Publications by authors named "Sainan Liu"

26 Publications

  • Page 1 of 1

Facile synthesis of Fe-baicalein nanoparticles for photothermal/chemodynamic therapy with accelerated Fe/Fe conversion.

J Mater Chem B 2021 Apr 12;9(15):3295-3299. Epub 2021 Apr 12.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Fe-baicalein-polyethylene glycol (Fe-BaP) nanoparticles were synthesized by a room temperature wet chemical method via coordination between Fe and baicalein. Fe-BaP possessed high photothermal conversion efficiency (η = 45.6%) and excellent antitumor efficacy was achieved with the synergistic photothermal/chemodynamic tumor therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1tb00200gDOI Listing
April 2021

Covalent Organic Framework-Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy.

Bioconjug Chem 2021 04 12;32(4):661-666. Epub 2021 Mar 12.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable of generating large amounts of reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO NPs) were successfully synthesized by using COF as a template. Under ultrasound (US) irradiation, large quantities of ROS can be generated, and compared with pure TiO NPs, the SDT performance of COF-TiO nanoparticles was significantly improved due to the narrower band gap. Both in vitro and in vivo experiments demonstrated the great tumor inhibitory effect via COF-TiO-mediated SDT. This work broadens the biomedical applications of COF-based composites.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.1c00039DOI Listing
April 2021

Biofunctionalized fibrin gel co-embedded with BMSCs and VEGF for accelerating skin injury repair.

Mater Sci Eng C Mater Biol Appl 2021 Feb 27;121:111749. Epub 2020 Nov 27.

Key Laboratory of Advanced Technology of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address:

Rapid and effective repair of epithelial tissue is desirable for improving the success rate of operation and reducing postoperative complications. Hydrogel is a widely studied wound repair material, especially as a wound dressing for damaged epithelial tissue. Based on the catalytic effect of thrombin on fibrinogen, in this study, a three-dimensional fibrin gel which of adequate epithelial cell compatibility was constructed by using thrombin and fibrinogen under the cross-linking action of calcium ion. Immunofluorescence staining and hematoxylin-eosin (H&E) staining showed that bone marrow mesenchymal stem cell (BMSC) was embedded in fibrin gel. Furthermore, vascular endothelial growth factor (VEGF) was used to induce BMSC to differentiate into CD31+ and vWF+ endothelial cell (EC) in fibrin gel. The results showed that the fibrin gel surface may effectively promote the adhesion and proliferation of EC and smooth muscle cell (SMC). After 15 days of culture, it was found that the BMSC embedded in the hydrogel had differentiated into EC. The results of in vivo skin wound experiment in rats further proved that the fibrin gel containing BMSC could promote wound healing and repair, and showed the potential to promote neovascularization at the injured site. The construction method of hydrogel materials proposed in this study has potential application value in the field of regenerative medicine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2020.111749DOI Listing
February 2021

Urchin-Shaped Metal Organic/Hydrogen-Bonded Framework Nanocomposite as a Multifunctional Nanoreactor for Catalysis-Enhanced Synergetic Therapy.

ACS Appl Mater Interfaces 2021 Feb 26;13(4):4825-4834. Epub 2021 Jan 26.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Ultrasound (US)-induced sonodynamic therapy (SDT) is an efficient and precise method against tumor, and the integration of multiple cancer therapies has been proved as a promising strategy for better therapeutic effects. Herein, for the first time, a multifunctional nanoreactor has been fabricated by integrating Fe-MIL-88B-NH, PFC-1, and glucose oxidase (GO) to form urchin-like Fe-MIL-88B-NH@PFC-1-GO (MPG) nanoparticles as Fenton's reagent, a sonosensitizer, and a tumor microenvironment (TME) modulator. In detail, MPG can generate OH for chemodynamic therapy (CDT) and deplete glutathione (GSH) to alleviate the antioxidant ability of cancer cells. Moreover, catalase (CAT)-like MPG can react with HO to generate O for relieving hypoxia in TME, enhancing GO-catalyzed glucose oxidation to produce HO and gluconic acid. Then, the regenerated HO can promote the Fenton reaction to achieve GO catalysis-enhanced CDT. Owing to its large π-electron conjugated system, MPG also serves as an ideal sonosensitizer, realizing a burst generation of O under US irradiation for efficient SDT. Therefore, the tumor treatment will be notably enhanced by MPG-based synergetic CDT/SDT/starvation therapy via a series of cascade reactions. Overall, this work develops a versatile nanoreactor with improved tumor treatment effectiveness and broadens the application prospects of porous materials in the field of biomedical research.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c19584DOI Listing
February 2021

Effect of Biochar on the Production of L-Histidine From Glucose Through Metabolism.

