Emmanuelle Nicolas-Virelizier Didier Blaise Clément Korenbaum Armando Santoro Mareike Verbeek William Krüger Salvatore Siena Jakob R Passweg Massimo Di Nicola Jose Rifón Peter Dreger Ulrike Koehl Christian Chabannon Paolo Pedrazzoli

ESMO Open 2020 10;5(5)

Internal Medicine and Medical Therapy, Università degli Studi di Pavia, Pavia, Lombardia, Italy.

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October 2020

Oxaliplatin retreatment in metastatic colorectal cancer: Systematic review and future research opportunities.

Authors:
Gianluca Mauri Viviana Gori Erica Bonazzina Alessio Amatu Federica Tosi Katia Bencardino Lorenzo Ruggieri Giorgio Patelli Sabrina Arena Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2020 Dec 9;91:102112. Epub 2020 Oct 9.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milano, Italy. Electronic address:

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December 2020

Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial.

Authors:
Andrea Sartore-Bianchi Sara Lonardi Cosimo Martino Elisabetta Fenocchio Federica Tosi Silvia Ghezzi Francesco Leone Francesca Bergamo Vittorina Zagonel Fortunato Ciardiello Andrea Ardizzoni Alessio Amatu Katia Bencardino Emanuele Valtorta Elena Grassi Valter Torri Emanuela Bonoldi Anna Sapino Angelo Vanzulli Daniele Regge Giovanni Cappello Alberto Bardelli Livio Trusolino Silvia Marsoni Salvatore Siena

ESMO Open 2020 09;5(5)

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy

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September 2020

Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer.

Authors:
Federica Tosi Andrea Sartore-Bianchi Sara Lonardi Alessio Amatu Francesco Leone Silvia Ghezzi Cosimo Martino Katia Bencardino Erica Bonazzina Francesca Bergamo Elisabetta Fenocchio Erika Martinelli Teresa Troiani Giulia Siravegna Gianluca Mauri Valter Torri Giovanna Marrapese Emanuele Valtorta Andrea Cassingena Giovanni Cappello Emanuela Bonoldi Angelo Vanzulli Daniele Regge Fortunato Ciardiello Vittorina Zagonel Alberto Bardelli Livio Trusolino Silvia Marsoni Salvatore Siena

Clin Colorectal Cancer 2020 Dec 27;19(4):256-262.e2. Epub 2020 Jun 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milan, Italy. Electronic address:

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December 2020

Entrectinib approval by EMA reinforces options for ROS1 and tumour agnostic targeted cancer therapies.

Authors:
Elena Ardini Salvatore Siena

ESMO Open 2020 09;5(5)

Oncology and Hemato-Oncology, Università degli Studi di Milano, Milano, Italy

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September 2020

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions.

Authors:
Rossana Roncato Jacopo Angelini Arianna Pani Erika Cecchin Andrea Sartore-Bianchi Salvatore Siena Elena De Mattia Francesco Scaglione Giuseppe Toffoli

Int J Mol Sci 2020 Sep 1;21(17). Epub 2020 Sep 1.

Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, 33081 Aviano, Italy.

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September 2020

Radiomics predicts response of individual HER2-amplified colorectal cancer liver metastases in patients treated with HER2-targeted therapy.

Authors:
Valentina Giannini Samanta Rosati Arianna Defeudis Gabriella Balestra Lorenzo Vassallo Giovanni Cappello Simone Mazzetti Cristina De Mattia Francesco Rizzetto Alberto Torresin Andrea Sartore-Bianchi Salvatore Siena Angelo Vanzulli Francesco Leone Vittorina Zagonel Silvia Marsoni Daniele Regge

Int J Cancer 2020 Dec 14;147(11):3215-3223. Epub 2020 Sep 14.

Radiology Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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December 2020

Breaking Barriers in HER2+ Cancers.

Authors:
Salvatore Siena Silvia Marsoni Andrea Sartore-Bianchi

Cancer Cell 2020 Sep 27;38(3):317-319. Epub 2020 Aug 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano (La Statale), Milano, Italy.

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September 2020

A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with -mutant Solid Tumors.

Authors:
Ryan J Sullivan Jeffrey Weber Sapna Patel Reinhard Dummer Matteo S Carlino Daniel S W Tan Celeste Lebbé Salvatore Siena Elena Elez Lance Wollenberg Michael D Pickard Victor Sandor Paolo A Ascierto

Clin Cancer Res 2020 Oct 15;26(19):5102-5112. Epub 2020 Jul 15.

Istituto Nazionale Tumori, IRCCS "Fondazione G. Pascale," Naples, Italy.

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October 2020

Efficacy and Safety of Anti-PD-1 Immunotherapy in Patients Aged ≥ 75 Years With Non-small-cell Lung Cancer (NSCLC): An Italian, Multicenter, Retrospective Study.

Authors:
Andrea Luciani Antonio Marra Luca Toschi Diego Cortinovis Sergio Fava Virginio Filipazzi Alessandro Tuzi Giulio Cerea Sabrina Rossi Vittorio Perfetti Antonio Rossi Laura Giannetta Luca Sala Giovanna Finocchiaro Elio Gregory Pizzutilo Stephana Carelli Francesco Agustoni Massimiliano Cergnul Sabrina Zonato Salvatore Siena Paolo Bidoli Daris Ferrari

Clin Lung Cancer 2020 Nov 13;21(6):e567-e571. Epub 2020 May 13.

Medical Oncology Unit, ASST Santi Paolo e Carlo, Università̀ di Milano, Milan, Italy.

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November 2020

The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Authors:
Roberta Lombardo Federica Tosi Annunziata Nocerino Katia Bencardino Valentina Gambi Riccardo Ricotta Francesco Spina Salvatore Siena Andrea Sartore-Bianchi

Front Oncol 2020 8;10:533. Epub 2020 May 8.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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May 2020

EGFR Blockade Reverts Resistance to KRAS Inhibition in Colorectal Cancer.

Authors:
Vito Amodio Rona Yaeger Pamela Arcella Carlotta Cancelliere Simona Lamba Annalisa Lorenzato Sabrina Arena Monica Montone Benedetta Mussolin Yu Bian Adele Whaley Marika Pinnelli Yonina R Murciano-Goroff Efsevia Vakiani Nicola Valeri Wei-Li Liao Anuja Bhalkikar Sheeno Thyparambil Hui-Yong Zhao Elisa de Stanchina Silvia Marsoni Salvatore Siena Andrea Bertotti Livio Trusolino Bob T Li Neal Rosen Federica Di Nicolantonio Alberto Bardelli Sandra Misale

Cancer Discov 2020 Aug 19;10(8):1129-1139. Epub 2020 May 19.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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August 2020

A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment.

Authors:
Jean-Pierre Delord Guillem Argilés Jerôme Fayette Lori Wirth Stefan Kasper Salvatore Siena Ricard Mesia Rossana Berardi Andrés Cervantes Jeroen Dekervel Sylvia Zhao Yongjian Sun Huai-Xiang Hao Ralph Tiedt Sergio Vicente Andrea Myers Lillian L Siu

Invest New Drugs 2020 12 14;38(6):1774-1783. Epub 2020 May 14.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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December 2020

Central Nervous System as Possible Site of Relapse in ERBB2-Positive Metastatic Colorectal Cancer: Long-term Results of Treatment With Trastuzumab and Lapatinib.

Authors:
Andrea Sartore-Bianchi Sara Lonardi Massimo Aglietta Cosimo Martino Fortunato Ciardiello Silvia Marsoni Salvatore Siena

JAMA Oncol 2020 06;6(6):927-929

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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June 2020

Imaging and clinical correlates with regorafenib in metastatic colorectal cancer.

