Sabine Tejpar

Sabine Tejpar

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Sabine Tejpar

Publications by authors named "Sabine Tejpar"

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Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.

Cell Mol Gastroenterol Hepatol 2019 5;8(2):269-290. Epub 2019 Apr 5.

Conjoint Gastroenterology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia; School of Medicine, University of Queensland, Queensland, Australia; Chemical Pathology Department, Pathology Queensland, Queensland, Australia.

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http://dx.doi.org/10.1016/j.jcmgh.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699251PMC
April 2019

Deregulation of ZIC Family Members in Oncogenesis.

Adv Exp Med Biol 2018 ;1046:329-338

Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-981-10-7311-3_16DOI Listing
July 2018

Steps forward for cancer precision medicine.

Nat Rev Drug Discov 2018 01 24;17(1):1-2. Epub 2017 Nov 24.

EORTC Headquarters, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1038/nrd.2017.218DOI Listing
January 2018

Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes.

Eur J Cancer 2017 10 5;84:69-80. Epub 2017 Aug 5.

USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.016DOI Listing
October 2017

Societal challenges of precision medicine: Bringing order to chaos.

Eur J Cancer 2017 10 4;84:325-334. Epub 2017 Sep 4.

EORTC Headquarters, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.028DOI Listing
October 2017

Virtual chromoendoscopy (I-SCAN) detects more polyps in patients with Lynch syndrome: a randomized controlled crossover trial.

Endoscopy 2017 Apr 20;49(4):342-350. Epub 2017 Jan 20.

Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-121005
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http://dx.doi.org/10.1055/s-0042-121005DOI Listing
April 2017

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer.

Nat Rev Cancer 2017 02 4;17(2):79-92. Epub 2017 Jan 4.

Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/nrc.2016.126DOI Listing
February 2017

Charting the Course for a New Cancer Clinical Research Culture.

Public Health Genomics 2015 20;18(6):381-5. Epub 2015 Nov 20.

Laboratory of Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000441558DOI Listing
October 2016

Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.

Hum Mol Genet 2016 09 27;25(18):3946-3959. Epub 2016 Jul 27.

John Curtin School of Medical Research and Research School of Biology, Australian National University, Canberra, Australia

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http://dx.doi.org/10.1093/hmg/ddw235DOI Listing
September 2016

Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer.

Clin Cancer Res 2016 06 9;22(12):3037-47. Epub 2016 Feb 9.

Division of Anatomic Pathology, Department of Surgical and Diagnostic Sciences, University of Genoa and IRCCS S. Martino/IST University Hospital, Genoa, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0939DOI Listing
June 2016

Microsatellite Instability and BRAF and KRAS Mutations in Stage III Colon Cancer: Requirements for Accurate Prognosis Assessment.

JAMA Oncol 2016 May;2(5):653-654

Molecular Digestive Oncology Unit, Leuven University Hospital, Leuven, Belgium.

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http://dx.doi.org/10.1001/jamaoncol.2015.5226DOI Listing
May 2016

Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.

Biomed Res Int 2015 7;2015:321276. Epub 2015 Jun 7.

Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2015/321276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475562PMC
March 2016

Integrating biomarkers in colorectal cancer trials in the West and China.

Nat Rev Clin Oncol 2015 Sep 12;12(9):553-60. Epub 2015 May 12.

American Society of Clinical Oncology, 2318 Mill Road, Suite 800, Alexandria, VA 22314, USA.

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http://dx.doi.org/10.1038/nrclinonc.2015.88DOI Listing
September 2015

Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer.

J Clin Oncol 2015 Mar 20;33(7):692-700. Epub 2015 Jan 20.

Eric Van Cutsem and Sabine Tejpar, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium; Heinz-Josef Lenz, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Claus-Henning Köhne, Klinikum Oldenburg, Oldenburg; Volker Heinemann, University Hospital Grosshadern, Munich; Ivan Melezínek, Frank Beier, and Christopher Stroh, Merck KGaA, Darmstadt, Germany; Philippe Rougier, Paris Descartes University, Hôpital Européen Georges Pompidou, Paris, France; J. Han van Krieken, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; and Fortunato Ciardiello, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1200/JCO.2014.59.4812DOI Listing
March 2015

Response.

J Natl Cancer Inst 2015 Mar 10;107(5). Epub 2015 Mar 10.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland (MD); Ludwig Center for Cancer Research and Oncology Department, University of Lausanne, Lausanne, Switzerland (MD); Digestive Oncology Unit and Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium (ST); Oncosurgery, Geneva University Hospital Geneva, Switzerland (AR); Department of Pathology, Lausanne University, Lausanne, Switzerland (FTB).

