Saadi Khochbin

State Key Laboratory for Medical Genomics, Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

View Article and Find Full Text PDF

February 2018

Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia.

Authors:

Tao Wang Chunyan Cheng Lijun Peng Mengqing Gao Mengping Xi Sophie Rousseaux Saadi Khochbin Jin Wang Jianqing Mi

J Cell Mol Med 2018 03 20;22(3):1614-1626. Epub 2017 Dec 20.

State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

View Article and Find Full Text PDF

March 2018

Histone variants: essential actors in male genome programming.

Authors:

Naghmeh Hoghoughi Sophie Barral Alexandra Vargas Sophie Rousseaux Saadi Khochbin

J Biochem 2018 Feb;163(2):97-103

CNRS UMR 5309, Inserm, U1209, Université Grenoble Alpes, Institut Albert Bonniot, Grenoble F-38700, France.

View Article and Find Full Text PDF

February 2018

[The mystery of histone disappearance during spermatogenesis].

Authors:

Sophie Barral Yuichi Morozumi Naghmeh Hoghoughi Sophie Rousseaux Saadi Khochbin

Med Sci (Paris) 2017 Jun-Jul;33(6-7):588-590. Epub 2017 Jul 19.

CNRS UMR 5309 ; Inserm, U1209 ; université Grenoble Alpes ; Institute for Advanced Biosciences, Grenoble, F-38700 France.

View Article and Find Full Text PDF

April 2019

Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

Authors:

Clovis Chabert Saadi Khochbin Sophie Rousseaux Rebecca Furze Nicholas Smithers Rab Prinjha Uwe Schlattner Christophe Pison Hervé Dubouchaud

Sci Rep 2017 09 21;7(1):12133. Epub 2017 Sep 21.

Univ. Grenoble Alpes, Inserm, Laboratoire de Bioénergétique Fondamentale et Appliquée (LBFA), Grenoble, 38000, France.

View Article and Find Full Text PDF

September 2017

Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.

Authors:

Edwige Col Neda Hoghoughi Solenne Dufour Jessica Penin Sivan Koskas Virginie Faure Maria Ouzounova Hector Hernandez-Vargash Nicolas Reynoird Sylvain Daujat Eric Folco Marc Vigneron Robert Schneider André Verdel Saadi Khochbin Zdenko Herceg Cécile Caron Claire Vourc'h

Sci Rep 2017 07 14;7(1):5418. Epub 2017 Jul 14.

Université Grenoble Alpes, CNRS UMR 5309, INSERM U1209, Institute for Advanced Biosciences (IAB), Site Santé - Allée des Alpes, 38700, La Tronche, France.

View Article and Find Full Text PDF

July 2017

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.

Authors:

Ekaterina Bourova-Flin Florent Chuffart Sophie Rousseaux Saadi Khochbin

Cell J 2017 17;19(Suppl 1):1-8. Epub 2017 May 17.

CNRS UMR 5309, Inserm, U1209, University of Grenoble Alpes, Institute for Advanced Biosciences, Grenoble, France.

View Article and Find Full Text PDF

May 2017

Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Mol Cell 2017 Apr 30;66(1):89-101.e8. Epub 2017 Mar 30.

CNRS UMR 5309, Inserm U1209, Université Grenoble Alpes, Institute for Advanced Biosciences, Grenoble 38700, France. Electronic address:

View Article and Find Full Text PDF

April 2017

MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones.

Authors:

Sara El Kennani Annie Adrait Alexey K Shaytan Saadi Khochbin Christophe Bruley Anna R Panchenko David Landsman Delphine Pflieger Jérôme Govin

Epigenetics Chromatin 2017 10;10. Epub 2017 Jan 10.

INSERM, U1038, CEA, BIG FR CNRS 3425-BGE, Université Grenoble Alpes, Grenoble, France.

View Article and Find Full Text PDF

January 2018

A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.

