Sachio Morimoto

Sachio Morimoto

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Sachio Morimoto

Publications by authors named "Sachio Morimoto"

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Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.

Am J Physiol Heart Circ Physiol 2018 06 16;314(6):H1192-H1202. Epub 2018 Feb 16.

Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University , Tokyo , Japan.

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http://dx.doi.org/10.1152/ajpheart.00696.2017DOI Listing
June 2018

CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.

Biochem Biophys Res Commun 2018 02 31;496(4):1250-1256. Epub 2018 Jan 31.

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.01.181DOI Listing
February 2018

Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca transients.

Arch Biochem Biophys 2018 01 21;637:40-47. Epub 2017 Nov 21.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1016/j.abb.2017.11.009DOI Listing
January 2018

Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes.

Sci Rep 2017 08 24;7(1):9363. Epub 2017 Aug 24.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1038/s41598-017-09716-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571012PMC
August 2017

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation.

Auton Neurosci 2017 07 16;205:33-40. Epub 2017 Mar 16.

Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.

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http://dx.doi.org/10.1016/j.autneu.2017.03.002DOI Listing
July 2017

2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.

Hypertens Res 2017 Feb 15;40(2):130-139. Epub 2016 Sep 15.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1038/hr.2016.122DOI Listing
February 2017

GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy.

Am J Physiol Heart Circ Physiol 2016 06 22;310(11):H1808-15. Epub 2016 Apr 22.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

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http://dx.doi.org/10.1152/ajpheart.00771.2015DOI Listing
June 2016

Connexin45 contributes to global cardiovascular development by establishing myocardial impulse propagation.

Mech Dev 2016 05 23;140:41-52. Epub 2016 Feb 23.

Department of Anatomy and Neurobiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mod.2016.02.003DOI Listing
May 2016

Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.

Circ Heart Fail 2015 Jul 2;8(4):799-808. Epub 2015 Jun 2.

From the Departments of Cardiovascular Medicine (K.O., A.T.N., T.H., A.N., M.S., T.S., A.H., Y.K., T.O., Y.S.) and Cardiovascular Regenerative Medicine (J.-K.L.), Osaka University Graduate School of Medicine, Osaka, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan (A.T.N., T.S., S.N., T.O., H.A., J.-K.L., I.S., I.K.); Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (A.T.N., T.S., S.N., M.I., T.Y., H.A., I.K.); Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.M.); Department of Medicine II, Kansai Medical University, Osaka, Japan (I.S.); and Institute for Academic Initiatives, Osaka University, Osaka, Japan (I.K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001958DOI Listing
July 2015

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.

J Pharmacol Sci 2015 Apr 24;127(4):446-55. Epub 2015 Mar 24.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1016/j.jphs.2015.03.005DOI Listing
April 2015

Experimental models of inherited cardiomyopathy and its therapeutics.

World J Cardiol 2014 Dec;6(12):1245-51

Miki Nonaka, Sachio Morimoto, Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.4330/wjc.v6.i12.1245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278159PMC
December 2014

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.

Br J Pharmacol 2014 Oct 14;171(19):4440-54. Epub 2014 Aug 14.

Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1111/bph.12795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209150PMC
October 2014

Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy.

Pharmacol Res Perspect 2014 Oct 24;2(5):e00064. Epub 2014 Aug 24.

Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka, Japan.

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http://dx.doi.org/10.1002/prp2.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186424PMC
October 2014

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis.

Biochem Pharmacol 2014 Aug 20;90(4):397-405. Epub 2014 Jun 20.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.bcp.2014.06.011DOI Listing
August 2014

In vivo effects of propyl gallate, a novel Ca(2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation.

Life Sci 2014 Jul 12;109(1):15-9. Epub 2014 Jun 12.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.lfs.2014.06.004DOI Listing
July 2014

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice.

Biochem Pharmacol 2014 Jun 23;89(3):340-8. Epub 2014 Mar 23.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.03.006DOI Listing
June 2014

Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines.

J Pharmacol Sci 2013 25;121(2):103-9. Epub 2013 Jan 25.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1254/jphs.12204fpDOI Listing
February 2014

Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β.

Biochem Biophys Res Commun 2013 Nov 4;440(4):677-82. Epub 2013 Oct 4.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X130163
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http://dx.doi.org/10.1016/j.bbrc.2013.09.126DOI Listing
November 2013

Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.

J Mol Cell Cardiol 2013 Oct 14;63:69-78. Epub 2013 Jul 14.

Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan; Department of Cardiac Surgery, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.yjmcc.2013.07.001DOI Listing
October 2013

Inherited cardiomyopathies caused by troponin mutations.

