Publications by authors named "Saadi Khochbin"

100Publications

Marginal band microtubules are acetylated by αTAT1.

Platelets 2020 May 2:1-5. Epub 2020 May 2.

Institute for Advanced Biosciences, University Grenoble Alpes, INSERM, CNRS, Grenoble, France.

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May 2020

RNA-Guided Genomic Localization of H2A.L.2 Histone Variant.

Cells 2020 02 18;9(2). Epub 2020 Feb 18.

CNRS UMR 5309, Inserm, U1209, Université Grenoble Alpes, Institute for Advanced Biosciences, F-38700 Grenoble, France.

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February 2020

[Regulators of the male epigenome: Markers and potential targets for anticancer therapy].

Bull Cancer 2019 Oct 23;106(10):836-838. Epub 2019 Aug 23.

Université Grenoble-Alpes, Institut pour l'avancée des biosciences, CNRS UMR 5309, U1209, Inserm, 38700 Grenoble, France. Electronic address:

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October 2019

Histone variants: critical determinants in tumour heterogeneity.

Front Med 2019 Jun 11;13(3):289-297. Epub 2019 Jun 11.

CNRS UMR 5309, Inserm, U1209, University of Grenoble Alpes, Institute for Advanced Biosciences, 38706, Grenoble, France.

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June 2019

Characterization of Post-Meiotic Male Germ Cell Genome Organizational States.

Methods Mol Biol 2018 ;1832:293-307

Institut Albert Bonniot, CNRS UMR 5309, INSERM U1209, Université Grenoble Alpes, Grenoble, France.

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April 2019

Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044.

Cancer Med 2018 02 26;7(2):380-396. Epub 2017 Dec 26.

State Key Laboratory for Medical Genomics, Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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February 2018

Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia.

J Cell Mol Med 2018 03 20;22(3):1614-1626. Epub 2017 Dec 20.

State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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March 2018

Histone variants: essential actors in male genome programming.

J Biochem 2018 Feb;163(2):97-103

CNRS UMR 5309, Inserm, U1209, Université Grenoble Alpes, Institut Albert Bonniot, Grenoble F-38700, France.

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February 2018

[The mystery of histone disappearance during spermatogenesis].

Med Sci (Paris) 2017 Jun-Jul;33(6-7):588-590. Epub 2017 Jul 19.

CNRS UMR 5309 ; Inserm, U1209 ; université Grenoble Alpes ; Institute for Advanced Biosciences, Grenoble, F-38700 France.

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April 2019

Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

Sci Rep 2017 09 21;7(1):12133. Epub 2017 Sep 21.

Univ. Grenoble Alpes, Inserm, Laboratoire de Bioénergétique Fondamentale et Appliquée (LBFA), Grenoble, 38000, France.

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September 2017

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.

Cell J 2017 17;19(Suppl 1):1-8. Epub 2017 May 17.

CNRS UMR 5309, Inserm, U1209, University of Grenoble Alpes, Institute for Advanced Biosciences, Grenoble, France.

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May 2017

A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.

Nat Commun 2016 12 19;7:13855. Epub 2016 Dec 19.

European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Meyerhofstrasse 1, Heidelberg 69117, Germany.

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December 2016

Structure of p300 in complex with acyl-CoA variants.

Nat Chem Biol 2017 Jan 31;13(1):21-29. Epub 2016 Oct 31.

European Molecular Biology Laboratory, Grenoble, France.

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January 2017

Purification and Analysis of Male Germ Cells from Adult Mouse Testis.

Methods Mol Biol 2017 ;1510:159-168

CNRS UMR 5209, INSERM U1209, CR UGA, Institute for Advanced Biosciences, La Tronche, 38700, France.

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January 2018

Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer.

Nat Protoc 2016 Nov 6;11(11):2170-2188. Epub 2016 Oct 6.

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

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November 2016

The growing landscape of tubulin acetylation: lysine 40 and many more.

Biochem J 2016 07;473(13):1859-68

CNRS UMR 5309, INSERM U1209, Institut Albert Bonniot, Université Grenoble Alpes, Grenoble F-38700, France

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July 2016

Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures.

Cell Rep 2015 Dec 25;13(9):1765-71. Epub 2015 Nov 25.

Faculty of Veterinary Medicine, University of Teramo, Renato Balzarini Street 1, Campus Coste Sant'Agostino, 64100 Teramo, Italy. Electronic address:

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December 2015

Arsenic trioxide rewires mantle cell lymphoma response to bortezomib.

Cancer Med 2015 Nov 26;4(11):1754-66. Epub 2015 Aug 26.

State Key Laboratory for Medical Genomics and Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Systems Biomedicine, Pôle Sino-Français des Sciences du Vivant et Genomique, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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November 2015

Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.

J Biol Chem 2015 Feb 15;290(7):4215-24. Epub 2014 Dec 15.

From the Ecole Normale Supérieure de Lyon; CNRS UMR 5239; Equipe Différenciation Neuromusculaire, Université de Lyon, 46 allée d'Italie 69364 Lyon cedex 07, France, Université Lyon 1; Hospices civils de Lyon,

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February 2015

Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.