Authors:
Khurum Khan Stefano Cascinu David Cunningham Sun-Young Kim Eiji Oki Tara Seery Lin Shen Salvatore Siena Christophe Tournigand Nazim Serdar Turhal Alain Hendlisz

Cancer Treat Rev 2020 Jun 4;86:102020. Epub 2020 Apr 4.

Institut Jules Bordet, 121 Boulevard de Waterloo, 1000 Brussels, Belgium. Electronic address:

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June 2020

Entrectinib for the treatment of metastatic NSCLC: safety and efficacy.

Authors:
Andrea Sartore-Bianchi Elio Gregory Pizzutilo Giovanna Marrapese Federica Tosi Giulio Cerea Salvatore Siena

Expert Rev Anticancer Ther 2020 05 8;20(5):333-341. Epub 2020 Apr 8.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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May 2020

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer.

Authors:
Annalisa Lorenzato Alessandro Magrì Vittoria Matafora Valentina Audrito Pamela Arcella Luca Lazzari Monica Montone Simona Lamba Silvia Deaglio Salvatore Siena Andrea Bertotti Livio Trusolino Angela Bachi Federica Di Nicolantonio Alberto Bardelli Sabrina Arena

Cancers (Basel) 2020 Mar 14;12(3). Epub 2020 Mar 14.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo 10060 (TO), Italy.

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March 2020

Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients.

Authors:
Giovanni Crisafulli Benedetta Mussolin Andrea Cassingena Monica Montone Alice Bartolini Ludovic Barault Antonia Martinetti Federica Morano Filippo Pietrantonio Andrea Sartore-Bianchi Salvatore Siena Federica Di Nicolantonio Silvia Marsoni Alberto Bardelli Giulia Siravegna

ESMO Open 2019 11;4(6)

University of Turin, Department of Oncology, Candiolo (TO), Italy

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November 2019

-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer.

Authors:
Gary Middleton Yiqun Yang Catarina D Campbell Thierry André Chloe E Atreya Jan H M Schellens Takayuki Yoshino Johanna C Bendell Antoine Hollebecque Autumn J McRee Salvatore Siena Michael S Gordon Josep Tabernero Rona Yaeger Peter J O'Dwyer Filip De Vos Eric Van Cutsem John M Millholland Jan C Brase Fatima Rangwala Eduard Gasal Ryan B Corcoran

Clin Cancer Res 2020 06 11;26(11):2466-2476. Epub 2020 Feb 11.

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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June 2020

Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.

Authors:
Alexander Drilon Salvatore Siena Rafal Dziadziuszko Fabrice Barlesi Matthew G Krebs Alice T Shaw Filippo de Braud Christian Rolfo Myung-Ju Ahn Jürgen Wolf Takashi Seto Byoung Chul Cho Manish R Patel Chao-Hua Chiu Thomas John Koichi Goto Christos S Karapetis Hendrick-Tobias Arkenau Sang-We Kim Yuichiro Ohe Yu-Chung Li Young K Chae Christine H Chung Gregory A Otterson Haruyasu Murakami Chia-Chi Lin Daniel S W Tan Hans Prenen Todd Riehl Edna Chow-Maneval Brian Simmons Na Cui Ann Johnson Susan Eng Timothy R Wilson Robert C Doebele

Lancet Oncol 2020 02 11;21(2):261-270. Epub 2019 Dec 11.

School of Medicine, University of Colorado, Aurora, CO, USA. Electronic address:

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February 2020

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials.

Authors:
Robert C Doebele Alexander Drilon Luis Paz-Ares Salvatore Siena Alice T Shaw Anna F Farago Collin M Blakely Takashi Seto Byung Chul Cho Diego Tosi Benjamin Besse Sant P Chawla Lyudmila Bazhenova John C Krauss Young Kwang Chae Minal Barve Ignacio Garrido-Laguna Stephen V Liu Paul Conkling Thomas John Marwan Fakih Darren Sigal Herbert H Loong Gary L Buchschacher Pilar Garrido Jorge Nieva Conor Steuer Tobias R Overbeck Daniel W Bowles Elizabeth Fox Todd Riehl Edna Chow-Maneval Brian Simmons Na Cui Ann Johnson Susan Eng Timothy R Wilson George D Demetri

Lancet Oncol 2020 02 11;21(2):271-282. Epub 2019 Dec 11.

Dana-Farber Cancer Institute and Ludwig Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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February 2020

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.

Authors:
Sabrina Arena Giorgio Corti Erika Durinikova Monica Montone Nicole M Reilly Mariangela Russo Annalisa Lorenzato Pamela Arcella Luca Lazzari Giuseppe Rospo Massimiliano Pagani Carlotta Cancelliere Carola Negrino Claudio Isella Alice Bartolini Andrea Cassingena Alessio Amatu Gianluca Mauri Andrea Sartore-Bianchi Gloria Mittica Enzo Medico Silvia Marsoni Michael Linnebacher Sergio Abrignani Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Clin Cancer Res 2020 03 12;26(6):1372-1384. Epub 2019 Dec 12.

Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Torino, Italy.

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March 2020

Adaptive mutability of colorectal cancers in response to targeted therapies.

Authors:
Mariangela Russo Giovanni Crisafulli Alberto Sogari Nicole M Reilly Sabrina Arena Simona Lamba Alice Bartolini Vito Amodio Alessandro Magrì Luca Novara Ivana Sarotto Zachary D Nagel Cortt G Piett Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena Andrea Bertotti Livio Trusolino Mattia Corigliano Marco Gherardi Marco Cosentino Lagomarsino Federica Di Nicolantonio Alberto Bardelli

Science 2019 12 7;366(6472):1473-1480. Epub 2019 Nov 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy.

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December 2019

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell-Intrinsic Transcriptional MSI Traits.

Authors:
Simona Corso Claudio Isella Sara E Bellomo Maria Apicella Stefania Durando Cristina Migliore Stefano Ughetto Laura D'Errico Silvia Menegon Daniel Moya-Rull Marilisa Cargnelutti Tânia Capelôa Daniela Conticelli Jessica Giordano Tiziana Venesio Antonella Balsamo Caterina Marchiò Maurizio Degiuli Rossella Reddavid Uberto Fumagalli Stefano De Pascale Giovanni Sgroi Emanuele Rausa Gian Luca Baiocchi Sarah Molfino Filippo Pietrantonio Federica Morano Salvatore Siena Andrea Sartore-Bianchi Maria Bencivenga Valentina Mengardo Riccardo Rosati Daniele Marrelli Paolo Morgagni Stefano Rausei Giovanni Pallabazzer Michele De Simone Dario Ribero Silvia Marsoni Antonino Sottile Enzo Medico Paola Cassoni Anna Sapino Eirini Pectasides Aaron R Thorner Anwesha Nag Samantha D Drinan Bruce M Wollison Adam J Bass Silvia Giordano

Cancer Res 2019 11 4;79(22):5884-5896. Epub 2019 Oct 4.

Department of Oncology, University of Torino, Candiolo, Italy.

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November 2019

Liquid biopsy for rectal cancer: A systematic review.

