Sabine Merkelbach-Bruse

Sabine Merkelbach-Bruse

UNVERIFIED PROFILE

Are you Sabine Merkelbach-Bruse?   Register this Author

Register author
Sabine Merkelbach-Bruse

Sabine Merkelbach-Bruse

Publications by authors named "Sabine Merkelbach-Bruse"

Are you Sabine Merkelbach-Bruse?   Register this Author

96Publications

2705Reads

31Profile Views

Comparison of in Situ and Extraction-Based Methods for the Detection of ROS1 Rearrangements in Solid Tumors.

J Mol Diagn 2019 Aug 2. Epub 2019 Aug 2.

Institute of Pathology, University Hospital Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2019.06.006DOI Listing
August 2019

Monitoring Treatment Response to Erlotinib in EGFR-mutated Non-small-cell Lung Cancer Brain Metastases Using Serial O-(2-[F]fluoroethyl)-L-tyrosine PET.

Clin Lung Cancer 2019 03 5;20(2):e148-e151. Epub 2018 Nov 5.

Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Center for Integrated Oncology Köln, Bonn, Germany; Network Genomic Medicine (NGM) Lung Cancer, Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2018.10.011DOI Listing
March 2019

Lung cancer as a paradigm for precision oncology in solid tumours.

Virchows Arch 2017 Aug 20;471(2):221-233. Epub 2017 Jul 20.

Institute of Pathology, University Hospital and Center for Integrated Oncology Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-017-2183-2DOI Listing
August 2017

Block Excision of Iridociliary Tumors Enables Molecular Profiling and Immune Vaccination.

Ophthalmology 2017 02 27;124(2):268-270. Epub 2016 Oct 27.

Department of Ophthalmology, University of Cologne, Cologne, Germany; Center for Integrated Oncology (CIO) Cologne-Bonn, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2016.09.011DOI Listing
February 2017

The impact of sequencing on diagnosis and treatment of malignant melanoma.

Expert Rev Mol Diagn 2016 19;16(4):423-33. Epub 2016 Feb 19.

a Institute of Pathology , University Hospital Cologne , Cologne , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/14737159.2016.1147958DOI Listing
December 2016

MDM2 gene amplification in esophageal carcinoma.

Oncol Rep 2016 Apr 20;35(4):2223-7. Epub 2016 Jan 20.

Institute for Pathology, University Hospital of Cologne, Cologne 50924, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2016.4578DOI Listing
April 2016

Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases.

Exp Mol Pathol 2015 Dec 10;99(3):682-6. Epub 2015 Nov 10.

Institute of Pathology, University Hospital Cologne, Kerpener Straße 62, 50937 Cologne, Germany; Center for Integrated Oncology Cologne/Bonn, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany; Lung Cancer Group Cologne, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2015.11.002DOI Listing
December 2015

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.

J Thorac Oncol 2015 Jul;10(7):1049-57

*Institute of Pathology, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Cologne/Bonn, University Hospital of Cologne, Cologne, Germany; ‡Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; §Labor Dr. Quade und Kollegen GmbH, Cologne, Germany; ‖Institute of Human Genetics, University of Cologne, Cologne, Germany; ¶Targos Molecular Pathology GmbH, Kassel, Germany; #Department of Translational Genomics, University of Cologne, Cologne, Germany; **Cologne Center for Genomics, Cologne, Germany; ††GENterprise GENOMICS GmbH, Mainz, Germany; ‡‡Bristol-Myers Squibb R&D, Princeton, New Jersey; §§Evangelische Kliniken Johanniter, Bonn, Germany; ‖‖Malteser Krankenhaus, Lung Cancer Center, Bonn, Germany; ¶¶Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ##Institute for Hematopathology Hamburg, Hamburg, Germany; and ***New Oncology, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTO.0000000000000570DOI Listing
July 2015

Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.

J Thorac Oncol 2015 Jun;10(6):e40-3

*Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Köln Bonn, Institute of Pathology, University Hospital of Cologne, Cologne, Germany; ‡Department of Translational Genomics, Center for Integrated Oncology Köln Bonn, University of Cologne, Cologne, Germany; §Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ‖Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ¶Center for Integrated Oncology Köln Bonn, Institute of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; and #Institute of Hematopathology Hamburg, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTO.0000000000000503DOI Listing
June 2015

MET amplification status in therapy-naïve adeno- and squamous cell carcinomas of the lung.

Clin Cancer Res 2015 Feb 9;21(4):907-15. Epub 2014 Dec 9.

Institute of Pathology, University Hospital Cologne, Cologne, Germany. Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany. Targos Molecular Pathology, Kassel, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-0450DOI Listing
February 2015

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia.