Front Bioeng Biotechnol 2020 7;8:605096. Epub 2021 Jan 7.

Guizhou Tobacco Company in Bijie Company, Bijie, China.

The organic compounds from biochar play a role of hormone analogs, stimulating the expression of metabolites by controlling related gene and protein. In this experiment, we reported the L-histidine biosysthesis was promoted by biochar treatment in unlike genetic engineering of the traditional method. The related results indicated the most optimal concentration was found to be 3%, and 7% is the lethal dose. was inhibited in the high-concentration treatment. On the other hand, docking technology was usually used as drug screening, basing on Lock-and-key model of protein in order to better understand mechanisms. So the organic compounds of biochar from GC-MS analysis that acted as ligands were connected to HisG protein controlling L-histidine biosysthesis in . The result showed that the three organic molecules interacted with HisG protein by hydrogen bond. So we considered that these three compounds play regulatory roles in L-histidine biosysthesis, and the G expression fully supports this conclusion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fbioe.2020.605096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818517PMC
January 2021

A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy.

Small 2021 Feb 20;17(6):e2005728. Epub 2021 Jan 20.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

In order to achieve better antitumor therapeutic efficacy and inhibit tumor metastasis, a multifunctional nanovaccine based on L-arginine (LA)-loaded black mesoporous titania (BMT) is fabricated. In this system, LA is utilized as the exogenous NO supplementation for gas therapy, and BMT is served as acoustic sensitizer for sonodynamic therapy. The ultrasound (US) as the exogenous stimulus can simultaneously trigger BMT and LA to produce singlet oxygen ( O ) and NO gas at tumor sites, respectively. Interestingly, O from US-excited BMT can promote the oxidation of LA to produce more NO. The high concentration of O and NO in cancer cell can cause intracellular strong oxidative stress level and DNA double-strand breaks to induce cancer cell apoptosis ultimately. The US-triggered BMT@LA "nanovaccine" combining with immune checkpoint inhibitor PD-L1 antibody (αPD-L1) can induce strong antitumor immune response thus effectively killing primary tumors and further inhibiting metastatic tumors. Hence, BMT@LA-based "nanovaccine" combining with αPD-L1 checkpoint blockade treatment can realize synergetic sonodynamic/gas/immunotherapy with enhanced antitumor therapeutic effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.202005728DOI Listing
February 2021

Effect of corn straw biochar on corn straw composting by affecting effective bacterial community.

Prep Biochem Biotechnol 2020 Dec 25:1-11. Epub 2020 Dec 25.

Agricultural College, Shenyang Agricultural University, Shenyang, China.

This study investigated the effect of corn straw biochar on the decomposition, nutrient transformation, and bacterial community characteristics in the corn straw decomposition process. A 90-day microcosm incubation experiment was performed to assess the effects of corn straw biochar (500 °C, 1 h) on the corn straw decomposition process and the resulting product. Four biochar amendment rates (0%, 5, 10, and 15%, as mass fractions of biochar) and three different addition times (1st day, 30th day, and 60th day) were set in total. The results showed that corn straw biochar significantly increased the pH of the corn straw decomposition process by 0.71-0.73 and increased the electrical conductivity value by 0.64-1.07 μS/cm over that of the controls. In addition, biochar was shown to increase the temperature rise rate and temperature peak of the straw maturation system, and advance the process of straw maturation by 10 days. Thus, treatment with corn straw biochar could accelerate the corn straw decomposition process and change the conditions for microorganisms involved in the process. Furthermore, biochar additions significantly decreased the organic matter content by 9.67% under B3 and T treatment, and enhanced the N, PO, and KO contents of the straw decomposition product by 0.36, 0.19, and 0.88% under B3 and T treatment. Biochar additions could increase the abundance of several effective bacteria closely related to the N, PO, and KO contents of the straw maturation product. The growth of these bacteria was likely to be affected by the increase in pH with biochar addition, which enabled the improvement of the nutrient mineralization process.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/10826068.2020.1858428DOI Listing
December 2020

Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies.

