Publications by authors named "Sabrina Arena"

38Publications

Oxaliplatin retreatment in metastatic colorectal cancer: Systematic review and future research opportunities.

Authors:
Gianluca Mauri Viviana Gori Erica Bonazzina Alessio Amatu Federica Tosi Katia Bencardino Lorenzo Ruggieri Giorgio Patelli Sabrina Arena Alberto Bardelli Salvatore Siena Andrea Sartore-Bianchi

Cancer Treat Rev 2020 Dec 9;91:102112. Epub 2020 Oct 9.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Milano, Italy. Electronic address:

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December 2020

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.

Authors:
Emiliano Cocco Ji Eun Lee Srinivasaraghavan Kannan Alison M Schram Helen H Won Sophie Shifman Amanda Kulick Laura Baldino Eneda Toska Amaia Arruabarrena-Aristorena Srushti Kittane Fan Wu Yanyan Cai Sabrina Arena Benedetta Mussolin Ram Kannan Neil Vasan Alexander N Gorelick Michael F Berger Ofra Novoplansky Sankar Jagadeeshan Yi Liao Uwe Rix Sandra Misale Barry S Taylor Alberto Bardelli Jaclyn F Hechtman David M Hyman Moshe Elkabets Elisa de Stanchina Chandra S Verma Andrea Ventura Alexander Drilon Maurizio Scaltriti

Cancer Discov 2020 Oct 1. Epub 2020 Oct 1.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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October 2020

EGFR Blockade Reverts Resistance to KRAS Inhibition in Colorectal Cancer.

Authors:
Vito Amodio Rona Yaeger Pamela Arcella Carlotta Cancelliere Simona Lamba Annalisa Lorenzato Sabrina Arena Monica Montone Benedetta Mussolin Yu Bian Adele Whaley Marika Pinnelli Yonina R Murciano-Goroff Efsevia Vakiani Nicola Valeri Wei-Li Liao Anuja Bhalkikar Sheeno Thyparambil Hui-Yong Zhao Elisa de Stanchina Silvia Marsoni Salvatore Siena Andrea Bertotti Livio Trusolino Bob T Li Neal Rosen Federica Di Nicolantonio Alberto Bardelli Sandra Misale

Cancer Discov 2020 Aug 19;10(8):1129-1139. Epub 2020 May 19.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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August 2020

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer.

Authors:
Annalisa Lorenzato Alessandro Magrì Vittoria Matafora Valentina Audrito Pamela Arcella Luca Lazzari Monica Montone Simona Lamba Silvia Deaglio Salvatore Siena Andrea Bertotti Livio Trusolino Angela Bachi Federica Di Nicolantonio Alberto Bardelli Sabrina Arena

Cancers (Basel) 2020 Mar 14;12(3). Epub 2020 Mar 14.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo 10060 (TO), Italy.

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March 2020

High-dose vitamin C enhances cancer immunotherapy.

Authors:
Alessandro Magrì Giovanni Germano Annalisa Lorenzato Simona Lamba Rosaria Chilà Monica Montone Vito Amodio Tommaso Ceruti Francesco Sassi Sabrina Arena Sergio Abrignani Maurizio D'Incalci Massimo Zucchetti Federica Di Nicolantonio Alberto Bardelli

Sci Transl Med 2020 02;12(532)

Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.

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February 2020

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin.

Authors:
Sabrina Arena Giorgio Corti Erika Durinikova Monica Montone Nicole M Reilly Mariangela Russo Annalisa Lorenzato Pamela Arcella Luca Lazzari Giuseppe Rospo Massimiliano Pagani Carlotta Cancelliere Carola Negrino Claudio Isella Alice Bartolini Andrea Cassingena Alessio Amatu Gianluca Mauri Andrea Sartore-Bianchi Gloria Mittica Enzo Medico Silvia Marsoni Michael Linnebacher Sergio Abrignani Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Clin Cancer Res 2020 03 12;26(6):1372-1384. Epub 2019 Dec 12.

Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Torino, Italy.

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March 2020

Adaptive mutability of colorectal cancers in response to targeted therapies.

