Publications by authors named "Sally A Cowley"

54 Publications

Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.

Front Immunol 2020 3;11:617860. Epub 2021 Feb 3.

Roche Pharma Research and Early Development, Neuroscience and Rare Diseases Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

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February 2021

Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages.

Sci Rep 2021 Feb 19;11(1):4245. Epub 2021 Feb 19.

Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.

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February 2021

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models.

Front Immunol 2020 8;11:614972. Epub 2020 Dec 8.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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December 2020

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.

EMBO J 2020 Sep 26;39(17):e104415. Epub 2020 Jul 26.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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September 2020

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening.

Int J Mol Sci 2020 Jul 7;21(13). Epub 2020 Jul 7.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

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July 2020

Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs.

Sci Rep 2020 06 29;10(1):10542. Epub 2020 Jun 29.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

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June 2020

Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells.

Stem Cell Res 2020 07 1;46:101852. Epub 2020 Jun 1.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, United Kingdom. Electronic address:

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July 2020

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936.

Stem Cell Res 2020 07 20;46:101851. Epub 2020 May 20.

iPSC Core, The David Janet Polak Foundation Stem Cell Core Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Cedars-Sinai Biomanufacturing Center, West Hollywood, CA 90069, USA; Board of Governors-Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Electronic address:

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July 2020

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

Stem Cell Reports 2020 05 30;14(5):940-955. Epub 2020 Apr 30.

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

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May 2020

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.

Stem Cell Reports 2020 05 23;14(5):892-908. Epub 2020 Apr 23.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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May 2020

A causal role for TRESK loss of function in migraine mechanisms.

Brain 2019 12;142(12):3852-3867

Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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December 2019

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

J Biol Chem 2019 04 14;294(17):7085-7097. Epub 2019 Mar 14.

From the Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT,

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April 2019

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets.

Br J Pharmacol 2019 09 11;176(18):3515-3532. Epub 2019 May 11.

Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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September 2019

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Cell Stem Cell 2019 01 29;24(1):93-106.e6. Epub 2018 Nov 29.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK. Electronic address:

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January 2019

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.

Cell Death Dis 2018 09 24;9(10):973. Epub 2018 Sep 24.

Instituto de Biomedicina de Sevilla-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, 41012, Spain.

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September 2018

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Acta Neuropathol Commun 2018 09 24;6(1):99. Epub 2018 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK.

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September 2018

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

Elife 2018 06 13;7. Epub 2018 Jun 13.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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June 2018

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.

Cerebellum 2018 Aug;17(4):419-427

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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August 2018