Sakari Knuutila

Sakari Knuutila

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Sakari Knuutila

Publications by authors named "Sakari Knuutila"

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Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms.

Dig Dis Sci 2018 11 11;63(11):2950-2958. Epub 2018 Jul 11.

Department of Pathology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10620-018-5190-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182444PMC
November 2018

Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.

Anticancer Res 2018 Oct;38(10):5627-5634

Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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http://dx.doi.org/10.21873/anticanres.12897DOI Listing
October 2018

Low Expression of miR-18a as a Characteristic of Pediatric Acute Lymphoblastic Leukemia.

J Pediatr Hematol Oncol 2017 11;39(8):585-588

*Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki †Hematology Research Unit, University of Helsinki, Helsinki, Finland ‡Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

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http://Insights.ovid.com/crossref?an=00043426-201711000-0000
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http://dx.doi.org/10.1097/MPH.0000000000000921DOI Listing
November 2017

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma.

BMC Cancer 2017 03 31;17(1):236. Epub 2017 Mar 31.

Department of Pathology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12885-017-3233-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374569PMC
March 2017

Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome Tumor Heterogeneity in Clear-cell Renal Cell Carcinoma.

Appl Immunohistochem Mol Morphol 2017 01;25(1):39-43

*Department of Medical Oncology §Urologic Clinic ¶Department of Pathology and Diagnostic, University and Hospital Trust, Verona †Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, Pavia, Italy ‡Department of Pathology, Laboratory of Molecular Cytogenetic, University of Helsinki, Helsinki, Finland ∥Department of Pathology and Laboratory Medicine, Indiana University, Bloomington, IN.

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http://dx.doi.org/10.1097/PAI.0000000000000257DOI Listing
January 2017

Exhaled breath condensate as a source of biomarkers for lung carcinomas. A focus on genetic and epigenetic markers-A mini-review.

Genes Chromosomes Cancer 2016 12 13;55(12):905-914. Epub 2016 Aug 13.

Faculty of Medicine, Department of Pathology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.22399DOI Listing
December 2016

Hot spot mutations in Finnish non-small cell lung cancers.

Lung Cancer 2016 09 27;99:102-10. Epub 2016 Jun 27.

University of Helsinki, Faculty of Medicine, Department of Pathology, P.O. Box 21, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2016.06.024DOI Listing
September 2016

Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing.

J Mol Diagn 2016 07 4;18(4):471-9. Epub 2016 May 4.

Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.01.008DOI Listing
July 2016

Hotspot mutations in polyomavirus positive and negative Merkel cell carcinomas.

Cancer Genet 2016 Jan-Feb;209(1-2):30-5. Epub 2015 Dec 4.

Department of Pathology, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2015.11.006DOI Listing
June 2016

Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer.

Cancer Biomark 2015 ;15(2):189-95

Department of Pathology, Haartman Institute, Helsinki University, Helsinki, Finland.

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http://dx.doi.org/10.3233/CBM-140453DOI Listing
February 2016

Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement.

Mutat Res 2015 Nov 29;781:1-6. Epub 2015 Aug 29.

University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2015.08.006DOI Listing
November 2015

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma.

Iran J Cancer Prev 2015 May 22;8(3):e2329. Epub 2015 May 22.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IR Iran.

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http://dx.doi.org/10.17795/ijcp2329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581368PMC
May 2015

Biomarker analysis in human neoplasias: superior next-generation sequencing on frozen bone marrow cells and on formalin-fixed, paraffin-embedded tumor tissues.

Authors:
Sakari Knuutila

BMC Proc 2013 4;7 Suppl 2:K18. Epub 2013 Apr 4.

Department of Pathology and Genetics, Haartman Institute, Helsinki University and HUSLAB, Finland.

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http://dx.doi.org/10.1186/1753-6561-7-S2-K18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624673PMC
April 2015

Driver gene mutations of non-small-cell lung cancer are rare in primary carcinoids of the lung: NGS study by ion Torrent.

Lung 2015 Apr 14;193(2):303-8. Epub 2015 Feb 14.

Unit of Biological Anthropology, Department of Animal Biology, Plant Biology and Ecology, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1007/s00408-015-9690-1DOI Listing
April 2015

Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of SUCLA2 point mutation and 13q14 deletion.

Eur J Hum Genet 2015 Mar 2;23(3):325-30. Epub 2014 Jul 2.

1] Research Programs Unit, Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, Helsinki, Finland [2] Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland [3] Neuroscience center, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/ejhg.2014.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326715PMC
March 2015

miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma.

Virchows Arch 2015 Mar 10;466(3):289-95. Epub 2014 Dec 10.