Authors:

Thomas C R Miller Bernd Simon Vladimir Rybin Helga Grötsch Sandrine Curtet Saadi Khochbin Teresa Carlomagno Christoph W Müller

Nat Commun 2016 12 19;7:13855. Epub 2016 Dec 19.

European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.

View Article and Find Full Text PDF

December 2016

Structure of p300 in complex with acyl-CoA variants.

Authors:

Zuzanna Kaczmarska Esther Ortega Afsaneh Goudarzi He Huang Sunjoo Kim José A Márquez Yingming Zhao Saadi Khochbin Daniel Panne

Nat Chem Biol 2017 Jan 31;13(1):21-29. Epub 2016 Oct 31.

European Molecular Biology Laboratory, Grenoble, France.

View Article and Find Full Text PDF

January 2017

Purification and Analysis of Male Germ Cells from Adult Mouse Testis.

Authors:

Thierry Buchou Minjia Tan Sophie Barral Anne-Laure Vitte Sophie Rousseaux Juan Arechaga Saadi Khochbin

Methods Mol Biol 2017 ;1510:159-168

CNRS UMR 5209, INSERM U1209, CR UGA, Institute for Advanced Biosciences, La Tronche, 38700, France.

View Article and Find Full Text PDF

January 2018

Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer.

Authors:

Marta Czernik Domenico Iuso Paola Toschi Saadi Khochbin Pasqualino Loi

Nat Protoc 2016 Nov 6;11(11):2170-2188. Epub 2016 Oct 6.

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

View Article and Find Full Text PDF

November 2016

The growing landscape of tubulin acetylation: lysine 40 and many more.

Authors:

Karin Sadoul Saadi Khochbin

Biochem J 2016 07;473(13):1859-68

CNRS UMR 5309, INSERM U1209, Institut Albert Bonniot, Université Grenoble Alpes, Grenoble F-38700, France

View Article and Find Full Text PDF

July 2016

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.

Mol Cell 2016 04;62(2):169-180

CNRS UMR 5309, INSERM, U1209, Université Grenoble Alpes, Institut Albert Bonniot, 38700 Grenoble, France. Electronic address:

View Article and Find Full Text PDF

April 2016

Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures.

Authors:

Domenico Iuso Marta Czernik Paola Toschi Antonella Fidanza Federica Zacchini Robert Feil Sandrine Curtet Thierry Buchou Hitoshi Shiota Saadi Khochbin Grazyna Ewa Ptak Pasqualino Loi

Cell Rep 2015 Dec 25;13(9):1765-71. Epub 2015 Nov 25.

Faculty of Veterinary Medicine, University of Teramo, Renato Balzarini Street 1, Campus Coste Sant'Agostino, 64100 Teramo, Italy. Electronic address:

View Article and Find Full Text PDF

December 2015

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.

J Mol Cell Biol 2016 08 12;8(4):349-62. Epub 2015 Oct 12.

INSERM, U823; Université Grenoble Alpes; Institut Albert Bonniot Grenoble, F-38700 Grenoble, France

View Article and Find Full Text PDF

August 2016

Arsenic trioxide rewires mantle cell lymphoma response to bortezomib.

Authors:

Ling-Ling Zhao Yuan-Fang Liu Li-Jun Peng Ai-Mei Fei Wen Cui Sheng-Chao Miao Olivier Hermine Remy Gressin Saadi Khochbin Sai-Juan Chen Jin Wang Jian-Qing Mi

Cancer Med 2015 Nov 26;4(11):1754-66. Epub 2015 Aug 26.

State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

View Article and Find Full Text PDF

November 2015

A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia.

Authors:

Jin Wang Jian-Qing Mi Alexandra Debernardi Anne-Laure Vitte Anouk Emadali Julia A Meyer Konstantina Charmpi Bernard Ycart Mary B Callanan William L Carroll Saadi Khochbin Sophie Rousseaux

Oncotarget 2015 Jun;6(18):16527-42

INSERM, Université Grenoble Alpes, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

June 2015

Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology.

Authors:

Sophie Rousseaux Saadi Khochbin

Cell J 2015 8;17(1):1-6. Epub 2015 Apr 8.

