Salim Merali

Salim Merali

UNVERIFIED PROFILE

Are you Salim Merali?   Register this Author

Register author
Salim Merali

Salim Merali

Publications by authors named "Salim Merali"

Are you Salim Merali?   Register this Author

61Publications

1177Reads

11Profile Views

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.

Mol Psychiatry 2019 11 4;24(11):1696-1706. Epub 2018 May 4.

Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41380-018-0062-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215750PMC
November 2019

The central role of protein kinase C epsilon in cyanide cardiotoxicity and its treatment.

Toxicol Sci 2019 Jun 7. Epub 2019 Jun 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/toxsci/kfz137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735853PMC
June 2019

Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses.

J Biol Chem 2017 08 6;292(34):14108-14121. Epub 2017 Jul 6.

From the Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.770925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572918PMC
August 2017

Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.

Hum Mol Genet 2017 05;26(10):1855-1862

Department of Pharmacology and Center for Translational Medicine, Lewis Katz School of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddx088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075360PMC
May 2017

Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers.

Respir Res 2017 05 2;18(1):78. Epub 2017 May 2.

Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-017-0561-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414124PMC
May 2017

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.

Aging Cell 2017 04 29;16(2):273-280. Epub 2016 Nov 29.

Department of Pharmacology and Center for Translational Medicine, Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334532PMC
April 2017

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.

Sci Rep 2017 04 6;7:46002. Epub 2017 Apr 6.

Department of Pharmacology and Center for Translational Medicine, Lewis Katz School of Medicine, Temple University Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep46002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382538PMC
April 2017

Glutamate metabolism in HIV-1 infected macrophages: Role of HIV-1 Vpr.

Cell Cycle 2016 Sep 31;15(17):2288-98. Epub 2016 May 31.

a Department of Neuroscience and Comprehensive NeuroAIDS Center , Lewis Katz School of Medicine at Temple University , Philadelphia , PA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2016.1190054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004675PMC
September 2016

Disruption of NAD(+) binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions.

World J Biol Chem 2015 Nov;6(4):366-78

Manali Phadke, Natalia Krynetskaia, Carlos Barrero, Salim Merali, Scott A Gothe, Evgeny Krynetskiy, Temple University School of Pharmacy, Philadelphia, PA 19140, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4331/wjbc.v6.i4.366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657119PMC
November 2015

Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men.

Sci Transl Med 2015 Sep;7(304):304re7

Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery, Proteomics/Metabolomics Facility, Temple University School of Pharmacy, Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aac4765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600191PMC
September 2015

A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.

Curr Pharm Des 2014 ;20(2):245-52

Department of Biochemistry and Fels Institute for Cancer Research, School of Medicine and 2 Moulder Center for Drug Discovery, School of Pharmacy, Temple University 3307 N. Broad Street, Philadelphia, PA 19140.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871977PMC
http://dx.doi.org/10.2174/13816128113199990035DOI Listing
October 2014

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.

Ann Neurol 2014 Jun 28;75(6):851-63. Epub 2014 May 28.

Department of Pharmacology and Center for Translational Medicine, School of Medicine, Temple University, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ana.24145
Publisher Site
http://dx.doi.org/10.1002/ana.24145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362695PMC
June 2014

Modulation of polyamine metabolic flux in adipose tissue alters the accumulation of body fat by affecting glucose homeostasis.

Amino Acids 2014 Mar 24;46(3):701-15. Epub 2013 Jul 24.

AHB/552, Department of Biochemistry, Temple University School of Medicine, 3307N. Broad Street, Philadelphia, PA, 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-013-1548-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184767PMC
March 2014

Insulin regulates the unfolded protein response in human adipose tissue.

Diabetes 2014 Mar 15;63(3):912-22. Epub 2013 Oct 15.

Division of Endocrinology/Diabetes/Metabolism, Temple University School of Medicine, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db13-0906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931405PMC
March 2014

HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis.

PLoS One 2013 12;8(7):e68376. Epub 2013 Jul 12.

Department of Biochemistry, Temple University School of Medicine, Fels Institute, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068376PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709966PMC
February 2014

Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders.

J AIDS Clin Res 2014;5(6):1000312

Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4172/2155-6113.1000312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397651PMC
January 2014

Translational control of Nrf2 within the open reading frame.

Biochem Biophys Res Commun 2013 Jul 24;437(1):134-9. Epub 2013 Jun 24.

Department of Biochemistry and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2013.06.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780388PMC
July 2013

Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics.

J Proteome Res 2012 Dec 29;11(12):5947-58. Epub 2012 Oct 29.

Developmental Therapeutics Program, Fox Chase Cancer Center, Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr300686kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518753PMC
December 2012

Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.

Mol Cell Biol 2012 Apr 21;32(8):1453-67. Epub 2012 Feb 21.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.06444-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318587PMC
April 2012

Regulation of polyamine metabolism by translational control.

Amino Acids 2012 Feb 3;42(2-3):611-7. Epub 2011 Aug 3.

AHB/552, Department of Biochemistry, Temple University of School of Medicine, 3307 N. Broad Street, Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-011-1036-6DOI Listing
February 2012

Pneumocystis S-adenosylmethionine transport: a potential drug target.

Am J Respir Cell Mol Biol 2011 Dec 3;45(6):1142-6. Epub 2011 Jun 3.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2011-0009OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262670PMC
December 2011

Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver.

