Saar Gill

Saar Gill

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Saar Gill

Publications by authors named "Saar Gill"

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56Publications

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Bispecific Antibodies in the Treatment of Hematologic Malignancies.

Authors:
Johannes Duell Philip E Lammers Ivana Djuretic Allison G Chunyk Shilpa Alekar Ira Jacobs Saar Gill

Clin Pharmacol Ther 2019 Oct 29;106(4):781-791. Epub 2019 Mar 29.

Blood and Marrow Transplantation Program, Abramson Cancer Center and the Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/cpt.1396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766786PMC
October 2019

Chimeric antigen receptor T-cell therapy for acute myeloid leukemia: how close to reality?

Authors:
Katherine D Cummins Saar Gill

Haematologica 2019 Jul 20;104(7):1302-1308. Epub 2019 Jun 20.

Division of Hematology-Oncology and Center for Cellular Immunotherapies, University of Pennsylvania, PA, USA

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http://dx.doi.org/10.3324/haematol.2018.208751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601074PMC
July 2019

Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients.

Authors:
Alex Ganetsky Jennifer H Han Mitchell E Hughes Daria V Babushok Noelle V Frey Saar I Gill Elizabeth O Hexner Alison W Loren Selina M Luger James K Mangan Mary Ellen Martin Jacqueline Smith Craig W Freyer Cheryl Gilmar Mindy Schuster Edward A Stadtmauer David L Porter

Clin Infect Dis 2019 May;68(12):2003-2009

Blood and Marrow Transplantation Program, Abramson Cancer Center and the Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1093/cid/ciy822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541731PMC
May 2019

Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT).

Authors:
Ankit J Kansagra Noelle V Frey Merav Bar Theodore W Laetsch Paul A Carpenter Bipin N Savani Helen E Heslop Catherine M Bollard Krishna V Komanduri Dennis A Gastineau Christian Chabannon Miguel A Perales Michael Hudecek Mahmoud Aljurf Leslie Andritsos John A Barrett Veronika Bachanova Chiara Bonini Armin Ghobadi Saar I Gill Joshua A Hill Saad Kenderian Partow Kebriaei Arnon Nagler David Maloney Hien D Liu Nirali N Shah Mohamed A Kharfan-Dabaja Elizabeth J Shpall Ghulam J Mufti Laura Johnston Elad Jacoby Ali Bazarbachi John F DiPersio Steven Z Pavletic David L Porter Stephan A Grupp Michel Sadelain Mark R Litzow Mohamad Mohty Shahrukh K Hashmi

Bone Marrow Transplant 2019 May 15. Epub 2019 May 15.

Division of Hematology, Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://www.nature.com/articles/s41409-019-0451-2
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http://dx.doi.org/10.1038/s41409-019-0451-2DOI Listing
May 2019

Will CAR T cell therapy have a role in AML? Promises and pitfalls.

Authors:
Katherine D Cummins Saar Gill

Semin Hematol 2019 Apr 29;56(2):155-163. Epub 2018 Aug 29.

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Center for Cellular Immunotherapies, The University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2018.08.008DOI Listing
April 2019

Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the American Society for Blood and Marrow Transplantation.

Authors:
Ankit J Kansagra Noelle V Frey Merav Bar Theodore W Laetsch Paul A Carpenter Bipin N Savani Helen E Heslop Catherine M Bollard Krishna V Komanduri Dennis A Gastineau Christian Chabannon Miguel A Perales Michael Hudecek Mahmoud Aljurf Leslie Andritsos John A Barrett Veronika Bachanova Chiara Bonini Armin Ghobadi Saar I Gill Joshua Hill Saad Kenderian Partow Kebriaei Arnon Nagler David Maloney Hien D Liu Nirali N Shah Mohamed A Kharfan-Dabaja Elizabeth J Shpall Ghulam J Mufti Laura Johnston Elad Jacoby Ali Bazarbachi John F DiPersio Steven Z Pavletic David L Porter Stephan A Grupp Michel Sadelain Mark R Litzow Mohamad Mohty Shahrukh K Hashmi

Biol Blood Marrow Transplant 2019 03 18;25(3):e76-e85. Epub 2018 Dec 18.