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http://dx.doi.org/10.1093/jnci/djv056DOI Listing
March 2015

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

Sci Transl Med 2015 Jan;7(272):272ra12

Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy. Translational Cancer Medicine, Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 10060 Candiolo, Torino, Italy. National Institute of Biostructures and Biosystems, 00136 Rome, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3010445DOI Listing
January 2015

Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data.

J Natl Cancer Inst 2014 Oct 22;106(10). Epub 2014 Sep 22.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland (AFDN, SR, VP, PW, EB, MD); Digestive Oncology Unit and Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium (ST); Department of Pathology, Lausanne University, Lausanne, Switzerland (PY, FB); Oncology Research Unit, Worldwide Research and Development, Pfizer Inc., La Jolla, CA (TX, HE, AP, MM, EM, WS); Oncosurgery, Geneva University Hospital Geneva, Switzerland (AR); SAKK Coordination Center, Bern, Switzerland (AR); Ludwig Center for Cancer Research (MD) and Oncology Department, University of Lausanne, Lausanne, Switzerland (MD).

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http://dx.doi.org/10.1093/jnci/dju247DOI Listing
October 2014

European perspective for effective cancer drug development.

Nat Rev Clin Oncol 2014 08 17;11(8):492-8. Epub 2014 Jun 17.

UniversitaetsSpital Zurich, Division of Oncology, Raemistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nrclinonc.2014.98DOI Listing
August 2014

Hsa-miR-31-3p expression is linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy.

Clin Cancer Res 2014 Jun 25;20(12):3338-47. Epub 2014 Apr 25.

Authors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, service d'Hépato-Gastro-Entérologie et d'Oncologie Digestive; Université Paris-Est Créteil; Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil; Department of Medicine, Institut Gustave Roussy, Villejuif; and Department of Biology, Assistance Publique-Hôpitaux de Paris, European Georges Pompidou, Paris; Université de Reims Champagne-Ardenne; Centre Hospitalier Universitaire de Reims, Reims; Service d'Anatomo-Pathologie, Centre Val d'Aurelle Paul-Lamarque, Montpellier; Université Clermont-Ferrand, Centre Jean Perrin, Clermont-Ferrand, France; Department of Gastroenterology, GI Cancer Unit; Department of Pathological Anatomy, Erasme University Hospital, Brussels; Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland; Haartman Institute, University of Helsinki; Department of Oncology, Helsinki University Central Hospital and Helsinki University; HUSLAB, Department of Pathology and Genetic Laboratory, Helsinki; and Department of Oncology and Radiotherapy, Turku University Hospital, Turku, FinlandAuthors' Affiliations: Université Paris Sorbonne Cité; INSERM UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques; INSERM UMR-S674 Genomique Fonctionnelle des Tumeurs; Integragen S.A., Evry; Université Pierre et Marie Curie; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière; Université Pierre et Marie Curie; Assistance Publique-Hôpit

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2750DOI Listing
June 2014

High-dosage tamoxifen as neoadjuvant treatment in minimally invasive surgery for Dupuytren disease in patients with a strong predisposition toward fibrosis: a randomized controlled trial.

J Bone Joint Surg Am 2014 Apr;96(8):655-62

Hand Unit, Orthopaedic Department, Pellenberg Campus, University Hospitals Leuven, Weligerveld 1, 3212 Pellenberg, Belgium. E-mail address for I. Degreef: E-mail address for L. De Smet:

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https://insights.ovid.com/crossref?an=00004623-201404160-000
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http://dx.doi.org/10.2106/JBJS.L.01623DOI Listing
April 2014

Personalized medicine in metastatic colorectal cancer treated with anti-epidermal growth factor receptor agents: a future opportunity?

Asia Pac J Clin Oncol 2014 Mar;10 Suppl 1:2-10

Digestive Oncology Unit, University Hospital Gasthiusberg, Leuven, Belgium.

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http://dx.doi.org/10.1111/ajco.12176DOI Listing
March 2014

The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.

Cell Mol Life Sci 2013 Oct 27;70(20):3791-811. Epub 2013 Feb 27.

Department of Oncology, Katholieke Universiteit Leuven, O&N1, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00018-013-1285-5DOI Listing
October 2013

Use of early tumor shrinkage to predict long-term outcome in metastatic colorectal cancer treated with cetuximab.

J Clin Oncol 2013 Oct 16;31(30):3764-75. Epub 2013 Sep 16.

Hubert Piessevaux, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels; Marc Buyse, International Drug Development Institute, Louvain-la-Neuve; Eric Van Cutsem and Sabine Tejpar, University Hospital Gasthuisberg, Leuven, Belgium; Michael Schlichting and Steffen Heeger, Merck KGaA, Darmstadt; and Carsten Bokemeyer, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1200/JCO.2012.42.8532DOI Listing
October 2013

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer.