View Article and Find Full Text PDF

April 2015

Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.

Authors:

Francesca Ratti Francis Ramond Vincent Moncollin Thomas Simonet Giulia Milan Alexandre Méjat Jean-Luc Thomas Nathalie Streichenberger Benoit Gilquin Patrick Matthias Saadi Khochbin Marco Sandri Laurent Schaeffer

J Biol Chem 2015 Feb 15;290(7):4215-24. Epub 2014 Dec 15.

From the Ecole Normale Supérieure de Lyon; CNRS UMR 5239; Equipe Différenciation Neuromusculaire, Université de Lyon, 46 allée d'Italie 69364 Lyon cedex 07, France, Université Lyon 1; Hospices civils de Lyon,

View Article and Find Full Text PDF

February 2015

Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.

Authors:

Matteo Cattaneo Yuichi Morozumi Daniel Perazza Fayçal Boussouar Mahya Jamshidikia Sophie Rousseaux André Verdel Saadi Khochbin

Mol Cells 2014 Dec 5;37(12):851-6. Epub 2014 Nov 5.

Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.

View Article and Find Full Text PDF

December 2014

HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.

Authors:

Lydia Pernet Virginie Faure Benoit Gilquin Solenne Dufour-Guérin Saadi Khochbin Claire Vourc'h

Mol Biol Cell 2014 Dec 8;25(25):4187-94. Epub 2014 Oct 8.

University Grenoble-Alpes, CRI INSERM, U823, Institut Albert Bonniot, La Tronche 38042, Grenoble Cedex 9, France

View Article and Find Full Text PDF

December 2014

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

Authors:

Christian Brambilla Julien Laffaire Sylvie Lantuejoul Denis Moro-Sibilot Hélène Mignotte François Arbib Anne-Claire Toffart Fabien Petel Pierre Hainaut Sophie Rousseaux Saadi Khochbin Aurélien de Reyniès Elisabeth Brambilla

Clin Cancer Res 2014 Nov 4;20(22):5777-86. Epub 2014 Sep 4.

Département d'Anatomie et Cytologie Pathologique, Centre Hospitalier Universitaire de Grenoble, Institut Albert Bonniot, INSERM U823, Université Joseph Fourrier, Grenoble, France.

View Article and Find Full Text PDF

November 2014

The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.

Authors:

Maïlys Le Borgne Nicolas Chartier Karine Buchet-Poyau Olivier Destaing Eva Faurobert Chantal Thibert Jean-Pierre Rouault Julien Courchet Didier Nègre Daniel Bouvard Corinne Albiges-Rizo Sophie Rousseaux Saadi Khochbin Dominique Segretain Pascale Crépieux Florian Guillou Philippe Durand Marie-Hélène Perrard Marc Billaud

Development 2014 May;141(10):2096-107

INSERM, U823; Université Joseph Fourier-Grenoble 1; Institut Albert Bonniot, Grenoble F-38700, France.

View Article and Find Full Text PDF

May 2014

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

Authors:

Lunzhi Dai Chao Peng Emilie Montellier Zhike Lu Yue Chen Haruhiko Ishii Alexandra Debernardi Thierry Buchou Sophie Rousseaux Fulai Jin Benjamin R Sabari Zhiyou Deng C David Allis Bing Ren Saadi Khochbin Yingming Zhao

Nat Chem Biol 2014 May 30;10(5):365-70. Epub 2014 Mar 30.

Ben May Department of Cancer Research, The University of Chicago, Chicago, Illinois, USA.

View Article and Find Full Text PDF

May 2014

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.

Elife 2014 Mar 25;3:e01632. Epub 2014 Mar 25.

Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR, Strasbourg, France.

View Article and Find Full Text PDF

March 2014

Genome-scale acetylation-dependent histone eviction during spermatogenesis.

Authors:

Afsaneh Goudarzi Hitoshi Shiota Sophie Rousseaux Saadi Khochbin

J Mol Biol 2014 Oct 5;426(20):3342-9. Epub 2014 Mar 5.

Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France. Electronic address:

View Article and Find Full Text PDF

October 2014

Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.

Authors:

Aurore Le Bescont Anne-Laure Vitte Alexandra Debernardi Sandrine Curtet Thierry Buchou Jessica Vayr Aurélien de Reyniès Akihiro Ito Philippe Guardiola Christian Brambilla Minoru Yoshida Elisabeth Brambilla Sophie Rousseaux Saadi Khochbin

Antioxid Redox Signal 2015 Jul 6;23(1):1-14. Epub 2014 Mar 6.

1 INSERM U823, Université Joseph Fourier-Grenoble 1 , Institut Albert Bonniot, Grenoble, France .

View Article and Find Full Text PDF

July 2015

Motor-driven marginal band coiling promotes cell shape change during platelet activation.

Authors:

Boubou Diagouraga Alexei Grichine Arnold Fertin Jin Wang Saadi Khochbin Karin Sadoul

J Cell Biol 2014 Jan 13;204(2):177-85. Epub 2014 Jan 13.

Institut Albert Bonniot, Institut National de la Santé et de la Recherche Médicale U823; and 2 Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques et Applications, Grenoble, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5525; Université Joseph Fourier-Grenoble 1, F-38041 Grenoble, France.

View Article and Find Full Text PDF

January 2014

Sustaining cancer through addictive ectopic gene activation.

Authors:

Jin Wang Sophie Rousseaux Saadi Khochbin

Curr Opin Oncol 2014 Jan;26(1):73-7

aINSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, La Tronche, France bState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

View Article and Find Full Text PDF

January 2014

Histone variants and sensing of chromatin functional states.

Authors:

Jérôme Govin Saadi Khochbin

Nucleus 2013 Nov-Dec;4(6):438-42. Epub 2013 Nov 8.

Université Grenoble-Alpes; Grenoble, France; INSERM, U823; Institut Albert Bonniot; Grenoble, France.

View Article and Find Full Text PDF

October 2014

Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.

Genes Dev 2013 Aug 24;27(15):1680-92. Epub 2013 Jul 24.

U823, Institut National de la Santé et de la Recherche Médicale INSERM, Institut Albert Bonniot, Université Joseph Fourier, Grenoble F-38700 France.

View Article and Find Full Text PDF

August 2013

Cancer hallmarks sustained by ectopic activations of placenta/male germline genes.

Authors:

Sophie Rousseaux Jin Wang Saadi Khochbin

Cell Cycle 2013 Aug 11;12(15):2331-2. Epub 2013 Jul 11.

INSERM; U823; Université Joseph Fourier-Grenoble 1; Institut Albert Bonniot; Grenoble, France.

View Article and Find Full Text PDF

August 2013

Malignant genome reprogramming by ATAD2.

Authors:

Fayçal Boussouar Mahya Jamshidikia Yuichi Morozumi Sophie Rousseaux Saadi Khochbin

Biochim Biophys Acta 2013 Oct 3;1829(10):1010-4. Epub 2013 Jul 3.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

View Article and Find Full Text PDF

October 2013

Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.

EMBO Mol Med 2013 Aug 4;5(8):1180-95. Epub 2013 Jul 4.

CEA, iRTSV, Biologie à Grande Echelle, Grenoble, France.

View Article and Find Full Text PDF

August 2013

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers.

Authors:

Sophie Rousseaux Alexandra Debernardi Baptiste Jacquiau Anne-Laure Vitte Aurélien Vesin Hélène Nagy-Mignotte Denis Moro-Sibilot Pierre-Yves Brichon Sylvie Lantuejoul Pierre Hainaut Julien Laffaire Aurélien de Reyniès David G Beer Jean-François Timsit Christian Brambilla Elisabeth Brambilla Saadi Khochbin

Sci Transl Med 2013 May;5(186):186ra66

INSERM, U823, Université Joseph Fourier, Grenoble 1, Institut Albert Bonniot, Grenoble F-38700, France.

