Sakari Kauppinen

Sakari Kauppinen

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Sakari Kauppinen

Publications by authors named "Sakari Kauppinen"

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73Publications

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Intragenic antagonistic roles of protein and circRNA in tumorigenesis.

Cell Res 2019 Aug 17;29(8):628-640. Epub 2019 Jun 17.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41422-019-0192-1DOI Listing
August 2019

Identification of antisense long noncoding RNAs that function as SINEUPs in human cells.

Sci Rep 2016 09 20;6:33605. Epub 2016 Sep 20.

Division of Genomic Technologies, RIKEN Center for Life Science Technologies, RIKEN Yokohama Campus, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan.

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http://dx.doi.org/10.1038/srep33605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028707PMC
September 2016

Long Noncoding RNA Expression during Human B-Cell Development.

PLoS One 2015 22;10(9):e0138236. Epub 2015 Sep 22.

Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark; Department of Haematology, Aalborg University Hospital, Aalborg, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578992PMC
May 2016

Transcriptome dynamics of the microRNA inhibition response.

Nucleic Acids Res 2016 05 9;44(9):4486. Epub 2016 Feb 9.

The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, Denmark Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis street, #07-01, Singapore 138671

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http://dx.doi.org/10.1093/nar/gkw091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872088PMC
May 2016

Transcriptome dynamics of the microRNA inhibition response.

Nucleic Acids Res 2015 07 18;43(13):6207-21. Epub 2015 Jun 18.

The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, Denmark Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis street, #07-01, Singapore 138671

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http://dx.doi.org/10.1093/nar/gkv603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513874PMC
July 2015

Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance.

Epilepsia 2014 Dec 19;55(12):2017-27. Epub 2014 Nov 19.

Department of Cellular and Molecular Medicine, Wilhelm Johannsen Center for Functional Genome Research, University of Copenhagen, Copenhagen, Denmark; Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/epi.12839DOI Listing
December 2014

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

PLoS One 2014 27;9(2):e90337. Epub 2014 Feb 27.

Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia ; Departments of Medicine Monash University, Clayton, Victoria, Australia ; Departments of Physiology, Monash University, Clayton, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937392PMC
October 2014

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics.

Drug Discov Today Technol 2005 ;2(3):287-90

Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark. Electronic

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http://dx.doi.org/10.1016/j.ddtec.2005.08.012DOI Listing
July 2014

Development of microRNA therapeutics is coming of age.

EMBO Mol Med 2014 Jul;6(7):851-64

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark Department of Haematology, Aalborg University Hospital, Aalborg, Denmark

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http://embomolmed.embopress.org/cgi/doi/10.15252/emmm.201100
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http://dx.doi.org/10.15252/emmm.201100899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119351PMC
July 2014

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

Sci Rep 2013 ;3:2535

1] Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Denmark [2].

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http://dx.doi.org/10.1038/srep02535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756333PMC
June 2014

Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Cancer Res 2013 Dec 21;73(23):7068-78. Epub 2013 Oct 21.

Authors' Affiliations: Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee; Santaris Pharma, Hørsholm; and Department of Haematology, Aalborg University Hospital, Copenhagen, Denmark.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-0927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857104PMC
December 2013

The therapeutic potential of microRNAs in cancer.

Cancer J 2012 May-Jun;18(3):275-84

Sino-Danish Breast Cancer Research Centre and Institute of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

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http://dx.doi.org/10.1097/PPO.0b013e318258b5d6DOI Listing
November 2012

Discovering the first microRNA-targeted drug.

J Cell Biol 2012 Oct;199(3):407-12

Department of Biology, The Bioinformatics Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1083/jcb.201208082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483128PMC
October 2012

mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

RNA Biol 2011 Jul-Aug;8(4):607-15. Epub 2011 Jul 1.

School of Biological Sciences, University of East Anglia, Norwich, UK.

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http://dx.doi.org/10.4161/rna.8.4.15390DOI Listing
April 2012

Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation.

Eur J Endocrinol 2012 Mar 14;166(3):359-71. Epub 2011 Nov 14.

