Publications by authors named "S Zeng"

2,828 Publications

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Low Dose Soft X-Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti-Tumor Immunoresponse.

Adv Sci (Weinh) 2021 Jun 8;8(12):e2004391. Epub 2021 Apr 8.

Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, 999077, P. R. China.

Gas-based therapy has emerged as a new green therapy strategy for anti-tumor treatment. However, the therapeutic efficacy is still restricted by the deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment (TME). Herein, a new type of nanovaccine is designed by integrating low dose soft X-ray-triggered CO releasing lanthanide scintillator nanoparticles (ScNPs: NaLuF :Gd,[email protected] ) with photo-responsive CO releasing moiety (PhotoCORM) for synergistic CO gas/immuno-therapy of tumors. The designed nanovaccine presents significantly boosted radioluminescence and enables deep tissue CO generation at unprecedented tissue depths of 5 cm under soft X-ray irradiation. Intriguingly, CO as a superior immunogenic cell death (ICD) inducer further reverses the deep tissue immunosuppressive TME and concurrently activates adaptive anti-tumor immunity through efficient reactive oxygen species (ROS) generation. More importantly, the designed nanovaccine presents efficient growth inhibition of both local and distant tumors via a soft X-ray activated systemic anti-tumor immunoresponse. This work provides a new strategy of designing anti-tumor nanovaccines for synergistic deep tissue gas-therapy and remote soft X-ray photoactivation of the immune response.
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http://dx.doi.org/10.1002/advs.202004391DOI Listing
June 2021

Correlation between the positive rate of SAA in children with respiratory tract infection and ambient temperature.

Environ Sci Pollut Res Int 2021 Jun 24. Epub 2021 Jun 24.

Department of Clinical Laboratory, Guangzhou Women and Children's Medical Centre of Guangzhou Medical University, No. 9, Jinsui Road, Guangzhou, 510623, Guangdong, China.

The purpose of this study was to explore the application of serum amyloid A (SAA) in the outcome of upper respiratory tract infection in children by analyzing the correlation between the change of mean air temperature and the positive rate of SAA detection in children. Daily data on upper respiratory tract infection diseases and weather conditions were collected in 2016-2019. A quasi-Poisson regression with a distributed lag non-linear model was used to examine the association between temperature and SAA-positive rate. The positive rate of SAA had a moderate correlation with the temperature and a weak correlation with relative humidity. Low ambient temperature (7 °C, P) was related to the increase in the positive rate of SAA, with the effect lag for 0-7 days (RR 1.34 (1.19~1.74)). The increase in the SAA-positive case induced by 27 °C (P) could last for 0-14 days (RR 1.07 (1.01-1.08)), and high temperature (30 °C, P) could reduce the positive rate of SAA. Our findings add additional evidence to the adverse effects of sub-optimal ambient temperature and provide useful information for public health programs targeting pediatric patients.
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http://dx.doi.org/10.1007/s11356-021-15033-8DOI Listing
June 2021

Dynamic characteristics and fractal representations of crack propagation of rock with different fissures under multiple impact loadings.

Sci Rep 2021 Jun 22;11(1):13071. Epub 2021 Jun 22.

College of Civil Engineering, Guangxi University, Nanning, 530004, China.

To investigate the influence of the fissure morphology on the dynamic mechanical properties of the rock and the crack propagation, a drop hammer impact test device was used to conduct impact failure tests on sandstones with different fissure numbers and fissure dips, simultaneously recorded the crack growth after each impact. The box fractal dimension is used to quantitatively analyze the dynamic change in the sandstone cracks and a fractal model of crack growth over time is established based on fractal theory. The results demonstrate that under impact test conditions of the same mass and different heights, the energy absorbed by sandstone accounts for about 26.7% of the gravitational potential energy. But at the same height and different mass, the energy absorbed by the sandstone accounts for about 68.6% of the total energy. As the fissure dip increases and the number of fissures increases, the dynamic peak stress and dynamic elastic modulus of the fractured sandstone gradually decrease. The fractal dimensions of crack evolution tend to increase with time as a whole and assume as a parabolic. Except for one fissure, 60° and 90° specimens, with the extension of time, the increase rate of fractal dimension is decreasing correspondingly.
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http://dx.doi.org/10.1038/s41598-021-92277-xDOI Listing
June 2021

Application of Platelet-rich Fibrin Grafts Following Pterygium Excision.

