Sabina Signoretti

Sabina Signoretti

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Sabina Signoretti

Sabina Signoretti

Publications by authors named "Sabina Signoretti"

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Mutations and Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma.

Mol Cancer Ther 2020 Feb 25;19(2):690-696. Epub 2019 Oct 25.

Cancer Genetics Lab, Division of Pulmonary Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0642DOI Listing
February 2020

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.

Sci Signal 2019 Oct 1;12(601). Epub 2019 Oct 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aay0482DOI Listing
October 2019

Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma.

Clin Genitourin Cancer 2018 10 25;16(5):341-348. Epub 2018 Apr 25.

Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175670PMC
October 2018

Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers.

J Clin Oncol 2018 Oct 29:JCO2018792259. Epub 2018 Oct 29.

Sabina Signoretti and Abdallah Flaifel, Brigham and Women's Hospital; Sabina Signoretti, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Ying-Bei Chen and Victor E. Reuter, Memorial Sloan Kettering Cancer Center; and Victor E. Reuter, Weill Cornell Medical College, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2018.79.2259
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http://dx.doi.org/10.1200/JCO.2018.79.2259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299340PMC
October 2018

A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model.

Mol Ther Methods Clin Dev 2018 Jun 23;9:203-210. Epub 2018 Feb 23.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.omtm.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948229PMC
June 2018

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.

Nat Med 2018 02 8;24(2):165-175. Epub 2018 Jan 8.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4463DOI Listing
February 2018

In Reply.

Oncologist 2017 12 11;22(12):1561. Epub 2017 Sep 11.

Departments of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2017-0283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728026PMC
December 2017

Evolution of Circulating Tumor DNA Profile from First-line to Subsequent Therapy in Metastatic Renal Cell Carcinoma.

Eur Urol 2017 10 14;72(4):557-564. Epub 2017 Apr 14.

Department of Medical Oncology, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.eururo.2017.03.046DOI Listing
October 2017

Differential Expression of PD-L1 in High Grade T1 vs Muscle Invasive Bladder Carcinoma and its Prognostic Implications.

J Urol 2017 10 6;198(4):817-823. Epub 2017 May 6.

Bladder Cancer Center, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2017.04.102DOI Listing
October 2017

Renal cell carcinoma.

Nat Rev Dis Primers 2017 Mar 9;3:17009. Epub 2017 Mar 9.

Department of Experimental and Clinical Medical Sciences - Urologic Clinic, University of Udine, Udine, Italy.

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http://dx.doi.org/10.1038/nrdp.2017.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936048PMC
March 2017

Intratumor Heterogeneity of Perfusion and Diffusion in Clear-Cell Renal Cell Carcinoma: Correlation With Tumor Cellularity.

Clin Genitourin Cancer 2016 12 22;14(6):e585-e594. Epub 2016 Apr 22.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX; Kidney Cancer Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075271PMC
http://dx.doi.org/10.1016/j.clgc.2016.04.007DOI Listing
December 2016

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

Nature 2016 11 5;539(7627):107-111. Epub 2016 Sep 5.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature19795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499381PMC
November 2016

Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations.

J Clin Oncol 2016 Oct;34(30):3655-3663

Laurence Albiges, Wanling Xie, Rana R. McKay, Andre P. Fay, Guillermo de Velasco, Sabina Signoretti, and Toni K. Choueiri, Dana-Farber Cancer Institute; Wanling Xie, Rana R. McKay, Mark A. Preston, Eunyoung Cho, Sabina Signoretti, and Toni K. Choueiri, Brigham and Women's Hospital; Laurence Albiges, Wanling Xie, Rana R. McKay, Andre P. Fay, Guillermo de Velasco, Eunyoung Cho, David F. McDermott, Sabina Signoretti, and Toni K. Choueiri, Harvard Medical School; Mark A. Preston and Kathryn M. Wilson, Harvard School of Public Health; David F. McDermott, Beth Israel Deaconess Medical Center, Boston, MA; Laurence Albiges, Gustave Roussy, Université Paris-Saclay, Villejuif, France; A. Ari Hakimi, Emily C. Zabor, Anders J. Skanderup, and Helena Furberg, Memorial Sloan Kettering Cancer Center, New York; Ronit Simantov and Xun Lin, Pfizer Oncology, New York, NY; Jae-Lyun Lee, University of Ulsan College of Medicine, Asan; Sun-Young Rha, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea; Brian I. Rini, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; Sandy Srinivas, Stanford Cancer Institute, Stanford; Sumanta K. Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Georg A. Bjarnason, Sunnybrook Odette Cancer Center, Toronto; Scott Ernst, London Health Sciences Center, London, Ontario; Lori A. Wood, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia; Daniel Y.C. Heng, Tom Baker Cancer Center; University of Calgary, Calgary, Alberta, Canada; Ulka N. Vaishamayan, Karmanos Cancer Center, Detroit, MI; Neeraj Agarwal, University of Utah Huntsman Cancer Institute, Salt Lake City, UT; Takeshi Yuasa, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan; Aristotelis Bamias, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; and Eunyoung Cho, The Warren Alpert Medical School of Brown University; Brown University School of Public Health, Providence, RI.

