Saima Hilal

Saima Hilal

UNVERIFIED PROFILE

Are you Saima Hilal?   Register this Author

Register author
Saima Hilal

Saima Hilal

Publications by authors named "Saima Hilal"

Are you Saima Hilal?   Register this Author

71Publications

1786Reads

20Profile Views

Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease.

Am J Geriatr Psychiatry 2019 Sep 18;27(9):948-959. Epub 2019 Apr 18.

Department of Neurology (CY, DL, KPN, RC, DN, NK), National Neuroscience Institute, Singapore, Singapore; Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program (FJ, HYS, JZ, NK), Duke-NUS Medical School, Singapore. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10647481193033
Publisher Site
http://dx.doi.org/10.1016/j.jagp.2019.04.004DOI Listing
September 2019

Prevalence and clinical relevance of diffusion-weighted imaging lesions: The Rotterdam study.

Neurology 2019 Aug 7. Epub 2019 Aug 7.

From the Departments of Radiology and Nuclear Medicine (S.H., M.d.G., W.J.N., M.W.V.), Epidemiology (S.H., L.G.A.B., M.K.I., M.A.I., M.W.V.), Medical Informatics (M.d.G., W.J.N.), and Neurology (M.K.I.), Erasmus University Medical Center, Rotterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000008090DOI Listing
August 2019

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Authors:
Duncan Wilson Gareth Ambler Keon-Joo Lee Jae-Sung Lim Masayuki Shiozawa Masatoshi Koga Linxin Li Caroline Lovelock Hugues Chabriat Michael Hennerici Yuen Kwun Wong Henry Ka Fung Mak Luis Prats-Sánchez Alejandro Martínez-Domeño Shigeru Inamura Kazuhisa Yoshifuji Ethem Murat Arsava Solveig Horstmann Jan Purrucker Bonnie Yin Ka Lam Adrian Wong Young Dae Kim Tae-Jin Song Maarten Schrooten Robin Lemmens Sebastian Eppinger Thomas Gattringer Ender Uysal Zeynep Tanriverdi Natan M Bornstein Einor Ben Assayag Hen Hallevi Jun Tanaka Hideo Hara Shelagh B Coutts Lisa Hert Alexandros Polymeris David J Seiffge Philippe Lyrer Ale Algra Jaap Kappelle Rustam Al-Shahi Salman Hans R Jäger Gregory Y H Lip Heinrich P Mattle Leonidas D Panos Jean-Louis Mas Laurence Legrand Christopher Karayiannis Thanh Phan Sarah Gunkel Nicolas Christ Jill Abrigo Thomas Leung Winnie Chu Francesca Chappell Stephen Makin Derek Hayden David J Williams M Eline Kooi Dianne H K van Dam-Nolen Carmen Barbato Simone Browning Kim Wiegertjes Anil M Tuladhar Noortje Maaijwee Christine Guevarra Chathuri Yatawara Anne-Marie Mendyk Christine Delmaire Sebastian Köhler Robert van Oostenbrugge Ying Zhou Chao Xu Saima Hilal Bibek Gyanwali Christopher Chen Min Lou Julie Staals Régis Bordet Nagaendran Kandiah Frank-Erik de Leeuw Robert Simister Aad van der Lugt Peter J Kelly Joanna M Wardlaw Yannie Soo Felix Fluri Velandai Srikanth David Calvet Simon Jung Vincent I H Kwa Stefan T Engelter Nils Peters Eric E Smith Yusuke Yakushiji Dilek Necioglu Orken Franz Fazekas Vincent Thijs Ji Hoe Heo Vincent Mok Roland Veltkamp Hakan Ay Toshio Imaizumi Beatriz Gomez-Anson Kui Kai Lau Eric Jouvent Peter M Rothwell Kazunori Toyoda Hee-Joon Bae Joan Marti-Fabregas David J Werring

Lancet Neurol 2019 Jul 23;18(7):653-665. Epub 2019 May 23.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(19)30197-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562236PMC
July 2019

and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.