Department of Pathology, University of Helsinki and HUSLAB, P.O. Box 21, 00014, Helsinki, Finland,

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http://link.springer.com/content/pdf/10.1007/s00428-014-1700
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http://link.springer.com/10.1007/s00428-014-1700-9
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http://dx.doi.org/10.1007/s00428-014-1700-9DOI Listing
March 2015

RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup.

APMIS 2014 Dec 16;122(12):1157-66. Epub 2014 Apr 16.

Department of Pathology, Helsinki University and HUSLAB, Helsinki, Finland; Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/apm.12274
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http://dx.doi.org/10.1111/apm.12274DOI Listing
December 2014

Erratum to: High-resolution SNP array analysis of patients with developmental disorder and normal array CGH result.

BMC Med Genet 2014 Nov 18;15:124. Epub 2014 Nov 18.

Department of Pathology, Haartman Institute, University of Helsinki, and Laboratory of Helsinki and Uusimaa University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12881-014-0124-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429685PMC
November 2014

ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients.

Genes Chromosomes Cancer 2014 Nov 19;53(11):895-901. Epub 2014 Jun 19.

Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.22198DOI Listing
November 2014

Burkitt lymphoma and Ewing sarcoma in a child with Williams syndrome.

Pediatr Blood Cancer 2014 Oct 19;61(10):1877-9. Epub 2014 Apr 19.

Tampere Center for Child Health Research, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1002/pbc.25055DOI Listing
October 2014

Differentiating soft tissue leiomyosarcoma and undifferentiated pleomorphic sarcoma: A miRNA analysis.

Genes Chromosomes Cancer 2014 Aug 26;53(8):693-702. Epub 2014 Apr 26.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.22179DOI Listing
August 2014

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.

Genes Chromosomes Cancer 2014 Jul 24;53(7):579-88. Epub 2014 Mar 24.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1002/gcc.22168
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http://dx.doi.org/10.1002/gcc.22168DOI Listing
July 2014

Hsa-miR-31-3p expression is linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy.

Clin Cancer Res 2014 Jun 25;20(12):3338-47. Epub 2014 Apr 25.

Authors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, service d'Hépato-Gastro-Entérologie et d'Oncologie Digestive; Université Paris-Est Créteil; Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil; Department of Medicine, Institut Gustave Roussy, Villejuif; and Department of Biology, Assistance Publique-Hôpitaux de Paris, European Georges Pompidou, Paris; Université de Reims Champagne-Ardenne; Centre Hospitalier Universitaire de Reims, Reims; Service d'Anatomo-Pathologie, Centre Val d'Aurelle Paul-Lamarque, Montpellier; Université Clermont-Ferrand, Centre Jean Perrin, Clermont-Ferrand, France; Department of Gastroenterology, GI Cancer Unit; Department of Pathological Anatomy, Erasme University Hospital, Brussels; Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Haartman Institute, University of Helsinki; Department of Oncology, Helsinki University Central Hospital and Helsinki University; HUSLAB, Department of Pathology and Genetic Laboratory, Helsinki; and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandAuthors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpit

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2750DOI Listing
June 2014

Epidermal growth factor receptor mutations in 510 Finnish non--small-cell lung cancer patients.

J Thorac Oncol 2014 Jun;9(6):886-91

*Department of Pathology, Haartman Institute, University of Helsinki; †Department of Pathology, HUSLAB, Helsinki University Central Hospital, Helsinki, Finland; ‡Clinical Laboratory, Lab21 Ltd, Cambridge, United Kingdom; and §Division of Pulmonary Medicine, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1097/JTO.0000000000000132DOI Listing
June 2014

ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.

J Thorac Oncol 2014 May;9(5):729-32

Departments of *Pathology and Diagnostics, †Surgery and Oncology, Medical Oncology Unit, University and Hospital Trust of Verona, Verona, Italy; ‡Cytomolecular Lab, Hartmann Institute, University of Helsinki, Finland; §Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino, Italy; and ‖ARC-NET Research Centre, University and Hospital Trust of Verona, Verona, Italy.

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http://dx.doi.org/10.1097/JTO.0000000000000109DOI Listing
May 2014

MicroRNA expression profiles in Kaposi's sarcoma.

Pathol Oncol Res 2014 Jan 13;20(1):153-9. Epub 2013 Sep 13.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095, Bucharest, Romania.

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http://dx.doi.org/10.1007/s12253-013-9678-1DOI Listing
January 2014

[MicroRNAs and cancer].

Duodecim 2013 ;129(16):1661-9

Helsingin yliopisto, Haartman-Instituutti, patologian osasto.

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December 2013

Targeted resequencing of 9p in acute lymphoblastic leukemia yields concordant results with array CGH and reveals novel genomic alterations.

Genomics 2013 Sep 16;102(3):182-8. Epub 2013 Jan 16.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Finland.