Int J Clin Pract 2021 Jun 22:e14560. Epub 2021 Jun 22.

Eye Center, Renmin Hospital of Wuhan University, #238 Jiefang Road, Wuhan, 430060, China.

Purpose: To compare the efficacy, safety, and recurrence rate of platelet-rich fibrin (PRF) grafts and limbal conjunctival autografts (LCA) following pterygium excision.

Methods: A total of 108 patients (108 eyes) with primary pterygium were included in this study and were divided into group A (56 eyes) and group B (52 eyes). Patients in group A underwent excision of the pterygium followed by LCA, while patients in group B underwent PRF grafts following pterygium excision. The PRF was produced using the patient's own whole-blood sample by centrifugation and extrusion. The surgery time, intraoperative complications, postoperative complications, recurrence rate, intraocular pressure (IOP), and follow-up period were recorded and evaluated between the two groups.

Results: The mean surgery time was significantly shorter in group B (25.0 ± 4.2 min) than in group A (36.5 ± 6.3 min) (P<0.001). Recurrence was observed in two cases (3.6%) in group A, while no recurrence was observed in group B. No graft loss was observed in either group. No other intra/postoperative complications such as a tear in the graft, injury to the medial rectus muscle, excessive bleeding, scleral necrosis, graft edema, graft necrosis, pannus formation, or symblepharon appeared in either group.

Conclusions: This study presented with a promising outcome of PRF grafts applications in primary pterygium surgery. The use of PRF following pterygium excision is a simple, easily applicable, and comfortable method for both patients and surgeons, with low time consuming, recurrence rate, and complications, which could be widely used in pterygium management.
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http://dx.doi.org/10.1111/ijcp.14560DOI Listing
June 2021

Gastroesophageal reflux is associated with an increased risk of gastric cardiac polyps: a case-control study of 140 cases.

Ann Palliat Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: The pathogenesis of gastric cardiac polyps is not yet clear, and there is little research on their clinical and histopathologic characteristics and correlation with gastroesophageal reflux. Early detection and treatment of premalignant lesions in this area can prevent the development of cancer. We aimed to evaluate the clinical and histopathologic characteristics and risk factors of gastric cardiac polyps to improve the current understanding of the disease.

Methods: Patients diagnosed with gastric cardiac polyps at the Third Affiliated Hospital of Sun Yat-Sen University between January 1, 2010, and December 31, 2019, were sought for the study. The exclusion criteria were missing clinical data, insufficient pathological reports, gastric malignancy, or a previous history of gastroduodenal surgery. Ultimately, 140 patients were included in the case group, while 140 patients diagnosed with chronic superficial gastritis from the same 10-year period were identified randomly and selected as a control group. The exclusion criteria for this group were the same as those for the case group. Patients in both groups were matched in age and gender to ensure comparability between the two groups. We evaluated and compared the demographic and clinical data and endoscopic impressions of each group and analyzed the endoscopic, histologic features of gastric cardiac polyps.

Results: Gastroesophageal reflux was significantly associated with a higher risk of gastric cardiac polyps after adjustment for other covariates [adjusted odds ratio (OR) =2.809; 95% confidence interval (CI):1.178-6.697; P=0.020]. Most gastric polyps were single (97.9%), sessile (92.8%), and small polyps with a diameter less than 1 cm (88.6%). Most were located in the gastroesophageal junction region (65.0%) with a smooth surface (56.4%) or surface congestion (30.0%). Hyperplastic (inflammatory) polyps (88.0%) were the most common pathological type and comprised gastric-type foveolar epithelium, squamous epithelium, or admixture of the two epithelia, with a minority showing intestinal metaplasia, mild, or moderate epithelial dysplasia.

Conclusions: Gastroesophageal reflux was associated with a significantly higher incidence of gastric cardiac polyps with a 2.8-fold increased risk. Most gastric cardiac polyps were found to be benign lesions and had a favorable prognosis in the clinic despite their malignant potential.
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http://dx.doi.org/10.21037/apm-21-260DOI Listing
June 2021