Mol Cells 2014 Dec 5;37(12):851-6. Epub 2014 Nov 5.

Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.

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December 2014

HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.

Mol Biol Cell 2014 Dec 8;25(25):4187-94. Epub 2014 Oct 8.

University Grenoble-Alpes, CRI INSERM, U823, Institut Albert Bonniot, La Tronche 38042, Grenoble Cedex 9, France

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December 2014

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

Clin Cancer Res 2014 Nov 4;20(22):5777-86. Epub 2014 Sep 4.

Département d'Anatomie et Cytologie Pathologique, Centre Hospitalier Universitaire de Grenoble, Institut Albert Bonniot, INSERM U823, Université Joseph Fourrier, Grenoble, France.

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November 2014

Genome-scale acetylation-dependent histone eviction during spermatogenesis.

J Mol Biol 2014 Oct 5;426(20):3342-9. Epub 2014 Mar 5.

Institut National de la Santé et de la Recherche Médicale U823 and Université Grenoble Alpes Institut Albert Bonniot, Grenoble F-38700, France. Electronic address:

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October 2014

Motor-driven marginal band coiling promotes cell shape change during platelet activation.

J Cell Biol 2014 Jan 13;204(2):177-85. Epub 2014 Jan 13.

Institut Albert Bonniot, Institut National de la Santé et de la Recherche Médicale U823; and 2 Techniques de l'Ingénierie Médicale et de la Complexité-Informatique, Mathématiques et Applications, Grenoble, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5525; Université Joseph Fourier-Grenoble 1, F-38041 Grenoble, France.

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January 2014

Sustaining cancer through addictive ectopic gene activation.

Curr Opin Oncol 2014 Jan;26(1):73-7

aINSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, La Tronche, France bState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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January 2014

Histone variants and sensing of chromatin functional states.

Nucleus 2013 Nov-Dec;4(6):438-42. Epub 2013 Nov 8.

Université Grenoble-Alpes; Grenoble, France; INSERM, U823; Institut Albert Bonniot; Grenoble, France.

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October 2014

Cancer hallmarks sustained by ectopic activations of placenta/male germline genes.

Cell Cycle 2013 Aug 11;12(15):2331-2. Epub 2013 Jul 11.

INSERM; U823; Université Joseph Fourier-Grenoble 1; Institut Albert Bonniot; Grenoble, France.

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August 2013

Malignant genome reprogramming by ATAD2.

Biochim Biophys Acta 2013 Oct 3;1829(10):1010-4. Epub 2013 Jul 3.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

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October 2013

Shielding Cenp-A removal in post-meiotic male cells.

Epigenomics 2013 Apr;5(2):122

INSERM, U823, Université Joseph Fourier – Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

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April 2013

Transgenerational inheritance of chromatin states.

Epigenomics 2013 Apr;5(2):121-2

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38700, France.

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April 2013

When are the BET factors the most sensitive to bromodomain inhibitors?

Authors:
Saadi Khochbin

Transcription 2013 Mar-Apr;4(2):54-7. Epub 2013 Feb 14.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot Grenoble, France.

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December 2013

Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells.

PLoS One 2012 5;7(9):e44265. Epub 2012 Sep 5.

Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America.

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February 2013

HDAC6 controls the kinetics of platelet activation.

Blood 2012 Nov 6;120(20):4215-8. Epub 2012 Sep 6.

Inserm U823, Université Joseph Fourier, Grenoble 1, Institut Albert Bonniot, F-38700 Grenoble, France.

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November 2012

Combined proteomic and in silico approaches to decipher post-meiotic male genome reprogramming in mice.

Syst Biol Reprod Med 2012 Aug;58(4):191-6

Faculté de Médecine, INSERM, U823, Université Joseph Fourier - Grenoble, Institut Albert Bonniot, La Tronche Cedex, France.

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August 2012

[Cross-fire over the nucleosome: molecular basis of post-meiotic male haploid genome compaction].

Med Sci (Paris) 2012 May 30;28(5):485-9. Epub 2012 May 30.

Inserm, U823, université Joseph Fourier Grenoble 1 ; institut Albert Bonniot, Grenoble, Domaine de la Merci, 38706 La Tronche, France.

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May 2012

Histone crotonylation specifically marks the haploid male germ cell gene expression program: post-meiotic male-specific gene expression.

Bioessays 2012 Mar 15;34(3):187-93. Epub 2011 Dec 15.

INSERM, U823, Université Joseph Fourier-Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, La Tronche Cedex, France.

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March 2012

Induced malignant genome reprogramming in somatic cells by testis-specific factors.

Biochim Biophys Acta 2011 Apr-Jun;1809(4-6):221-5. Epub 2011 Apr 21.

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Grenoble, F-38706, France.

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August 2011

In the heart of a dynamic chromatin.

Authors:
Saadi Khochbin

Chem Biol 2011 Apr;18(4):410-2

INSERM, U823, Grenoble, F-38706 France.

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April 2011

Molecular models for post-meiotic male genome reprogramming.

Syst Biol Reprod Med 2011 Feb 6;57(1-2):50-3. Epub 2011 Jan 6.

