Salar Vaseghi, Ph.D. - Postdoctoral Researcher at Tehran University of Medical Sciences, National Elites Foundation - Dr.

Salar Vaseghi

Ph.D.

Postdoctoral Researcher at Tehran University of Medical Sciences, National Elites Foundation

Dr.

Tehran | Iran (Islamic Republic of)

Main Specialties: Medical Genetics, Pharmacology, Psychiatry, Sleep Medicine, Statistics

ORCID logohttps://orcid.org/0000-0002-2436-9887

Salar Vaseghi, Ph.D. - Postdoctoral Researcher at Tehran University of Medical Sciences, National Elites Foundation - Dr.

Salar Vaseghi

Ph.D.

Introduction

Primary Affiliation: Postdoctoral Researcher at Tehran University of Medical Sciences, National Elites Foundation - Tehran , Iran (Islamic Republic of)

Specialties:

Research Interests:

Publications

12Publications

39Reads

36Profile Views

The role of sleep disturbances in depressive-like behavior with emphasis on α-ketoglutarate dehydrogenase activity in rats.

Physiol Behav 2020 Oct 20;224:113023. Epub 2020 Jun 20.

Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroendocrinology Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.physbeh.2020.113023DOI Listing
October 2020
2.976 Impact Factor

The neuroprotective effect of NeuroAid on morphine-induced amnesia with respect to the expression of TFAM, PGC-1α, ΔfosB and CART genes in the hippocampus of male Wistar rats.

Gene 2020 Jun 19;742:144601. Epub 2020 Mar 19.

Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.gene.2020.144601DOI Listing
June 2020
2.138 Impact Factor

The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jun 24. Epub 2020 Jun 24.

Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, P.O. Box: 13145-784, Tehran, Iran.

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http://dx.doi.org/10.1007/s00210-020-01916-zDOI Listing
June 2020
2.471 Impact Factor

Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (TSD) and REM Sleep Deprivation (RSD) on Memory Acquisition, Locomotor Activity and Pain Perception.

Neuroscience 2020 May 19;433:200-211. Epub 2020 Mar 19.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran.

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http://dx.doi.org/10.1016/j.neuroscience.2020.03.006DOI Listing
May 2020
3.357 Impact Factor

The fluctuations of metabotropic glutamate receptor subtype 5 (mGluR5) in the amygdala in fear conditioning model of male Wistar rats following sleep deprivation, reverse circadian and napping.

Brain Res 2020 May 19;1734:146739. Epub 2020 Feb 19.

Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

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http://dx.doi.org/10.1016/j.brainres.2020.146739DOI Listing
May 2020
2.843 Impact Factor

RehaCom rehabilitation training improves a wide-range of cognitive functions in multiple sclerosis patients

Applied Neuropsychology: Adult

Multiple sclerosis (MS) is a chronic neurodegenerative disease that impairs cognitive performance. Attention, response control, working memory, and processing speed are highly impaired in MS. On the other hand, RehaCom is a computerized software that improves cognitive dysfunctions. In this study, we aimed to investigate the effect of RehaCom on attention, response control, processing speed, working memory, visuospatial skills, and verbal/non-verbal executive functions in MS patients. Sixty patients were selected randomly and divided into control (n = 30) and experimental (n = 30) groups. Integrated Auditory Visual-2 (IVA-2), Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Judgment of Line Orientation (JLO) and The Delis–Kaplan Executive Function System (DKEFS) were used to assess cognitive functions. Patients in the experimental group were treated by RehaCom for 5 weeks (two 60-min sessions per week). Cognitive performance of all patients in both groups was assessed at weeks 5 and 10 (post-test and follow-up stages, respectively). The results showed that RehaCom treatment improved all studied cognitive functions at the post-test stage. This effect also remained at the follow-up stage for some cognitive functions. In conclusion, treatment with RehaCom may have significant therapeutic effects on cognitive dysfunctions in MS patients.

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May 2020

The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD).

Physiol Behav 2020 03 18;215:112788. Epub 2019 Dec 18.

Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.physbeh.2019.112788DOI Listing
March 2020
2.976 Impact Factor

Synergistic but not additive effect between ACPA and lithium in the dorsal hippocampal region on spatial learning and memory in rats: Isobolographic analyses.

Chem Biol Interact 2020 Jan 9;315:108895. Epub 2019 Nov 9.

Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Lithium and cannabinoids can disrupt learning and memory performance. The goal of the present study is to investigate the additive or synergistic effect of lithium and cannabinoid combination doses on spatial learning and memory in rats by isobolographic analyses. Although several studies have suggested synergistic effects of cannabinoids or lithium in response to other compounds, in most of them isobolographic analyses were not used; Thus, there is a need for more detailed studies using isobolographic analyses. In this study, spatial memory was evaluated in the Morris Water Maze (MWM) apparatus by eight trials in the training day and one trial in the test day. Lithium was injected intraperitoneal and ACPA (cannabinoid type 1 receptor agonist) was injected into the dorsal hippocampal region (intra-CA1). For the isobolographic analyses, the ED50 of lithium (2.5?mg/kg) and ACPA (0.5 ?g/rat) was measured by linear regression analysis, considering the doses were tested in our previous research. The results showed that, combinations of low, medium and high doses of lithium (0.312?mg/kg, 0.625?mg/kg and 1.25?mg/kg, respectively) and ACPA (0.0625 ?g/rat, 0.125 ?g/rat and 0.25 ?g/rat, respectively) had synergistic but not additive effect on spatial learning and spatial memory. In conclusion, we suggest that combination doses of lithium and ACPA have synergistic but not additive effect on spatial learning and memory in the rat's dorsal hippocampal region.

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http://dx.doi.org/10.1016/j.cbi.2019.108895DOI Listing
January 2020
5 Reads
3.407 Impact Factor

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients.

J Clin Neurosci 2020 Jan 5;71:101-107. Epub 2019 Sep 5.

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address:

Background: Our world is unfortunately facing a huge number of stroke. Attention, response control and activities of daily living (ADL) are important cognitive functions affected by stroke. In line with this explanation, we aimed to investigate the effect of RehaCom rehabilitation software on ADL, attention and response control in chronic stroke patients with damage to middle and anterior cerebral arteries.

Method: For selecting participants, among chronic stroke patients who referred to our special rehabilitation clinic for patients with stroke, fifty patients selected. Participants were assigned to control (n?=?25) and experimental (n?=?25) groups. The experimental group was compared with the control group before and after using RehaCom (ten 45-min sessions in five weeks).

Results: There is a significant enhancement in ADL, attention and response control scores in the experimental group compared with the control group. In fact, treatment with RehaCom significantly improved the score of all studied variables in chronic stroke patients.

Conclusions: In conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients.

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http://dx.doi.org/10.1016/j.jocn.2019.08.114DOI Listing
January 2020
16 Reads
1.593 Impact Factor

Baclofen as an adjuvant therapy for autism: a randomized, double-blind, placebo-controlled trial.

Eur Child Adolesc Psychiatry 2019 Dec 12;28(12):1619-1628. Epub 2019 Apr 12.

Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran, 13337, Iran.

Increasing evidence suggests that the function of the GABAergic system is abnormally low in autism spectrum disorder (ASD). Baclofen, which functions as a selective agonist for GABA receptors, does appear promising for the treatment of ASD. We conducted a 10-week randomized-controlled study aimed at evaluating the potential of baclofen as an adjuvant therapy to enhance the effect of risperidone in children with ASD. Sixty-four children (3-12 years) with moderate-to-severe irritability symptoms of ASD were included. We used the Aberrant Behavior Checklist-Community Edition (ABC-C) for the outcome measures on each of the follow-up visits (weeks 0, 5, and 10). Analysis of the combined data revealed significant improvement for all the ABC subscales (irritability: F?=?51.644, df?=?1.66, p?

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http://dx.doi.org/10.1007/s00787-019-01333-5DOI Listing
December 2019
6 Reads
3.740 Impact Factor

The role of CA1 CB1 receptors on lithium-induced spatial memory impairment in rats.

EXCLI J 2018 20;17:916-934. Epub 2018 Sep 20.

Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Lithium, a glycogen synthase kinase-3? (GSK-3?) inhibitor, prevents cannabinoid withdrawal syndrome, but there is limited data exploring the interaction between lithium and cannabinoid system on memory processes. The present study aimed to test the interaction between dorsal hippocampal (CA1 region) cannabinoid system and lithium on spatial memory in rats. Spatial memory was assessed in Morris Water Maze (MWM) apparatus by a single training session of eight trials. The results showed that pre-training intra-CA1 microinjection of ACPA, the cannabinoid type 1 receptor (CB1r) agonist, at doses of 0.001, 0.01 or 1 µg/rat, or AM251, the cannabinoid type 1 receptor (CB1r) antagonist, at doses of 1, 10 or 100 ng/rat, increased escape latency and traveled distance to the platform, suggesting a spatial learning impairment, whereas intraperitoneal administration of lithium (0.5, 1 or 5 mg/kg) had no effect on spatial learning. Also, rats that received lithium plus a lower dose of ACPA (0.001 µg/rat) or AM251 (1 ng/rat) had successful performance in the MWM. In the probe test, the results showed that pre-training administration of lithium (5 mg/kg) and ACPA (0.01 or 1 µg/rat) but not AM251 (at all doses used) impaired spatial memory retrieval. Also, lower dose of ACPA (0.001 µg/rat) or AM251 (1 ng/rat) potentiated the effect of ineffective doses of lithium (0.5 and 1 mg/kg) on spatial memory retrieval, while restored the effect of effective dose of lithium (5 mg/kg). In conclusion, cannabinoids may have a dual effect on lithium-induced spatial memory impairment in rats.

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http://dx.doi.org/10.17179/excli2018-1511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295625PMC
September 2018
7 Reads
2.112 Impact Factor

Top co-authors

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