Saar Gill

Saar Gill

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Saar Gill

Saar Gill

Publications by authors named "Saar Gill"

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Bispecific Antibodies in the Treatment of Hematologic Malignancies.

Clin Pharmacol Ther 2019 Oct 29;106(4):781-791. Epub 2019 Mar 29.

Blood and Marrow Transplantation Program, Abramson Cancer Center and the Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/cpt.1396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766786PMC
October 2019

Chimeric antigen receptor T-cell therapy for acute myeloid leukemia: how close to reality?

Haematologica 2019 Jul 20;104(7):1302-1308. Epub 2019 Jun 20.

Division of Hematology-Oncology and Center for Cellular Immunotherapies, University of Pennsylvania, PA, USA

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http://dx.doi.org/10.3324/haematol.2018.208751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601074PMC
July 2019

Will CAR T cell therapy have a role in AML? Promises and pitfalls.

Semin Hematol 2019 Apr 29;56(2):155-163. Epub 2018 Aug 29.

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Center for Cellular Immunotherapies, The University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2018.08.008DOI Listing
April 2019

Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract.

Bone Marrow Transplant 2019 02 24;54(2):212-217. Epub 2018 May 24.

Blood and Marrow Transplantation Program, Abramson Cancer Center and the Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41409-018-0236-z
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http://dx.doi.org/10.1038/s41409-018-0236-zDOI Listing
February 2019

21 Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX.

Cell Stem Cell 2019 Feb;24(2):208-209

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183063
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http://dx.doi.org/10.1016/j.stem.2018.12.016DOI Listing
February 2019

Novel Approaches to Acute Myeloid Leukemia Immunotherapy.

Clin Cancer Res 2018 11 14;24(22):5502-5515. Epub 2018 Jun 14.

Division of Hematology-Oncology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3016DOI Listing
November 2018

Anti-CD123 chimeric antigen receptor T-cells (CART): an evolving treatment strategy for hematological malignancies, and a potential ace-in-the-hole against antigen-negative relapse.

Leuk Lymphoma 2018 07 13;59(7):1539-1553. Epub 2017 Sep 13.

a Center for Cellular Immunotherapies, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2017.1
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http://dx.doi.org/10.1080/10428194.2017.1375107DOI Listing
July 2018

Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia.

Methods Mol Biol 2017 ;1633:267-276

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7142-8_17DOI Listing
May 2018

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 Apr;24(4):526

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http://dx.doi.org/10.1038/nm0418-526cDOI Listing
April 2018

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 03 12;24(3):282-291. Epub 2018 Feb 12.

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.4484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029618PMC
March 2018

Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease.

Blood Adv 2018 03;2(5):575-585

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/bloodadvances.2017012500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851417PMC
March 2018

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.

Cancer Discov 2017 10 2;7(10):1154-1167. Epub 2017 Jun 2.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628114PMC
October 2017

Improved surfaceome coverage with a label-free nonaffinity-purified workflow.

Proteomics 2017 04 6;17(7). Epub 2017 Mar 6.

Protein and Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pmic.201600344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518111PMC
April 2017

Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.

Biol Blood Marrow Transplant 2017 Feb 13;23(2):235-246. Epub 2016 Sep 13.

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Hematology/Oncology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237606PMC
February 2017

Monkey business: Repurposing a protein from the simian immunodeficiency virus to enhance cytotoxic chemotherapy.

Authors:
Saar Gill

Sci Transl Med 2017 02 1;9(375). Epub 2017 Feb 1.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aam6051DOI Listing
February 2017

CAR T cells engage in anticancer martial arts.

Authors:
Saar Gill

Sci Transl Med 2017 01;9(373)

Hematology-Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aal4996DOI Listing
January 2017

Chimeric antigen receptor T cell therapy in AML: How close are we?

Authors:
Saar Gill

Best Pract Res Clin Haematol 2016 12 18;29(4):329-333. Epub 2016 Oct 18.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Room 8-101, Smilow Research Center, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131522PMC
December 2016

Planes, Trains, and Automobiles: Perspectives on CAR T Cells and Other Cellular Therapies for Hematologic Malignancies.

Authors:
Saar Gill

Curr Hematol Malig Rep 2016 08;11(4):318-25

Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11899-016-0330-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018307PMC
August 2016

Chimeric antigen receptor T cell therapy: 25years in the making.

Blood Rev 2016 05 6;30(3):157-67. Epub 2015 Nov 6.

Division of Hematology/Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.blre.2015.10.003DOI Listing
May 2016

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Cancer Discov 2015 Dec 29;5(12):1282-95. Epub 2015 Oct 29.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Cell & Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670800PMC
December 2015

How to train your T cell: genetically engineered chimeric antigen receptor T cells versus bispecific T-cell engagers to target CD19 in B acute lymphoblastic leukemia.