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http://dx.doi.org/10.1016/j.ygeno.2013.01.001DOI Listing
September 2013

Report of interstitial 22q13.1q13.2 microduplication in two siblings with distinctive dysmorphic features, heart defect and mental retardation.

Eur J Med Genet 2013 Jul 22;56(7):389-96. Epub 2013 May 22.

Department of Clinical Genetics, Oulu University Hospital, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.ejmg.2013.05.004DOI Listing
July 2013

Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia.

Mol Cytogenet 2013 Jul 16;6(1):27. Epub 2013 Jul 16.

Department of Pathology, Haartman Institute, and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/1755-8166-6-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751646PMC
July 2013

MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone.

Histol Histopathol 2013 05 21;28(5):671-8. Epub 2012 Nov 21.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.14670/HH-28.671DOI Listing
May 2013

Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma.

Mod Pathol 2013 Feb 28;26(2):213-22. Epub 2012 Sep 28.

Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1038/modpathol.2012.154DOI Listing
February 2013

MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF.

Cancer Genet 2012 Nov 23;205(11):545-51. Epub 2012 Oct 23.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S221077621200229
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http://dx.doi.org/10.1016/j.cancergen.2012.08.003DOI Listing
November 2012

Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study.

Cancer Genet 2012 Nov 10;205(11):588-93. Epub 2012 Nov 10.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S22107762120023
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http://dx.doi.org/10.1016/j.cancergen.2012.09.007DOI Listing
November 2012

Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.

World J Gastroenterol 2012 Aug;18(29):3896-903

Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

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http://www.wjgnet.com/1007-9327/full/v18/i29/3896.htm
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http://dx.doi.org/10.3748/wjg.v18.i29.3896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413063PMC
August 2012

Morphology antibody chromosome technique for determining phenotype and genetic status of the same cell.

Curr Protoc Hum Genet 2012 Jul;Chapter 4:Unit4.7

University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/0471142905.hg0407s74DOI Listing
July 2012

BRAF V600E mutation does not predict recurrence after long-term follow-up in TNM stage I or II papillary thyroid carcinoma patients.

APMIS 2012 May 25;120(5):380-6. Epub 2011 Nov 25.

Division of Endocrinology, Department of Medicine, Helsinki University Central Hospital, Finland.

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http://dx.doi.org/10.1111/j.1600-0463.2011.02844.xDOI Listing
May 2012

An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma.

J Exp Clin Cancer Res 2012 Mar 20;31:24. Epub 2012 Mar 20.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/1756-9966-31-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338077PMC
March 2012

MicroRNA profiling differentiates colorectal cancer according to KRAS status.

Genes Chromosomes Cancer 2012 Jan 15;51(1):1-9. Epub 2011 Sep 15.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.20925DOI Listing
January 2012

Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma.

Bioinformatics 2012 Jan 20;28(2):246-53. Epub 2011 Nov 20.

Helsinki Institute for Information Technology HIIT, Department of Information and Computer Science, Aalto University, Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btr634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259436PMC
January 2012

High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients.

ISRN Oncol 2011 2;2011:168712. Epub 2011 Oct 2.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, 00014, Helsinki, Finland.

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http://dx.doi.org/10.5402/2011/168712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196920PMC
November 2011

Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer.

Genes Chromosomes Cancer 2011 Aug 11;50(8):585-97. Epub 2011 May 11.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1002/gcc.20880
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http://dx.doi.org/10.1002/gcc.20880DOI Listing
August 2011

miRNA expression profiles in myelodysplastic syndromes reveal Epstein-Barr virus miR-BART13 dysregulation.

Leuk Lymphoma 2011 Aug 8;52(8):1567-73. Epub 2011 Jun 8.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2011.56
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http://dx.doi.org/10.3109/10428194.2011.568652DOI Listing
August 2011

Familial 6p22.2 duplication associates with mild developmental delay and increased SSADH activity.

Am J Med Genet B Neuropsychiatr Genet 2011 Jun 22;156B(4):448-53. Epub 2011 Mar 22.

Department of Pathology, Haartman Institute, University of Helsinki, Finland.

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http://doi.wiley.com/10.1002/ajmg.b.31180
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http://dx.doi.org/10.1002/ajmg.b.31180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082589PMC
June 2011

9q22 Deletion--first familial case.

Orphanet J Rare Dis 2011 Jun 22;6:45. Epub 2011 Jun 22.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 3, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1186/1750-1172-6-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135502PMC
June 2011

Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone.

Genes Chromosomes Cancer 2011 May 19;50(5):291-306. Epub 2011 Jan 19.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1002/gcc.20851
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http://dx.doi.org/10.1002/gcc.20851DOI Listing
May 2011

A microduplication on chromosome 17p13.1p13.3 including the PAFAH1B1 (LIS1) gene.