View Article and Find Full Text PDF

May 2013

Shielding Cenp-A removal in post-meiotic male cells.

Authors:

Hitoshi Shiota Afsaneh Goudarzi Sophie Rousseaux Saadi Khochbin

Epigenomics 2013 Apr;5(2):122

INSERM, U823, Université Joseph Fourier – Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

View Article and Find Full Text PDF

April 2013

Transgenerational inheritance of chromatin states.

Authors:

Hitoshi Shiota Afsaneh Goudarzi Sophie Rousseaux Saadi Khochbin

Epigenomics 2013 Apr;5(2):121-2

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

View Article and Find Full Text PDF

April 2013

When are the BET factors the most sensitive to bromodomain inhibitors?

Authors:

Saadi Khochbin

Transcription 2013 Mar-Apr;4(2):54-7. Epub 2013 Feb 14.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot Grenoble, France.

View Article and Find Full Text PDF

December 2013

Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells.

Authors:

Lei Wang Shengyan Xiang Kendra A Williams Huiqin Dong Wenlong Bai Santo V Nicosia Saadi Khochbin Gerold Bepler Xiaohong Zhang

PLoS One 2012 5;7(9):e44265. Epub 2012 Sep 5.

Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America.

View Article and Find Full Text PDF

February 2013

HDAC6 controls the kinetics of platelet activation.

Authors:

Karin Sadoul Jin Wang Boubou Diagouraga Anne-Laure Vitte Thierry Buchou Thérèse Rossini Benoît Polack Xiaodong Xi Patrick Matthias Saadi Khochbin

Blood 2012 Nov 6;120(20):4215-8. Epub 2012 Sep 6.

Inserm U823, Université Joseph Fourier, Grenoble 1, Institut Albert Bonniot, F-38700 Grenoble, France.

View Article and Find Full Text PDF

November 2012

Bromodomain-dependent stage-specific male genome programming by Brdt.

EMBO J 2012 Oct 24;31(19):3809-20. Epub 2012 Aug 24.

INSERM, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

October 2012

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

EMBO J 2012 Sep 14;31(18):3730-44. Epub 2012 Aug 14.

Unité Inserm U, Grenoble Institute of Neuroscience, Université Joseph Fourier, La Tronche, France.

View Article and Find Full Text PDF

September 2012

Combined proteomic and in silico approaches to decipher post-meiotic male genome reprogramming in mice.

Authors:

Sophie Rousseaux Saadi Khochbin

Syst Biol Reprod Med 2012 Aug;58(4):191-6

Faculté de Médecine, INSERM, U823, Université Joseph Fourier - Grenoble, Institut Albert Bonniot, La Tronche Cedex, France.

View Article and Find Full Text PDF

August 2012

A unified phylogeny-based nomenclature for histone variants.

Epigenetics Chromatin 2012 Jun 21;5. Epub 2012 Jun 21.

Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

View Article and Find Full Text PDF

June 2012

[Cross-fire over the nucleosome: molecular basis of post-meiotic male haploid genome compaction].

Authors:

Emilie Montellier Sophie Rousseaux Saadi Khochbin

Med Sci (Paris) 2012 May 30;28(5):485-9. Epub 2012 May 30.

Inserm, U823, université Joseph Fourier Grenoble 1 ; institut Albert Bonniot, Grenoble, Domaine de la Merci, 38706 La Tronche, France.

View Article and Find Full Text PDF

May 2012

Histone crotonylation specifically marks the haploid male germ cell gene expression program: post-meiotic male-specific gene expression.

Authors:

Emilie Montellier Sophie Rousseaux Yingming Zhao Saadi Khochbin

Bioessays 2012 Mar 15;34(3):187-93. Epub 2011 Dec 15.

INSERM, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, La Tronche Cedex, France.

View Article and Find Full Text PDF

March 2012

Proteomic strategy for the identification of critical actors in reorganization of the post-meiotic male genome.