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http://dx.doi.org/10.1200/JCO.2016.66.7311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065111PMC
October 2016

Phase 2 Study of Bevacizumab and Temsirolimus After VEGFR TKI in Metastatic Renal Cell Carcinoma.

Clin Genitourin Cancer 2016 08 23;14(4):304-313.e6. Epub 2016 Feb 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2016.02.007DOI Listing
August 2016

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy.

Genome Biol 2016 08 22;17(1):174. Epub 2016 Aug 22.

Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, 450 Brookline Ave., Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-016-1028-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993001PMC
August 2016

Landscape of tumor-infiltrating T cell repertoire of human cancers.

Nat Genet 2016 07 30;48(7):725-32. Epub 2016 May 30.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298896PMC
July 2016

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Cell 2016 Jun;166(1):126-39

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930557PMC
June 2016

Cell kinetic studies fail to identify sequentially proliferating progenitors as the major source of epithelial renewal in the adult murine prostate.

PLoS One 2015 29;10(5):e0128489. Epub 2015 May 29.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449166PMC
March 2016

Tumor Vascularity in Renal Masses: Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments.

Clin Genitourin Cancer 2016 Feb 29;14(1):e25-36. Epub 2015 Aug 29.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698181PMC
February 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

Adult Renal Cell Carcinoma: A Review of Established Entities from Morphology to Molecular Genetics.

Surg Pathol Clin 2015 Dec;8(4):587-621

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.path.2015.09.003DOI Listing
December 2015

Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma.

Cancer Immunol Res 2015 Oct 26;3(10):1158-64. Epub 2015 May 26.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Kidney Cancer Program, Dana-Farber Harvard Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596765PMC
October 2015

Phase 2 trial of sunitinib and gemcitabine in patients with sarcomatoid and/or poor-risk metastatic renal cell carcinoma.

Cancer 2015 Oct 8;121(19):3435-43. Epub 2015 Jun 8.

Kidney Cancer Center, The Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.29503DOI Listing
October 2015

Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo.

Mol Cancer 2015 Jun 11;14:119. Epub 2015 Jun 11.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA, USA.

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http://dx.doi.org/10.1186/s12943-015-0384-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464115PMC
June 2015

Immunohistochemical staining for BRAF V600E supports the diagnosis of metanephric adenoma.

Histopathology 2015 May 23;66(6):901-4. Epub 2015 Jan 23.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.12509DOI Listing
May 2015

Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer.

Clin Cancer Res 2015 Apr 14;21(8):1925-1934. Epub 2015 Jan 14.

Division of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts, 02215, United States of America.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419371PMC
April 2015

ΔNp63 (p40) expression in prostatic adenocarcinoma with diffuse p63 positivity.

Hum Pathol 2015 Mar 2;46(3):384-9. Epub 2014 Dec 2.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, 21231. Electronic address:

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http://search.proquest.com/openview/fac973b2cd820099f2ce4719
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http://dx.doi.org/10.1016/j.humpath.2014.11.011DOI Listing
March 2015

Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study.

J Immunother Cancer 2015 17;3. Epub 2015 Feb 17.

Dana-Farber Cancer Institute, 450 Brookline Avenue (DANA 1230), Boston, MA 02215 USA ; Brigham and Women's Hospital, 75 Francis Street (Thorn Building 504A), Boston, MA 02215 USA ; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 USA.

