Salima Hacein-Bey-Abina

Salima Hacein-Bey-Abina

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Salima Hacein-Bey-Abina

Salima Hacein-Bey-Abina

Publications by authors named "Salima Hacein-Bey-Abina"

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Gene therapy for severe combined immunodeficiencies and beyond.

J Exp Med 2020 Jan;217(2)

Unité de Technologies Chimiques et Biologiques pour la Santé, UMR8258 Centre National de la Recherche Scientifique - U1267 Institut National de la Santé et de la Recherche Médicale, Faculté de Pharmacie de Paris, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1084/jem.20190607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041706PMC
January 2020

Etanercept concentration and immunogenicity do not influence the response to Etanercept in patients with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2019 06 17;48(6):1014-1018. Epub 2018 Sep 17.

Unité de Recherche Clinique Paris Descartes Necker Cochin, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Tarnier, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, EA 7323, Paris, France.

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http://dx.doi.org/10.1016/j.semarthrit.2018.09.002DOI Listing
June 2019

Methotrexate and BAFF interaction prevents immunization against TNF inhibitors.

Ann Rheum Dis 2018 10 23;77(10):1463-1470. Epub 2018 Jun 23.

Rheumatology Department, Université Paris-Sud-CEA-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, Hôpitaux Universitaires Paris-Sud-Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre, France.

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http://dx.doi.org/10.1136/annrheumdis-2018-213403DOI Listing
October 2018

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.

N Engl J Med 2018 04;378(16):1479-1493

From the Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago (A.A.T., M.K.); University of California, San Francisco, Benioff Children's Hospital, Oakland (M.C.W., E.V.), Lucile Salter Packard Children's Hospital at Stanford, Palo Alto (S.S.), and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (G.J.S.) - all in California; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia (J.K., D.T.T.); Centenary Institute (J.E.J.R.), University of Sydney, Sydney Medical School (J.E.J.R., P.J.H.), and Royal Prince Alfred Hospital (J.E.J.R., P.J.H.), Camperdown, NSW, Australia; Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (J.-A.R., E.M., D.M., F.L., P.B., A.M., L.C., J.-S.D., F.S., F.M., V.B., C.B., O.H., M.D.M., S.B., M.C.), Groupe Hospitalier Universitaire Ouest (J.-A.R., A.M., L.C., M.C.), IMAGINE Institute (E.M., M.S., D.M., M.C.), Université Paris Descartes (M.S., C. Poirot, S.H.-B.-A.), Université Paris Diderot (H.P., T.L.), Pierre et Marie Curie University (C. Poirot), and Hôpital Cochin (J.-F.M.), Paris, CEA University Paris-Sud, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Hôpital Louis-Mourier, Colombes (H.P., T.L.), Centre Hospitalier Intercommunal de Créteil, Créteil (C. Pondarré), and Hôpital Bicêtre, Le Kremlin-Bicêtre (S.H.-B.-A.) - all in France; Bluebird Bio, Cambridge (J.-A.R., S.S., G.V., O.N., R.W.R., D.D., A.P., L.S., M.A.), and Harvard Medical School, Brigham and Women's Hospital, Boston (P.L.) - both in Massachusetts; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (S.H., U.A., P.L.); and the National Center for Tumor Diseases-German Cancer Research Center, Heidelberg, Germany (C.K.).

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http://dx.doi.org/10.1056/NEJMoa1705342DOI Listing
April 2018

Gene Therapy in a Patient with Sickle Cell Disease.