ACS Appl Mater Interfaces 2020 Sep 16;12(39):43456-43465. Epub 2020 Sep 16.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Cancer deaths are mainly caused by tumor metastases. However, tumor ablation therapies can only target the primary tumor but not inhibit tumor metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, the synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser irradiation. After being metallized with FeCl, -phenylenediamine is polymerized on the surface of COF with Fe as the oxidant. The obtained poly(-phenylenediamine) can be used for photothermal therapy. Meanwhile, the overexpressed HO in the tumor would be further catalyzed and decomposed into hydroxyl radicals (OH) by the Fe/Fe redox couple via Fenton reaction. Intriguingly, the increase of temperature caused by photothermal therapy can accelerate the production of OH. Moreover, the tumor-associated antigen induced a robust antitumor immune response and effectively inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a COF-based multifunctional nanoplatform provides an efficacious treatment strategy for both the primary tumor and tumor metastasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c12824DOI Listing
September 2020

A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy.

J Mater Chem B 2020 07;8(25):5451-5459

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. and University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence. Herein, in order to prevent intermolecular accumulation and improve photostability, indocyanine green (ICG) is spontaneously adsorbed onto a covalent organic framework (COF) with high affinity through π-π conjugation, and then chicken ovalbumin (OVA) is coated on the surface of COF@ICG via an electrostatic interaction force. The resultant COF@ICG@OVA can ablate primary tumors under 650 nm and 808 nm laser irradiation due to its high photothermal conversion efficiency (η = 35.75%) and ability to produce reactive oxygen species (ROS). Tumor-associated antigens are also produced after combinational PTT/PDT therapy. By further combining with anti-PD-L1 checkpoint blockade therapy, it can effectively eliminate primary tumors and inhibit the metastasis of cancer cells by generating strong immune responses. Taken together, COF@ICG@OVA nanoparticles offer an efficient synergistic therapeutic modality for the treatment of tumor metastasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0tb00679cDOI Listing
July 2020

Copper-Doped Nanoscale Covalent Organic Polymer for Augmented Photo/Chemodynamic Synergistic Therapy and Immunotherapy.

Bioconjug Chem 2020 06 26;31(6):1661-1670. Epub 2020 May 26.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Due to the specific tumor microenvironment (TME) and immunosuppressive state of cancer cells, conventional antitumor therapies face severe challenges, such as high rates of recurrence and metastasis. Herein, Cu-PPT nanoparticles were synthesized based on copper acetate, -phenylenediamine, and 5,10,15,20-tetra-(4-aminophenyl)porphyrin via oxidative coupling reaction for the first time, and the resultant product was used for synergistic photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The polymer nanoparticles exhibited excellent photodynamic and photothermal effect with a photothermal conversion efficacy of 40.1% under 650 and 808 nm laser irradiation, respectively. Encapsulated Cu(I)/Cu(II) ions permitted Cu-PPT with glutathione (GSH) peroxidase-mimicking, catalase-mimicking, and Fenton-like activity to regulate TME. Depletion of overexpressed GSH would reduce antioxidant capacity, generated O could relieve hypoxia for enhancing PDT, and hyperthermia from PTT could promote the yield of ·OH. This multifunctional nanosystem with cascade reactions could inhibit tumor growth and activate immune responses effectively. By further combining with antiprogrammed death-ligand 1 (anti-PD-L1) checkpoint blockade therapy, distant tumor growth and cancer metastasis were successfully suppressed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.0c00209DOI Listing
June 2020

Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy.

J Mater Chem B 2020 05;8(17):3801-3813

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education, Key Laboratory for the Green Preparation and Application of Functional Materials of Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China. and The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.

