Publications by authors named "Sagrario Ortega"

61Publications

A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics.

Dev Cell 2020 02 9;52(3):350-363.e6. Epub 2020 Jan 9.

Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374559PMC
February 2020

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells.

Cell Rep 2019 07;28(3):597-604.e4

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 21 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656781PMC
July 2019

Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments.

Cancer Immunol Res 2019 08 11;7(8):1345-1358. Epub 2019 Jun 11.

Department of Surgery, Plastic and Reconstructive Surgery Service, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677612PMC
August 2019

Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging.

Aging Cell 2018 Oct 20;17(5):e12834. Epub 2018 Aug 20.

Laboratorio de Células Madre en Cáncer y Envejecimiento, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), Santiago de Compostela, Spain.

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http://dx.doi.org/10.1111/acel.12834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156495PMC
October 2018

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Genes Dev 2018 04 12;32(7-8):568-576. Epub 2018 Apr 12.

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1101/gad.310086.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959239PMC
April 2018

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.

Cell Rep 2018 01;22(2):396-410

Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775503PMC
January 2018

A p53-dependent response limits the viability of mammalian haploid cells.

Proc Natl Acad Sci U S A 2017 08 14;114(35):9367-9372. Epub 2017 Aug 14.

Genomic Instability Group, Spanish National Cancer Research Center, Madrid 28029, Spain;

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http://dx.doi.org/10.1073/pnas.1705133114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584429PMC
August 2017

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.

Cell Rep 2017 05;19(5):928-938

DNA Replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernández Almagro, 28029 Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173052
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http://dx.doi.org/10.1016/j.celrep.2017.04.032DOI Listing
May 2017

Lymph Node Transplantation Decreases Swelling and Restores Immune Responses in a Transgenic Model of Lymphedema.

PLoS One 2016 12;11(12):e0168259. Epub 2016 Dec 12.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168259PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152898PMC
June 2017

Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.

JCI Insight 2016 09 22;1(15):e84095. Epub 2016 Sep 22.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033805PMC
http://dx.doi.org/10.1172/jci.insight.84095DOI Listing
September 2016

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.

Dis Model Mech 2016 09 4;9(9):975-84. Epub 2016 Aug 4.

Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain Spanish Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid 28029, Spain

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047686PMC
http://dx.doi.org/10.1242/dmm.025890DOI Listing
September 2016

Erratum to: Vegfr3-CreER mouse, a new genetic tool for targeting the lymphatic system.

Angiogenesis 2016 Jul;19(3):447

Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://dx.doi.org/10.1007/s10456-016-9518-5DOI Listing
July 2016

Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations.

Nat Commun 2016 06 2;7:11739. Epub 2016 Jun 2.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/ncomms11739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895768PMC
June 2016

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.

Mol Cell 2016 04 7;62(2):307-313. Epub 2016 Apr 7.

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 21 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029544PMC
April 2016

Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system.

Angiogenesis 2016 07 18;19(3):433-45. Epub 2016 Mar 18.

Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://dx.doi.org/10.1007/s10456-016-9505-xDOI Listing
July 2016

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Cell Rep 2015 Mar 12;10(10):1708-1721. Epub 2015 Mar 12.

The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.026DOI Listing
March 2015

Nonvenous origin of dermal lymphatic vasculature.

Circ Res 2015 May 3;116(10):1649-54. Epub 2015 Mar 3.

From the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (I.M.-C., M.H.U., L.S., T.M.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom (I.M.-C., L.S., F.T., T.M.); Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME (K.K., S.W.M.J.); Wihuri Research Institute, Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (K.A.); Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306170DOI Listing
May 2015

Functional reprogramming of polyploidization in megakaryocytes.

Dev Cell 2015 Jan;32(2):155-67

Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.12.015DOI Listing
January 2015

CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.

J Cell Sci 2015 Jan 6;128(1):88-99. Epub 2014 Nov 6.

Unidad de Biología Celular, Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Madrid, Spain

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http://dx.doi.org/10.1242/jcs.154922DOI Listing
January 2015

SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.

Stem Cell Reports 2014 May 17;2(5):690-706. Epub 2014 Apr 17.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.stemcr.2014.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050480PMC
May 2014

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Circulation 2014 May 19;129(19):1962-71. Epub 2014 Feb 19.

Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002779DOI Listing
May 2014

Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.

Plast Reconstr Surg 2014 Feb;133(2):301-10

New York, N.Y.; and Madrid, Spain From the Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center; and the Biotechnology Programme, Spanish National Cancer Research Centre.