Obesity (Silver Spring) 2011 Jul 7;19(7):1366-73. Epub 2011 Apr 7.

Division of Endocrinology/Diabetes/Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2011.71DOI Listing
July 2011

Pneumocystis pneumonia and S-adenosylmethionine plasma levels.

J Infect 2011 Jun 1;62(6):490-2; author reply 493-5. Epub 2011 May 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinf.2011.04.012DOI Listing
June 2011

Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos.

J Proteome Res 2010 Nov 20;9(11):6025-6032. Epub 2010 Oct 20.

The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr100827jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316211PMC
November 2010

SILAC analysis of oxidative stress-mediated proteins in human pneumocytes: new role for treacle.

Proteomics 2010 Jun;10(11):2165-74

Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201000020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184769PMC
June 2010

Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells.

Int J Cancer 2009 Sep;125(5):1038-44

Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.24372DOI Listing
September 2009

Proteomic analysis of oxidative stress-responsive proteins in human pneumocytes: insight into the regulation of DJ-1 expression.

J Proteome Res 2008 Nov 26;7(11):4955-61. Epub 2008 Sep 26.

Department of Biochemistry and Department of Medicine, Division of Pulmonary Critical Care and Pulmonary Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr800295jDOI Listing
November 2008

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.

Diabetes 2008 Sep 20;57(9):2438-44. Epub 2008 Jun 20.

Division of Endocrinology, Diabetes, and Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db08-06
Publisher Site
http://dx.doi.org/10.2337/db08-0604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518495PMC
September 2008

Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach.

Am J Respir Cell Mol Biol 2008 May 13;38(5):541-50. Epub 2007 Dec 13.

Department of Biochemistry, Temple University Hospital, 3401 N. Broad Street, Philadelphia, PA 19140, USA.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/abs/10.1165/rcmb.2007-0221OC
Publisher Site
http://dx.doi.org/10.1165/rcmb.2007-0221OCDOI Listing
May 2008

Mechanism and tissue specificity of nicotine-mediated lung S-adenosylmethionine reduction.

J Biol Chem 2008 Mar 7;283(12):7690-6. Epub 2008 Jan 7.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M709399200DOI Listing
March 2008

Ubiquinone synthesis and its regulation in Pneumocystis carinii.

J Eukaryot Microbiol 2006 Nov-Dec;53(6):435-44

Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1550-7408.2006.00127.xDOI Listing
February 2008

Polyamine acetylation modulates polyamine metabolic flux, a prelude to broader metabolic consequences.

J Biol Chem 2008 Feb 18;283(7):4241-51. Epub 2007 Dec 18.

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M706806200DOI Listing
February 2008

S-adenosylmethionine levels in the diagnosis of Pneumocystis carinii pneumonia in patients with HIV infection.

Clin Infect Dis 2008 Feb;46(3):467-71

Department of Infectious Diseases, Lincoln Medical and Mental Health Center, Bronx, New York 10451, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/525854DOI Listing
February 2008

S-adenosylmethionine as a biomarker for the early detection of lung cancer.

Chest 2007 Oct;132(4):1247-52

Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.07-0622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562751PMC
October 2007

Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia.

J Biol Chem 2007 Apr 21;282(15):11009-20. Epub 2007 Feb 21.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M611686200DOI Listing
April 2007

Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.

J Biol Chem 2007 Mar 21;282(11):8404-13. Epub 2006 Dec 21.

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M610265200DOI Listing
March 2007

Effect of nicotine on lung S-adenosylmethionine and development of Pneumocystis pneumonia.

J Biol Chem 2005 Apr 24;280(15):15219-28. Epub 2005 Jan 24.

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M413946200DOI Listing
April 2005

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice.

J Biol Chem 2004 Sep 13;279(38):40076-83. Epub 2004 Jul 13.

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M406002200DOI Listing
September 2004

S-adenosylmethionine and Pneumocystis.

FEMS Microbiol Lett 2004 Aug;237(2):179-86

Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY, USA.

View Article

Download full-text PDF

Source
http://www.researchgate.net/profile/Salim_Merali/publication
Web Search
http://femsle.oxfordjournals.org/content/femsle/237/2/179.fu
Web Search
http://www.jbc.org/content/275/20/14958.full.pdf
Web Search
http://doi.wiley.com/10.1016/j.femsle.2004.06.039
Publisher Site
http://dx.doi.org/10.1016/j.femsle.2004.06.039DOI Listing
August 2004

Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.

J Biol Chem 2004 Jun 19;279(26):27050-8. Epub 2004 Apr 19.

Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M403323200DOI Listing
June 2004

Summary of pneumocystis research presented at the 8th International Workshop on Opportunistic Protists.

J Eukaryot Microbiol 2003 ;50 Suppl:602-4

Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1550-7408.2003.tb00645.xDOI Listing
March 2004

Oxidosqualene cyclase inhibitors as antimicrobial agents.

J Med Chem 2003 Sep;46(20):4240-3

Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm034126tDOI Listing
September 2003

S-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia.

Lancet 2003 Apr;361(9365):1267-8

Department of Medicine, New York University-Bellevue Hospital Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(03)12984-4DOI Listing
April 2003

The enteric parasite Entamoeba uses an autocrine catecholamine system during differentiation into the infectious cyst stage.

J Biol Chem 2002 Mar 4;277(10):8083-90. Epub 2002 Jan 4.

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111895200DOI Listing
March 2002