Neurology 2019 Jul 26;93(4):e358-e371. Epub 2019 Jun 26.

From the Hemorrhagic Stroke Research Program, Department of Neurology (A.C., M.P., A.B., M.E.G., J.N.G., J.R., S.M.G., A.V.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Alzheimer Center and the Neuroscience Campus Amsterdam and Departments of Radiology and Nuclear Medicine (H.I.Z., F.B.), VU University Medical Center, the Netherlands; Karolinska Institutet (S.S., L.-O.W.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (K.K., J.R.C.), Mayo Clinic, Rochester, MN; Department of Medicine (Neurology) (A.S.), McMaster University and Population Health Research Institute, Hamilton, Canada; Memory, Aging and Cognition Center (S.H., Y.L.C., J.R.C., C.C.), National University Health System, Singapore; Department of Pharmacology (S.H., Y.L.C., J.R.C., C.C.), National University of Singapore; Department of Nuclear Medicine and Centre for PET (P.A.Y.), The University of Melbourne, Parkville, Australia; Department of Neuroradiology (G.B.), Université Paris-Descartes, INSERM U894, CH Sainte-Anne, Paris, France; Department of Neurology and Neuroscience Center (H.K.N., D.L.N., S.W.S.), Samsung Medical Center, Seoul, Republic of Korea; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK; and Center for Genomic Medicine (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007818DOI Listing
July 2019

Prevalence and Risk Factors for Cognitive Impairment and Dementia in Indians: A Multiethnic Perspective from a Singaporean Study.

J Alzheimers Dis 2019 Jul 27. Epub 2019 Jul 27.

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-190610DOI Listing
July 2019

Cortical cerebral microinfarcts predict cognitive decline in memory clinic patients.

J Cereb Blood Flow Metab 2019 Mar 19:271678X19835565. Epub 2019 Mar 19.

1 Department of Pharmacology, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X19835565DOI Listing
March 2019

Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study.

J Alzheimers Dis 2018 ;62(2):877-885

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-170796DOI Listing
February 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.

Neurology 2018 08 1;91(9):e832-e842. Epub 2018 Aug 1.

From the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133622PMC
August 2018

Prevalence and association of syphilis reactivity in an Asian memory clinic population.

Int J STD AIDS 2018 Aug 2:956462418787627. Epub 2018 Aug 2.

4 Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0956462418787627DOI Listing
August 2018

Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.

Alzheimers Res Ther 2018 08 18;10(1):82. Epub 2018 Aug 18.

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-018-0413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098837PMC
August 2018

Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study.

Alzheimers Res Ther 2018 06 30;10(1):63. Epub 2018 Jun 30.

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Office no. 2505, Wytemaweg 80, 3015, CN, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-018-0395-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026500PMC
June 2018

Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study.

J Alzheimers Dis 2017 ;60(3):977-987

Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-170458DOI Listing
May 2018

Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

Curr Alzheimer Res 2017 ;14(6):620-627

Academia, 20 College Road, Discovery Tower Level 6, Room 119, Lower Kent, Ridge Road, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1567205012666151002123813DOI Listing
April 2018

Serum Hepatocyte Growth Factor Is Associated with Small Vessel Disease in Alzheimer's Dementia.

Front Aging Neurosci 2018 23;10. Epub 2018 Jan 23.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnagi.2018.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787106PMC
January 2018

Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore.

Alzheimer Dis Assoc Disord 2018 Apr-Jun;32(2):94-100

Memory Aging & Cognition Centre, National University Health System.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WAD.0000000000000227DOI Listing
December 2017

Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease.

Brain 2017 Nov;140(11):3012-3022

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Programme, Duke-National University of Singapore Medical School, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awx224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841199PMC
November 2017

Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries.

J Neurol Neurosurg Psychiatry 2017 08 9;88(8):669-674. Epub 2017 Jun 9.