Authors:
Daniela Massihnia Elio Gregory Pizzutilo Alessio Amatu Federica Tosi Silvia Ghezzi Katia Bencardino Pietro Di Masi Elena Righetti Giorgio Patelli Francesco Scaglione Angelo Vanzulli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Sep 31;79:101893. Epub 2019 Aug 31.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Department of Oncology and Hemato-Oncology, Milan, Italy. Electronic address:

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September 2019

The Amount of Evidence Needed to Support ERBB2 as a Biomarker for Resistance to EGFR Inhibitors in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2019 Aug 15. Epub 2019 Aug 15.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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August 2019

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Authors:
Luca Lazzari Giorgio Corti Gabriele Picco Claudio Isella Monica Montone Pamela Arcella Erika Durinikova Eugenia R Zanella Luca Novara Fabiane Barbosa Andrea Cassingena Carlotta Cancelliere Enzo Medico Andrea Sartore-Bianchi Salvatore Siena Mathew J Garnett Andrea Bertotti Livio Trusolino Federica Di Nicolantonio Michael Linnebacher Alberto Bardelli Sabrina Arena

Clin Cancer Res 2019 10 2;25(20):6243-6259. Epub 2019 Aug 2.

Department of Oncology, University of Torino, Candiolo, Torino, Italy.

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October 2019

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Authors:
Alessio Amatu Marta Schirripa Federica Tosi Sara Lonardi Katia Bencardino Erica Bonazzina Laura Palmeri Damiano Alfio Patanè Elio Gregory Pizzutilo Benedetta Mussolin Francesca Bergamo Giulia Alberti Rossana Intini Letizia Procaccio Marco Arese Silvia Marsoni Michele Nichelatti Vittorina Zagonel Salvatore Siena Alberto Bardelli Fotios Loupakis Federica Di Nicolantonio Andrea Sartore-Bianchi Ludovic Barault

Front Oncol 2019 12;9:622. Epub 2019 Jul 12.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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July 2019

A validated prognostic classifier for BRAF-mutated metastatic colorectal cancer: the 'BRAF BeCool' study.

Authors:
Fotios Loupakis Rossana Intini Chiara Cremolini Armando Orlandi Andrea Sartore-Bianchi Filippo Pietrantonio Nicoletta Pella Andrea Spallanzani Emanuela Dell'Aquila Mario Scartozzi Emmanuele De Luca Lorenza Rimassa Vincenzo Formica Francesco Leone Lorenzo Calvetti Giuseppe Aprile Lorenzo Antonuzzo Federica Urbano Hans Prenen Francesca Negri Samantha Di Donato Pasquale Buonandi Gianluca Tomasello Antonio Avallone Fable Zustovich Roberto Moretto Carlotta Antoniotti Lisa Salvatore Maria Alessandra Calegari Salvatore Siena Federica Morano Elena Ongaro Stefano Cascinu Daniele Santini Pina Ziranu Marta Schirripa Federica Buggin Alessandra Anna Prete Ilaria Depetris Paola Biason Sara Lonardi Vittorina Zagonel Matteo Fassan Massimo Di Maio

Eur J Cancer 2019 09 19;118:121-130. Epub 2019 Jul 19.

S.C.D.U. Medical Oncology, A.O. Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.

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September 2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Authors:
Giorgio Corti Alice Bartolini Giovanni Crisafulli Luca Novara Giuseppe Rospo Monica Montone Carola Negrino Benedetta Mussolin Michela Buscarino Claudio Isella Ludovic Barault Giulia Siravegna Salvatore Siena Silvia Marsoni Federica Di Nicolantonio Enzo Medico Alberto Bardelli

Clin Colorectal Cancer 2019 06 7;18(2):91-101.e3. Epub 2019 Mar 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; University of Turin, Department of Oncology, Candiolo (TO), Italy. Electronic address:

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June 2019

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Alessio Amatu Luca Porcu Silvia Ghezzi Sara Lonardi Francesco Leone Francesca Bergamo Elisabetta Fenocchio Erika Martinelli Beatrice Borelli Federica Tosi Patrizia Racca Emanuele Valtorta Emanuela Bonoldi Cosimo Martino Caterina Vaghi Giovanna Marrapese Fortunato Ciardiello Vittorina Zagonel Alberto Bardelli Livio Trusolino Valter Torri Silvia Marsoni Salvatore Siena

Oncologist 2019 10 5;24(10):1395-1402. Epub 2019 Apr 5.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy

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October 2019

Plasma HER2 () Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Authors:
Giulia Siravegna Andrea Sartore-Bianchi Rebecca J Nagy Kanwal Raghav Justin I Odegaard Richard B Lanman Livio Trusolino Silvia Marsoni Salvatore Siena Alberto Bardelli

Clin Cancer Res 2019 05 26;25(10):3046-3053. Epub 2019 Feb 26.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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May 2019

Combined Low Densities of FoxP3 and CD3 Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression.

Authors:
Tommaso Cavalleri Paolo Bianchi Gianluca Basso Giuseppe Celesti Fabio Grizzi Paola Bossi Luana Greco Calogero Pitrone Emanuele Valtorta Gianluca Mauri Mauro Truini Filippo Gustavo Dall'Olio Giovanni Brandi Andrea Sartore-Bianchi Luigi Ricciardiello Valter Torri Lorenza Rimassa Salvatore Siena Alberto Mantovani Alberto Malesci Luigi Laghi

Cancer Immunol Res 2019 05 25;7(5):751-758. Epub 2019 Feb 25.

Department of Internal Medicine, Humanitas University, Pieve Emanuele, Milan, Italy

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May 2019

Retreatment with anti-EGFR monoclonal antibodies in metastatic colorectal cancer: Systematic review of different strategies.

Authors:
Gianluca Mauri Elio Gregory Pizzutilo Alessio Amatu Katia Bencardino Laura Palmeri Erica Francesca Bonazzina Federica Tosi Giulia Carlo Stella Giovanni Burrafato Francesco Scaglione Silvia Marsoni Giulia Siravegna Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2019 Feb 27;73:41-53. Epub 2018 Dec 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-Oncologia, Milano, Italy. Electronic address:

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February 2019

Early-onset colorectal cancer in young individuals.

Authors:
Gianluca Mauri Andrea Sartore-Bianchi Antonio-Giampiero Russo Silvia Marsoni Alberto Bardelli Salvatore Siena

Mol Oncol 2019 02 22;13(2):109-131. Epub 2018 Dec 22.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

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February 2019

A Multicenter Phase II Study of AMG 337 in Patients with -Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other -Amplified Solid Tumors.

Authors:
Eric Van Cutsem Boguslawa Karaszewska Yoon-Koo Kang Hyun Cheol Chung Veena Shankaran Salvatore Siena Ning F Go Hui Yang Marco Schupp David Cunningham

Clin Cancer Res 2019 Apr 26;25(8):2414-2423. Epub 2018 Oct 26.

Department of Medicine, Royal Marsden Hospital, London, United Kingdom.

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April 2019

Relationships between tumour response and primary tumour location, and predictors of long-term survival, in patients with RAS wild-type metastatic colorectal cancer receiving first-line panitumumab therapy: retrospective analyses of the PRIME and PEAK clinical trials.

Authors:
Marc Peeters Timothy Price Julien Taieb Michael Geissler Fernando Rivera Jean-Luc Canon George Pentheroudakis Reija Koukakis Peter Burdon Salvatore Siena

Br J Cancer 2018 08 17;119(3):303-312. Epub 2018 Jul 17.

Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, 20162, Milan, Italy.

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August 2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.

Authors:
Giulia Siravegna Luca Lazzari Giovanni Crisafulli Andrea Sartore-Bianchi Benedetta Mussolin Andrea Cassingena Cosimo Martino Richard B Lanman Rebecca J Nagy Stephen Fairclough Giuseppe Rospo Giorgio Corti Alice Bartolini Pamela Arcella Monica Montone Francesca Lodi Annalisa Lorenzato Alice Vanzati Emanuele Valtorta Giovanni Cappello Andrea Bertotti Sara Lonardi Vittorina Zagonel Francesco Leone Mariangela Russo Antonella Balsamo Mauro Truini Federica Di Nicolantonio Alessio Amatu Erica Bonazzina Silvia Ghezzi Daniele Regge Angelo Vanzulli Livio Trusolino Salvatore Siena Silvia Marsoni Alberto Bardelli

Cancer Cell 2018 07;34(1):148-162.e7

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, Candiolo, TO 10060, Italy. Electronic address:

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July 2018

Exploring the links between cancer and placenta development.