Oncology Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183089
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http://dx.doi.org/10.1016/j.bbmt.2018.12.068DOI Listing
March 2019

Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract.

Authors:
Alex Ganetsky Noelle V Frey Elizabeth O Hexner Alison W Loren Saar I Gill Selina M Luger James K Mangan Mary Ellen Martin Daria V Babushok William R Drobyski Jacqueline Smith Colleen Timlin Craig W Freyer Edward A Stadtmauer David L Porter

Bone Marrow Transplant 2019 02 24;54(2):212-217. Epub 2018 May 24.

Blood and Marrow Transplantation Program, Abramson Cancer Center and the Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41409-018-0236-z
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http://dx.doi.org/10.1038/s41409-018-0236-zDOI Listing
February 2019

21 Century FOX: Toward Gene Therapy for the Regulatory T Cell Deficiency Syndrome IPEX.

Authors:
Nicholas E Petty Saar I Gill

Cell Stem Cell 2019 Feb;24(2):208-209

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183063
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http://dx.doi.org/10.1016/j.stem.2018.12.016DOI Listing
February 2019

Novel Approaches to Acute Myeloid Leukemia Immunotherapy.

Authors:
Ofrat Beyar-Katz Saar Gill

Clin Cancer Res 2018 11 14;24(22):5502-5515. Epub 2018 Jun 14.

Division of Hematology-Oncology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3016DOI Listing
November 2018

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.

Authors:
Marco Ruella Jun Xu David M Barrett Joseph A Fraietta Tyler J Reich David E Ambrose Michael Klichinsky Olga Shestova Prachi R Patel Irina Kulikovskaya Farzana Nazimuddin Vijay G Bhoj Elena J Orlando Terry J Fry Hans Bitter Shannon L Maude Bruce L Levine Christopher L Nobles Frederic D Bushman Regina M Young John Scholler Saar I Gill Carl H June Stephan A Grupp Simon F Lacey J Joseph Melenhorst

Nat Med 2018 10 1;24(10):1499-1503. Epub 2018 Oct 1.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41591-018-0201-9
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http://dx.doi.org/10.1038/s41591-018-0201-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511988PMC
October 2018

Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma.

Authors:
Jakub Svoboda Susan R Rheingold Saar I Gill Stephan A Grupp Simon F Lacey Irina Kulikovskaya Megan M Suhoski J Joseph Melenhorst Brandon Loudon Anthony R Mato Sunita Dwivedy Nasta Daniel J Landsburg Matthew R Youngman Bruce L Levine David L Porter Carl H June Stephen J Schuster

Blood 2018 09 20;132(10):1022-1026. Epub 2018 Jun 20.

Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-03
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http://dx.doi.org/10.1182/blood-2018-03-837609DOI Listing
September 2018

Anti-CD123 chimeric antigen receptor T-cells (CART): an evolving treatment strategy for hematological malignancies, and a potential ace-in-the-hole against antigen-negative relapse.

Authors:
Katherine D Cummins Saar Gill

Leuk Lymphoma 2018 07 13;59(7):1539-1553. Epub 2017 Sep 13.

a Center for Cellular Immunotherapies, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2017.1
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http://dx.doi.org/10.1080/10428194.2017.1375107DOI Listing
July 2018

Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia.

Authors:
Saad S Kenderian Carl H June Saar Gill

Methods Mol Biol 2017 ;1633:267-276

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7142-8_17DOI Listing
May 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Authors:
Miriam Y Kim Kyung-Rok Yu Saad S Kenderian Marco Ruella Shirley Chen Tae-Hoon Shin Aisha A Aljanahi Daniel Schreeder Michael Klichinsky Olga Shestova Miroslaw S Kozlowski Katherine D Cummins Xinhe Shan Maksim Shestov Adam Bagg Jennifer J D Morrissette Palak Sekhri Cicera R Lazzarotto Katherine R Calvo Douglas B Kuhns Robert E Donahue Gregory K Behbehani Shengdar Q Tsai Cynthia E Dunbar Saar Gill

Cell 2018 05 31;173(6):1439-1453.e19. Epub 2018 May 31.

Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183059
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http://dx.doi.org/10.1016/j.cell.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003425PMC
May 2018

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 Apr;24(4):526

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http://dx.doi.org/10.1038/nm0418-526cDOI Listing
April 2018

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 03 12;24(3):282-291. Epub 2018 Feb 12.

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.4484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029618PMC
March 2018

Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease.

Authors:
Hitomi Hosoya Jeffrey Levine Peter Abt David Henry David L Porter Saar Gill

Blood Adv 2018 03;2(5):575-585

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/bloodadvances.2017012500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851417PMC
March 2018

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

Authors:
Mireia Uribe-Herranz Kyle Bittinger Stavros Rafail Sonia Guedan Stefano Pierini Ceylan Tanes Alex Ganetsky Mark A Morgan Saar Gill Janos L Tanyi Frederic D Bushman Carl H June Andrea Facciabene

JCI Insight 2018 02 22;3(4). Epub 2018 Feb 22.

Ovarian Cancer Research Center, and.

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http://dx.doi.org/10.1172/jci.insight.94952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916241PMC
February 2018

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.

Authors:
Marco Ruella Michael Klichinsky Saad S Kenderian Olga Shestova Amy Ziober Daniel O Kraft Michael Feldman Mariusz A Wasik Carl H June Saar Gill

Cancer Discov 2017 10 2;7(10):1154-1167. Epub 2017 Jun 2.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628114PMC
October 2017

Improved surfaceome coverage with a label-free nonaffinity-purified workflow.

Authors:
Tina Glisovic-Aplenc Saar Gill Lynn A Spruce Ian R Smith Hossein Fazelinia Olga Shestova Hua Ding Sarah K Tasian Richard Aplenc Steven H Seeholzer

Proteomics 2017 04 6;17(7). Epub 2017 Mar 6.

Protein and Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pmic.201600344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518111PMC
April 2017

Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia.

Authors:
Sarah K Tasian Saad S Kenderian Feng Shen Marco Ruella Olga Shestova Miroslaw Kozlowski Yong Li April Schrank-Hacker Jennifer J D Morrissette Martin Carroll Carl H June Stephan A Grupp Saar Gill

Blood 2017 04 28;129(17):2395-2407. Epub 2017 Feb 28.

Center for Cellular Immunotherapies, Translational Research Program, University of Pennsylvania School of Medicine, Philadelphia, PA.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2016-08
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http://dx.doi.org/10.1182/blood-2016-08-736041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409446PMC
April 2017

Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.

Authors:
Saad S Kenderian David L Porter Saar Gill

Biol Blood Marrow Transplant 2017 Feb 13;23(2):235-246. Epub 2016 Sep 13.

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Hematology/Oncology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237606PMC
February 2017

Monkey business: Repurposing a protein from the simian immunodeficiency virus to enhance cytotoxic chemotherapy.

Authors:
Saar Gill

Sci Transl Med 2017 02 1;9(375). Epub 2017 Feb 1.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aam6051DOI Listing
February 2017

CAR T cells engage in anticancer martial arts.

Authors:
Saar Gill

Sci Transl Med 2017 01;9(373)

Hematology-Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aal4996DOI Listing
January 2017

Chimeric antigen receptor T cell therapy in AML: How close are we?

Authors:
Saar Gill

Best Pract Res Clin Haematol 2016 12 18;29(4):329-333. Epub 2016 Oct 18.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Room 8-101, Smilow Research Center, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131522PMC
December 2016

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.

Authors:
Marco Ruella David M Barrett Saad S Kenderian Olga Shestova Ted J Hofmann Jessica Perazzelli Michael Klichinsky Vania Aikawa Farzana Nazimuddin Miroslaw Kozlowski John Scholler Simon F Lacey Jan J Melenhorst Jennifer J D Morrissette David A Christian Christopher A Hunter Michael Kalos David L Porter Carl H June Stephan A Grupp Saar Gill

J Clin Invest 2016 10 29;126(10):3814-3826. Epub 2016 Aug 29.

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http://dx.doi.org/10.1172/JCI87366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096828PMC
October 2016

Planes, Trains, and Automobiles: Perspectives on CAR T Cells and Other Cellular Therapies for Hematologic Malignancies.

Authors:
Saar Gill

Curr Hematol Malig Rep 2016 08;11(4):318-25

Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11899-016-0330-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018307PMC
August 2016

The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.

