Publications by authors named "Salih Guler"

14 Publications

  • Page 1 of 1

A rare case of recurrence presenting with bilateral exudative retinal detachment in a child with acute lymphoblastic leukemia.

Pediatr Blood Cancer 2021 Dec 16;68(12):e29291. Epub 2021 Aug 16.

Department of Pediatric Hematology, Bursa Uludag University School of Medicine, Bursa, Turkey.

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http://dx.doi.org/10.1002/pbc.29291DOI Listing
December 2021

The effect of maternal depression symptoms on the outcomes of infant care.

Perspect Psychiatr Care 2021 Jul 30;57(3):1137-1144. Epub 2020 Oct 30.

Department of Public Health Nursing, Faculty of Nursing, Akdeniz University, Antalya, Turkey.

Purpose: This study evaluated the effect of the maternal risk of depression on the outcomes of infant care.

Design And Methods: This study was conducted as a cross-sectional and analytical study with 229 mothers who had 6-month-old infants and who were enrolled in a family health center.

Findings: The results show that mothers at risk of depression have a negative impact on the care and growth of their infants.

Practice Implications: Providing support to the mothers is suggested for preventive infant health behaviors and monitoring their infants.
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http://dx.doi.org/10.1111/ppc.12667DOI Listing
July 2021

Impact of additional annuloplasty on tricuspid valve and cardiac functions after atrial septal defect closure in adults.

J Card Surg 2020 Nov 2;35(11):2895-2901. Epub 2020 Aug 2.

Department of Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Background: Surgical indications for moderate to severe tricuspid regurgitation (TR) during atrial septal defect (ASD) closure are still unclear. Additional tricuspid valve annuloplasty (TVP) can be beneficial to avoid postoperative persistent TR. Therefore, we compared the results of surgical ASD closure with or without additional TVP in patients who presented with moderate-to-severe TR.

Methods: Between November 2009 and June 2016, 103 patients with ASD and moderate-to-severe TR underwent surgical ASD closure without (n = 76, group 1) and with additional TVP (n = 27, group 2). Clinical outcomes and echocardiographic data were analyzed.

Results: There was no mortality. Postoperative outcomes were similar despite significantly longer aortic clamping time in group 2 (P = .003). Mean TR grade, right atrial diameter, right ventricular end-diastolic diameter, pulmonary artery pressure, and Qp/Qs ratio decreased significantly in both groups (P < .05). Mean follow-up time was 5.3 months (range: 1 month-6.2 years) in group 1 and 6.1 months (range: 1 month-4.1 years) in group 2 (P = .66). Echocardiography results showed significant decrease in TR grade in both groups (P = .93). The incidence of persistent moderate to severe TR was higher in isolated ASD closure group (14.4% vs 3.7%, P = .086). Additional TVP provided greater regression in TR grade (-1.49 ± 0.9 vs -1.89 ± 0.8, P = .041).

Conclusion: Despite TVP being associated with longer ischemic time, postoperative outcomes were comparable to ASD closure alone. Both approach demonstrated an effective decrease in TR, but TVP provided greater regression and lower incidence of persistent TR. Therefore, additional TVP should be considered in patients undergoing ASD closure with moderate-to-severe TR.
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http://dx.doi.org/10.1111/jocs.14905DOI Listing
November 2020

Port-a-cath and ventriculoatrial shunt at the same atrium: technical note.

Childs Nerv Syst 2019 05 6;35(5):857-860. Epub 2019 Feb 6.

Department of Neurosurgery, University of Health Sciences, Gulhane Training and Research Hospital, 06010 Etlik, Ankara, Turkey.