Authors:
Vincenzo Costanzo Alberto Bardelli Salvatore Siena Sergio Abrignani

Open Biol 2018 06;8(6)

INGM, Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy.

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June 2018

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Authors:
Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2018 06 12;9(1):2287. Epub 2018 Jun 12.

Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo, Turin, Italy.

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June 2018

TRKA expression and gene copy number across solid tumours.

Authors:
Gianluca Mauri Emanuele Valtorta Giulio Cerea Alessio Amatu Michele Schirru Giovanna Marrapese Vincenzo Fiorillo Patrizia Recchimuzzo Ivana Stella Cavenago Erica Francesca Bonazzina Valentina Motta Calogero Lauricella Silvio Veronese Federica Tosi Martina Maiolani Giuseppe Rospo Mauro Truini Emanuela Bonoldi Jason Christiansen Steven J Potts Salvatore Siena Andrea Sartore-Bianchi

J Clin Pathol 2018 Oct 25;71(10):926-931. Epub 2018 May 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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October 2018

Optimising the use of cetuximab in the continuum of care for patients with metastatic colorectal cancer.

Authors:
Richard M Goldberg Clara Montagut Zev A Wainberg Philippe Ronga François Audhuy Julien Taieb Sebastian Stintzing Salvatore Siena Daniele Santini

ESMO Open 2018 5;3(4):e000353. Epub 2018 May 5.

Unit of Medical Oncology, Università Campus Bio-Medico, Rome, Italy.

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May 2018

Effect of Primary Tumor Location on Second- or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies.

Authors:
Nele Boeckx Reija Koukakis Ken Op de Beeck Christian Rolfo Guy Van Camp Salvatore Siena Josep Tabernero Jean-Yves Douillard Thierry André Marc Peeters

Clin Colorectal Cancer 2018 09 8;17(3):170-178.e3. Epub 2018 Mar 8.

Center for Oncological Research, University of Antwerp, Wilrijk, Belgium; Department of Oncology, Antwerp University Hospital, Edegem, Belgium. Electronic address:

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September 2018

Author Correction: Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials.

Authors:
Julien Taieb Fernando Rivera Salvatore Siena Meinolf Karthaus Manuel Valladares-Ayerbes Javier Gallego Michael Geissler Reija Koukakis Gaston Demonty Marc Peeters

J Cancer Res Clin Oncol 2018 04;144(4):795-797

Antwerp University Hospital, Antwerp, Belgium.

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April 2018

Combined BRAF, EGFR, and MEK Inhibition in Patients with -Mutant Colorectal Cancer.

Authors:
Ryan B Corcoran Thierry André Chloe E Atreya Jan H M Schellens Takayuki Yoshino Johanna C Bendell Antoine Hollebecque Autumn J McRee Salvatore Siena Gary Middleton Kei Muro Michael S Gordon Josep Tabernero Rona Yaeger Peter J O'Dwyer Yves Humblet Filip De Vos A Scott Jung Jan C Brase Savina Jaeger Severine Bettinger Bijoyesh Mookerjee Fatima Rangwala Eric Van Cutsem

Cancer Discov 2018 04 5;8(4):428-443. Epub 2018 Feb 5.

University Hospitals Leuven and KU Leuven, Leuven, Belgium.

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April 2018

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.

Authors:
Clara Montagut Guillem Argilés Fortunato Ciardiello Thomas T Poulsen Rodrigo Dienstmann Michael Kragh Scott Kopetz Trine Lindsted Cliff Ding Joana Vidal Jenifer Clausell-Tormos Giulia Siravegna Francisco J Sánchez-Martín Klaus Koefoed Mikkel W Pedersen Michael M Grandal Mikhail Dvorkin Lucjan Wyrwicz Ana Rovira Antonio Cubillo Ramon Salazar Françoise Desseigne Cristina Nadal Joan Albanell Vittorina Zagonel Salvatore Siena Guglielmo Fumi Giuseppe Rospo Paul Nadler Ivan D Horak Alberto Bardelli Josep Tabernero

JAMA Oncol 2018 Apr 12;4(4):e175245. Epub 2018 Apr 12.

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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April 2018

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

Authors:
Erika Martinelli Teresa Troiani Vincenzo Sforza Giulia Martini Claudia Cardone Pietro Paolo Vitiello Davide Ciardiello Anna Maria Rachiglio Nicola Normanno Andrea Sartore-Bianchi Silvia Marsoni Alberto Bardelli Salvatore Siena Fortunato Ciardiello

ESMO Open 2018 10;3(1):e000299. Epub 2018 Jan 10.

Dipartimento di Internistica Clinica e Sperimentale 'F Magrassi', Università degli Studi della Campania L Vanvitelli, Napoli, Italy.

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January 2018

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

Authors:
Filippo Pietrantonio Federica Di Nicolantonio Alexa B Schrock Jeeyun Lee Sabine Tejpar Andrea Sartore-Bianchi Jaclyn F Hechtman Jason Christiansen Luca Novara Niall Tebbutt Giovanni Fucà Carlotta Antoniotti Seung Tae Kim Danielle Murphy Rosa Berenato Federica Morano James Sun Bosun Min Philip J Stephens Marissa Chen Luca Lazzari Vincent A Miller Robert Shoemaker Alessio Amatu Massimo Milione Jeffrey S Ross Salvatore Siena Alberto Bardelli Siraj M Ali Alfredo Falcone Filippo de Braud Chiara Cremolini

J Natl Cancer Inst 2017 12;109(12)

Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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December 2017

The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer.

Authors:
Eric Van Cutsem Robert J Mayer Stéphanie Laurent Robert Winkler Cristina Grávalos Manuel Benavides Federico Longo-Munoz Fabienne Portales Fortunato Ciardiello Salvatore Siena Kensei Yamaguchi Kei Muro Tadamichi Denda Yasushi Tsuji Lukas Makris Patrick Loehrer Heinz-Josef Lenz Atsushi Ohtsu

Eur J Cancer 2018 02 21;90:63-72. Epub 2017 Dec 21.

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. Electronic address:

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February 2018

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Authors:
Giovanni Germano Gianluca Mauri Giulia Siravegna Caroline Dive Jackie Pierce Federica Di Nicolantonio Maurizio D'Incalci Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Clin Colorectal Cancer 2018 03 1;17(1):80-83. Epub 2017 Nov 1.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address:

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March 2018

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Authors:
Giovanni Germano Simona Lamba Giuseppe Rospo Ludovic Barault Alessandro Magrì Federica Maione Mariangela Russo Giovanni Crisafulli Alice Bartolini Giulia Lerda Giulia Siravegna Benedetta Mussolin Roberta Frapolli Monica Montone Federica Morano Filippo de Braud Nabil Amirouchene-Angelozzi Silvia Marsoni Maurizio D'Incalci Armando Orlandi Enrico Giraudo Andrea Sartore-Bianchi Salvatore Siena Filippo Pietrantonio Federica Di Nicolantonio Alberto Bardelli

Nature 2017 12 29;552(7683):116-120. Epub 2017 Nov 29.

Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.

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December 2017

Survival Outcomes in Patients With RAS Wild Type Metastatic Colorectal Cancer Classified According to Köhne Prognostic Category and BRAF Mutation Status.