Authors:

Jerome Govin Jonathan Gaucher Myriam Ferro Alexandra Debernardi Jerome Garin Saadi Khochbin Sophie Rousseaux

Mol Hum Reprod 2012 Jan 4;18(1):1-13. Epub 2011 Oct 4.

Biologie à Grande Echelle, CEA, iRTSV, F-38054 Grenoble, France.

View Article and Find Full Text PDF

January 2012

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

Authors:

Minjia Tan Hao Luo Sangkyu Lee Fulai Jin Jeong Soo Yang Emilie Montellier Thierry Buchou Zhongyi Cheng Sophie Rousseaux Nisha Rajagopal Zhike Lu Zhen Ye Qin Zhu Joanna Wysocka Yang Ye Saadi Khochbin Bing Ren Yingming Zhao

Cell 2011 Sep;146(6):1016-28

Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA.

View Article and Find Full Text PDF

September 2011

Induced malignant genome reprogramming in somatic cells by testis-specific factors.

Authors:

Jin Wang Anouk Emadali Aurore Le Bescont Mary Callanan Sophie Rousseaux Saadi Khochbin

Biochim Biophys Acta 2011 Apr-Jun;1809(4-6):221-5. Epub 2011 Apr 21.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38706, France.

View Article and Find Full Text PDF

August 2011

In the heart of a dynamic chromatin.

Authors:

Saadi Khochbin

Chem Biol 2011 Apr;18(4):410-2

INSERM, U823, Grenoble, F-38706 France.

View Article and Find Full Text PDF

April 2011

Differentiation of NUT midline carcinoma by epigenomic reprogramming.

Authors:

Brian E Schwartz Matthias D Hofer Madeleine E Lemieux Daniel E Bauer Michael J Cameron Nathan H West Elin S Agoston Nicolas Reynoird Saadi Khochbin Tan A Ince Amanda Christie Katherine A Janeway Sara O Vargas Antonio R Perez-Atayde Jon C Aster Stephen E Sallan Andrew L Kung James E Bradner Christopher A French

Cancer Res 2011 Apr 29;71(7):2686-96. Epub 2011 Mar 29.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article and Find Full Text PDF

April 2011

Molecular models for post-meiotic male genome reprogramming.

Authors:

Sophie Rousseaux Fayçal Boussouar Jonathan Gaucher Nicolas Reynoird Emilie Montellier Sandrine Curtet Anne-Laure Vitte Saadi Khochbin

Syst Biol Reprod Med 2011 Feb 6;57(1-2):50-3. Epub 2011 Jan 6.

INSERM, U823, Université Joseph Fourier Grenoble, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

February 2011

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

Authors:

Valerie Edmond Elodie Moysan Saadi Khochbin Patrick Matthias Christian Brambilla Elisabeth Brambilla Sylvie Gazzeri Beatrice Eymin

EMBO J 2011 Feb 14;30(3):510-23. Epub 2010 Dec 14.

INSERM, U823, Equipe 2 Bases Moléculaires de la Progression des Cancers du Poumon, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

February 2011

The tale of protein lysine acetylation in the cytoplasm.

Authors:

Karin Sadoul Jin Wang Boubou Diagouraga Saadi Khochbin

J Biomed Biotechnol 2011 28;2011:970382. Epub 2010 Nov 28.

INSERM, U823, Institut Albert Bonniot, Université Joseph Fourier Grenoble 1, 38700 Grenoble, France.

View Article and Find Full Text PDF

April 2011

Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis.

Authors:

Jérôme Govin Jean Dorsey Jonathan Gaucher Sophie Rousseaux Saadi Khochbin Shelley L Berger

Genes Dev 2010 Aug;24(16):1772-86

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF

August 2010

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

Authors:

Nicolas Reynoird Brian E Schwartz Manuela Delvecchio Karin Sadoul David Meyers Chandrani Mukherjee Cécile Caron Hiroshi Kimura Sophie Rousseaux Philip A Cole Daniel Panne Christopher A French Saadi Khochbin

EMBO J 2010 Sep 30;29(17):2943-52. Epub 2010 Jul 30.