Memory Aging and Cognition Center, National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-315324DOI Listing
August 2017

Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study.

Atherosclerosis 2017 08 5;263:272-277. Epub 2017 Jul 5.

Memory Aging & Cognition Centre, National University Health System, Singapore; Department of Pharmacology, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2017.07.002DOI Listing
August 2017

Intracranial stenosis in cognitive impairment and dementia.

J Cereb Blood Flow Metab 2017 Jun 1;37(6):2262-2269. Epub 2016 Jan 1.

1 Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X16663752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464715PMC
June 2017

Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort.

J Neurol Neurosurg Psychiatry 2017 Jan 3;88(1):7-11. Epub 2016 Jun 3.

Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2016-313271DOI Listing
January 2017

Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease.

Alzheimers Dement (Amst) 2017 23;7:41-47. Epub 2017 Jan 23.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore; Memory Aging and Cognition Centre, National University Health System, Kent Ridge, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dadm.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318538PMC
January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Authors:
Hieab H H Adams Derrek P Hibar Vincent Chouraki Jason L Stein Paul A Nyquist Miguel E Rentería Stella Trompet Alejandro Arias-Vasquez Sudha Seshadri Sylvane Desrivières Ashley H Beecham Neda Jahanshad Katharina Wittfeld Sven J Van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Alexa Beiser Manon Bernard Joshua C Bis Laura M E Blanken Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R K Ching Gabriel Cuellar-Partida Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Corina U Greven Oliver Grimm Michael E Griswold Tulio Guadalupe Johanna Hass Unn K Haukvik Saima Hilal Edith Hofer David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee Jiemin Liao David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre Marquand Mar Matarin Karen A Mather Manuel Mattheisen Bernard Mazoyer David R McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza-Schreiber Ryan L Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B Rajan Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Russell Thomson Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Dhananjay Vaidya Jeroen Van der Grond Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Girma Woldehawariat Christiane Wolf Thomas Wolfers Bing Xu Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Neelum T Aggarwal Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Christopher Chen Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Eco J C De Geus Philip L De Jager Greig I de Zubicaray Norman Delanty Chantal Depondt Anita L DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Susanne Erk Thomas Espeseth Denis A Evans Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Hans J Grabe Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Hilleke E Hulshoff Pol Masashi Ikeda M Kamran Ikram Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo W T Longstreth Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Katie L McMahon Francis J McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Peter R Schofield Sigurdur Sigurdsson Andy Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Velandai Srikanth Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Henning Tiemeier Arthur W Toga Bryan J Traynor Juan Troncoso Jessica A Turner Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad Van der Lugt Nic J A Van der Wee Cornelia M Van Duijn Neeltje E M Van Haren Dennis Van T Ent Marie-Jose Van Tol Badri N Vardarajan Dick J Veltman Meike W Vernooij Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright H Ronald Zielke Alan B Zonderman Ian J Deary Charles DeCarli Helena Schmidt Nicholas G Martin Anton J M De Craen Margaret J Wright Lenore J Launer Gunter Schumann Myriam Fornage Barbara Franke Stéphanie Debette Sarah E Medland M Arfan Ikram Paul M Thompson

Nat Neurosci 2016 12 3;19(12):1569-1582. Epub 2016 Oct 3.

Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112PMC
December 2016

Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease.

Neurology 2016 Oct 2;87(15):1583-1590. Epub 2016 Sep 2.

From the Memory Ageing and Cognition Centre (S.H., M.A.S., Q.L.C., C.C., M.K.I.), National University Health System, Singapore; Department of Pharmacology (S.H., M.A.S., Q.L.C., C.C.), National University of Singapore; Department of Neurology (E.S., S.J.v.V., G.J.B., M.K.I.), Brain Center Rudolf Magnus, University Medical Center Utrecht; Departments of Radiology and Medical Informatics (H.V.) and Neurology and Epidemiology (M.K.I.), Erasmus University Medical Center, Rotterdam, the Netherlands; Singapore Eye Research Institute (C.-Y. Cheng, C.S., C.Y. Cheung, T.Y.W.), Singapore National Eye Center; Academic Medicine Research Institute (T.Y.W., M.K.I.), Duke-NUS Graduate Medical School; and Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003110DOI Listing
October 2016

Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore.