Oncotarget 2015 Jan;6(2):825-35

Institute of Pathology, Center for Integrated Oncology, University of Bonn, 53127 Bonn, Germany.Institute of Pathology, Center for Integrated Oncology, University of Cologne, 50937 Cologne, Germany.Institute of Pathology, University of Göttingen, 37075 Göttingen, Germany.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/2706
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359258PMC
http://dx.doi.org/10.18632/oncotarget.2706DOI Listing
January 2015

High-resolution melting analysis is a sensitive diagnostic tool to detect imatinib-resistant and imatinib-sensitive PDGFRA exon 18 mutations in gastrointestinal stromal tumors.

Hum Pathol 2014 Mar 4;45(3):573-82. Epub 2013 Nov 4.

Institute of Pathology, University Hospital Cologne, D-50942 Cologne, Germany; Institute of Pathology, University Hospital Göttingen, D-37075 Göttingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2013.10.025DOI Listing
March 2014

Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung.

Mod Pathol 2013 Nov 7;26(11):1468-77. Epub 2013 Jun 7.

Institute of Pathology, University Hospital Cologne (as part of the Lung Cancer Group Cologne (LCGC)), Cologne, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/modpathol201395
Publisher Site
http://dx.doi.org/10.1038/modpathol.2013.95DOI Listing
November 2013

Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing.

Am J Surg Pathol 2013 Nov;37(11):1648-59

*Institute of Pathology, University of Cologne Medical Center, Cologne †Gerhard-Domagk-Institute of Pathology, University of Münster Medical Center, Münster ‡Department of General and Abdominal Surgery, University of Mainz Medical Center, Mainz §Division of Surgical Oncology and Thoracic Surgery, University of Mannheim Medical Center, Mannheim ∥Department of Hematology, Oncology and Palliative Care, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0b013e3182986b88DOI Listing
November 2013

Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization.

Histopathology 2012 Jul 6;61(1):59-68. Epub 2012 Mar 6.

Institute of Pathology, University of Cologne Medical Center, Cologne, Germany Institute of Pathology, University of Bonn Medical Center, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2559.2012.04203.xDOI Listing
July 2012

Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.

Pathol Res Pract 2009 10;205(10):716-25. Epub 2009 Jul 10.

Institute of Pathology, Medical Faculty of the University of Bonn, Sigmund Freud Str. 25, D-53127 Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2009.06.003DOI Listing
December 2009

Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling.

J Cancer Res Clin Oncol 2009 May 11;135(5):723-30. Epub 2008 Nov 11.

Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-008-0509-9
Publisher Site
http://dx.doi.org/10.1007/s00432-008-0509-9DOI Listing
May 2009

KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants.

Hum Pathol 2008 Dec 20;39(12):1728-36. Epub 2008 Aug 20.

Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2008.05.011DOI Listing
December 2008

Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy.

Virchows Arch 2007 Oct 14;451(4):743-9. Epub 2007 Aug 14.

Department of Pathology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-007-0473-9DOI Listing
October 2007

Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literature.

Pathol Res Pract 2007 26;203(4):227-31. Epub 2007 Mar 26.

Department of Pathology, University of Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2007.01.007DOI Listing
July 2007

Multiple colon carcinomas in a patient with Cowden syndrome.

Int J Mol Med 2006 Oct;18(4):643-7

Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany.

View Article

Download full-text PDF

Source
October 2006

Pitfalls in the detection of t(11;22) translocation by fluorescence in situ hybridization and RT-PCR: a single-blinded study.

Diagn Mol Pathol 2006 Jun;15(2):83-9

Institute of Pathology, University of Bonn Medical School, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.

View Article

Download full-text PDF

Source
June 2006

Detection of HPV 52, 58 and 87 in cervicovaginal intraepithelial lesions of HIV infected women.

Int J Mol Med 2005 Nov;16(5):815-9

Institute of Pathology, Medical Faculty of the University of Bonn, D-53127 Bonn, Germany.

View Article

Download full-text PDF

Source
November 2005

c-KIT codon 816 mutation in a recurrent and metastatic dysgerminoma of a 14-year-old girl: case study.

Virchows Arch 2004 Dec 29;445(6):651-4. Epub 2004 Sep 29.

Department of Pathology, University of Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-004-1112-3DOI Listing
December 2004

Analysis of chromosomal instability in focal cortical dysplasia of Taylor's balloon cell type.

Acta Neuropathol 2004 Aug 14;108(2):129-34. Epub 2004 May 14.

Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud Str. 25, 53105, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-004-0874-7DOI Listing
August 2004