Molecular Endocrinology Laboratory, KMEB, Department of Endocrinology and Metabolism, Medical Biotechnology Center, Odense University Hospital, University of Southern Denmark, SDU, DK-5000 Odense C, Denmark.

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http://dx.doi.org/10.1530/EJE-11-0646DOI Listing
March 2012

Inhibition of microRNA function by antimiR oligonucleotides.

Silence 2012 Jan 9;3(1). Epub 2012 Jan 9.

Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark.

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http://dx.doi.org/10.1186/1758-907X-3-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306207PMC
January 2012

Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice.

EMBO Mol Med 2011 Oct 1;3(10):605-15. Epub 2011 Sep 1.

Division of Rheumatology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://dx.doi.org/10.1002/emmm.201100171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258486PMC
October 2011

Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry.

J Mol Histol 2011 Aug 5;42(4):289-99. Epub 2011 Jun 5.

Department of Clinical Biochemistry and Pharmacology, Laboratory for Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1007/s10735-011-9332-8DOI Listing
August 2011

Recombinant Adeno-Associated Virus-Mediated microRNA Delivery into the Postnatal Mouse Brain Reveals a Role for miR-134 in Dendritogenesis in Vivo.

Front Neural Circuits 2010 12;3:16. Epub 2010 Jan 12.

Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Institut für Neuroanatomie, Universitätsklinikum Heidelberg Heidelberg, Germany.

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http://dx.doi.org/10.3389/neuro.04.016.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809579PMC
July 2011

Involvement of microRNAs in lung cancer biology and therapy.

Transl Res 2011 Apr 4;157(4):200-8. Epub 2011 Feb 4.

Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.trsl.2011.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072599PMC
April 2011

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo.

Proc Natl Acad Sci U S A 2011 Apr 28;108(15):6139-44. Epub 2011 Mar 28.

Molecular Endocrinology Laboratory, KMEB, Odense University Hospital, University of South Denmark, DK-5000 Odense C, Denmark.

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http://dx.doi.org/10.1073/pnas.1016758108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076836PMC
April 2011

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice.

J Clin Invest 2010 Nov 18;120(11):3912-6. Epub 2010 Oct 18.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1172/JCI43604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964990PMC
November 2010

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

Science 2010 Jan 3;327(5962):198-201. Epub 2009 Dec 3.

Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1178178
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http://dx.doi.org/10.1126/science.1178178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436126PMC
January 2010

miRMaid: a unified programming interface for microRNA data resources.

BMC Bioinformatics 2010 Jan 14;11:29. Epub 2010 Jan 14.

The Bioinformatics Centre, Department of biology, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1186/1471-2105-11-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831003PMC
January 2010

microRNAs in CNS disorders.

Neuromolecular Med 2009 18;11(3):162-72. Epub 2009 Jun 18.

Department of Molecular and Integrative Neurosciences, Scripps Research Institute, Jupiter, FL 33458, USA.

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http://dx.doi.org/10.1007/s12017-009-8066-1DOI Listing
December 2009

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.

Proc Natl Acad Sci U S A 2009 Mar 5;106(9):3507-12. Epub 2009 Feb 5.

Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

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http://dx.doi.org/10.1073/pnas.0805854106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651305PMC
March 2009

MicroRNA silencing in primates: towards development of novel therapeutics.

Cancer Res 2009 Jan;69(2):393-5

Santaris Pharma, Kogle Allé 6, Hørsholm, Denmark and Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-2749DOI Listing
January 2009

Targeting of microRNAs for therapeutics.

Biochem Soc Trans 2008 Dec;36(Pt 6):1197-200

Santaris Pharma, Hørsholm, Denmark.

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http://dx.doi.org/10.1042/BST0361197DOI Listing
December 2008

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase.

Acta Crystallogr D Biol Crystallogr 2008 Aug 17;D64(Pt 8):851-63. Epub 2008 Jul 17.

Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.

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http://scripts.iucr.org/cgi-bin/paper?S0907444908017083
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http://dx.doi.org/10.1107/S0907444908017083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483496PMC
August 2008

Diagnostic and prognostic microRNAs in stage II colon cancer.