Hydrocephalus is a rare complication of brain involving acute lymphoblastic leukemia (ALL). The standard treatment is ventriculoperitoneal (VP) shunting, while ventriculoatrial (VA) shunting is the second option in a case of VP shunt failure in young children. But the presence of port catheter at the right atrium restricts and makes a VA shunt difficult to place in the same atrium. We presented a 4-year-old boy who had the diagnoses of ALL and underwent chemotherapy through a port-a-cath. He also had hydrocephalus due to the brain invasion of the ALL. He firstly underwent VP shunting for the treatment of hydrocephalus, but it failed due to an intraabdominal cyst. Then, he underwent VA shunting through the left internal jugular vein. This is the first case in the literature showing both catheters in the right atrium.
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http://dx.doi.org/10.1007/s00381-019-04079-2DOI Listing
May 2019

Late effects in patients with sacrococcygeal teratoma: A single center series.

Pediatr Hematol Oncol 2018 Apr 22;35(3):208-217. Epub 2018 Oct 22.

b Department of Pediatric Oncology , Uludag University Faculty of Medicine , Bursa , Turkey.

Introduction: The aim of this study is to evaluate late side effects that affect quality of life in children with sacrococcygeal teratoma (SCT).

Patients And Methods: The patients with SCT were evaluated retrospectively. The data were expressed by percentage and the subgroups were compared statistically.

Results: A total of 40 children with SCT were identified with median age 12 days (range: 1 day-14.6 years), 27 of whom were analyzed in this study with urodynamic data available for 24 and anal manometric evaluations for 20. Chronic constipation with need for laxative was reported in (7/27) 25.9%, fecal incontinence was present in (1/27) 3.7%, and urodynamic abnormalities were reported in (16/24) 66%. Among those with urodynamic abnormalities, low bladder capacity, dyssyergia and neurogenic bladder were observed in (21/24) 87.5% and anticholinergic treatment was applied. Urinary incontinence was present in (2/27) 7%, with clean intermittent catheterization utilized in (7/27) 25.9%. While defecation was observed more in the patients with Altman types II, III, and IV, micturation problems were observed more in the patients with Altman types II and IV. It was found that urodynamic dysfunctions were more frequent in the patients with increased number of operations.

Discussion: Although the rate of symptomatic patients was low, abnormalities determined by radiological and urodynamic evaluations were high.
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http://dx.doi.org/10.1080/08880018.2018.1504151DOI Listing
April 2018

Comparison of Continuous and Interrupted Suturing Techniques in Ventricular Septal Defect Closure.

Heart Surg Forum 2018 Oct 2;21(5):E418-E422. Epub 2018 Oct 2.

Department of Cardiovascular Surgery, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Background: Our goal is to evaluate postoperative outcomes of continuous versus interrupted suturing techniques in ventricular septal defect (VSD) closure surgery.

Methods: The study included 286 patients with isolated VSD who underwent VSD closure surgery between June 2010 and April 2017. VSD closure was performed by using the interrupted suturing technique in group 1 (n = 74, 25.9%) and the continuous suturing technique in group 2 (n = 212, 74.1%). The groups were compared in terms of mortality and rates of clinical morbidities such as infection and complete atrioventricular (AV) block.

Results: Early mortality occurred in 3 cases in group 1 (4.0%) and 5 cases in group 2 (2.3%). There was no late mortality in either group. One patient from both groups required extracorporeal membrane oxygenation (ECMO) at postoperative 48 hours. Five patients in group 1 (6.8%) and 11 patients in group 2 (5.2%) developed complete AV block postoperatively and received permanent pacemaker implants.

Conclusion: Complication rates were similar between the patient groups operated on by using continuous and interrupted suturing techniques in our study, suggesting that neither technique is superior for VSD closure surgery.
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http://dx.doi.org/10.1532/hsf.2045DOI Listing
October 2018

A prospective follow-up of quality of life, depression, and anxiety in children with lymphoma and solid tumors

Turk J Med Sci 2017 08 23;47(4):1078-1088. Epub 2017 Aug 23.