Authors:
Mariangela Russo Giovanni Crisafulli Alberto Sogari Nicole M Reilly Sabrina Arena Simona Lamba Alice Bartolini Vito Amodio Alessandro Magrì Luca Novara Ivana Sarotto Zachary D Nagel Cortt G Piett Alessio Amatu Andrea Sartore-Bianchi Salvatore Siena Andrea Bertotti Livio Trusolino Mattia Corigliano Marco Gherardi Marco Cosentino Lagomarsino Federica Di Nicolantonio Alberto Bardelli

Science 2019 12 7;366(6472):1473-1480. Epub 2019 Nov 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy.

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December 2019

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Authors:
Luca Lazzari Giorgio Corti Gabriele Picco Claudio Isella Monica Montone Pamela Arcella Erika Durinikova Eugenia R Zanella Luca Novara Fabiane Barbosa Andrea Cassingena Carlotta Cancelliere Enzo Medico Andrea Sartore-Bianchi Salvatore Siena Mathew J Garnett Andrea Bertotti Livio Trusolino Federica Di Nicolantonio Michael Linnebacher Alberto Bardelli Sabrina Arena

Clin Cancer Res 2019 10 2;25(20):6243-6259. Epub 2019 Aug 2.

Department of Oncology, University of Torino, Candiolo, Torino, Italy.

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October 2019

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

Authors:
Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Nat Commun 2018 06 12;9(1):2287. Epub 2018 Jun 12.

Candiolo Cancer Institute-FPO, IRCCS, 10060, Candiolo, Turin, Italy.

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June 2018

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.

Authors:
Moiez Ali Erin Kaltenbrun Grace R Anderson Sarah Jo Stephens Sabrina Arena Alberto Bardelli Christopher M Counter Kris C Wood

Nat Commun 2017 06 8;8:15617. Epub 2017 Jun 8.

Department of Pharmacology and Cancer Biology, Duke University, Durham, North California 27710, USA.

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June 2017

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Authors:
Beth O Van Emburgh Sabrina Arena Giulia Siravegna Luca Lazzari Giovanni Crisafulli Giorgio Corti Benedetta Mussolin Federica Baldi Michela Buscarino Alice Bartolini Emanuele Valtorta Joana Vidal Beatriz Bellosillo Giovanni Germano Filippo Pietrantonio Agostino Ponzetti Joan Albanell Salvatore Siena Andrea Sartore-Bianchi Federica Di Nicolantonio Clara Montagut Alberto Bardelli

Nat Commun 2016 12 8;7:13665. Epub 2016 Dec 8.

Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Torino, Italy.

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December 2016

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.

Authors:
Daniele Oddo Erin M Sennott Ludovic Barault Emanuele Valtorta Sabrina Arena Andrea Cassingena Genny Filiciotto Giulia Marzolla Elena Elez Robin M J M van Geel Alice Bartolini Giovanni Crisafulli Valentina Boscaro Jason T Godfrey Michela Buscarino Carlotta Cancelliere Michael Linnebacher Giorgio Corti Mauro Truini Giulia Siravegna Julieta Grasselli Margherita Gallicchio René Bernards Jan H M Schellens Josep Tabernero Jeffrey A Engelman Andrea Sartore-Bianchi Alberto Bardelli Salvatore Siena Ryan B Corcoran Federica Di Nicolantonio

Cancer Res 2016 08 16;76(15):4504-15. Epub 2016 Jun 16.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino, Italy.

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August 2016

The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer.

Authors:
Francisco J Sánchez-Martín Beatriz Bellosillo Mariona Gelabert-Baldrich Alba Dalmases Israel Cañadas Joana Vidal Alejandro Martinez Guillem Argilés Giulia Siravegna Sabrina Arena Klaus Koefoed Laura Visa Oriol Arpí Ivan David Horak Mar Iglesias Christopher Stroh Michael Kragh Ana Rovira Joan Albanell Josep Tabernero Alberto Bardelli Clara Montagut

Clin Cancer Res 2016 07 17;22(13):3260-7. Epub 2016 Feb 17.