Cancer Res 2008 Aug;68(15):6416-24

Department of Clinical Biochemistry, Molecular Diagnostic Laboratory, Aarhus University Hospital, Aarhus N, Denmark.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6110DOI Listing
August 2008

Detection of siRNAs and miRNAs.

Methods Mol Biol 2008 ;451:217-27

Wilhelm Johannsen Center for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/978-1-59745-102-4_15DOI Listing
June 2008

The utility of LNA in microRNA-based cancer diagnostics and therapeutics.

Semin Cancer Biol 2008 Apr 15;18(2):89-102. Epub 2008 Jan 15.

Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.semcancer.2008.01.004DOI Listing
April 2008

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Proc Natl Acad Sci U S A 2008 Apr 23;105(17):6415-20. Epub 2008 Apr 23.

Center for Human Genetics, Katholieke Universiteit Leuven and Department of Molecular and Developmental Genetics, VIB, Herestraat 49 bus 602, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1073/pnas.0710263105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359789PMC
April 2008

MicroRNA expression in the adult mouse central nervous system.

RNA 2008 Mar 29;14(3):432-44. Epub 2008 Jan 29.

Wilhelm Johannsen Center for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1261/rna.783108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248253PMC
March 2008

Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification.

Nat Protoc 2007 ;2(10):2520-8

Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1038/nprot.2007.313DOI Listing
January 2008

MicroRNAs as targets for antisense-based therapeutics.

Expert Opin Biol Ther 2008 Jan;8(1):59-81

University of Copenhagen, Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1517/14712598.8.1.59 DOI Listing
January 2008

Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.

Cancer Res 2007 Dec;67(24):11612-20

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5019DOI Listing
December 2007

Spatio-temporal accumulation of microRNAs is highly coordinated in developing plant tissues.

Plant J 2006 Jul;47(1):140-51

Agricultural Biotechnology Center, Plant Biology Institute, Szent-Györgyi Albert út 4, Gödöllo, H-2001, Hungary.

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http://doi.wiley.com/10.1111/j.1365-313X.2006.02766.x
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http://dx.doi.org/10.1111/j.1365-313X.2006.02766.xDOI Listing
July 2006

LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

Gene 2006 May 24;372:137-41. Epub 2006 Feb 24.

Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.gene.2005.12.031DOI Listing
May 2006

RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain.

RNA 2006 Feb 22;12(2):187-91. Epub 2005 Dec 22.

Division of Neuropathology and Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, 605A Stellar-Chance Bldg., 421 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1261/rna.2258506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370897PMC
February 2006

In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes.

Nat Methods 2006 Jan;3(1):27-9

Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nmeth843DOI Listing
January 2006

Expression profiling by oligonucleotide microarrays spotted on coated polymer slides.

J Biotechnol 2005 Mar 8;116(2):125-34. Epub 2004 Dec 8.

Department of Functional Genomics, Exiqon, Bygstubben 9, DK-2950 Vedbaek, Denmark.

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http://dx.doi.org/10.1016/j.jbiotec.2004.10.009DOI Listing
March 2005

Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes.

Nucleic Acids Res 2004 Dec 14;32(22):e175. Epub 2004 Dec 14.

Agricultural Biotechnology Center, Szent-Györgyi Albert ut 4, Gödöll H-2100, Hungary.

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http://dx.doi.org/10.1093/nar/gnh171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545470PMC
December 2004

LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E.

Nucleic Acids Res 2002 Oct;30(19):e100

Department of LNA Microarrays, Exiqon, Bygstubben 9, DK-2950 Vedbaek, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140560PMC
http://dx.doi.org/10.1093/nar/gnf099DOI Listing
October 2002

A stepwise optimization of crystals of rhamnogalacturonan lyase from Aspergillus aculeatus.

Acta Crystallogr D Biol Crystallogr 2002 Aug 20;58(Pt 8):1346-9. Epub 2002 Jul 20.

Centre for Crystallographic Studies, University of Copenhagen, Universitetsparken 5, DK 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1107/s0907444902009137DOI Listing
August 2002