Authors:
Salvatore Siena Fernando Rivera Julien Taieb Marc Peeters Hans Prenen Reija Koukakis Gaston Demonty Claus-Henning Köhne

Clin Colorectal Cancer 2018 03 28;17(1):50-57.e8. Epub 2017 Sep 28.

Klinikum Oldenburg, Oldenburg, Germany.

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March 2018

Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials.

Authors:
Julien Taieb Fernando Rivera Salvatore Siena Meinolf Karthaus Manuel Valladares-Ayerbes Javier Gallego Michael Geissler Reija Koukakis Gaston Demonty Marc Peeters

J Cancer Res Clin Oncol 2018 Feb 28;144(2):321-335. Epub 2017 Oct 28.

Antwerp University Hospital, Antwerp, Belgium.

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February 2018

Human Epidermal Growth Factor Receptor 2 as a Molecular Biomarker for Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Silvia Marsoni Salvatore Siena

JAMA Oncol 2018 Jan;4(1):19-20

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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January 2018

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

Authors:
Ludovic Barault Alessio Amatu Giulia Siravegna Agostino Ponzetti Sebastian Moran Andrea Cassingena Benedetta Mussolin Chiara Falcomatà Alexandra M Binder Carmen Cristiano Daniele Oddo Simonetta Guarrera Carlotta Cancelliere Sara Bustreo Katia Bencardino Sean Maden Alice Vanzati Patrizia Zavattari Giuseppe Matullo Mauro Truini William M Grady Patrizia Racca Karin B Michels Salvatore Siena Manel Esteller Alberto Bardelli Andrea Sartore-Bianchi Federica Di Nicolantonio

Gut 2018 11 5;67(11):1995-2005. Epub 2017 Oct 5.

Department of Oncology, University of Torino, Torino, Italy.

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November 2018

Identification and characterization of a novel rearrangement in a colorectal cancer patient.

Authors:
Massimo Milione Elena Ardini Jason Christiansen Emanuele Valtorta Silvio Veronese Roberta Bosotti Alessio Pellegrinelli Adele Testi Filippo Pietrantonio Giovanni Fucà Ge Wei Danielle Murphy Salvatore Siena Antonella Isacchi Filippo De Braud

Oncotarget 2017 Aug 24;8(33):55353-55360. Epub 2017 Jul 24.

Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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August 2017

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

Authors:
Riccardo Ricotta Antonella Verrioli Silvia Ghezzi Luca Porcu A Grothey Alfredo Falcone Eric Van Cutsem Guillem Argilés Antoine Adenis Marc Ychou Carlo Barone Olivier Bouché Marc Peeters Yves Humblet Laurent Mineur Alberto F Sobrero Joleen M Hubbard Chiara Cremolini Hans Prenen Josep Tabernero Hajer Jarraya Thibault Mazard Sophie Deguelte-Lardiere Konstantinos Papadimitriou Marc Van den Eynde Alessandro Pastorino Daniela Redaelli Katia Bencardino Chiara Funaioli Alessio Amatu Giulia Carlo-Stella Valter Torri Andrea Sartore-Bianchi Angelo Vanzulli Salvatore Siena

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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February 2017

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience.

Authors:
Andrea Sartore-Bianchi Alessio Amatu Erica Bonazzina Stefano Stabile Laura Giannetta Giulio Cerea Ilaria Schiavetto Katia Bencardino Chiara Funaioli Riccardo Ricotta Tiziana Cipani Michele Schirru Valentina Gambi Laura Palmeri Giulia Carlo-Stella Francesca Rusconi Sara Di Bella Giovanni Burrafato Andrea Cassingena Emanuele Valtorta Calogero Lauricella Federica Pazzi Alessandra Gambaro Silvia Ghezzi Giovanna Marrapese Emiliana Tarenzi Silvio Veronese Mauro Truini Angelo Vanzulli Salvatore Siena

Target Oncol 2017 08;12(4):525-533

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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August 2017

Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Salvatore Siena

Handb Exp Pharmacol 2018;249:145-159

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy.

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June 2019

Integrating liquid biopsies into the management of cancer.

Authors:
Giulia Siravegna Silvia Marsoni Salvatore Siena Alberto Bardelli

Nat Rev Clin Oncol 2017 Sep 2;14(9):531-548. Epub 2017 Mar 2.

Candiolo Cancer Institute - Fondazione del Piemonte per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Strada Provinciale 142, Km 3.95, 10060 Candiolo, Torino, Italy.

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September 2017

Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis.

Authors:
Federica Tosi Elena Magni Alessio Amatu Gianluca Mauri Katia Bencardino Mauro Truini Silvio Veronese Luciano De Carlis Giovanni Ferrari Michele Nichelatti Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2017 09 25;16(3):e153-e163. Epub 2017 Jan 25.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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September 2017

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).

Authors:
Alexander Drilon Salvatore Siena Sai-Hong Ignatius Ou Manish Patel Myung Ju Ahn Jeeyun Lee Todd M Bauer Anna F Farago Jennifer J Wheler Stephen V Liu Robert Doebele Laura Giannetta Giulio Cerea Giovanna Marrapese Michele Schirru Alessio Amatu Katia Bencardino Laura Palmeri Andrea Sartore-Bianchi Angelo Vanzulli Sara Cresta Silvia Damian Matteo Duca Elena Ardini Gang Li Jason Christiansen Karey Kowalski Ann D Johnson Rupal Patel David Luo Edna Chow-Maneval Zachary Hornby Pratik S Multani Alice T Shaw Filippo G De Braud

Cancer Discov 2017 04 9;7(4):400-409. Epub 2017 Feb 9.

Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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April 2017

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers.

Authors:
Takeo Fujii Afsaneh Barzi Andrea Sartore-Bianchi Andrea Cassingena Giulia Siravegna Daniel D Karp Sarina A Piha-Paul Vivek Subbiah Apostolia M Tsimberidou Helen J Huang Silvio Veronese Federica Di Nicolantonio Sandeep Pingle Cecile Rose T Vibat Saege Hancock David Berz Vladislava O Melnikova Mark G Erlander Rajyalakshmi Luthra E Scott Kopetz Funda Meric-Bernstam Salvatore Siena Heinz-Josef Lenz Alberto Bardelli Filip Janku

Clin Cancer Res 2017 Jul 17;23(14):3657-3666. Epub 2017 Jan 17.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas.

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July 2017

Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.

Authors:
Joyce F Liu Isabelle Ray-Coquard Frederic Selle Andrés M Poveda David Cibula Hal Hirte Felix Hilpert Francesco Raspagliesi Laurence Gladieff Philipp Harter Salvatore Siena Josep Maria Del Campo Isabelle Tabah-Fisch Joseph Pearlberg Victor Moyo Kaveh Riahi Rachel Nering William Kubasek Bambang Adiwijaya Akos Czibere R Wendel Naumann Robert L Coleman Ignace Vergote Gavin MacBeath Eric Pujade-Lauraine

J Clin Oncol 2016 12 23;34(36):4345-4353. Epub 2016 Oct 23.