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http://dx.doi.org/10.1186/s40425-015-0047-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357210PMC
March 2015

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Cancer Discov 2014 Aug 27;4(8):896-904. Epub 2014 May 27.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine; Divisions of

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http://dx.doi.org/10.1158/2159-8290.CD-13-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125493PMC
August 2014

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

Dev Cell 2014 Aug 31;30(3):255-67. Epub 2014 Jul 31.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134362PMC
August 2014

MET as a target in papillary renal cell carcinoma.

Clin Cancer Res 2014 Jul 8;20(13):3361-3. Epub 2014 May 8.

Authors' Affiliations: Dana-Farber Cancer Institute; Brigham and Women's Hospital; and Harvard Medical School, Boston, Massachusetts

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0690DOI Listing
July 2014

Neoadjuvant dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin with pegfilgrastim support in muscle-invasive urothelial cancer: pathologic, radiologic, and biomarker correlates.

J Clin Oncol 2014 Jun 12;32(18):1889-94. Epub 2014 May 12.

Toni K. Choueiri, Susanna Jacobus, Joaquim Bellmunt, Angela Qu, Edward C. Stack, Sabina Signoretti, Meghara Walsh, Graeme Steele, Michelle Hirsch, Christopher J. Sweeney, Mary-Ellen Taplin, Adam S. Kibel, Katherine M. Krajewski, Philip W. Kantoff, Robert W. Ross, and Jonathan E. Rosenberg, Dana-Farber Cancer Institute and Brigham and Women's Hospital; Christopher Tretter, Lahey Clinic, Burlington; Glenn J. Bubley, Beth Israel Deaconess Medical Center, Boston, MA; Leonard J. Appleman, University of Pittsburgh, Pittsburgh, PA; and Jonathan E. Rosenberg, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2013.52.4785DOI Listing
June 2014

Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α.

Eur J Cancer 2014 May 21;50(8):1531-40. Epub 2014 Feb 21.

Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.01.031DOI Listing
May 2014

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

Cancer Discov 2014 May 13;4(5):546-53. Epub 2014 Mar 13.

Departments of 1Medical Oncology and 2Biostatistics and Computational Biology, 3Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Departments of 4Medicine and 5Pathology, Brigham and Women's Hospital, Harvard Medical School; 6Division of Hematology/Oncology, Massachusetts General Hospital, Boston; 7Broad Institute of Harvard and MIT; 8Department of Biology, Whitehead Institute for Biomedical Research; 9Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; and 10Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122326PMC
May 2014

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Cell Metab 2014 May 10;19(5):795-809. Epub 2014 Apr 10.

Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096909PMC
May 2014

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

Clin Cancer Res 2014 Apr 31;20(7):1873-83. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Biostatistics and Computational Biology, and Medical Oncology; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Department of Biostatistics, Harvard School of Public Health; Department of Pathology; Translational Medicine Division, Brigham and Women's Hospital, Boston; Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Sidney Kimmel Cancer Center; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York; and Hospital del Mar Research Institute-IMIM, Barcelona; and Hospital Parc Tauli, Sabadell, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975677PMC
April 2014

GRK3 is essential for metastatic cells and promotes prostate tumor progression.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1521-6. Epub 2014 Jan 13.

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1320638111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910602PMC
January 2014

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.

Cancer Cell 2013 Dec;24(6):738-50

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910168PMC
December 2013

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Cell 2013 Nov;155(4):844-57

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070383PMC
November 2013

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.

Clin Cancer Res 2013 Sep 23;19(18):5218-26. Epub 2013 Jul 23.

Authors' Affiliations: Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; GlaxoSmithKline, Collegeville, Pennsylvania; Memorial Sloan-Kettering Cancer Center, New York, New York; and Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522695PMC
September 2013

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia.

Proc Natl Acad Sci U S A 2013 May 25;110(20):8105-10. Epub 2013 Apr 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1221216110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657776PMC
May 2013

Renal-cell carcinoma: a step closer to a new classification.

Lancet Oncol 2013 Feb 16;14(2):105-7. Epub 2013 Jan 16.

Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1470-2045(12)70599-5DOI Listing
February 2013