J Am Med Dir Assoc 2016 09 20;17(9):863.e9-863.e14. Epub 2016 Jul 20.

Department of Pharmacology, National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamda.2016.06.002DOI Listing
September 2016

The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease.

J Alzheimers Dis 2016 09;54(2):585-95

Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Medical School, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-160067DOI Listing
September 2016

Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI.

Sci Rep 2016 09 1;6:32573. Epub 2016 Sep 1.

Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/srep32573
Publisher Site
http://dx.doi.org/10.1038/srep32573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007647PMC
September 2016

Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia.

Medicine (Baltimore) 2016 Aug;95(33):e4566

aDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore bMemory Aging and Cognition Centre, National University Health System cCardiovascular Research Institute, National University Heart Centre, Singapore dDepartments of Neurology and Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands eRaffles Neuroscience Centre, Raffles Hospital, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000004566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370808PMC
August 2016

Subcortical Atrophy in Cognitive Impairment and Dementia.

J Alzheimers Dis 2015 ;48(3):813-23

Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-150473DOI Listing
July 2016

Posterior Eye Shape Measurement With Retinal OCT Compared to MRI.

Invest Ophthalmol Vis Sci 2016 07;57(9):OCT196-203

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States 5Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.15-18886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968781PMC
July 2016

Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.

J Alzheimers Dis 2015 ;45(1):45-56

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-141659DOI Listing
February 2016

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients.

Alzheimers Dement 2015 Dec 5;11(12):1500-1509. Epub 2015 May 5.

Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore; Department of Pharmacology, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2014.12.010DOI Listing
December 2015

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium.

Alzheimers Dement (Amst) 2015 Dec 31;1(4):513-20. Epub 2015 Oct 31.

Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dadm.2015.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879491PMC
December 2015

Intracranial stenosis, cerebrovascular diseases, and cognitive impairment in chinese.

Alzheimer Dis Assoc Disord 2015 Jan-Mar;29(1):12-7

Departments of *Pharmacology ††Ophthalmology, National University of Singapore ‡Saw Swee Hock School of Public Health, National University of Singapore †Memory Aging & Cognition Centre, National University Health System Departments of §Medicine #Diagnostic Imaging, National University Hospital **Singapore Eye Research Institute, Singapore National Eye Center ‡‡Neuroscience Clinic, Raffles Hospital, Singapore, Singapore ∥Departments of Radiology & Medical Informatics, Erasmus MC, Rotterdam ¶Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WAD.0000000000000045DOI Listing
November 2015

Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic?

Diagnostics (Basel) 2015 Nov 4;5(4):475-86. Epub 2015 Nov 4.

Memory, Aging and Cognition Center, Department of Pharmacology, National University Health System, Singapore 117600, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics5040475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728469PMC
November 2015

Prevalence and Risk Factors of Acute Incidental Infarcts.

Stroke 2015 Oct 20;46(10):2722-7. Epub 2015 Aug 20.

From the Department of Pharmacology, National University of Singapore, Singapore, Singapore (M.S., M.S.P.S., S.H., Y.H.D., C.C.); Department of Medicine, Changi General Hospital, Singapore, Singapore (M.S.); Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore (M.S.P.S., S.H., Y.H.D., N.V., M.K.I., C.C.); Raffles Neuroscience Centre, Department of Neurology, Raffles Hospital, Singapore, Singapore (N.V.); Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore (M.K.I.); and Department of Pharmacology, Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore (M.K.I.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.009963
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.115.009963DOI Listing
October 2015

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition.