INSERM, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

September 2010

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

Authors:

Rong Huang Marc A Holbert Mary Katherine Tarrant Sandrine Curtet David R Colquhoun Beverley M Dancy Blair C Dancy Yousang Hwang Yong Tang Katrina Meeth Ronen Marmorstein Robert N Cole Saadi Khochbin Philip A Cole

J Am Chem Soc 2010 Jul;132(29):9986-7

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article and Find Full Text PDF

July 2010

1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma.

EMBO Mol Med 2010 May;2(5):159-71

INSERM U823, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

May 2010

Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae.

Authors:

Jérôme Govin Jonathan Schug Thanuja Krishnamoorthy Jean Dorsey Saadi Khochbin Shelley L Berger

Nucleic Acids Res 2010 Aug 7;38(14):4599-606. Epub 2010 Apr 7.

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF

August 2010

[A novel key element in post-meiotic male genome reprogramming].

Authors:

Sophie Rousseaux Carlo Petosa Christoph W Müller Saadi Khochbin

Med Sci (Paris) 2010 Feb;26(2):130-2

Université Joseph Fourier, Institut Albert Bonniot, Grenoble, F-38700 France.

View Article and Find Full Text PDF

February 2010

From meiosis to postmeiotic events: the secrets of histone disappearance.

Authors:

Jonathan Gaucher Nicolas Reynoird Emilie Montellier Fayçal Boussouar Sophie Rousseaux Saadi Khochbin

FEBS J 2010 Feb 15;277(3):599-604. Epub 2009 Dec 15.

INSERM, U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

February 2010

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

Authors:

Sara A Wickström Katarzyna C Masoumi Saadi Khochbin Reinhard Fässler Ramin Massoumi

EMBO J 2010 Jan 5;29(1):131-44. Epub 2009 Nov 5.

Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.

View Article and Find Full Text PDF

January 2010

Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.

Authors:

Benoît Busser Lucie Sancey Véronique Josserand Carole Niang Saadi Khochbin Marie C Favrot Jean-Luc Coll Amandine Hurbin

Mol Ther 2010 Mar 13;18(3):536-43. Epub 2009 Oct 13.

INSERM, U823, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

March 2010

Real-time imaging of histone H4 hyperacetylation in living cells.

Authors:

Kazuki Sasaki Tamaki Ito Norikazu Nishino Saadi Khochbin Minoru Yoshida

Proc Natl Acad Sci U S A 2009 Sep 3;106(38):16257-62. Epub 2009 Sep 3.

Chemical Genetics Laboratory/Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.

View Article and Find Full Text PDF

September 2009

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.

Authors:

Jeanne Morinière Sophie Rousseaux Ulrich Steuerwald Montserrat Soler-López Sandrine Curtet Anne-Laure Vitte Jérôme Govin Jonathan Gaucher Karin Sadoul Darren J Hart Jeroen Krijgsveld Saadi Khochbin Christoph W Müller Carlo Petosa

Nature 2009 Oct;461(7264):664-8

European Molecular Biology Laboratory, Grenoble Outstation, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9, France.

View Article and Find Full Text PDF

October 2009

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Authors:

Sabrina Fritah Edwige Col Cyril Boyault Jérôme Govin Karin Sadoul Susanna Chiocca Elisabeth Christians Saadi Khochbin Caroline Jolly Claire Vourc'h

Mol Biol Cell 2009 Dec 30;20(23):4976-84. Epub 2009 Sep 30.

Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Université Joseph Fourier, F-38706 Grenoble, France.

View Article and Find Full Text PDF

December 2009

New hypotheses for large-scale epigenome alterations in somatic cancer cells: a role for male germ-cell-specific regulators.

Authors:

Sophie Rousseaux Saadi Khochbin

Epigenomics 2009 Oct;1(1):153-61

INSERM U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

October 2009

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

Authors:

Yuliya Zilberman Christoph Ballestrem Letizia Carramusa Ralph Mazitschek Saadi Khochbin Alexander Bershadsky

J Cell Sci 2009 Oct 8;122(Pt 19):3531-41. Epub 2009 Sep 8.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

View Article and Find Full Text PDF

October 2009

A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells.

