Publications by authors named "Sabine Tejpar"

100Publications

The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.

Oncogene 2020 04 6;39(17):3571-3587. Epub 2020 Mar 6.

Laboratory of Biochemical Neuroendocrinology, Department of Human Genetics, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41388-020-1238-zDOI Listing
April 2020

Radiomics Response Signature for Identification of Metastatic Colorectal Cancer Sensitive to Therapies Targeting EGFR Pathway.

J Natl Cancer Inst 2020 Sep;112(9):902-912

Department of Hepato-Gastroenterology, Cliniques Universitaires Saint-Luc, UCLouvain Brussels, Brussels, Belgium.

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http://dx.doi.org/10.1093/jnci/djaa017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492770PMC
September 2020

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology.

Oncoimmunology 2020 9;9(1):1703449. Epub 2020 Jan 9.

Cell Death Research & Therapy (CDRT) unit, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1080/2162402X.2019.1703449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959434PMC
January 2020

Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ.

EMBO Mol Med 2020 01 2;12(1):e10681. Epub 2019 Dec 2.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.15252/emmm.201910681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949488PMC
January 2020

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.

Cell Mol Gastroenterol Hepatol 2019 5;8(2):269-290. Epub 2019 Apr 5.

Conjoint Gastroenterology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia; School of Medicine, University of Queensland, Queensland, Australia; Chemical Pathology Department, Pathology Queensland, Queensland, Australia.

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699251PMC
July 2020

Deregulation of ZIC Family Members in Oncogenesis.

Adv Exp Med Biol 2018 ;1046:329-338

Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-981-10-7311-3_16DOI Listing
July 2018

Steps forward for cancer precision medicine.

Nat Rev Drug Discov 2018 01 24;17(1):1-2. Epub 2017 Nov 24.

EORTC Headquarters, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1038/nrd.2017.218DOI Listing
January 2018

Societal challenges of precision medicine: Bringing order to chaos.

Eur J Cancer 2017 10 4;84:325-334. Epub 2017 Sep 4.

EORTC Headquarters, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.028DOI Listing
October 2017

Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes.

Eur J Cancer 2017 10 5;84:69-80. Epub 2017 Aug 5.

USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505124PMC
October 2017

Virtual chromoendoscopy (I-SCAN) detects more polyps in patients with Lynch syndrome: a randomized controlled crossover trial.

Endoscopy 2017 Apr 20;49(4):342-350. Epub 2017 Jan 20.

Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-121005
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http://dx.doi.org/10.1055/s-0042-121005DOI Listing
April 2017

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer.

Nat Rev Cancer 2017 02 4;17(2):79-92. Epub 2017 Jan 4.

Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/nrc.2016.126DOI Listing
February 2017

Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.

Hum Mol Genet 2016 09 27;25(18):3946-3959. Epub 2016 Jul 27.

John Curtin School of Medical Research and Research School of Biology, Australian National University, Canberra, Australia

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http://dx.doi.org/10.1093/hmg/ddw235DOI Listing
September 2016

Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer.

Clin Cancer Res 2016 06 9;22(12):3037-47. Epub 2016 Feb 9.

Division of Anatomic Pathology, Department of Surgical and Diagnostic Sciences, University of Genoa and IRCCS S. Martino/IST University Hospital, Genoa, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0939DOI Listing
June 2016

Microsatellite Instability and BRAF and KRAS Mutations in Stage III Colon Cancer: Requirements for Accurate Prognosis Assessment.

JAMA Oncol 2016 May;2(5):653-654

Molecular Digestive Oncology Unit, Leuven University Hospital, Leuven, Belgium.

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http://dx.doi.org/10.1001/jamaoncol.2015.5226DOI Listing
May 2016

Charting the Course for a New Cancer Clinical Research Culture.

Public Health Genomics 2015 20;18(6):381-5. Epub 2015 Nov 20.

Laboratory of Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000441558DOI Listing
October 2016

Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.

Biomed Res Int 2015 7;2015:321276. Epub 2015 Jun 7.

Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2015/321276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475562PMC
March 2016

Integrating biomarkers in colorectal cancer trials in the West and China.