Background/aim: The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors. Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used. Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and in the group of patients whose diagnosis was delayed for more than 3 months. Total quality of life scores for children and their parents were 82.95 ± 14.59 vs. 83.61 ± 14.60 before, 54.69 ± 16.51 vs. 55.78 ± 16.05 during, and 83.88 ± 12.44 vs. 84.19 ± 13.22 at the end of treatment (P < 0.05). Anxiety and depression scores were significantly higher during treatment, in patients whose diagnoses were delayed for more than 3 months, and among inpatients. Conclusion: The quality of life of a majority of our patients was severely affected, and depression and anxiety were more frequently seen especially during treatment.
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http://dx.doi.org/10.3906/sag-1510-9DOI Listing
August 2017

Perforation of the Anterior Mitral Leaflet After Aortic Valve Replacement With Root Enlargement.

Ann Thorac Surg 2017 Oct;104(4):e345-e346

Department of Cardiovascular Surgery, Istanbul SBU Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery, Training and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.athoracsur.2017.06.013DOI Listing
October 2017

Robotic-assisted removal of an Amplatzer atrial septal occluder device for residual shunting, closure of septal defect and simultaneous tricuspid annuloplasty.

J Robot Surg 2018 Mar 3;12(1):185-188. Epub 2017 May 3.

Anesthesiology, Istanbul SBU Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.

Complications after percutaneous atrial septal defect closure such as residual shunting or device-related events are generally treated using conventional sternotomy or thoracotomy incisions. In these cases, minimally invasive approaches including mini-sternotomy, mini-thoracotomy or endoscopic techniques can also be used in the management of complications, residual defects and concomitant procedures. However, robotic surgery is a reasonable alternative for removal of septal occluder devices and concomitant repair procedures to prevent cardiopulmonary morbidities. Herein, we report an adult, who underwent a totally endoscopic robotic removal of septal occluder device, closure of septal defect with autologous pericardial patch and tricuspid valve annuloplasty through a right atriotomy approach.
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http://dx.doi.org/10.1007/s11701-017-0709-xDOI Listing
March 2018

Leptomeningeal dissemination and vertebral bone involvement in a child with pilocytic astrocytoma.

Pediatr Int 2016 Dec 13;58(12):1341-1344. Epub 2016 Nov 13.

Department of Pathology, Faculty of Medicine, Uludag University, Bursa, Turkey.

In low-grade glioma, metastasis is rarely seen. Few cases of leptomeningeal dissemination have been reported in children. Vertebral bone metastasis has not been reported so far. Herein is described the case of a pediatric patient with the diagnosis of pilocytic astrocytoma, and leptomeningeal dissemination detected at the time of diagnosis, who then received radiotherapy and chemotherapy upon development of vertebral bone metastasis during treatment.
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http://dx.doi.org/10.1111/ped.13121DOI Listing
December 2016

Acute Central Nervous System Complications in Pediatric Acute Lymphoblastic Leukemia.

Pediatr Neurol 2015 Oct 15;53(4):312-8. Epub 2015 May 15.

Department of Pediatric Neurology, Uludag University Medical Faculty, Bursa, Turkey.

Background: The outcome of childhood acute lymphoblastic leukemia has improved because of intensive chemotherapy and supportive care. The frequency of adverse events has also increased, but the data related to acute central nervous system complications during acute lymphoblastic leukemia treatment are sparse. The purpose of this study is to evaluate these complications and to determine their long term outcome.

Patients And Methods: We retrospectively analyzed the hospital reports of 323 children with de novo acute lymphoblastic leukemia from a 13-year period for acute neurological complications. The central nervous system complications of leukemic involvement, peripheral neuropathy, and post-treatment late-onset encephalopathy, and neurocognitive defects were excluded.

Results: Twenty-three of 323 children (7.1%) suffered from central nervous system complications during acute lymphoblastic leukemia treatment. The majority of these complications (n = 13/23; 56.5%) developed during the induction period. The complications included posterior reversible encephalopathy (n = 6), fungal abscess (n = 5), cerebrovascular lesions (n = 5), syndrome of inappropriate secretion of antidiuretic hormone (n = 4), and methotrexate encephalopathy (n = 3). Three of these 23 children (13%) died of central nervous system complications, one from an intracranial fungal abscess and the others from intracranial thrombosis. Seven of the survivors (n = 7/20; 35%) became epileptic and three of them had also developed mental and motor retardation.