Lack of sufficient tumor penetration of the current nanomedicines is a major reason limiting their clinical success in cancer therapy. In this work, we aimed at the development of a novel biodegradable nanoplatform for the selective and controlled delivery of anticancer agents, with improved tumor permeability and the ability to release ultrasmall nanovesicles in the tumor microenvironment. To this end, positively charged nanogels were obtained through the double-crosslinking of chitosan with an ionic physical gelator and a disulfide-containing chemical crosslinker. After conjugation to an anionic oligomer, the cationic nanogels were transformed into negatively charged nanocarriers (CTCP), enabling effective encapsulation of the cationic anticancer agent doxorubicin (DOX) to generate a biodegradable nanomedicine (DOX@CTCP). DOX@CTCP could maintain sustained DOX release and decreased DOX toxicity. Upon arrival at the tumor tissue, the reductive and lysozyme-high microenvironment drives the cleavage of the nanomedicine to release DOX-carrying nanoblocks of smaller size, which together with their acidic-protonable feature achieves an effective therapeutic delivery into cancer cells. The nanomedicine described here showed excellent biocompatibility/biosafety and enhanced in vivo antitumor efficacy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0tb00143kDOI Listing
May 2020

Flexible Self-Powered Real-Time Ultraviolet Photodetector by Coupling Triboelectric and Photoelectric Effects.

ACS Appl Mater Interfaces 2020 Apr 18;12(17):19384-19392. Epub 2020 Mar 18.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

The portable UV photodetector is used to timely remind humans of overexposure to UV radiation. However, the traditional UV photodetector cannot meet the practical demands, and the power supply problem hinders its further development. In this work, we demonstrated a flexible, transparent, and self-powered UV photodetector by coupling of triboelectric and photoelectric effects. The device integrates a flexible ZnO nanoparticle (NP) UV photodetector, a transparent- and flexible-film-based TENG (TFF-TENG), commercial chip resistors, and LEDs on the PET thin film. The TFF-TENG could harvest mechanical energy from finger tapping and sliding motion and power the ZnO NP UV photodetector to realize self-powered detection. The voltage of the constant resistors connected with the UV photodetector in series changes from 0.5 to 19 V under the UV light with power intensities increasing from 0.46 to 21.8 mW/cm, and the voltage variation is reflected by the number of LEDs directly. The excellent flexibility and transparency of the device could extend its application scenarios; for example, such a portable device could be applied to real-time monitoring of the UV radiation to remind humans of intense UV light.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b22572DOI Listing
April 2020

Template-free synthesis and metalation of hierarchical covalent organic framework spheres for photothermal therapy.

Chem Commun (Camb) 2019 Nov;55(95):14315-14318

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

Uniform micron sized hierarchical COF (HCOF) spheres were fabricated by a template-free solution-based aging method at room temperature for the first time. The postsynthetic metalation of HCOF with Fe3+ makes the metalated HCOF an excellent photothermal agent (PTA) for photothermal therapy (PTT).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc07809fDOI Listing
November 2019

Facile synthesis of Fe-p-aminophenol nanoparticles for photothermal therapy.

Dalton Trans 2019 Dec 5;48(45):16848-16852. Epub 2019 Nov 5.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. and University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.

Fe-p-aminophenol (Fe-PAP) nanoparticles, a newly developed photothermal agent (PTA), were successfully synthesized via a one-pot method at room temperature. The resultant product exhibited good photothermal effect with a photothermal conversion efficiency of 36%. In vitro and in vivo evaluation demonstrated that Fe-PAP was an effective PTA for photothermal therapy (PTT).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9dt03664dDOI Listing
December 2019

Fabrication of an Inexpensive Hydrophilic Bridge on a Carbon Substrate and Loading Vanadium Sulfides for Flexible Aqueous Zinc-Ion Batteries.

ACS Appl Mater Interfaces 2019 Oct 1;11(40):36676-36684. Epub 2019 Oct 1.