Stroke 2015 Oct 1;46(10):2808-14. Epub 2015 Sep 1.

From the Departments of Pharmacology (X.X., S.H., E.J.Y.C., C.L.-H.C.) and Psychology (S.L.C.) and Academic Medicine Research Institute, Duke-NUS Graduate Medical School (M.K.I.), National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore (X.X., S.H., E.J.Y.C., M.K.I., N.V., C.L.-H.C.); and Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore (N.V.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.010700
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.115.010700DOI Listing
October 2015

Risk Factors and Consequences of Cortical Thickness in an Asian Population.

Medicine (Baltimore) 2015 Jun;94(23):e852

From the Memory Ageing and Cognition Centre (MACC), National University Health System (SH, XX, SLA, CC, MKI); Department of Pharmacology, National University of Singapore (SH, XX, SLA, CC, MKI); Saw Swee Hock School of Public Health, National University of Singapore (CST); Raffles Neuroscience Centre, Raffles Hospital, Singapore (NV); Departments of Radiology and Medical Informatics, Erasmus University Medical Center, Rotterdam (WJN, HV); Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (WJN); Singapore Eye Research Institute, Singapore National Eye Center, Singapore (TYW, MKI); Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore (TYW, MKI); Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (MKI).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616471PMC
June 2015

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI.

Authors:
Benjamin F J Verhaaren Stéphanie Debette Joshua C Bis Jennifer A Smith M Kamran Ikram Hieab H Adams Ashley H Beecham Kumar B Rajan Lorna M Lopez Sandra Barral Mark A van Buchem Jeroen van der Grond Albert V Smith Katrin Hegenscheid Neelum T Aggarwal Mariza de Andrade Elizabeth J Atkinson Marian Beekman Alexa S Beiser Susan H Blanton Eric Boerwinkle Adam M Brickman R Nick Bryan Ganesh Chauhan Christopher P L H Chen Vincent Chouraki Anton J M de Craen Fabrice Crivello Ian J Deary Joris Deelen Philip L De Jager Carole Dufouil Mitchell S V Elkind Denis A Evans Paul Freudenberger Rebecca F Gottesman Vilmundur Guðnason Mohamad Habes Susan R Heckbert Gerardo Heiss Saima Hilal Edith Hofer Albert Hofman Carla A Ibrahim-Verbaas David S Knopman Cora E Lewis Jiemin Liao David C M Liewald Michelle Luciano Aad van der Lugt Oliver O Martinez Richard Mayeux Bernard Mazoyer Mike Nalls Matthias Nauck Wiro J Niessen Ben A Oostra Bruce M Psaty Kenneth M Rice Jerome I Rotter Bettina von Sarnowski Helena Schmidt Pamela J Schreiner Maaike Schuur Stephen S Sidney Sigurdur Sigurdsson P Eline Slagboom David J M Stott John C van Swieten Alexander Teumer Anna Maria Töglhofer Matthew Traylor Stella Trompet Stephen T Turner Christophe Tzourio Hae-Won Uh André G Uitterlinden Meike W Vernooij Jing J Wang Tien Y Wong Joanna M Wardlaw B Gwen Windham Katharina Wittfeld Christiane Wolf Clinton B Wright Qiong Yang Wei Zhao Alex Zijdenbos J Wouter Jukema Ralph L Sacco Sharon L R Kardia Philippe Amouyel Thomas H Mosley W T Longstreth Charles C DeCarli Cornelia M van Duijn Reinhold Schmidt Lenore J Launer Hans J Grabe Sudha S Seshadri M Arfan Ikram Myriam Fornage

Circ Cardiovasc Genet 2015 Apr 7;8(2):398-409. Epub 2015 Feb 7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.114.000858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427240PMC
April 2015

Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study.