BMC Cancer 2013 Sep 27;13:439. Epub 2013 Sep 27.

Institute of Biostatistics and Analyses, Masaryk University, Kotlarska 2, Brno, 611 37, Czech Republic.

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http://dx.doi.org/10.1186/1471-2407-13-439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849526PMC
September 2013

Biopsies: next-generation biospecimens for tailoring therapy.

Nat Rev Clin Oncol 2013 Aug 25;10(8):437-50. Epub 2013 Jun 25.

Department of Surgery, Jewish General Hospital, McGill University, 3755 Côte Sainte Catherine Road, Montreal, QC H3T 1E2, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2013.101DOI Listing
August 2013

Overcoming resistance to antiangiogenic therapies.

Oncologist 2012 6;17(8):1039-50. Epub 2012 Jul 6.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.

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http://dx.doi.org/10.1634/theoncologist.2012-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425522PMC
April 2013

Bevacizumab plus chemotherapy as salvage treatment in chemorefractory patients with metastatic colorectal cancer.

Onco Targets Ther 2013 25;6:53-8. Epub 2013 Jan 25.

Gastrointestinal Malignancies Service, Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; ; Department of Gastroenterology, Digestive Oncology Unit, University Hospitals Leuven, Leuven, Belgium;

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http://dx.doi.org/10.2147/OTT.S41383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558253PMC
February 2013

Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.

J Clin Oncol 2012 Oct 25;30(29):3570-7. Epub 2012 Jun 25.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, Leuven, Belgium B-3000.

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http://dx.doi.org/10.1200/JCO.2012.42.2592DOI Listing
October 2012

microRNAs in colon cancer: a roadmap for discovery.

FEBS Lett 2012 Sep;586(19):3000-7

Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.febslet.2012.07.048DOI Listing
September 2012

CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material.

Genes Chromosomes Cancer 2012 Apr 8;51(4):344-52. Epub 2011 Dec 8.

Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/gcc.21920DOI Listing
April 2012

Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer.

J Clin Oncol 2012 Apr 5;30(12):1288-95. Epub 2012 Mar 5.

Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Quartier Sorge, Genopode, CH-1015 Lausanne, Switzerland.

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http://ascopubs.org/doi/10.1200/JCO.2011.39.5814
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http://dx.doi.org/10.1200/JCO.2011.39.5814DOI Listing
April 2012

Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents.

Target Oncol 2011 Dec 24;6(4):227-33. Epub 2011 Nov 24.

Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11523-011-0200-yDOI Listing
December 2011

EGFR-targeted therapy.

Exp Cell Res 2011 Nov 7;317(19):2765-71. Epub 2011 Sep 7.

Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49 bus 602 Be 3000, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.yexcr.2011.08.021DOI Listing
November 2011

Targeted therapies: how personal should we go?

Nat Rev Clin Oncol 2011 Nov 15;9(2):87-97. Epub 2011 Nov 15.

Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, Strada Provinciale 142 km 3.95, 10060 Candiolo, Turin, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2011.164DOI Listing
November 2011

Uptake of KRAS mutation testing in patients with metastatic colorectal cancer in Europe, Latin America and Asia.

Target Oncol 2011 Sep 1;6(3):133-45. Epub 2011 Jun 1.

Division of Medical Oncology, Department of Experimental and Clinical Medicine and Surgery F. Magrassi and A. Lanzara, Second University of Naples, Via S. Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s11523-011-0181-xDOI Listing
September 2011

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

Lancet Oncol 2011 Jun 14;12(6):594-603. Epub 2010 Dec 14.

Centre for Human Genetics, Catholic University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(10)70209-6DOI Listing
June 2011

Improved postoperative outcome of segmental fasciectomy in Dupuytren disease by insertion of an absorbable cellulose implant.

J Plast Surg Hand Surg 2011 Jun;45(3):157-64

Orthopaedic Department, Hand Unit, University Hospitals Leuven, Pellenberg Campus, Pellenberg, Belgium.

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http://www.tandfonline.com/doi/full/10.3109/2000656X.2011.55
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http://dx.doi.org/10.3109/2000656X.2011.558725DOI Listing
June 2011

Biomarkers to predict response to anti-EGFR antibodies.

Authors:
Sabine Tejpar

Clin Adv Hematol Oncol 2011 Jun;9(6):486-7

Department of Gastro Enterology, Digestive Oncology Unit, University Hospital Gasthuisberg, 3000 Leuven, Belgium.

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June 2011