N Engl J Med 2017 03;376(9):848-855

From the Departments of Biotherapy (J.-A.R., A.M., E.M., L.C., M.C.), Clinical Pharmacy (P. Bourget), Pediatric Neuroradiology (D.G.), General Pediatrics (M.M.), and Pediatric Immunology-Hematology Unit (B.N., S.B.), Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (J.-A.R., A.M., E.M., L.C., L.W., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8258, INSERM Unité 1022, Faculté de Pharmacie de Paris, Université Paris Descartes, Chimie ParisTech (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, Hôpital Kremlin-Bicêtre, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), the Institute of Emerging Diseases and Innovative Therapies, Imagine Institute, Université Paris Descartes, Sorbonne Paris Cité University (M.S., B.N., L.W., M.C.), Mère-Enfant Clinical Investigation Center, Groupe Hospitalier Necker Cochin (M.S.), Université Paris Diderot, Sorbonne Paris Cité University, INSERM Institut National de Transfusion Sanguine, Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex (W.E.N.), and Laboratoires de Virologie, Hôpital Cochin (J.-F.M.), Paris, Atomic and Alternative Energy Commission, Université Paris-Sud, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Institut Mondor de Recherche Biomédicale, Equipe 2, Centre de Référence des Syndromes Drépanocytaires Majeurs, Centre Hospitalier Universitaire Henri Mondor, AP-HP, Laboratoire d'Excellence GR-Ex, Créteil (P. Bartolucci), and Université Paris Diderot, Sorbonne Paris Cité University, INSERM Unité 1149, Hôpital Louis-Mourier, AP-HP, Laboratoire d'Excellence GR-Ex, Colombes (H.P., T.L.) - all in France; Bluebird Bio, Cambridge (R.W.R., O.N., G.V., L.S., S.S.), and Brigham and Women's Hospital and Harvard Medical School, Boston (P.L.) - both in Massachusetts; and Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (P.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1609677
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http://dx.doi.org/10.1056/NEJMoa1609677DOI Listing
March 2017

Specific T cells for the treatment of cytomegalovirus and/or adenovirus in the context of hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2016 09 30;138(3):920-924.e3. Epub 2016 Apr 30.

Biotherapy Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immunology and Pediatric Hematology Department, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Human Lymphohematopoiesis-INSERM UMR1163, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.032DOI Listing
September 2016

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?

Hum Gene Ther 2016 Feb;27(2):108-16

1 Biotherapy Department, Necker Children's Hospital , Assistance Publique-Hôpitaux de Paris, Paris.

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http://dx.doi.org/10.1089/hum.2015.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779287PMC
February 2016

[Efficacy and safety of gene therapy for Wiskott-Aldrich syndrome].

Med Sci (Paris) 2015 Dec 16;31(12):1066-9. Epub 2015 Dec 16.

Département de biothérapies, hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France - CIC biothérapies, groupe hospitalier universitaire Ouest, Assistance Publique-Hôpitaux de Paris, Inserm, Paris, France - UTCBS CNRS 8258-Inserm U1022, Faculté des sciences pharmaceutiques et biologiques, université Paris Descartes, Paris, France - Service d'Immunologie Biologique, Groupe Hospitalier Universitaire Paris-Sud, Le-Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1051/medsci/20153112006DOI Listing
December 2015

Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1.

Blood 2015 Jun 13;125(23):3563-9. Epub 2015 Apr 13.

Département de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France;

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http://dx.doi.org/10.1182/blood-2014-12-616003DOI Listing
June 2015

A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.

N Engl J Med 2014 Oct;371(15):1407-17

From the Departments of Biotherapy (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.) and Immunology and Pediatric Hematology (S.B., G.C., D.M., B.N., C.P., F.T., A.F.) and the Centre d'Étude des Déficits Immunitaires (C.P.), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), the Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (S.H.-B.-A., J. Blondeau, L.C., F.T., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique, 8258-INSERM Unité 1022, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), Imagine Institute, Paris Descartes-Sorbonne Paris Cité University (S.B., J. Blondeau, L.C., D.M., B.N., C.P., E.S., A.F., M.C.), INSERM Unités Mixtes de Recherche 1163, Laboratory of Human Lymphohematopoiesis (J. Blondeau, L.C., E.S., F.T., A.F., M.C.), Groupe Immunoscope, Immunology Department, Institut Pasteur (A.L.), and Collège de France (A.F.) - all in Paris; Division of Hematology-Oncology (S.-Y.P., H.B., D.G., C.E.H., G.H., L.E.L., W.B.L., D.A.W.) and Division of Immunology (L.D.N.), Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute (S.-Y.P., D.G., L.E.L., W.B.L., D.A.W.), Harvard Medical School (S.-Y.P., M.A., L.E.L., W.B.L., J.R., L.E.S., A.T., L.D.N., D.A.W.), Center for Human Cell Therapy, Program in Cellular and Molecular Medicine, Boston Children's Hospital (M.A., J.R., L.E.S., A.T.), Division of Hematologic Malignancies, Dana-Farber Cancer Institute (J.R.), and the Manton Center for Orphan Disease Research (L.D.N.) - all in Boston; Great Ormond Street Hospital for Children NHS Foundation Trust (H.B.G., J.X.-B., A.J.T.) and Section of Molecular and Cellular Immunology, University College London Institute of Child Health (H.B.G., K.F.B., A.