Cancer Research Program, IMIM, Hospital del Mar, Barcelona, Spain. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain.

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July 2016

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

Authors:
Sabrina Arena Giulia Siravegna Benedetta Mussolin Jeffrey D Kearns Beni B Wolf Sandra Misale Luca Lazzari Andrea Bertotti Livio Trusolino Alex A Adjei Clara Montagut Federica Di Nicolantonio Rachel Nering Alberto Bardelli

Sci Transl Med 2016 Feb;8(324):324ra14

Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO), IRCCS, Candiolo, Torino 10060, Italy. Department of Oncology, University of Torino, Candiolo, Torino 10060, Italy.

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February 2016

Tivantinib (ARQ 197) affects the apoptotic and proliferative machinery downstream of c-MET: role of Mcl-1, Bcl-xl and Cyclin B1.

Authors:
Shuai Lu Helga-Paula Török Eike Gallmeier Frank T Kolligs Antonia Rizzani Sabrina Arena Burkhard Göke Alexander L Gerbes Enrico N De Toni

Oncotarget 2015 Sep;6(26):22167-78

Medizinische Klinik und Poliklinik 2, Klinikum der Universität München, Campus Grosshadern, Munich, Germany.

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September 2015

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

Authors:
Sabrina Arena Beatriz Bellosillo Giulia Siravegna Alejandro Martínez Israel Cañadas Luca Lazzari Noelia Ferruz Mariangela Russo Sandra Misale Iria González Mar Iglesias Elena Gavilan Giorgio Corti Sebastijan Hobor Giovanni Crisafulli Marta Salido Juan Sánchez Alba Dalmases Joaquim Bellmunt Gianni De Fabritiis Ana Rovira Federica Di Nicolantonio Joan Albanell Alberto Bardelli Clara Montagut

Clin Cancer Res 2015 May 26;21(9):2157-66. Epub 2015 Jan 26.

Cancer Research Program, IMIM (Institut Hospital del Mar Investigacions Mediques), Hospital del Mar, Barcelona, Spain. Department of Medical Oncology, Hospital del Mar, Barcelona, Spain.

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May 2015

The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.

Authors:
Martina Olivero Daniela Dettori Sabrina Arena Davide Zecchin Erica Lantelme Maria Flavia Di Renzo

Oncotarget 2014 Aug;5(15):5992-6002

Department of Oncology, University of Torino, Candiolo, Torino, Italy; Candiolo Cancer Institute - FPO IRCCS, Candiolo, Torino, Italy.

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August 2014

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

Authors:
Sandra Misale Sabrina Arena Simona Lamba Giulia Siravegna Alice Lallo Sebastijan Hobor Mariangela Russo Michela Buscarino Luca Lazzari Andrea Sartore-Bianchi Katia Bencardino Alessio Amatu Calogero Lauricella Emanuele Valtorta Salvatore Siena Federica Di Nicolantonio Alberto Bardelli

Sci Transl Med 2014 Feb;6(224):224ra26

Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.

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February 2014

Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels.

Authors:
Emily Hannah Crowley Sabrina Arena Simona Lamba Federica Di Nicolantonio Alberto Bardelli

Hum Mutat 2014 Feb 27;35(2):208-14. Epub 2013 Dec 27.

IRCC, Institute for Cancer Research at Candiolo, SP142 Km 3.95, Torino, Italy.

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February 2014

BRAF V600E is a determinant of sensitivity to proteasome inhibitors.

Authors:
Davide Zecchin Valentina Boscaro Enzo Medico Ludovic Barault Miriam Martini Sabrina Arena Carlotta Cancelliere Alice Bartolini Emily H Crowley Alberto Bardelli Margherita Gallicchio Federica Di Nicolantonio

Mol Cancer Ther 2013 Dec 9;12(12):2950-61. Epub 2013 Oct 9.

Corresponding Authors: Federica Di Nicolantonio, Department of Oncology, University of Torino, Institute for Cancer Research and Treatment at Candiolo, Strada Provinciale 142 Km 3.95, Candiolo, I-10060, Turin, Italy.

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December 2013