Nat Rev Clin Oncol 2015 Sep 12;12(9):553-60. Epub 2015 May 12.

American Society of Clinical Oncology, 2318 Mill Road, Suite 800, Alexandria, VA 22314, USA.

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http://dx.doi.org/10.1038/nrclinonc.2015.88DOI Listing
September 2015

Response.

J Natl Cancer Inst 2015 Mar 10;107(5). Epub 2015 Mar 10.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Ludwig Center for Cancer Research and Oncology Department, University of Lausanne, Lausanne, Switzerland (MD); Digestive Oncology Unit and Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium (ST); Oncosurgery, Geneva University Hospital Geneva, Switzerland (AR); Department of Pathology, Lausanne University, Lausanne, Switzerland (FTB).

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http://dx.doi.org/10.1093/jnci/djv056DOI Listing
March 2015

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

Sci Transl Med 2015 Jan;7(272):272ra12

Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy. Translational Cancer Medicine, Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 10060 Candiolo, Torino, Italy. National Institute of Biostructures and Biosystems, 00136 Rome, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3010445DOI Listing
January 2015

Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer.

J Clin Oncol 2015 Mar 20;33(7):692-700. Epub 2015 Jan 20.

Eric Van Cutsem and Sabine Tejpar, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium; Heinz-Josef Lenz, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Claus-Henning Köhne, Klinikum Oldenburg, Oldenburg; Volker Heinemann, University Hospital Grosshadern, Munich; Ivan Melezínek, Frank Beier, and Christopher Stroh, Merck KGaA, Darmstadt, Germany; Philippe Rougier, Paris Descartes University, Hôpital Européen Georges Pompidou, Paris, France; J. Han van Krieken, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; and Fortunato Ciardiello, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1200/JCO.2014.59.4812DOI Listing
March 2015

Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data.

J Natl Cancer Inst 2014 Oct 22;106(10). Epub 2014 Sep 22.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland (AFDN, SR, VP, PW, EB, MD); Digestive Oncology Unit and Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium (ST); Department of Pathology, Lausanne University, Lausanne, Switzerland (PY, FB); Oncology Research Unit, Worldwide Research and Development, Pfizer Inc., La Jolla, CA (TX, HE, AP, MM, EM, WS); Oncosurgery, Geneva University Hospital Geneva, Switzerland (AR); SAKK Coordination Center, Bern, Switzerland (AR); Ludwig Center for Cancer Research (MD) and Oncology Department, University of Lausanne, Lausanne, Switzerland (MD).

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http://dx.doi.org/10.1093/jnci/dju247DOI Listing
October 2014

European perspective for effective cancer drug development.

Nat Rev Clin Oncol 2014 08 17;11(8):492-8. Epub 2014 Jun 17.

UniversitaetsSpital Zurich, Division of Oncology, Raemistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nrclinonc.2014.98DOI Listing
August 2014

Hsa-miR-31-3p expression is linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy.

Clin Cancer Res 2014 Jun 25;20(12):3338-47. Epub 2014 Apr 25.

Authors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, service d'Hépato-Gastro-Entérologie et d'Oncologie Digestive; Université Paris-Est Créteil; Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil; Department of Medicine, Institut Gustave Roussy, Villejuif; and Department of Biology, Assistance Publique-Hôpitaux de Paris, European Georges Pompidou, Paris; Université de Reims Champagne-Ardenne; Centre Hospitalier Universitaire de Reims, Reims; Service d'Anatomo-Pathologie, Centre Val d'Aurelle Paul-Lamarque, Montpellier; Université Clermont-Ferrand, Centre Jean Perrin, Clermont-Ferrand, France; Department of Gastroenterology, GI Cancer Unit; Department of Pathological Anatomy, Erasme University Hospital, Brussels; Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Haartman Institute, University of Helsinki; Department of Oncology, Helsinki University Central Hospital and Helsinki University; HUSLAB, Department of Pathology and Genetic Laboratory, Helsinki; and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandAuthors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpit

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2750DOI Listing
June 2014

High-dosage tamoxifen as neoadjuvant treatment in minimally invasive surgery for Dupuytren disease in patients with a strong predisposition toward fibrosis: a randomized controlled trial.