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http://dx.doi.org/10.1056/NEJMoa1404588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274995PMC
October 2014

Gene therapy for inherited immunodeficiency.

Expert Opin Biol Ther 2014 Jun 8;14(6):789-98. Epub 2014 Mar 8.

U768 INSERM , Paris , France.

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http://dx.doi.org/10.1517/14712598.2014.895811DOI Listing
June 2014

Gene therapy of primary T cell immunodeficiencies.

Gene 2013 Aug 10;525(2):170-3. Epub 2013 Apr 10.

INSERM U768, Paris, France.

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http://dx.doi.org/10.1016/j.gene.2013.03.092DOI Listing
August 2013

Gene therapy for primary immunodeficiencies: Part 1.

Curr Opin Immunol 2012 Oct 12;24(5):580-4. Epub 2012 Sep 12.

U768 INSERM, Paris, France.

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http://dx.doi.org/10.1016/j.coi.2012.08.008DOI Listing
October 2012

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy.

Nucleic Acids Res 2011 Jun 16;39(11):e72. Epub 2011 Mar 16.

Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1093/nar/gkr140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113588PMC
June 2011

Gene therapy for primary adaptive immune deficiencies.

J Allergy Clin Immunol 2011 Jun;127(6):1356-9

INSERM U768, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2011.04.030DOI Listing
June 2011

Is normal hematopoiesis maintained solely by long-term multipotent stem cells?

Blood 2011 Apr 8;117(17):4420-4. Epub 2011 Feb 8.

Department of Biotherapy, Hopital Necker Enfants-Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

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http://dx.doi.org/10.1182/blood-2010-09-255679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099566PMC
April 2011

A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.

Blood 2010 Aug 10;116(6):900-8. Epub 2010 May 10.

Division of Experimental Hematology, Department of Hematology, St Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, TN 38105, USA.

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http://dx.doi.org/10.1182/blood-2009-10-250209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924228PMC
August 2010

Advances in adoptive immunotherapy to accelerate T-cellular immune reconstitution after HLA-incompatible hematopoietic stem cell transplantation.

Immunotherapy 2010 Jul;2(4):481-96

Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Biothérapie, Hopital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, and Université Paris Descartes 75015 Paris, France.

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http://dx.doi.org/10.2217/imt.10.36DOI Listing
July 2010

20 years of gene therapy for SCID.

Nat Immunol 2010 Jun;11(6):457-60

Institut National de la Santé et de la Recherche Médicale, Paris, France.

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http://dx.doi.org/10.1038/ni0610-457DOI Listing
June 2010

[Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector].

Bull Acad Natl Med 2010 Feb;194(2):255-64; discussion 264-8

Inserm U745, Facult6 de Pharmacie, 4, avenue de l'Observatoire, 75006 Paris.

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February 2010

Immune reconstitution after haematopoietic stem cell transplantation: obstacles and anticipated progress.

Curr Opin Immunol 2009 Oct 18;21(5):544-8. Epub 2009 Sep 18.

Assistance Publique Hôpitaux de Paris (AP-HP), Department of Biotherapy, Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1016/j.coi.2009.08.001DOI Listing
October 2009

DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer.

