Publications by authors named "Sadaf Mustafa"

8 Publications

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High-grade pleomorphic rhabdomyosarcoma in a 60-year-old male: a case report and review of the literature.

J Community Hosp Intern Med Perspect 2020 Jun 14;10(3):287-289. Epub 2020 Jun 14.

Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA.

Rhabdomyosarcoma is an aggressive malignant soft-tissue sarcoma that develop from undifferentiated mesenchymal cells. Less than 1% of all adult solid malignant cancers are sarcomas, and RMSs represent less than 2-5% of adult sarcomas.   RMS is divided into three main subtypes: Embryonal, alveolar and pleomorphic RMS (PRMS).   Most common subtype in adults is PRMS. Most common primary sites are extremities, trunk wall, and genitourinary organs. Metastasis are often found at diagnosis. 5-year overall survival rates were reported in the Surveillance, Epidemiology, and End Results database (SEER) to be 63% for pediatric patients and 27% for adults. Given the rarity of the adult PRMS, variation in its clinical presentation, characteristics of the tumor itself and the prognosis; there are very limited data available to guide the management of adults with PRMS. Herein we present a case report of pleomorphic rhabdomyosarcoma of the right thigh in a 60-year-old male who achieved a long-term survival (30 months) which was accomplished by multimodality treatment including surgery, radiotherapy, and chemotherapy.   .
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http://dx.doi.org/10.1080/20009666.2020.1766820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426990PMC
June 2020

Unusual presentation of parasitic leiomyoma; a tale of twists and turns.

J Community Hosp Intern Med Perspect 2019 Apr 12;9(2):168-170. Epub 2019 Apr 12.

Department of Internal Medicine, MedStar Good Samaritan Hospital, Baltimore, MD, USA.

Uterine leiomyoma is the most common benign pelvic tumor of the myometrium, as the prevalence could be as high as 70%. Major risk factors include age between 40-60 years and African descent. It usually presents with abnormal uterine bleeding and/or pelvic pain or pressure. Extra-uterine cases of leiomyoma have been reported including Leiomyomatosis Peritonealis Disseminata (LPD), in which multiple nodules are found in the pelvis, peritoneum, or intestine. The term parasitic leiomyoma has been used in literature to describe a non-disseminating pattern . There is no clear explanation for pathogenesis; however, some reports linked it to previous uterine procedures. We are presenting here a case report of an unusual presentation of extra-uterine leiomyoma in a patient with a remote history of hysterectomy for uterine fibroids.
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http://dx.doi.org/10.1080/20009666.2019.1591899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484481PMC
April 2019

Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin.

J Community Hosp Intern Med Perspect 2018 11;8(6):380-381. Epub 2018 Dec 11.

Department of Internal Medicine, MedStar Good Samaritan Hospital, Baltimore, MD, USA.

Fetal Hemoglobin (HbF, α2γ2) is produced from the eighth week of gestation, constitutes 60 - 80 % of total hemoglobin by birth, which is then replaced with adult Hemoglobin A1 (HbA1: α2β2) by 6-12 months. Hereditary Persistence of Fetal Hemoglobin (HPFH) is a rare benign asymptomatic genetic disorder where the HbF persists, and incidentally discovered on screening for other hemoglobinopathies. In adults, the variation in HbF levels could also be associated with other disease states, including hemoglobinopathies, leukemias and bone marrow failure syndromes. Here we present a case of a young asymptomatic female with the incidental finding of HPFH who was misdiagnosed as the sickle cell disease. It is important to have awareness about HPFH and should be distinguished from other causes of elevated HbF.
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http://dx.doi.org/10.1080/20009666.2018.1536241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292363PMC
December 2018

Aggressive Metastatic GATA3-Positive Sarcomatoid Carcinoma with Rapid Progression and Invasion of the Liver.

Case Rep Oncol Med 2018 10;2018:6469591. Epub 2018 Sep 10.

Department of Medicine, Med Star Good Samaritan Hospital, Baltimore, MD 21234, USA.

. GATA3-positive sarcomatoid carcinoma has never been documented in the past. It is a case of aggressive tumor, positive for GATA3, which should be further studied for its prognostic and therapeutic significance.
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http://dx.doi.org/10.1155/2018/6469591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151684PMC
September 2018

Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types

Asian Pac J Cancer Prev 2018 Apr 27;19(4):1119-1125. Epub 2018 Apr 27.

Department of Physiology, Institute of Medical Sciences, Kohat, Pakistan. Email:

The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells. Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in the expression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expression RNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multiple organs cancer tissue microarray (TMAs) experiment. We found that while some tumors (Breast, Bladder, Lymph-node, Lung, Esophagus and Ovary) showed higher differences between normal and malignant tumors in XPO5 expression, there were tissues (Kidney and Brain) that have a significantly lower XPO5 expression in malignant tumors. We further studies these observations of overexpression and down-regulation of XPO5 in breast and kidney cancer cell lines and found that XPO5 might have a dual role in promoting or inhibiting tumor growth in different cancer tissue types.
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http://dx.doi.org/10.22034/APJCP.2018.19.4.1119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031805PMC
April 2018

Giant Benign Prostatic Hyperplasia in a Pakistani Patient.

Urol Case Rep 2014 Jan 24;2(1):33-4. Epub 2014 Jan 24.

Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.

"Giant hyperplasia" of the prostate is a rare pathology of the prostate gland. We report one such case, in which a successful retropubic prostatectomy was performed on an elderly male patient in Pakistan. The weight of the resected prostate was 700 g, which is the eighth largest prostate with benign prostatic hyperplasia reported.
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http://dx.doi.org/10.1016/j.eucr.2013.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733002PMC
January 2014

Case of hereditary papillary renal cell carcinoma.

J Community Hosp Intern Med Perspect 2011 26;1(4). Epub 2012 Jan 26.

Department of Internal Medicine, Union Memorial Hospital, Baltimore, MD, USA.

Renal cell carcinoma is the most common type of renal malignancy and it originates from the renal tubular epithelium. Due to the diversity in the histopathological and molecular characteristics, it is typically subclassified into five different categories. Papillary renal cell carcinoma is one subclassification and it includes two variants: sporadic and hereditary. Although the hereditary form comprises a smaller number of cases of papillary renal cell carcinoma, an understanding of the molecular pathways and genetic changes continues to play a significant role in the development of new targeted therapies. Along with recommending appropriate lifestyle modification, further investigation into the molecular pathogenesis of hereditary papillary renal cell carcinoma will continue to be invaluable for the clinical management of renal cell carcinoma. In this article, we discuss a case of the hereditary papillary renal cell carcinoma along with an overview of the disease.
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http://dx.doi.org/10.3402/jchimp.v1i4.9468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714050PMC
July 2013

Preoperative diagnosis of malignant mesothelioma of the tunica vaginalis using Doppler ultrasound.

Urology 2010 Feb 6;75(2):251-2. Epub 2009 Dec 6.

James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Malignant mesothelioma (MM) of the tunica vaginalis is a rare aggressive tumor with a high predilection for metastatic spread. Because there is no preoperative diagnostic modality available, it has high recurrence and mortality rates, which emphasizes the importance of early preoperative diagnosis for proper and adequate treatment. We describe a case of MM of the tunica vaginalis in a 73-year-old man who presented with hydrocele and was preoperatively diagnosed with MM using Doppler in addition to scrotal ultrasound. He underwent early radical orchiectomy through an inguinal approach, resulting in improved survival.
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http://dx.doi.org/10.1016/j.urology.2009.07.1275DOI Listing
February 2010