Authors:
Marco Ruella Saad S Kenderian Olga Shestova Joseph A Fraietta Sohail Qayyum Qian Zhang Marcela V Maus Xiaobin Liu Selene Nunez-Cruz Michael Klichinsky Omkar U Kawalekar Michael Milone Simon F Lacey Anthony Mato Stephen J Schuster Michael Kalos Carl H June Saar Gill Mariusz A Wasik

Clin Cancer Res 2016 06 27;22(11):2684-96. Epub 2016 Jan 27.

Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1527DOI Listing
June 2016

Time to unrelated donor leukocyte infusion is longer, but incidence of GVHD and overall survival are similar for recipients of unrelated DLI compared to matched sibling DLI.

Authors:
Anita J Kumar Pavel Vassilev Alison W Loren Selina M Luger Ran Reshef Saar Gill Jacqueline Smith Steven C Goldstein Elizabeth Hexner Edward A Stadtmauer David Porter Noelle V Frey

Am J Hematol 2016 Jun;91(4):426-9

Division of Hematology/Oncology, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/ajh.24308DOI Listing
June 2016

Chimeric antigen receptor T cell therapy: 25years in the making.

Authors:
Saar Gill Marcela V Maus David L Porter

Blood Rev 2016 05 6;30(3):157-67. Epub 2015 Nov 6.

Division of Hematology/Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.blre.2015.10.003DOI Listing
May 2016

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.

Authors:
Joseph A Fraietta Kyle A Beckwith Prachi R Patel Marco Ruella Zhaohui Zheng David M Barrett Simon F Lacey Jan Joseph Melenhorst Shannon E McGettigan Danielle R Cook Changfeng Zhang Jun Xu Priscilla Do Jessica Hulitt Sagar B Kudchodkar Alexandria P Cogdill Saar Gill David L Porter Jennifer A Woyach Meixiao Long Amy J Johnson Kami Maddocks Natarajan Muthusamy Bruce L Levine Carl H June John C Byrd Marcela V Maus

Blood 2016 Mar 26;127(9):1117-27. Epub 2016 Jan 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1182/blood-2015-11-679134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778162PMC
March 2016

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Authors:
Elena Sotillo David M Barrett Kathryn L Black Asen Bagashev Derek Oldridge Glendon Wu Robyn Sussman Claudia Lanauze Marco Ruella Matthew R Gazzara Nicole M Martinez Colleen T Harrington Elaine Y Chung Jessica Perazzelli Ted J Hofmann Shannon L Maude Pichai Raman Alejandro Barrera Saar Gill Simon F Lacey Jan J Melenhorst David Allman Elad Jacoby Terry Fry Crystal Mackall Yoseph Barash Kristen W Lynch John M Maris Stephan A Grupp Andrei Thomas-Tikhonenko

Cancer Discov 2015 Dec 29;5(12):1282-95. Epub 2015 Oct 29.

Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Immunology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Cell & Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670800PMC
December 2015

High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning.

Authors:
Ran Reshef Austin P Huffman Amy Gao Marlise R Luskin Noelle V Frey Saar I Gill Elizabeth O Hexner Taku Kambayashi Alison W Loren Selina M Luger James K Mangan Sunita D Nasta Lee P Richman Mary Sell Edward A Stadtmauer Robert H Vonderheide Rosemarie Mick David L Porter

J Clin Oncol 2015 Jul 8;33(21):2392-8. Epub 2015 Jun 8.

All authors: Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2014.60.1203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500833PMC
July 2015

How to train your T cell: genetically engineered chimeric antigen receptor T cells versus bispecific T-cell engagers to target CD19 in B acute lymphoblastic leukemia.

Authors:
Marco Ruella Saar Gill

Expert Opin Biol Ther 2015 Jun 2;15(6):761-6. Epub 2015 Feb 2.

University of Pennsylvania, Perelman School of Medicine, Translational Research Program , Philadelphia, PA , USA.

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http://dx.doi.org/10.1517/14712598.2015.1009888DOI Listing
June 2015

The Yin and Yang of Alloreactivity: Chronic Graft-versus-Host Disease and Leukemia Relapse.