J Bone Joint Surg Am 2014 Apr;96(8):655-62

Hand Unit, Orthopaedic Department, Pellenberg Campus, University Hospitals Leuven, Weligerveld 1, 3212 Pellenberg, Belgium. E-mail address for I. Degreef: E-mail address for L. De Smet:

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https://insights.ovid.com/crossref?an=00004623-201404160-000
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http://dx.doi.org/10.2106/JBJS.L.01623DOI Listing
April 2014

Personalized medicine in metastatic colorectal cancer treated with anti-epidermal growth factor receptor agents: a future opportunity?

Asia Pac J Clin Oncol 2014 Mar;10 Suppl 1:2-10

Digestive Oncology Unit, University Hospital Gasthiusberg, Leuven, Belgium.

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http://dx.doi.org/10.1111/ajco.12176DOI Listing
March 2014

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer.

BMC Cancer 2013 Sep 27;13:439. Epub 2013 Sep 27.

Institute of Biostatistics and Analyses, Masaryk University, Kotlarska 2, Brno, 611 37, Czech Republic.

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http://dx.doi.org/10.1186/1471-2407-13-439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849526PMC
September 2013

Use of early tumor shrinkage to predict long-term outcome in metastatic colorectal cancer treated with cetuximab.

J Clin Oncol 2013 Oct 16;31(30):3764-75. Epub 2013 Sep 16.

Hubert Piessevaux, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels; Marc Buyse, International Drug Development Institute, Louvain-la-Neuve; Eric Van Cutsem and Sabine Tejpar, University Hospital Gasthuisberg, Leuven, Belgium; Michael Schlichting and Steffen Heeger, Merck KGaA, Darmstadt; and Carsten Bokemeyer, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1200/JCO.2012.42.8532DOI Listing
October 2013

Biopsies: next-generation biospecimens for tailoring therapy.

Nat Rev Clin Oncol 2013 Aug 25;10(8):437-50. Epub 2013 Jun 25.

Department of Surgery, Jewish General Hospital, McGill University, 3755 Côte Sainte Catherine Road, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2013.101DOI Listing
August 2013

The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.

Cell Mol Life Sci 2013 Oct 27;70(20):3791-811. Epub 2013 Feb 27.

Department of Oncology, Katholieke Universiteit Leuven, O&N1, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00018-013-1285-5DOI Listing
October 2013

Bevacizumab plus chemotherapy as salvage treatment in chemorefractory patients with metastatic colorectal cancer.

Onco Targets Ther 2013 25;6:53-8. Epub 2013 Jan 25.

Gastrointestinal Malignancies Service, Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; ; Department of Gastroenterology, Digestive Oncology Unit, University Hospitals Leuven, Leuven, Belgium;

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http://dx.doi.org/10.2147/OTT.S41383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558253PMC
February 2013

microRNAs in colon cancer: a roadmap for discovery.

FEBS Lett 2012 Sep;586(19):3000-7

Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.febslet.2012.07.048DOI Listing
September 2012

Overcoming resistance to antiangiogenic therapies.

Oncologist 2012 6;17(8):1039-50. Epub 2012 Jul 6.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.

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http://dx.doi.org/10.1634/theoncologist.2012-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425522PMC
April 2013

Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.

J Clin Oncol 2012 Oct 25;30(29):3570-7. Epub 2012 Jun 25.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium B-3000.

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http://dx.doi.org/10.1200/JCO.2012.42.2592DOI Listing
October 2012

Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer.

J Clin Oncol 2012 Apr 5;30(12):1288-95. Epub 2012 Mar 5.

Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Quartier Sorge, Genopode, CH-1015 Lausanne, Switzerland.

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http://ascopubs.org/doi/10.1200/JCO.2011.39.5814
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http://dx.doi.org/10.1200/JCO.2011.39.5814DOI Listing
April 2012

CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material.

Genes Chromosomes Cancer 2012 Apr 8;51(4):344-52. Epub 2011 Dec 8.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/gcc.21920DOI Listing
April 2012

Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents.

Target Oncol 2011 Dec 24;6(4):227-33. Epub 2011 Nov 24.

Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11523-011-0200-yDOI Listing
December 2011