Joyce F. Liu, Dana-Farber Cancer Institute, Boston; Isabelle Tabah-Fisch and Joseph Pearlberg, Sanofi Oncology; Victor Moyo, Kaveh Riahi, Rachel Nering, William Kubasek, Bambang Adiwijaya, Akos Czibere, and Gavin MacBeath, Merrimack Pharmaceuticals, Cambridge, MA; R. Wendel Naumann, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC; Robert L. Coleman, MD Anderson Cancer Center, Houston, TX; Isabelle Ray-Coquard, Centre Léon Bérard, University Claude Bernard, and Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO), Lyon; Frederic Selle, Hôpital Tenon and GINECO; Eric Pujade-Lauraine, Hôpital Hotel-Dieu, Université Paris Descartes, and GINECO, Paris; Laurence Gladieff, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse Oncopole, and GINECO, Toulouse, France; Andrés M. Poveda, Instituto Valenciano de Oncologia and Grupo Español de Investigación en Cáncer de Ovario (GEICO), Valencia; Josep Maria del Campo, Hospital Universitari Vall d'Hebron and GEICO, Barcelona, Spain; David Cibula, General University Hospital Prague and Charles University, Prague, Czech Republic; Hal Hirte, Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton, Ontario, Canada; Felix Hilpert, Universitätsklinikum Schleswig-Holstein, Kiel; Philipp Harter, Kliniken Essen Mitte and Arbeitsgemeinschaft Gynäkologische Onkologie, Essen, Germany; Francesco Raspagliesi, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori; Salvatore Siena, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Università degli Studi di Milano, Milano, Italy; and Ignace Vergote, University Hospital Katholieke Universiteit Leuven and Leuven Cancer Institute, Leuven, Belgium.

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December 2016

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

Authors:
Andrea Sartore-Bianchi Filippo Pietrantonio Alessio Amatu Massimo Milione Andrea Cassingena Silvia Ghezzi Marta Caporale Rosa Berenato Chiara Falcomatà Alessio Pellegrinelli Alberto Bardelli Michele Nichelatti Federica Tosi Filippo De Braud Federica Di Nicolantonio Ludovic Barault Salvatore Siena

Eur J Cancer 2017 01 18;71:43-50. Epub 2016 Dec 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Milan, Italy.

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January 2017

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Authors:
Beth O Van Emburgh Sabrina Arena Giulia Siravegna Luca Lazzari Giovanni Crisafulli Giorgio Corti Benedetta Mussolin Federica Baldi Michela Buscarino Alice Bartolini Emanuele Valtorta Joana Vidal Beatriz Bellosillo Giovanni Germano Filippo Pietrantonio Agostino Ponzetti Joan Albanell Salvatore Siena Andrea Sartore-Bianchi Federica Di Nicolantonio Clara Montagut Alberto Bardelli

Nat Commun 2016 12 8;7:13665. Epub 2016 Dec 8.

Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Torino, Italy.

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December 2016

Overcoming dynamic molecular heterogeneity in metastatic colorectal cancer: Multikinase inhibition with regorafenib and the case of rechallenge with anti-EGFR.

Authors:
Andrea Sartore-Bianchi Salvatore Siena Giuseppe Tonini Alberto Bardelli Daniele Santini

Cancer Treat Rev 2016 Dec 29;51:54-62. Epub 2016 Oct 29.

Department of Medical Oncology, Campus Bio-Medico University of Rome, 00128 Rome, Italy. Electronic address:

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December 2016

Clonal evolution and - coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

Authors:
Andrea Sartore-Bianchi Emanuele Valtorta Alessio Amatu Silvio Veronese Calogero Lauricella Erica Bonazzina Giulia Siravegna Mauro Truini Alberto Bardelli Salvatore Siena

ESMO Open 2016 4;1(4):e000079. Epub 2016 Aug 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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August 2016

Quality of life during first-line FOLFOX4±panitumumab in wild-type metastatic colorectal carcinoma: results from a randomised controlled trial.

Authors:
Salvatore Siena Josep Tabernero Gyorgy Bodoky David Cunningham Fernando Rivera Paul Ruff Jean Luc Canon Reija Koukakis Gaston Demonty Guy Hechmati Jean-Yves Douillard

ESMO Open 2016 31;1(2):e000041. Epub 2016 Mar 31.

Department of Medical Oncology , Institut de Cancérologie de l'Ouest (ICO) René Gauducheau , Nantes , France.

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March 2016

gene fusions as novel targets of cancer therapy across multiple tumour types.

Authors:
Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena

ESMO Open 2016 18;1(2):e000023. Epub 2016 Mar 18.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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March 2016

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.

Authors:
Daniele Oddo Erin M Sennott Ludovic Barault Emanuele Valtorta Sabrina Arena Andrea Cassingena Genny Filiciotto Giulia Marzolla Elena Elez Robin M J M van Geel Alice Bartolini Giovanni Crisafulli Valentina Boscaro Jason T Godfrey Michela Buscarino Carlotta Cancelliere Michael Linnebacher Giorgio Corti Mauro Truini Giulia Siravegna Julieta Grasselli Margherita Gallicchio René Bernards Jan H M Schellens Josep Tabernero Jeffrey A Engelman Andrea Sartore-Bianchi Alberto Bardelli Salvatore Siena Ryan B Corcoran Federica Di Nicolantonio

Cancer Res 2016 08 16;76(15):4504-15. Epub 2016 Jun 16.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.

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August 2016

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial.

Authors:
Andrea Sartore-Bianchi Livio Trusolino Cosimo Martino Katia Bencardino Sara Lonardi Francesca Bergamo Vittorina Zagonel Francesco Leone Ilaria Depetris Erika Martinelli Teresa Troiani Fortunato Ciardiello Patrizia Racca Andrea Bertotti Giulia Siravegna Valter Torri Alessio Amatu Silvia Ghezzi Giovanna Marrapese Laura Palmeri Emanuele Valtorta Andrea Cassingena Calogero Lauricella Angelo Vanzulli Daniele Regge Silvio Veronese Paolo M Comoglio Alberto Bardelli Silvia Marsoni Salvatore Siena

Lancet Oncol 2016 Jun 20;17(6):738-746. Epub 2016 Apr 20.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia Università degli Studi di Milano, Milano, Italy.

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June 2016

Skin toxicity and quality of life during treatment with panitumumab for RAS wild-type metastatic colorectal carcinoma: results from three randomised clinical trials.

Authors:
Reija Koukakis Francesca Gatta Guy Hechmati Salvatore Siena

Qual Life Res 2016 10 15;25(10):2645-2656. Epub 2016 Apr 15.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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October 2016

Oxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review Study.

Authors:
Katia Bencardino Gianluca Mauri Alessio Amatu Federica Tosi Erica Bonazzina Laura Palmeri Marialuisa Querques Federica Ravera Alberto Menegotto Elisa Boiani Andrea Sartore-Bianchi Salvatore Siena

Clin Colorectal Cancer 2016 09 19;15(3):213-21. Epub 2016 Feb 19.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milan, Italy.

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September 2016

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

Authors:
Mariangela Russo Giulia Siravegna Lawrence S Blaszkowsky Giorgio Corti Giovanni Crisafulli Leanne G Ahronian Benedetta Mussolin Eunice L Kwak Michela Buscarino Luca Lazzari Emanuele Valtorta Mauro Truini Nicholas A Jessop Hayley E Robinson Theodore S Hong Mari Mino-Kenudson Federica Di Nicolantonio Ashraf Thabet Andrea Sartore-Bianchi Salvatore Siena A John Iafrate Alberto Bardelli Ryan B Corcoran

Cancer Discov 2016 Feb 7;6(2):147-153. Epub 2015 Dec 7.

Massachusetts General Hospital Cancer Center, Boston, MA, USA.

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February 2016

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer.

Authors:
Alessio Amatu Alessio Somaschini Giulio Cerea Roberta Bosotti Emanuele Valtorta Pasquale Buonandi Giovanna Marrapese Silvio Veronese David Luo Zachary Hornby Pratik Multani Danielle Murphy Robert Shoemaker Calogero Lauricella Laura Giannetta Martina Maiolani Angelo Vanzulli Elena Ardini Arturo Galvani Antonella Isacchi Andrea Sartore-Bianchi Salvatore Siena

Br J Cancer 2015 Dec 3;113(12):1730-4. Epub 2015 Dec 3.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, 20162 Milan, Italy.