Authors:
Saar Gill

Clin Cancer Res 2015 May 2;21(9):1981-3. Epub 2015 Feb 2.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2930DOI Listing
May 2015

Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition.

Authors:
Stephen J Bagley Alison R Sehgal Saar Gill Noelle V Frey Elizabeth O Hexner Alison W Loren James K Mangan David L Porter Edward A Stadtmauer Ran Reshef Selina M Luger

Biol Blood Marrow Transplant 2015 Apr 24;21(4):768-71. Epub 2014 Dec 24.

Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.bbmt.2014.12.005DOI Listing
April 2015

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies.

Authors:
Saar Gill Carl H June

Immunol Rev 2015 Jan;263(1):68-89

Abramson Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/imr.12243DOI Listing
January 2015

Early donor chimerism levels predict relapse and survival after allogeneic stem cell transplantation with reduced-intensity conditioning.

Authors:
Ran Reshef Elizabeth O Hexner Alison W Loren Noelle V Frey Edward A Stadtmauer Selina M Luger James K Mangan Saar I Gill Pavel Vassilev Kathryn A Lafferty Jacqueline Smith Vivianna M Van Deerlin Rosemarie Mick David L Porter

Biol Blood Marrow Transplant 2014 Nov 10;20(11):1758-66. Epub 2014 Jul 10.

Abramson Cancer Center and the Division of Hematology & Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.bbmt.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194246PMC
November 2014

Chimeric antigen receptor T-cell therapy to target hematologic malignancies.

Authors:
Saad Sirop Kenderian Marco Ruella Saar Gill Michael Kalos

Cancer Res 2014 Nov 4;74(22):6383-9. Epub 2014 Nov 4.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/content/early/2014/11/04/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-1530DOI Listing
November 2014

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells.

Authors:
Saar Gill Sarah K Tasian Marco Ruella Olga Shestova Yong Li David L Porter Martin Carroll Gwenn Danet-Desnoyers John Scholler Stephan A Grupp Carl H June Michael Kalos

Blood 2014 Apr 4;123(15):2343-54. Epub 2014 Mar 4.

Abramson Cancer Center.

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http://dx.doi.org/10.1182/blood-2013-09-529537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983612PMC
April 2014

CAR-modified anti-CD19 T cells for the treatment of B-cell malignancies: rules of the road.

Authors:
Saar Gill David L Porter

Expert Opin Biol Ther 2014 Jan 21;14(1):37-49. Epub 2013 Nov 21.

University of Pennsylvania, Abramson Cancer Center, Perelman School of Medicine, Division of Hematology-Oncology, Department of Medicine , Philadelphia, PA 19106 , USA

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http://dx.doi.org/10.1517/14712598.2014.860442DOI Listing
January 2014

Reduced-intensity hematopoietic stem cell transplants for malignancies: harnessing the graft-versus-tumor effect.

Authors:
Saar Gill David L Porter

Annu Rev Med 2013 29;64:101-17. Epub 2012 Oct 29.

Abramson Cancer Center, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1146/annurev-med-121411-103452DOI Listing
July 2013

Spontaneous subcapsular splenic hematoma associated with filgrastim in a patient undergoing allogeneic hematopoietic stem cell transplantation.

Authors:
Alex Ganetsky Colleen Kucharczuk Sarah Del Percio Noelle Frey Saar Gill

Ann Pharmacother 2013 May 12;47(5):e22. Epub 2013 Apr 12.

Pharmacy Department, Hospital of University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1345/aph.1S005DOI Listing
May 2013

T cell-based gene therapy of cancer.

Authors:
Saar Gill Michael Kalos

Transl Res 2013 Apr 11;161(4):365-79. Epub 2012 Dec 11.

Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1016/j.trsl.2012.11.002DOI Listing
April 2013

Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.

Authors:
Saar Gill Adrianne E Vasey Alysha De Souza Jeanette Baker Aaron T Smith Holbrook E Kohrt Mareike Florek Kenneth D Gibbs Keri Tate David S Ritchie Robert S Negrin

Blood 2012 Jun 27;119(24):5758-68. Epub 2012 Apr 27.

Divisions of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-03-41
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http://dx.doi.org/10.1182/blood-2012-03-415364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382935PMC
June 2012

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.