Alzheimer Dis Assoc Disord 2014 Apr-Jun;28(2):106-12

*Department of Pharmacology ‡Saw Swee Hock School of Public Health #Department of Ophthalmology, National University of Singapore †Memory Aging & Cognition Centre, National University Health System ¶Singapore Eye Research Institute, Singapore National Eye Center ††Neuroscience Clinic, Raffles Hospital, Singapore, Singapore Departments of §Radiology & Medical Informatics **Ophthalmology, Erasmus MC, University Medical Center, Rotterdam ∥Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WAD.0000000000000015DOI Listing
January 2015

Retinal neurodegeneration on optical coherence tomography and cerebral atrophy.

Neurosci Lett 2015 Jan 19;584:12-6. Epub 2014 Oct 19.

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore; Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2014.10.010DOI Listing
January 2015

Markers of cardiac dysfunction in cognitive impairment and dementia.

Medicine (Baltimore) 2015 Jan;94(1):e297

From the Memory, Ageing and Cognition Centre (MACC), National University Health System, Singapore (SH, YLC, MKI, SE, XX, JYC, NV, MKPL, CC); Department of Pharmacology, National University of Singapore, Singapore (SH, YLC, XX, JYC, MKPL, CC); Singapore Eye Research Institute, Singapore National Eye Center, Singapore (MKI); Department of Ophthalmology, National University of Singapore, Singapore (MKI); St. Luke's Hospital, Singapore (TBY, NV); Neuroscience Clinic, Raffles Hospital, Singapore (NV); and Cardiovascular Research Institute, National University Heart Centre, Singapore (AMR, JPCC).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000000297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602830PMC
January 2015

Computer tomography for prediction of cognitive outcomes after ischemic cerebrovascular events.

J Stroke Cerebrovasc Dis 2014 Aug 1;23(7):1921-7. Epub 2014 May 1.

Department of Pharmacology, National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University Health System, Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.02.007DOI Listing
August 2014

Microvascular network alterations in retina of subjects with cerebral small vessel disease.

Neurosci Lett 2014 Aug 14;577:95-100. Epub 2014 Jun 14.

Memory, Aging & Cognition Center, National University Health System, Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2014.06.024DOI Listing
August 2014

Retinal vascular fractals and cognitive impairment.

Dement Geriatr Cogn Dis Extra 2014 May 27;4(2):305-13. Epub 2014 Aug 27.

Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore ; Department of Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000363286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176466PMC
May 2014

Microvascular network alterations in the retina of patients with Alzheimer's disease.

Alzheimers Dement 2014 Mar 15;10(2):135-42. Epub 2014 Jan 15.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2013.06.009DOI Listing
March 2014

The informant AD8 is superior to participant AD8 in detecting cognitive impairment in a memory clinic setting.

J Alzheimers Dis 2013 ;35(1):159-68

Memory Aging and Cognition Centre, Department of Pharmacology, National University Health System, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-122026DOI Listing
December 2013

Association of silent lacunar infarct with brain atrophy and cognitive impairment.

J Neurol Neurosurg Psychiatry 2013 Nov 9;84(11):1219-25. Epub 2013 Aug 9.

Department of Bioengineering, National University of Singapore, , Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2013-305310DOI Listing
November 2013

Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia.

J Neurol Sci 2013 Oct 25;333(1-2):5-8. Epub 2013 Jul 25.

Memory Aging and Cognition Centre, Department of Pharmacology, National University Health System, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, The University of New South Wales, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2013.05.011DOI Listing
October 2013

Silent stroke: not listened to rather than silent.

Stroke 2012 Nov 4;43(11):3102-4. Epub 2012 Sep 4.

Department of Pharmacology, Clinical Imaging Research Centre, National University of Singapore, Building MD11 Level 5, Medical Drive, NUH, Singapore 117597.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.112.666461DOI Listing
November 2012

Multi-stage segmentation of white matter hyperintensity, cortical and lacunar infarcts.

Neuroimage 2012 May 22;60(4):2379-88. Epub 2012 Feb 22.

Department of Pharmacology, National University of Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2012.02.034DOI Listing
May 2012