Am J Med Genet A 2011 Apr 15;155A(4):875-9. Epub 2011 Mar 15.

Vaestoliitto, The Family Federation of Finland, Department of Medical Genetics, Helsinki, Finland.

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http://dx.doi.org/10.1002/ajmg.a.33944DOI Listing
April 2011

MicroRNA microarrays on archive bone marrow core biopsies of leukemias--method validation.

Leuk Res 2011 Feb 9;35(2):188-95. Epub 2010 Sep 9.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.leukres.2010.08.005DOI Listing
February 2011

Unique microRNA profile in Dupuytren's contracture supports deregulation of β-catenin pathway.

Mod Pathol 2010 Nov 30;23(11):1544-52. Epub 2010 Jul 30.

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1038/modpathol.2010.146DOI Listing
November 2010

Array CGH in molecular diagnosis of mental retardation - A study of 150 Finnish patients.

Am J Med Genet A 2010 Jun;152A(6):1398-410

Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ajmg.a.33402DOI Listing
June 2010

CGHpower: exploring sample size calculations for chromosomal copy number experiments.

BMC Bioinformatics 2010 Jun 17;11:331. Epub 2010 Jun 17.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-11-331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911457PMC
June 2010

Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR.

Genomics 2010 Apr 11;95(4):203-9. Epub 2010 Feb 11.

Department of Animal Biology, Plant Biology and Ecology, Faculty of Biosciences, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ygeno.2010.02.003DOI Listing
April 2010

High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes.

Cancer Genet Cytogenet 2010 Mar;197(2):166-73

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 3, FI-00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.11.012DOI Listing
March 2010

Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study.

Genes Chromosomes Cancer 2010 Feb;49(2):132-43

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/gcc.20727DOI Listing
February 2010

Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia.

Leuk Lymphoma 2010 Jan;51(1):114-24

Unit of Biological Anthropology, Department of Animal Biology, Plant Biology and Ecology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.3109/10428190903350397DOI Listing
January 2010

CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis.

Genes Chromosomes Cancer 2009 Jul;48(7):615-23

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1002/gcc.20669
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http://dx.doi.org/10.1002/gcc.20669DOI Listing
July 2009

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.

J Clin Oncol 2009 May 23;27(13):2209-16. Epub 2009 Mar 23.

Laboratory of Oncologic Research, Orthopaedic Institute Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.

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http://dx.doi.org/10.1200/JCO.2008.19.2542DOI Listing
May 2009

Uniparental disomy in cancer.

Trends Mol Med 2009 Mar 25;15(3):120-8. Epub 2009 Feb 25.

Department of Cancer Genetics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.molmed.2009.01.005DOI Listing
March 2009

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV).

Leuk Res 2009 Jan 28;33(1):54-9. Epub 2008 Aug 28.

Department of Clinical Chemistry, Laboratory of Haematology, Helsinki University Central Hospital, Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S014521260800337
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http://dx.doi.org/10.1016/j.leukres.2008.07.008DOI Listing
January 2009

Molecular alterations at 9q33.1 and polyploidy in asbestos-related lung cancer.

Clin Cancer Res 2009 Jan;15(2):468-75

Health and Work Ability, Good Practices and Competence, and Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1852DOI Listing
January 2009

Does comparative genomic hybridization reveal distinct differences in DNA copy number sequence patterns between leiomyosarcoma and malignant fibrous histiocytoma?

Cancer Genet Cytogenet 2008 Nov;187(1):1-11

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, P.O. Box 21 (Haartmaninkatu 3), FI-00014 University of Helsinki, Helsinki, Finland

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http://dx.doi.org/10.1016/j.cancergencyto.2008.06.005DOI Listing
November 2008

Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients.

BMC Med Genomics 2008 Nov 11;1:55. Epub 2008 Nov 11.

Biological Mechanisms and Prevention of Work-related Diseases, Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1186/1755-8794-1-55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612681PMC
November 2008

Further evidence for a relationship between the 5p15 chromosome region and the oculoauriculovertebral anomaly.

Am J Med Genet A 2008 Oct;146A(19):2490-4

Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/ajmg.a.32479DOI Listing
October 2008

Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes.

Int J Cancer 2008 Aug;123(4):817-25

Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.23574DOI Listing
August 2008

Acute lymphoblastic leukemia in adolescents and young adults in Finland.

Haematologica 2008 Aug 12;93(8):1161-8. Epub 2008 Jun 12.

Hospital for Children and Adolescents, University of Helsinki, P.O. Box 281, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.3324/haematol.12466DOI Listing
August 2008

Epigenetic signatures of familial cancer are characteristic of tumor type and family category.

Cancer Res 2008 Jun;68(12):4597-605

Department of Medical Genetics, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6645DOI Listing
June 2008