Expert Opin Biol Ther 2015 Jun 2;15(6):761-6. Epub 2015 Feb 2.

University of Pennsylvania, Perelman School of Medicine, Translational Research Program , Philadelphia, PA , USA.

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http://dx.doi.org/10.1517/14712598.2015.1009888DOI Listing
June 2015

The Yin and Yang of Alloreactivity: Chronic Graft-versus-Host Disease and Leukemia Relapse.

Authors:
Saar Gill

Clin Cancer Res 2015 May 2;21(9):1981-3. Epub 2015 Feb 2.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2930DOI Listing
May 2015

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies.

Immunol Rev 2015 Jan;263(1):68-89

Abramson Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/imr.12243DOI Listing
January 2015

Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced-intensity conditioning.

Biol Blood Marrow Transplant 2014 Nov 10;20(11):1758-66. Epub 2014 Jul 10.

Abramson Cancer Center and the Division of Hematology & Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.bbmt.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194246PMC
November 2014

Chimeric antigen receptor T-cell therapy to target hematologic malignancies.

Cancer Res 2014 Nov 4;74(22):6383-9. Epub 2014 Nov 4.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/content/early/2014/11/04/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-1530DOI Listing
November 2014

CAR-modified anti-CD19 T cells for the treatment of B-cell malignancies: rules of the road.

Expert Opin Biol Ther 2014 Jan 21;14(1):37-49. Epub 2013 Nov 21.

University of Pennsylvania, Abramson Cancer Center, Perelman School of Medicine, Division of Hematology-Oncology, Department of Medicine , Philadelphia, PA 19106 , USA

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http://dx.doi.org/10.1517/14712598.2014.860442DOI Listing
January 2014

Reduced-intensity hematopoietic stem cell transplants for malignancies: harnessing the graft-versus-tumor effect.

Annu Rev Med 2013 29;64:101-17. Epub 2012 Oct 29.

Abramson Cancer Center, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1146/annurev-med-121411-103452DOI Listing
July 2013

Spontaneous subcapsular splenic hematoma associated with filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation.

Ann Pharmacother 2013 May 12;47(5):e22. Epub 2013 Apr 12.

Pharmacy Department, Hospital of University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1345/aph.1S005DOI Listing
May 2013

T cell-based gene therapy of cancer.

Transl Res 2013 Apr 11;161(4):365-79. Epub 2012 Dec 11.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1016/j.trsl.2012.11.002DOI Listing
April 2013

Biology and clinical effects of natural killer cells in allogeneic transplantation.

Curr Opin Oncol 2010 Mar;22(2):130-7

Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1097/CCO.0b013e328335a559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880497PMC
March 2010

Mantle cell lymphoma with central nervous system involvement: frequency and clinical features.

Br J Haematol 2009 Oct 19;147(1):83-8. Epub 2009 Aug 19.

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07835.xDOI Listing
October 2009

Natural killer cells in allogeneic transplantation: effect on engraftment, graft- versus-tumor, and graft-versus-host responses.

Biol Blood Marrow Transplant 2009 Jul 2;15(7):765-76. Epub 2009 Apr 2.

Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884143PMC
July 2009

What is the real risk of central nervous system involvement in mantle cell lymphoma?

Leuk Lymphoma 2008 Dec;49(12):2237-9

Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University, California, USA.

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http://dx.doi.org/10.1080/10428190802495855DOI Listing
December 2008

Prolonged haematological toxicity from the hyper-CVAD regimen: manifestations, frequency, and natural history in a cohort of 125 consecutive patients.

Ann Hematol 2008 Sep 10;87(9):727-34. Epub 2008 Apr 10.

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Victoria 8006, Australia.

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http://dx.doi.org/10.1007/s00277-008-0488-6DOI Listing
September 2008

What is the role of 18F-fluorodeoxyglucose positron emission tomography in mantle cell lymphoma?

Leuk Lymphoma 2008 Sep;49(9):1653-6

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Australia.

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http://dx.doi.org/10.1080/10428190802311433DOI Listing
September 2008

[18F]fluorodeoxyglucose positron emission tomography scanning for staging, response assessment, and disease surveillance in patients with mantle cell lymphoma.

Clin Lymphoma Myeloma 2008 Jun;8(3):159-65

Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3816/CLM.2008.n.019DOI Listing
June 2008

Therapeutic options in mantle cell lymphoma.

Leuk Lymphoma 2008 Mar;49(3):398-409

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre.

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http://dx.doi.org/10.1080/10428190701851364DOI Listing
March 2008

Long-term survival and secondary acute leukemia after fotemustine therapy for metastatic melanoma.

J Clin Oncol 2007 Oct;25(28):4493-4

Department of Oncology, Cabrini Medical Centre, Malvern, Australia.

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http://dx.doi.org/10.1200/JCO.2007.12.9338DOI Listing
October 2007