Conclusions: Acute central neurological complications are varied and require an urgent approach for proper diagnosis and treatment. Collaboration among the hematologist, radiologist, neurologist, microbiologist, and neurosurgeon is essential to prevent fatal outcome and serious morbidity.
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http://dx.doi.org/10.1016/j.pediatrneurol.2015.03.006DOI Listing
October 2015

The Preventive Effects of Posterior Pericardiotomy with Intrapericardial Tube on the Development of Pericardial Effusion, Atrial Fibrillation, and Acute Kidney Injury after Coronary Artery Surgery: A Prospective, Randomized, Controlled Trial.

Thorac Cardiovasc Surg 2016 Apr 14;64(3):217-24. Epub 2015 Apr 14.

Department of Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Background:  Pericardial effusion (PE), atrial fibrillation (AF), and acute kidney injury (AKI) are commonly found after coronary artery surgery. These adverse events may also be interwoven in the postoperative period. In this prospective study, we investigated whether posterior pericardiotomy (PP) with intrapericardial tube positioned along the right atrium (pericardial space intervention) is effective in the prevention of these adverse events.

Methods:  The patients were randomly distributed to the study and control groups. The study group consisted of patients with pericardial space intervention, whereas the control group consisted of patients without pericardial space interventions. In all patients, a straight tube was placed in the anterior mediastinum and an angled tube was placed into the left hemithorax.

Results:  A total of 210 patients were studied: 107 in the control group and 103 in the study group. Statistically significant results were obtained in the amount of PE, cardiac tamponade, AF (p = 0.019), and AKI during the postoperative period, in favor of the study group. Length of hospital stay was significantly shorter in the study group (6.11 ± 2.31, p = 0.009).

Conclusion:  The PP with intrapericardial tube approach is safe, easy, and effective in the prevention of PE, cardiac tamponade, and AF. The use of this approach may reduce the risk of developing AKI during the postoperative period. Besides, this technique also reduces the length of hospital stay.
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http://dx.doi.org/10.1055/s-0035-1548737DOI Listing
April 2016

The effects of posterior pericardiotomy on pericardial effusion, tamponade, and atrial fibrillation after coronary artery surgery.

Kardiochir Torakochirurgia Pol 2014 Jun 29;11(2):113-8. Epub 2014 Jun 29.

Department of Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: Pericardial effusion and atrial fibrillation occur commonly after coronary artery surgery.

Aim Of The Study: A prospective randomized clinical trial was conducted to evaluate the effects of posterior pericardiotomy on the occurrence of pericardial effusion, tamponade, and atrial fibrillation.

Material And Methods: The study group consisted of 96 patients (77 male and 19 female) at a mean age of 58.1 ± 9.8 years. The patients were randomly assigned to one of three study groups: patients undergoing posterior pericardiotomy (group I, n = 30), controls (group II, n = 33), and patients with additional posterior pericardial drainage tubes (28 mm) who did not undergo posterior pericardiotomy (group III, n = 33).

Results: Postoperative hospitalization (p = 0.03; 11.56 ± 10.64) and reoperation due to tamponade (p = 0.019; 12.1%) were significantly higher in group II. Extensive pericardial effusions were detected in one patient on the first postoperative day (group II, n = 1), in one patient on the fifth postoperative day (group III, n = 1), and in one patient on the 30(th) day after the operation (group III, n = 1). Pericardial effusion exhibited regression in group I on postoperative day 30 (p = 0.028). A higher rate of postoperative atrial fibrillation was noted in group I, but no significant differences were found between the groups with regard to postoperative atrial fibrillation.

Conclusions: Patients who did not undergo posterior pericardiotomy or did not receive posterior chest tubes exhibited residual pericardial effusion, required longer hospitalization, and had to be reoperated due to tamponade. Both posterior pericardiotomy and the use of posterior tubes are effective in the early postoperative period.
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http://dx.doi.org/10.5114/kitp.2014.43835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283862PMC
June 2014
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