INSERM, U823, Université Joseph Fourier Grenoble, Institut Albert Bonniot, Grenoble, France.

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February 2011

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

EMBO J 2011 Feb 14;30(3):510-23. Epub 2010 Dec 14.

INSERM, U823, Equipe 2 Bases Moléculaires de la Progression des Cancers du Poumon, Institut Albert Bonniot, Grenoble, France.

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February 2011

The tale of protein lysine acetylation in the cytoplasm.

J Biomed Biotechnol 2011 28;2011:970382. Epub 2010 Nov 28.

INSERM, U823, Institut Albert Bonniot, Université Joseph Fourier Grenoble 1, 38700 Grenoble, France.

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April 2011

Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis.

Genes Dev 2010 Aug;24(16):1772-86

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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August 2010

Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae.

Nucleic Acids Res 2010 Aug 7;38(14):4599-606. Epub 2010 Apr 7.

Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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August 2010

[A novel key element in post-meiotic male genome reprogramming].

Med Sci (Paris) 2010 Feb;26(2):130-2

Université Joseph Fourier, Institut Albert Bonniot, Grenoble, F-38700 France.

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February 2010

From meiosis to postmeiotic events: the secrets of histone disappearance.

FEBS J 2010 Feb 15;277(3):599-604. Epub 2009 Dec 15.

INSERM, U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

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February 2010

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

EMBO J 2010 Jan 5;29(1):131-44. Epub 2009 Nov 5.

Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.

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January 2010

Real-time imaging of histone H4 hyperacetylation in living cells.

Proc Natl Acad Sci U S A 2009 Sep 3;106(38):16257-62. Epub 2009 Sep 3.

Chemical Genetics Laboratory/Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.

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September 2009

Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

Mol Biol Cell 2009 Dec 30;20(23):4976-84. Epub 2009 Sep 30.

Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Université Joseph Fourier, F-38706 Grenoble, France.

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December 2009

New hypotheses for large-scale epigenome alterations in somatic cancer cells: a role for male germ-cell-specific regulators.

Epigenomics 2009 Oct;1(1):153-61

INSERM U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

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October 2009

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

J Cell Sci 2009 Oct 8;122(Pt 19):3531-41. Epub 2009 Sep 8.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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October 2009

A new insight into male genome reprogramming by histone variants and histone code.

Cell Cycle 2008 Nov 12;7(22):3499-502. Epub 2008 Nov 12.

INSERM, U823, Grenoble, France, and Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.

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November 2008

[Intrusion of male epigenome regulators in somatic cancer cells].

Med Sci (Paris) 2008 Aug-Sep;24(8-9):735-41

Equipe épigénétique et signalisation cellulaire. Inserm U823, Institut Albert Bonniot, Grenoble, F-38706 France.

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December 2008

Testis-specific histone variants H2AL1/2 rapidly disappear from paternal heterochromatin after fertilization.

J Reprod Dev 2008 Dec 12;54(6):413-7. Epub 2008 Aug 12.

Institut National de la Santé et de la Recherche Médicale, U823, Grenoble, France.

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December 2008

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.

Biochem Biophys Res Commun 2008 Sep 3;374(1):84-9. Epub 2008 Jul 3.

Chemical Genetics Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.

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September 2008

[HDAC6 orchestrates cell defense responses against cytotoxic protein aggregates].

Med Sci (Paris) 2008 Jan;24(1):15-7

INSERM U823, Equipe épigénétique et signalisation cellulaire, Institut Albert Bonniot, Rond-point de la Chantourne, La Tronche Cedex Grenoble, France.

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January 2008

HDAC6 a new cellular stress surveillance factor.

Cell Cycle 2008 Jan 15;7(1):7-10. Epub 2007 Oct 15.

Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland.

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January 2008

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Mol Cell Biol 2008 Mar 7;28(5):1688-701. Epub 2008 Jan 7.

Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, P.O. Box 2543, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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March 2008

Asymmetric nuclear reprogramming in somatic cell nuclear transfer?

Bioessays 2008 Jan;30(1):66-74

Department of Comparative Biomedical Sciences, Teramo, Italy.

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January 2008

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

Genes Dev 2007 Sep;21(17):2172-81

Institut National de la Santé et de la Recherche Médicale (INSERM), U823, Institut Albert Bonniot, Grenoble F-38706, France.

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September 2007

Design and synthesis of cyclopeptide analogues of the potent histone deacetylase inhibitor FR235222.

ChemMedChem 2007 Oct;2(10):1511-9

Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano (Salerno), Italy.

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October 2007

Regulation of protein turnover by acetyltransferases and deacetylases.

Biochimie 2008 Feb 1;90(2):306-12. Epub 2007 Jul 1.

INSERM U823, Equipe Epigénétique et Signalisation Cellulaire, F-38706 Grenoble, France.

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February 2008

Differential histone modifications mark mouse imprinting control regions during spermatogenesis.

EMBO J 2007 Feb 25;26(3):720-9. Epub 2007 Jan 25.

Institute of Molecular Genetics, CNRS and University of Montpellier II, Montpellier, France.

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February 2007