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https://insights.ovid.com/crossref?an=00006534-201402000-000
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http://dx.doi.org/10.1097/01.prs.0000436840.69752.7eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066306PMC
February 2014

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Nature 2013 Oct 11;502(7471):340-5. Epub 2013 Sep 11.

Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/nature12586DOI Listing
October 2013

TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.

Nat Commun 2013 ;4:1946

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/ncomms2946DOI Listing
December 2013

The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.

PLoS Genet 2013 31;9(1):e1003261. Epub 2013 Jan 31.

Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1003261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561109PMC
May 2013

In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6223-8. Epub 2012 Apr 2.

Biotechnology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1115542109
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http://dx.doi.org/10.1073/pnas.1115542109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341065PMC
April 2012

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.

PLoS One 2011 12;6(10):e25680. Epub 2011 Oct 12.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025680PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192133PMC
February 2012

Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells.

Proc Natl Acad Sci U S A 2011 Sep 24;108(37):15207-12. Epub 2011 Aug 24.

Telomeres and Telomerase Group, Spanish National Cancer Research Centre, Madrid E-28029, Spain.

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http://dx.doi.org/10.1073/pnas.1105414108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174656PMC
September 2011

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.

Development 2011 Jul 25;138(13):2661-72. Epub 2011 May 25.

Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1242/dev.066381DOI Listing
July 2011

A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka.

Genesis 2011 Jan 3;49(1):36-45. Epub 2011 Jan 3.

Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1002/dvg.20685DOI Listing
January 2011

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.

Nature 2009 Aug 9;460(7259):1149-53. Epub 2009 Aug 9.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain.

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http://www.nature.com/articles/nature08287
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http://dx.doi.org/10.1038/nature08287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624089PMC
August 2009

The Ink4/Arf locus is a barrier for iPS cell reprogramming.

Nature 2009 Aug 9;460(7259):1136-9. Epub 2009 Aug 9.

Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/nature08290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578184PMC
August 2009

CDK2 is required for proper homologous pairing, recombination and sex-body formation during male mouse meiosis.

J Cell Sci 2009 Jun;122(Pt 12):2149-59

Unidad de Biología Celular, Departamento de Biología, Edificio de Ciencias Biológicas, Facultad de Ciencias, Universidad Autónoma de Madrid, Calle Darwin 2, 28049 Madrid, Spain.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.046706
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http://dx.doi.org/10.1242/jcs.046706DOI Listing
June 2009

Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells.

Cell Stem Cell 2009 Feb;4(2):141-54

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909090000
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http://dx.doi.org/10.1016/j.stem.2008.12.010DOI Listing
February 2009

Mice thrive without Cdk4 and Cdk2.

Mol Oncol 2007 Jun 14;1(1):72-83. Epub 2007 Mar 14.

Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.molonc.2007.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543859PMC
June 2007

Cyclins and CDKS in development and cancer: lessons from genetically modified mice.

Front Biosci 2006 Jan 1;11:1164-88. Epub 2006 Jan 1.

Molecular Oncology Program, Spanish National Cancer Centre (CNIO), 28029-Madrid, Spain.

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http://dx.doi.org/10.2741/1871DOI Listing
January 2006

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

Cancer Cell 2005 Jun;7(6):591-8

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ccr.2005.05.006DOI Listing
June 2005

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.

Cell 2004 Aug;118(4):493-504

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740400750
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http://dx.doi.org/10.1016/j.cell.2004.08.002DOI Listing
August 2004

Cohesin component dynamics during meiotic prophase I in mammalian oocytes.

Chromosome Res 2004 ;12(3):197-213

Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, Madrid E-28049, Spain.

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http://dx.doi.org/10.1023/b:chro.0000021945.83198.0eDOI Listing
November 2004

Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer.

Cancer Res 2003 Sep;63(18):5754-60

Department of Pathology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA.

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September 2003

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

Nat Genet 2003 Sep 17;35(1):25-31. Epub 2003 Aug 17.

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/ng1232DOI Listing
September 2003

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.

Oncogene 2003 Aug;22(34):5261-9

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/sj.onc.1206506DOI Listing
August 2003

Driving the cell cycle to cancer.

Adv Exp Med Biol 2003 ;532:1-11

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1007/978-1-4615-0081-0_1DOI Listing
February 2004

Cyclin D-dependent kinases, INK4 inhibitors and cancer.

Biochim Biophys Acta 2002 Mar;1602(1):73-87

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/s0304-419x(02)00037-9DOI Listing
March 2002