Authors:
Mark P Chao Ash A Alizadeh Chad Tang June H Myklebust Bindu Varghese Saar Gill Max Jan Adriel C Cha Charles K Chan Brent T Tan Christopher Y Park Feifei Zhao Holbrook E Kohrt Raquel Malumbres Javier Briones Randy D Gascoyne Izidore S Lossos Ronald Levy Irving L Weissman Ravindra Majeti

Cell 2010 Sep;142(5):699-713

Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, and Ludwig Center at Stanford, Stanford University, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.cell.2010.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943345PMC
September 2010

NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects.

Authors:
Janelle A Olson Dennis B Leveson-Gower Saar Gill Jeanette Baker Andreas Beilhack Robert S Negrin

Blood 2010 May 16;115(21):4293-301. Epub 2010 Mar 16.

Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA 94305, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-05-22
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http://dx.doi.org/10.1182/blood-2009-05-222190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879101PMC
May 2010

Biology and clinical effects of natural killer cells in allogeneic transplantation.

Authors:
Jonathan E Benjamin Saar Gill Robert S Negrin

Curr Opin Oncol 2010 Mar;22(2):130-7

Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1097/CCO.0b013e328335a559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880497PMC
March 2010

Mantle cell lymphoma with central nervous system involvement: frequency and clinical features.

Authors:
Saar Gill Kirsten E Herbert H Miles Prince Max M Wolf Andrew Wirth Gail Ryan Dennis A Carney David S Ritchie John M Davies John F Seymour

Br J Haematol 2009 Oct 19;147(1):83-8. Epub 2009 Aug 19.

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07835.xDOI Listing
October 2009

Natural killer cells in allogeneic transplantation: effect on engraftment, graft- versus-tumor, and graft-versus-host responses.

Authors:
Saar Gill Janelle A Olson Robert S Negrin

Biol Blood Marrow Transplant 2009 Jul 2;15(7):765-76. Epub 2009 Apr 2.

Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884143PMC
July 2009

What is the real risk of central nervous system involvement in mantle cell lymphoma?

Authors:
Saar Gill John F Seymour

Leuk Lymphoma 2008 Dec;49(12):2237-9

Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University, California, USA.

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http://dx.doi.org/10.1080/10428190802495855DOI Listing
December 2008

Prolonged haematological toxicity from the hyper-CVAD regimen: manifestations, frequency, and natural history in a cohort of 125 consecutive patients.

Authors:
Saar Gill Steven W Lane Julie Crawford Gavin Cull David Joske Paula Marlton Peter N Mollee H Miles Prince John F Seymour

Ann Hematol 2008 Sep 10;87(9):727-34. Epub 2008 Apr 10.

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Victoria 8006, Australia.

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http://dx.doi.org/10.1007/s00277-008-0488-6DOI Listing
September 2008

What is the role of 18F-fluorodeoxyglucose positron emission tomography in mantle cell lymphoma?

Authors:
Saar Gill Rodney J Hicks John F Seymour

Leuk Lymphoma 2008 Sep;49(9):1653-6

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Australia.

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http://dx.doi.org/10.1080/10428190802311433DOI Listing
September 2008

[18F]fluorodeoxyglucose positron emission tomography scanning for staging, response assessment, and disease surveillance in patients with mantle cell lymphoma.

Authors:
Saar Gill Max Wolf H Miles Prince Henry Januszewicz David Ritchie Rodney J Hicks John F Seymour

Clin Lymphoma Myeloma 2008 Jun;8(3):159-65

Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3816/CLM.2008.n.019DOI Listing
June 2008

Therapeutic options in mantle cell lymphoma.

Authors:
Saar Gill David Ritchie

Leuk Lymphoma 2008 Mar;49(3):398-409

Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre.

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http://dx.doi.org/10.1080/10428190701851364DOI Listing
March 2008

Long-term survival and secondary acute leukemia after fotemustine therapy for metastatic melanoma.

Authors:
Saar Gill Jeremy Shapiro David Westerman H Miles Prince

J Clin Oncol 2007 Oct;25(28):4493-4

Department of Oncology, Cabrini Medical Centre, Malvern, Australia.

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http://dx.doi.org/10.1200/JCO.2007.12.9338DOI Listing
October 2007