Coupling electrode materials with carbon substrates to construct flexible aqueous Zn-ion batteries (ZIBs) with excellent electrochemical performance is an attractive research focus. However, further improving the Zn/electron diffusion kinetics in such systems is still desirable. Herein, we present a novel hydrophilic carbon substrate that employs acid-treated natural halloysite and carbon nanotubes for the first time as structural and interfacial modifiers for loading VS as a composite cathode (denoted as HCC-VS) for flexible ZIBs. The devices exhibit a high specific capacity of 148 mA h·g under a current density of 0.5 A·g (95% retention after 200 cycles), excellent rate performance, and a high energy density of 155.7 W h·kg, together with a high-power density of 5000 W·kg. The promising electrochemical property can be associated with the formation of the hydrophilic surface/interface and with the good conductivity of the composite electrode, which increases the Zn/electron transmission rate. Owing to the cost-effective design of the flexible substrate and the ZIB's impressive electrochemical performance, the fabricated device shows good potential applications in portable and wearable electronics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b12128DOI Listing
October 2019

Integration of a highly monodisperse covalent organic framework photosensitizer with cation exchange synthesized AgSe nanoparticles for enhanced phototherapy.

Chem Commun (Camb) 2019 Aug 15;55(62):9164-9167. Epub 2019 Jul 15.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. and University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.

COF-AgSe nanoparticles were successfully synthesized under mild conditions via a cation exchange approach using COF and CuSe as templates. The in vitro and in vivo experiments verified the excellent cancer cell killing effect and antitumor efficacy of COF-AgSe nanoparticles via combined photodynamic and photothermal therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc04668bDOI Listing
August 2019

Monodispersed CuSe Sensitized Covalent Organic Framework Photosensitizer with an Enhanced Photodynamic and Photothermal Effect for Cancer Therapy.

ACS Appl Mater Interfaces 2019 Jul 18;11(26):23072-23082. Epub 2019 Jun 18.

State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry, Chinese Academy of Science , Changchun , Jilin 130022 , P. R. China.

Attributed to its simplicity, noninvasive features, and excellent therapeutic effect, phototherapy has recently received considerable interest. The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) holds great promise in the treatment of tumors, and in order to achieve satisfactory antitumor efficacy, suitable photosensitizers are a prerequisite. In this paper, highly monodispersed covalent organic framework (COF) nanoparticles were first prepared by a mild solution-phase synthesis method at room temperature. The as-synthesized nonporphyrin containing COF nanoparticle was employed as a novel photosensitizer for PDT, which exhibited an excellent photodynamic effect under 650 or 808 nm laser irradiation. Then, CuSe nanoparticles, an ideal photothermal agent, were successfully conjugated with COF to form a dual functional photosensitizer for phototherapy. The resultant COF-CuSe platform possesses an excellent synergistic photothermal and photodynamic effect. The in vitro and in vivo experiments indicated an enhanced therapeutic effect on killing cancer cells and inhibiting the tumor growth. This work demonstrates the great potential of nonporphyrin containing COF as a photosensitizer for photodynamic cancer therapy and provides a facile and efficient approach to construct COF-based multifunctional theranostic agents for cancer diagnosis and treatment by combining COFs with other functional materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b08394DOI Listing
July 2019

Boosting the antitumor efficacy over a nanoscale porphyrin-based covalent organic polymer via synergistic photodynamic and photothermal therapy.

Chem Commun (Camb) 2019 May;55(44):6269-6272

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.

Porphyrin-based covalent organic polymer nanoparticles were synthesized via a Schiff base reaction at room temperature. The resulting product showed a good photodynamic effect and a high photothermal conversion efficiency (34.88%). Both in vitro and in vivo experiments demonstrated the enhanced antitumor efficacy via synergistic photodynamic and photothermal therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc02345cDOI Listing
May 2019

Facile Fabrication of Nanoscale Porphyrinic Covalent Organic Polymers for Combined Photodynamic and Photothermal Cancer Therapy.

ACS Appl Mater Interfaces 2019 Apr 21;11(13):12321-12326. Epub 2019 Mar 21.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun 130022 , P. R. China.

Photodynamic therapy (PDT) of cancers is usually inefficient due to the relatively low level of oxygen in cancer cells; therefore, it needs to combine with other treatment strategies such as chemotherapy or photothermal therapy (PTT) to achieve the best anticancer efficacy. Although porphyrin-containing materials have been widely studied for PDT, the photothermal effect is rarely reported. Herein, nanoscale porphyrin-containing covalent organic polymers (PCOPs) were produced via a room temperature solution-based aging method. The resulting nanoparticles possess high photothermal conversion efficiency (21.7%) and excellent photodynamic effect. For the first time, the in vitro and in vivo tests indicated an enhanced antitumor efficacy for PCOP with combined PDT and PTT. This study provides an efficient approach to fabricate nanoCOP and also demonstrates the great potential of porphyrin-containing COP for biomedical applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b00361DOI Listing
April 2019

One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy.