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December 2015

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.

Authors:
Andrea Sartore-Bianchi Elena Ardini Roberta Bosotti Alessio Amatu Emanuele Valtorta Alessio Somaschini Laura Raddrizzani Laura Palmeri Patrizia Banfi Erica Bonazzina Sandra Misale Giovanna Marrapese Antonella Leone Rachele Alzani David Luo Zachary Hornby Jonathan Lim Silvio Veronese Angelo Vanzulli Alberto Bardelli Marcella Martignoni Cristina Davite Arturo Galvani Antonella Isacchi Salvatore Siena

J Natl Cancer Inst 2016 Jan 12;108(1). Epub 2015 Nov 12.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy (ASB, AA, EV, LP, EB, GM, SV, AV, SS); Nerviano Medical Sciences S.r.l Nerviano, Milan, Italy (EA, RB, AS, LR, PB, AL, RA, AG, AI); Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy (SM, AB); University of Torino, Department of Oncology, Candiolo, Torino, Italy (AB); FIRC Institute of Molecular Oncology (IFOM), Milano, Italy (SM); Ignyta, Inc., San Diego, CA (DL, ZH, JL); Clioss S.r.l. Nerviano, Milan, Italy (MM, CD); Università degli Studi di Milano, Milan, Italy (SS).

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January 2016

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

Authors:
Mariangela Russo Sandra Misale Ge Wei Giulia Siravegna Giovanni Crisafulli Luca Lazzari Giorgio Corti Giuseppe Rospo Luca Novara Benedetta Mussolin Alice Bartolini Nicholas Cam Roopal Patel Shunqi Yan Robert Shoemaker Robert Wild Federica Di Nicolantonio Andrea Sartore Bianchi Gang Li Salvatore Siena Alberto Bardelli

Cancer Discov 2016 Jan 6;6(1):36-44. Epub 2015 Nov 6.

Department of Oncology, University of Torino, Torino, Italy. Candiolo Cancer Institute, FPO, IRCCS, Torino, Italy.

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January 2016

Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: A randomized phase 2 trial (Vecti-BIL study).

Authors:
Francesco Leone Donatella Marino Stefano Cereda Roberto Filippi Carmen Belli Rosella Spadi Guglielmo Nasti Massimo Montano Alessio Amatu Giuseppe Aprile Celeste Cagnazzo Gianpiero Fasola Salvatore Siena Libero Ciuffreda Michele Reni Massimo Aglietta

Cancer 2016 Feb 5;122(4):574-81. Epub 2015 Nov 5.

Department of Oncology, University of Turin Medical School/Piedmont Foundation for Oncology, Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy.

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February 2016

Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.

Authors:
Emanuele Valtorta Cosimo Martino Andrea Sartore-Bianchi Frédérique Penaullt-Llorca Giuseppe Viale Mauro Risio Massimo Rugge Walter Grigioni Katia Bencardino Sara Lonardi Vittorina Zagonel Francesco Leone Johannes Noe Fortunato Ciardiello Carmine Pinto Roberto Labianca Stefania Mosconi Claudio Graiff Giuseppe Aprile Barbara Frau Carlo Garufi Fotios Loupakis Patrizia Racca Giuseppe Tonini Calogero Lauricella Silvio Veronese Mauro Truini Salvatore Siena Silvia Marsoni Marcello Gambacorta

Mod Pathol 2015 Nov 9;28(11):1481-91. Epub 2015 Oct 9.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milano, Italy.

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November 2015

The genomic landscape of response to EGFR blockade in colorectal cancer.

Authors:
Andrea Bertotti Eniko Papp Siân Jones Vilmos Adleff Valsamo Anagnostou Barbara Lupo Mark Sausen Jillian Phallen Carolyn A Hruban Collin Tokheim Noushin Niknafs Monica Nesselbush Karli Lytle Francesco Sassi Francesca Cottino Giorgia Migliardi Eugenia R Zanella Dario Ribero Nadia Russolillo Alfredo Mellano Andrea Muratore Gianluca Paraluppi Mauro Salizzoni Silvia Marsoni Michael Kragh Johan Lantto Andrea Cassingena Qing Kay Li Rachel Karchin Robert Scharpf Andrea Sartore-Bianchi Salvatore Siena Luis A Diaz Livio Trusolino Victor E Velculescu

Nature 2015 Oct 30;526(7572):263-7. Epub 2015 Sep 30.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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October 2015

Pilot evaluation of scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies.

Authors:
Paolo Notaro Carlo Alberto Dell'Agnola Alessandro J Dell'Agnola Alessio Amatu Katia Bruna Bencardino Salvatore Siena

Support Care Cancer 2016 Apr 26;24(4):1649-54. Epub 2015 Sep 26.

Dipartimento di Ematologia e Oncologia, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milano, Italy.

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April 2016

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Authors:
Bruno Vincenzi Chiara Cremolini Andrea Sartore-Bianchi Antonio Russo Francesco Mannavola Giuseppe Perrone Francesco Pantano Fotios Loupakis Daniele Rossini Elena Ongaro Erica Bonazzina Emanuela Dell'Aquila Marco Imperatori Alice Zoccoli Giuseppe Bronte Giovanna De Maglio Gabriella Fontanini Clara Natoli Alfredo Falcone Daniele Santini Andrea Onetti-Muda Salvatore Siena Giuseppe Tonini Giuseppe Aprile

Oncotarget 2015 Oct;6(31):31604-12

Department of Medical Oncology, Azienda Ospedaliero-Universitaria, Udine, Italy.

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October 2015

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.

Authors:
Josep Tabernero Heinz-Josef Lenz Salvatore Siena Alberto Sobrero Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Takayuki Yoshino Richard M Goldberg Daniel J Sargent Andrea Wagner Dirk Laurent Michael Teufel Michael Jeffers Axel Grothey Eric Van Cutsem

Lancet Oncol 2015 Aug 13;16(8):937-48. Epub 2015 Jul 13.

University Hospital Gasthuisberg/Leuven and KU Leuven, Leuven, Belgium.

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August 2015

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Authors:
Giulia Siravegna Benedetta Mussolin Michela Buscarino Giorgio Corti Andrea Cassingena Giovanni Crisafulli Agostino Ponzetti Chiara Cremolini Alessio Amatu Calogero Lauricella Simona Lamba Sebastijan Hobor Antonio Avallone Emanuele Valtorta Giuseppe Rospo Enzo Medico Valentina Motta Carlotta Antoniotti Fabiana Tatangelo Beatriz Bellosillo Silvio Veronese Alfredo Budillon Clara Montagut Patrizia Racca Silvia Marsoni Alfredo Falcone Ryan B Corcoran Federica Di Nicolantonio Fotios Loupakis Salvatore Siena Andrea Sartore-Bianchi Alberto Bardelli

Nat Med 2015 Jul;21(7):827

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July 2015

Effects of Cancer Therapy Targeting Vascular Endothelial Growth Factor Receptor on Central Blood Pressure and Cardiovascular System.

Authors:
Antonella Moreo Paola Vallerio Riccardo Ricotta Miriam Stucchi Mattia Pozzi Francesco Musca Paolo Meani Alessandro Maloberti Rita Facchetti Sara Di Bella Maria Olga Giganti Andrea Sartore-Bianchi Salvatore Siena Giuseppe Mancia Cristina Giannattasio

Am J Hypertens 2016 Feb 1;29(2):158-62. Epub 2015 Jun 1.

Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; Health Science Department, Milano-Bicocca University, Milan, Italy;

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February 2016

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Authors:
Giulia Siravegna Benedetta Mussolin Michela Buscarino Giorgio Corti Andrea Cassingena Giovanni Crisafulli Agostino Ponzetti Chiara Cremolini Alessio Amatu Calogero Lauricella Simona Lamba Sebastijan Hobor Antonio Avallone Emanuele Valtorta Giuseppe Rospo Enzo Medico Valentina Motta Carlotta Antoniotti Fabiana Tatangelo Beatriz Bellosillo Silvio Veronese Alfredo Budillon Clara Montagut Patrizia Racca Silvia Marsoni Alfredo Falcone Ryan B Corcoran Federica Di Nicolantonio Fotios Loupakis Salvatore Siena Andrea Sartore-Bianchi Alberto Bardelli

Nat Med 2015 Jul 1;21(7):795-801. Epub 2015 Jun 1.

1] University of Torino, Department of Oncology, Torino, Italy. [2] Candiolo Cancer Institute - Fondazione Piemontese per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Torino, Italy.

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July 2015

Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer.

Authors:
Jean-Yves Douillard Salvatore Siena Marc Peeters Reija Koukakis Jan-Henrik Terwey Josep Tabernero

Eur J Cancer 2015 Jul 5;51(10):1231-42. Epub 2015 May 5.

Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain. Electronic address:

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July 2015

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Authors:
Enzo Medico Mariangela Russo Gabriele Picco Carlotta Cancelliere Emanuele Valtorta Giorgio Corti Michela Buscarino Claudio Isella Simona Lamba Barbara Martinoglio Silvio Veronese Salvatore Siena Andrea Sartore-Bianchi Marco Beccuti Marcella Mottolese Michael Linnebacher Francesca Cordero Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2015 Apr 30;6:7002. Epub 2015 Apr 30.

1] Department of Oncology, University of Torino, SP 142, Km 3.95, 10060, Candiolo, Torino, Italy [2] Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo (TO), Italy.

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April 2015

nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial.

Authors:
David Goldstein Robert Hassan El-Maraghi Pascal Hammel Volker Heinemann Volker Kunzmann Javier Sastre Werner Scheithauer Salvatore Siena Josep Tabernero Luis Teixeira Giampaolo Tortora Jean-Luc Van Laethem Rosemary Young Darryl Neil Penenberg Brian Lu Alfredo Romano Daniel D Von Hoff

J Natl Cancer Inst 2015 Feb 31;107(2). Epub 2015 Jan 31.

Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia (DG); Royal Victoria Regional Health Centre, Barrie, ON, Canada (RHEM); Hôpital Beaujon, Clichy, France (PH); Klinikum Grosshadern, University of Munich, Munich, Germany (VH); Universitätsklinikum Würzburg, Würzburg, Germany (VK); Hospital Clinico San Carlos, Madrid, Spain (JS); Medizinische Universität Wien, Wien, Austria (WS); Ospedale Niguarda Ca' Granda, Milan, Italy (SS); Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain (JT); Hôpital Saint Antoine, Paris, France (LT); Azienda Ospedaliera Universitaria Integrata and University of Verona, Verona, Italy (GT); Hôpital Erasme, Brussels, Belgium (JLVL); Royal Hobart Hospital, Hobart, Australia (RY); Celgene Corporation, Summit, NJ (DNP); Celgene Corporation, Summit, NJ (BL); Celgene Corporation, Boudry, Switzerland (AR); Virginia G. Piper Cancer Center at Scottsdale Healthcare/TGen, Scottsdale, AZ (DDVH).

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February 2015

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Authors:
Sandra Misale Federica Di Nicolantonio Andrea Sartore-Bianchi Salvatore Siena Alberto Bardelli

Cancer Discov 2014 Nov 7;4(11):1269-80. Epub 2014 Oct 7.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. FIRC Institute of Molecular Oncology (IFOM), Milano, Italy.

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November 2014

Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast.

Authors:
Filippo Venturini Valentina Gambi Stefano Di Lernia Angelo Vanzulli Manuela Bramerio Katia Bencardino Alessio Amatu Tiziana Cipani Edoardo Forti Emiliana Tarenzi Andrea Sartore-Bianchi Raffaele Pugliese Salvatore Siena

J Clin Oncol 2016 Mar 30;34(7):e54-6. Epub 2014 Jun 30.

Ospedale Niguarda Ca' Granda, Milan, Italy

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March 2016

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

Authors:
Elena Ardini Roberta Bosotti Andrea Lombardi Borgia Cristina De Ponti Alessio Somaschini Rosaria Cammarota Nadia Amboldi Laura Raddrizzani Andrea Milani Paola Magnaghi Dario Ballinari Daniele Casero Fabio Gasparri Patrizia Banfi Nilla Avanzi Maria B Saccardo Rachele Alzani Tiziano Bandiera Eduard Felder Daniele Donati Enrico Pesenti Andrea Sartore-Bianchi Marcello Gambacorta Marco A Pierotti Salvatore Siena Silvio Veronese Arturo Galvani Antonella Isacchi

Mol Oncol 2014 Dec 12;8(8):1495-507. Epub 2014 Jun 12.

Nerviano Medical Sciences S.r.l., Nerviano (Milan), Italy.

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December 2014

Translational challenges from the 2014 Gastrointestinal Cancers Symposium: toward a true tailored therapy through effective research.

Authors:
Giuseppe Aprile Francesco Giuliani Stefano Cordio Andrea Sartore-Bianchi Katia Bencardino Elena Ongaro Concetta Martines Riccardo Giampieri Roberto Bordonaro Salvatore Siena Stefano Cascinu Mario Scartozzi

Future Oncol 2014 May;10(7):1125-8

Medical Oncology, University & General Hospital, Udine, Italy.

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May 2014

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Authors:
Beth O Van Emburgh Andrea Sartore-Bianchi Federica Di Nicolantonio Salvatore Siena Alberto Bardelli

Mol Oncol 2014 Sep 14;8(6):1084-94. Epub 2014 May 14.

Candiolo Cancer Institute - FPO, IRCCS, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy; University of Torino, Department of Oncology, Strada Provinciale, 142 km 3.95, 10060 Candiolo, Torino, Italy. Electronic address:

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September 2014

Advanced non-small cell lung cancer management in patients progressing after first-line treatment: results of the cross-sectional phase of the Italian LIFE observational study.

Authors:
Cesare Gridelli Filippo de Marinis Andrea Ardizzoni Silvia Novello Gabriella Fontanini Federico Cappuzzo Francesco Grossi Antonio Santo Diego Cortinovis Adolfo Favaretto Vito Lorusso Domenico Galetta Salvatore Siena Anna Bettini Monica Iurlaro Alberto Caprioli

J Cancer Res Clin Oncol 2014 Oct 6;140(10):1783-93. Epub 2014 Jun 6.

A.O.R.N. San Giuseppe Moscati, Contrada Amoretta, 83100, Avellino, AV, Italy,

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October 2014

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial.

Authors:
Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Peña István Molnár Martin J Schlumberger

Lancet 2014 Jul 24;384(9940):319-28. Epub 2014 Apr 24.

Gustave Roussy and University Paris Sud, Villejuif, France.

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July 2014

Regorafenib in metastatic colorectal cancer.

Authors:
Andrea Sartore-Bianchi Annalisa Zeppellini Alessio Amatu Riccardo Ricotta Katia Bencardino Salvatore Siena

Expert Rev Anticancer Ther 2014 Mar;14(3):255-65

Department of Hematology and Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy.

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March 2014