J Geriatr Cardiol 2013 Mar;10(1):91-101

Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China.

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http://dx.doi.org/10.3969/j.issn.1671-5411.2013.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627712PMC
March 2013

Cardiomyopathies: classification, clinical characterization, and functional phenotypes.

Biochem Res Int 2012 4;2012:870942. Epub 2012 Dec 4.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1155/2012/870942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529434PMC
January 2013

Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure.

J Mol Cell Cardiol 2012 Dec 19;53(6):760-7. Epub 2012 Aug 19.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.yjmcc.2012.08.006DOI Listing
December 2012

DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines.

Biochem Pharmacol 2012 Jan 8;83(1):47-56. Epub 2011 Oct 8.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.bcp.2011.10.001DOI Listing
January 2012

β(1)-Adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects.

J Pharmacol Sci 2011 16;115(4):490-9. Epub 2011 Mar 16.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan.

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http://dx.doi.org/10.1254/jphs.10332fpDOI Listing
August 2011

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts.

Biochem Biophys Res Commun 2011 May 3;409(1):108-13. Epub 2011 May 3.

Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.124DOI Listing
May 2011

Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity.

J Pharmacol Sci 2010 20;112(3):320-6. Epub 2010 Feb 20.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1254/jphs.09348fpDOI Listing
October 2010

Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.

Cardiovasc Res 2010 Sep 7;87(4):636-46. Epub 2010 May 7.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1093/cvr/cvq133DOI Listing
September 2010

Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins.

J Mol Cell Cardiol 2010 May 15;48(5):934-42. Epub 2010 Jan 15.

Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854196PMC
May 2010

Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation.

Cardiovasc Res 2009 Oct 28;84(1):64-71. Epub 2009 May 28.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1093/cvr/cvp168DOI Listing
October 2009

Role of protein kinase C in thin filament activation by rigor-like cross-bridges under ischemic conditions.

Authors:
Sachio Morimoto

J Mol Cell Cardiol 2009 Sep 21;47(3):350-1. Epub 2009 Jun 21.

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http://dx.doi.org/10.1016/j.yjmcc.2009.06.007DOI Listing
September 2009

The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells.

Hypertens Res 2009 Aug 29;32(8):690-9. Epub 2009 May 29.

Faculty of Medical Sciences, Department of Clinical Pharmacology, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1038/hr.2009.76DOI Listing
August 2009

Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament.

J Pharmacol Sci 2009 Mar;109(3):456-8

Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan.

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http://dx.doi.org/10.1254/jphs.08266scDOI Listing
March 2009

Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice.

Biochem Biophys Res Commun 2009 Jan 12;378(4):851-6. Epub 2008 Dec 12.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.152DOI Listing
January 2009

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells.

Biochem Biophys Res Commun 2008 Dec 5;377(4):1185-90. Epub 2008 Nov 5.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.10.115DOI Listing
December 2008

Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.

Dev Biol 2008 Oct 16;322(1):65-73. Epub 2008 Jul 16.

Department of Developmental Molecular Anatomy, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.ydbio.2008.07.007DOI Listing
October 2008

Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion.

Cardiovasc Res 2008 Sep 5;79(4):589-99. Epub 2008 Jun 5.

Center for Gene Research, Yamaguchi University, Yamaguchi 755-8505, Japan.

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http://dx.doi.org/10.1093/cvr/cvn148DOI Listing
September 2008

Troponin: regulatory function and disorders.

Biochem Biophys Res Commun 2008 Apr 26;369(1):62-73. Epub 2007 Dec 26.

Department of Cell Physiology, Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.11.187DOI Listing
April 2008

Sarcomeric proteins and inherited cardiomyopathies.

Authors:
Sachio Morimoto

Cardiovasc Res 2008 Mar 4;77(4):659-66. Epub 2007 Dec 4.

Laboratory of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1093/cvr/cvm084DOI Listing
March 2008

Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects.

Hypertens Res 2008 Jan;31(1):75-81

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fuuoka, Japan.

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http://dx.doi.org/10.1291/hypres.31.75DOI Listing
January 2008

Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation.

Circ Res 2007 Jul 7;101(2):185-94. Epub 2007 Jun 7.

Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Maidashi, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1161/CIRCRESAHA.106.146670DOI Listing
July 2007

Celecoxib induces apoptosis by inhibiting the expression of survivin in HeLa cells.

Biochem Biophys Res Commun 2007 Jun 19;357(4):1166-71. Epub 2007 Apr 19.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.04.077DOI Listing
June 2007

Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells.