Authors:

Angéline Eymery Béatrice Horard Michèle El Atifi-Borel Geneviève Fourel François Berger Anne-Laure Vitte Arnaud Van den Broeck Elisabeth Brambilla Alexandra Fournier Mary Callanan Sylvie Gazzeri Saadi Khochbin Sophie Rousseaux Eric Gilson Claire Vourc'h

Nucleic Acids Res 2009 Oct 31;37(19):6340-54. Epub 2009 Aug 31.

INSERM, U823, Université Joseph Fourier, Institut Albert Bonniot, La Tronche F-38706, Grenoble.

View Article and Find Full Text PDF

October 2009

Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.

Authors:

Delphine Quénet Manuel Mark Jérôme Govin A van Dorsselear Valérie Schreiber Saadi Khochbin Françoise Dantzer

Exp Cell Res 2009 Oct 14;315(16):2824-34. Epub 2009 Jul 14.

IREBS-FRE 3211, Ecole Supérieure de Biotechnologie de Strasbourg, F-67412 Illkirch cedex, France.

View Article and Find Full Text PDF

October 2009

Preface to the "epigenetics and development" special issue.

Authors:

Saadi Khochbin Stefan Nonchev

Int J Dev Biol 2009 ;53(2-3):189-90

View Article and Find Full Text PDF

September 2009

A new insight into male genome reprogramming by histone variants and histone code.

Authors:

Fayçal Boussouar Sophie Rousseaux Saadi Khochbin

Cell Cycle 2008 Nov 12;7(22):3499-502. Epub 2008 Nov 12.

INSERM, U823, Grenoble, France, and Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

View Article and Find Full Text PDF

November 2008

HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids.

Authors:

Raffaella Catena Emmanuelle Escoffier Cécile Caron Saadi Khochbin Igor Martianov Irwin Davidson

Biol Reprod 2009 Feb 5;80(2):358-66. Epub 2008 Nov 5.

ALMA Consulting Group, European Research Project Management, 69338 Lyon, France.

View Article and Find Full Text PDF

February 2009

[Intrusion of male epigenome regulators in somatic cancer cells].

Authors:

Sophie Rousseaux Nicolas Reynoird Jonathan Gaucher Saadi Khochbin

Med Sci (Paris) 2008 Aug-Sep;24(8-9):735-41

Equipe épigénétique et signalisation cellulaire. Inserm U823, Institut Albert Bonniot, Grenoble, F-38706 France.

View Article and Find Full Text PDF

December 2008

Testis-specific histone variants H2AL1/2 rapidly disappear from paternal heterochromatin after fertilization.

Authors:

Fang Wu Cécile Caron Christine De Robertis Saadi Khochbin Sophie Rousseaux

J Reprod Dev 2008 Dec 12;54(6):413-7. Epub 2008 Aug 12.

Institut National de la Santé et de la Recherche Médicale, U823, Grenoble, France.

View Article and Find Full Text PDF

December 2008

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.

Authors:

Kazuo Kamemura Akihiro Ito Tadahiro Shimazu Akihisa Matsuyama Satoko Maeda Tso-Pang Yao Sueharu Horinouchi Saadi Khochbin Minoru Yoshida

Biochem Biophys Res Commun 2008 Sep 3;374(1):84-9. Epub 2008 Jul 3.

Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.

View Article and Find Full Text PDF

September 2008

[HDAC6 orchestrates cell defense responses against cytotoxic protein aggregates].

Authors:

Cyril Boyault Saadi Khochbin

Med Sci (Paris) 2008 Jan;24(1):15-7

INSERM U823, Equipe épigénétique et signalisation cellulaire, Institut Albert Bonniot, Rond-point de la Chantourne, La Tronche Cedex Grenoble, France.

View Article and Find Full Text PDF

January 2008