Chemistry 2019 Mar 1;25(17):4315-4319. Epub 2019 Mar 1.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Covalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time. The resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201806242DOI Listing
March 2019

Influence of biochar application on potassium-solubilizing Bacillus mucilaginosus as potential biofertilizer.

Prep Biochem Biotechnol 2017 Jan 25;47(1):32-37. Epub 2016 Feb 25.

b School of Biological Engineering , Dalian Polytechnic University , Dalian , China.

Biochar can enhance soil fertility to increase agricultural productivity, whereas its improvement in soil microbial activity is still unclear. In this article, the influence of biochar on the cell growth and the potassium-solubilizing activity of Bacillus mucilaginosus AS1153 was examined. The impact on cell growth is related to the biochar-derived feedstocks and the particle size of biochar. Both intrinsic features and inner component fraction can promote the cell growth of B. mucilaginosus AS1153. The potassium-solubilizing activity was increased by 80% when B. mucilaginosus was incubated in conjunction with the biochar derived from corn stover. The survival time of B. mucilaginosus also was prolonged by adsorption in biochar. The experimental results suggested that the biochar containing B. mucilaginosus could be used as a potential biofertilizer to sustain crop production.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/10826068.2016.1155062DOI Listing
January 2017

NbO microstructures: a high-performance anode for lithium ion batteries.

Nanotechnology 2016 Nov 13;27(46):46LT01. Epub 2016 Oct 13.

School of Materials Science and Engineering, Central South University, Changsha 410083, Hunan, People's Republic of China.

We report the synthesis of three-dimensional (3D) urchin-like NbO microstructures by a facile hydrothermal approach with subsequent annealing treatment. As anode materials for lithium-ion batteries, the 3D urchin-like NbO microstructures exhibit superior electrochemical performance with excellent rate capability as well as long-term cycling stability. The electrode delivers high capacity of 131 mA h g after 1000 cycles at a high current density of 1 A g. The excellent electrochemical performance suggests the 3D urchin-like NbO microstructures may be a promising anode candidate for high-power lithium ion batteries.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/0957-4484/27/46/46LT01DOI Listing
November 2016

Role of hypothalamic cannabinoid receptors in post-stroke depression in rats.

Brain Res Bull 2016 Mar 14;121:91-7. Epub 2016 Jan 14.

Geriatric Neurology Department of Nanlou Clinical Division, PLA General Hospital, Fuxing Road 28, Beijing 100853, China. Electronic address:

One of the most common psychological consequences of stroke is post-stroke depression (PSD). While more than 30 percent of stroke patients eventually develop PSD, the neurobiological mechanisms underlying such a phenomenon have not been well investigated. Given the critical involvement of hypothalamic-pituitary-adrenal axis and endocannabinoid system in response to stressful stimuli, we evaluated the hypothesis that cannabinoid receptors in the hypothalamus are critical for modulation of post-stroke depression-like behaviors in rats. To this end, rats were treated with middle cerebral artery occlusion (MCAO) followed by chronic unpredictable mild stress (CUMS) treatment procedure. We then assessed the expression of CB1 and CB2 receptors in the hypothalamus, and evaluated the effects of pharmacological stimulations of CB1 or CB2 receptors on the expression and development of depression-like behaviors in PSD rats. We found that PSD rats exhibited decreased the expression of CB1 receptor, but not CB2 receptor, in the ventral medial hypothalamus (VMH). Such an effect was not observed in the dorsally adjacent brain regions. Furthermore, intra-VMH injections of CB2 receptor agonist, but not CB1 receptor agonist, attenuated the expression of depression-like behaviors in PSD rats. Finally, repeated intraperitoneal injections of CB1 or CB2 receptor agonists during CUMS treatment inhibited the development of depression-like behaviors in PSD rats. Taken together, these results suggest that decreased CB1 receptor expression is likely associated with the development of post-stroke depression, and CB2 receptor may be a potential therapeutic target for the treatment post-stroke depressive disorders.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2016.01.006DOI Listing
March 2016

Perceptual and response interference in Alzheimer's disease and mild cognitive impairment.