Biochem Pharmacol 2007 May 5;73(9):1318-29. Epub 2007 Jan 5.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.bcp.2006.12.033DOI Listing
May 2007

Molecular pathogenic mechanisms of cardiomyopathies caused by mutations in cardiac troponin T.

Authors:
Sachio Morimoto

Adv Exp Med Biol 2007 ;592:227-39

Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1007/978-4-431-38453-3_19DOI Listing
March 2007

Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.

J Biol Chem 2006 Dec 17;281(50):38489-97. Epub 2006 Oct 17.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1074/jbc.M605205200DOI Listing
December 2006

Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells.

Biochem Biophys Res Commun 2005 Dec 14;338(2):903-9. Epub 2005 Oct 14.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.018DOI Listing
December 2005

Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

Biochem Biophys Res Commun 2005 Dec 2;338(3):1519-26. Epub 2005 Nov 2.

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.116DOI Listing
December 2005

Synthetic peptides of actin-tropomyosin binding region of troponin I and heat shock protein 20 modulate the relaxation process of skinned preparations of taenia caeci from guinea pig.

Jpn J Physiol 2005 Dec 19;55(6):373-8. Epub 2006 Jan 19.

Department of Physiology, Tokyo Medical University, Tokyo 160-8402, Japan.

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http://dx.doi.org/10.2170/jjphysiol.RP002605DOI Listing
December 2005

Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma.

Exp Cell Res 2005 Nov 8;310(2):426-33. Epub 2005 Sep 8.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.yexcr.2005.07.024DOI Listing
November 2005

Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells.

Arterioscler Thromb Vasc Biol 2005 May 17;25(5):970-5. Epub 2005 Feb 17.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://atvb.ahajournals.org/content/25/5/970.full.pdf
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http://atvb.ahajournals.org/cgi/doi/10.1161/01.ATV.000015970
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http://dx.doi.org/10.1161/01.ATV.0000159702.68591.0dDOI Listing
May 2005

SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure.

J Pharmacol Sci 2005 Jan 8;97(1):53-60. Epub 2005 Jan 8.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1254/jphs.fp0040654DOI Listing
January 2005

Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.

Anat Rec A Discov Mol Cell Evol Biol 2004 Oct;280(2):973-9

Department of Developmental Molecular Anatomy, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/ar.a.20110DOI Listing
October 2004

PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.

Eur J Pharmacol 2004 Aug;497(2):155-60

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2004.06.050DOI Listing
August 2004

Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation.

Biochem Biophys Res Commun 2004 Jun;319(1):163-8

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2004.04.163DOI Listing
June 2004

Several aspects of calcium regulator mechanisms linked to troponin.

Adv Exp Med Biol 2003 ;538:221-9; discussion 229

Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1007/978-1-4419-9029-7_21DOI Listing
May 2004

Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts.

Biochem Biophys Res Commun 2004 Apr;316(2):411-5

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0400319
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http://dx.doi.org/10.1016/j.bbrc.2004.02.061DOI Listing
April 2004

Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization.

J Mol Cell Cardiol 2003 Dec;35(12):1421-7

Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.yjmcc.2003.09.003DOI Listing
December 2003

[The crystal structure of troponin and the mechanism of calcium regulation].

Tanpakushitsu Kakusan Koso 2003 Nov;48(14):1877-89

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November 2003

15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells.

Am J Physiol Heart Circ Physiol 2003 Jul 6;285(1):H38-46. Epub 2003 Mar 6.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1152/ajpheart.01037.2002DOI Listing
July 2003

Troponin I inhibitory peptide suppresses the force generation in smooth muscle by directly interfering with cross-bridge formation.

Biochem Biophys Res Commun 2003 Jul;307(2):236-40

Department of Physiology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1016/s0006-291x(03)01170-7DOI Listing
July 2003

Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.

J Biol Chem 2003 Mar 8;278(11):9663-70. Epub 2003 Jan 8.

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M205768200
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http://dx.doi.org/10.1074/jbc.M205768200DOI Listing
March 2003

Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis.

J Invest Dermatol 2002 Nov;119(5):1008-13

Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1046/j.1523-1747.2002.19525.xDOI Listing
November 2002

[Abnormal myocardial contractile regulation mechanism in familial hypertrophic and dilated cardiomyopathies--functional analysis of molecular mutant troponin in in-vitro].

Authors:
Sachio Morimoto

Fukuoka Igaku Zasshi 2002 Jan;93(1):1-5

Laboratory of Clinical Pharmacology, Department of Molecular Physiology, Kyushu University Graduate School of Medicine 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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January 2002