Nucleic Acids Res 2008 May 14;36(9):e49. Epub 2008 Apr 14.

University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1093/nar/gkn125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396413PMC
May 2008

[Cell therapy for inherited diseases of the hematopoietic system].

C R Biol 2007 Jun-Jul;330(6-7):538-42. Epub 2007 May 15.

Inserm, U768, Paris & université René-Descartes (Paris-5), hôpital Necker-Enfants-Malades, 149, rue de Sevres, 75743 Paris cedex 15, France.

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http://dx.doi.org/10.1016/j.crvi.2007.04.003DOI Listing
September 2007

Real-time definition of non-randomness in the distribution of genomic events.

PLoS One 2007 Jun 27;2(6):e570. Epub 2007 Jun 27.

Department of Translational Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany; Department of Medical Biostatistics, Tumor Center Heidelberg-Mannheim, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892803PMC
June 2007

Gene therapy of metabolic diseases.

J Inherit Metab Dis 2006 Apr-Jun;29(2-3):409-12

Inserm, U768, Paris, France.

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http://dx.doi.org/10.1007/s10545-006-0270-7DOI Listing
January 2007

Gene therapy: X-SCID transgene leukaemogenicity.

Nature 2006 Sep;443(7109):E5-6; discussion E6-7

Molecular Immunology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1038/nature05219DOI Listing
September 2006

Gene therapy for severe combined immunodeficiency.

Annu Rev Med 2005 ;56:585-602

Département de Biothérapie, Hôpital Necker Enfants Malades, 75015 Paris, France.

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http://dx.doi.org/10.1146/annurev.med.56.090203.104142DOI Listing
July 2005

[Gene therapy, where does it stand today].

J Med Liban 2004 Jan-Mar;52(1):32

Unité Inserm 429, Développement normal et pathologique du système immunitaire, Hôpital Necker Enfants Malades, Paris.

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May 2005

[Gene therapy of severe combined immunodeficiency disease: proof of principle of efficiency and safety issues. Gene therapy, primary immunodeficiencies, retrovirus, lentivirus, genome].

Bull Acad Natl Med 2005 May;189(5):779-85; discussion 786-8

INSERM U 429, Unité d'Immunologie et Hématologie Pédiatrique et Département de Biothérapie, Hôpital Necker Enfants Malades, 149 rue de Sèvres, 75015 Paris.

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May 2005

Gene therapy for immunodeficiency diseases.

Semin Hematol 2004 Oct;41(4):272-8

INSERM U 429, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1053/j.seminhematol.2004.07.003DOI Listing
October 2004

[Gene therapy of children with X-linked severe combined immune deficiency: efficiency and complications].

Med Sci (Paris) 2004 Jan;20(1):115-7

Inserm U.429, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/2004201115DOI Listing
January 2004

Gene therapy of X-linked severe combined immunodeficiency.

Methods Mol Biol 2003 ;215:247-59

Gene and Cell Therapy Unit, Institut National de la Santé et de la Recherche Médicale, Hôpital Necker Enfants Malades, Paris, France.

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http://dx.doi.org/10.1385/1-59259-345-3:247DOI Listing
June 2003

Gene therapy of X-linked severe combined immunodeficiency.

Curr Opin Allergy Clin Immunol 2002 Dec;2(6):507-9

INSERM U429, Hôpital Necker Enfants Malades, Paris, France.

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http://dx.doi.org/10.1097/00130832-200212000-00005DOI Listing
December 2002

Gene therapy of X-linked severe combined immunodeficiency.

Int J Hematol 2002 Nov;76(4):295-8

INSERM U 429, Gene and Cell Therapy Unit, Hĵpital Necker Enfants Malades, Paris, France.

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http://dx.doi.org/10.1007/bf02982686DOI Listing
November 2002

Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation.

Semin Hematol 2002 Jan;39(1):32-40

Laboratoire de Thérapie Cellulaire et Génique, INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1053/shem.2002.29251DOI Listing
January 2002