Clin Neurophysiol 2013 Dec 17;124(12):2389-96. Epub 2013 Jun 17.

Department of Neurology, Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing 100853, China.

Objectives: The ability to resolve conflicts is indispensable to the function of daily life and decreases with cognitive decline. We hypothesized that subjects with different levels of cognitive impairment exhibit different conflict resolution performances and may be susceptible to interference effects at different stages.

Methods: Sixteen normal controls (NC), 15 mild cognitive impairment (MCI) and seven Alzheimer's disease (AD) patients were recruited to perform in a modified Eriksen flanker task.

Results: We observed that the AD and MCI patients exhibited smaller accuracy rate and longer response time compared to NC subjects. Longer N2 and P300 latencies were observed in the AD group. Furthermore, the MCI group showed a longer latency than the NC group in the P300 latency. The magnitude of the perceptual and response interference effects was larger in the AD group than the other groups, and the MCI group significantly differed from the NC group at the perceptual level.

Conclusion: The ability to resolve conflict decreased with impaired cognition and the perceptual and response interference effects may be useful in distinguishing MCI and AD.

Significance: The perceptual or response interference effect may potentially be employed as a useful non-invasive probe for the clinical diagnosis of MCI and AD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2013.05.014DOI Listing
December 2013

Allelic analyses of the Arabidopsis YUC1 locus reveal residues and domains essential for the functions of YUC family of flavin monooxygenases.

J Integr Plant Biol 2011 Jan 22;53(1):54-62. Epub 2010 Dec 22.

National Laboratory for Protein Engineering and Plant Genetic Engineering, Peking-Yale Joint Research Center for Plant Molecular Genetics and AgroBiotechnology, College of Life Sciences, Peking University, Beijing 100871, China.

Flavin monooxygenases (FMOs) play critical roles in plant growth and development by synthesizing auxin and other signaling molecules. However, the structure and function relationship within plant FMOs is not understood. Here we defined the important residues and domains of the Arabidopsis YUC1 FMO, a key enzyme in auxin biosynthesis. We previously showed that simultaneous inactivation of YUC1 and its homologue YUC4 caused severe defects in vascular and floral development. We mutagenized the yuc4 mutant and screened for mutants with phenotypes similar to those of yuc1 yuc4 double mutants. Among the isolated mutants, five of them contained mutations in the YUC1 gene. Interestingly, the mutations identified in the new yuc1 alleles were concentrated in the two GXGXXG motifs that are highly conserved among the plant FMOs. One such motif presumably binds to flavin adenine dinucleotide (FAD) cofactor and the other binds to nicotinamide adenine dinucleotide phosphate (NADPH). We also identified the Ser(139) to Phe conversion in yuc1, a mutation that is located between the two nucleotide-binding sites. By analyzing a series of yuc1 mutants, we identified key residues and motifs essential for the functions of YUC1 FMO.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1744-7909.2010.01007.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060657PMC
January 2011

Effect of task complexity on intelligence and neural efficiency in children: an event-related potential study.

Neuroreport 2007 Oct;18(15):1599-602

Department of Psychology, Zhejiang University, Hangzhou, Zhejiang, PR China.

The present study investigates the effects of task complexity, intelligence and neural efficiency on children's performance on an Elementary Cognitive Task. Twenty-three children were divided into two groups on the basis of their Raven Progressive Matrix scores and were then asked to complete a choice reaction task with two test conditions. We recorded the electroencephalogram and calculated the peak latencies and amplitudes for anteriorly distributed P225, N380 and late positive component. Our results suggested shorter late positive component latencies in brighter children, possibly reflecting a higher processing speed in these individuals. Increased P225 amplitude and increased N380 amplitudes for brighter children may indicate a more efficient allocation of attention for brighter children. No moderating effect of task complexity on brain-intelligence relationship was found.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNR.0b013e3282f03f22DOI Listing
October 2007