Publications by authors named "S W W Yoon"

9,340 Publications

Whole blood viscosity is associated with extrahepatic metastases and survival in patients with hepatocellular carcinoma.

PLoS One 2021 2;16(12):e0260311. Epub 2021 Dec 2.

The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Whole blood viscosity (WBV) is increased in cancer patients and associated with the advanced stage with systemic metastases. However, relevance of WBV in hepatocellular carcinoma (HCC) remains unclear. This pilot study included a discovery cohort of 148 treatment-naïve HCC patients with preserved liver function, and a validation cohort of 33 treatment-experienced HCC patients with nivolumab. Systolic and diastolic WBV was measured using an automated scanning capillary tube viscometer at diagnosis or before the nivolumab treatment. Extrahepatic metastases were observed in 15 treatment-naïve patients (11.3%) at diagnosis. Portal vein tumor thrombosis (PVTT), tumor size, number of tumors, and systolic/diastolic WBV were factors associated with extrahepatic metastases. Systolic WBV and diastolic WBV were significantly increased in patients with metastases compared with patients without metastases. Multivariate logistic regression showed that high diastolic WBV > 16 cP was an independent factor associated with metastases. Notably, patients who developed extrahepatic metastases during the observation period among patients without metastases at diagnosis had higher diastolic WBV initially. Patients with high diastolic WBV had poor survival, and multivariate Cox regression analyses showed high diastolic WBV was an independent risk factor for poor survival with the Child-Pugh B7 and PVTT. High diastolic WBV also predicted poor survival in patients with low alpha-fetoprotein (AFP) and proteins induced by vitamin K antagonist-II (PIVKA-II) levels. In 33 nivolumab-treated patients, high diastolic WBV before the treatment was also tended to be associated with overall and progression-free survival. Our study is the first in which high WBV is associated with the distant metastases and survival in patients with HCC, but future prospective, large cohort studies are necessary to validate the results.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260311PLOS
December 2021

Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children.

JCI Insight 2021 Dec 2. Epub 2021 Dec 2.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, United States of America.

Background: While most children experience mild COVID-19, high-risk children with underlying conditions may develop severe disease, requiring interventions. Kinetics of antibodies transferred via COVID-19 convalescent plasma early in disease, have not been characterized.

Methods: In this study (NCT04377672), high-risk children were prospectively enrolled to receive high-titer COVID-19 convalescent plasma (>1:320 anti-spike IgG; Euroimmun). Passive transfer of antibodies and endogenous antibody production were serially evaluated for up to 2 months after transfusion. Commercial and research ELISA assays, virus neutralization assays, high-throughput phage-display assay utilizing a coronavirus epitope library and pharmacokinetic analyses were performed.

Results: Fourteen high-risk children (median age 7.5 years) received high-titer COVID-19 convalescent plasma, nine children within five days (range 2-7) of symptom onset and five children within 4 days (range 3-5) after exposure to SARS-CoV-2. There were no serious adverse events related to transfusion. Antibodies to SARS-CoV-2 were transferred from the donor to the recipient, but antibody titers declined by 14-21 days with a 15.1-day t½ for spike protein IgG. Donor plasma had significant neutralization capacity which was transferred to the recipient. However, as early as 30 minutes post-transfusion, recipient plasma had low neutralization capacity.

Conclusions: Convalescent plasma transfused to high-risk children appears to be safe with expected antibody kinetics, regardless of weight or age. However, current use of convalescent plasma in high-risk children achieves low neutralizing capacity.
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http://dx.doi.org/10.1172/jci.insight.151518DOI Listing
December 2021

Semitransparent Perovskite Solar Cells with Enhanced Light Utilization Efficiencies by Transferable Ag Nanogrid Electrodes.

ACS Appl Mater Interfaces 2021 Dec 2. Epub 2021 Dec 2.

Department of Mechanical Engineering, Seoul National University, Seoul 08826, Republic of Korea.

Solar cells that are semitransparent and highly efficient can find diverse applications in automobile windows, building walls, and wearable devices. Here, we present a semitransparent perovskite thin-film solar cell with an Ag nanogrid transparent electrode, where electrospun poly(ethylene oxide) (PEO) nanofibers are used as an etching mask. Directional electrospinning has allowed us to obtain a grid-shaped electrode of well-aligned Ag nanogrids. The performance of transparent electrodes can be controlled by the electrospinning conditions and the choice of substrate materials. We theoretically analyze the transmittance and sheet resistance of the electrode. Furthermore, transferable Ag nanogrid transparent electrodes are fabricated on poly(dimethylsiloxane) (PDMS) substrates for application in semitransparent perovskite solar cells. Using an electrode that shows a high transmittance (92.7%) with a low sheet resistance (18.0 Ω·sq), a semitransparent perovskite thin-film solar cell demonstrates average visible wavelength transmittance, power conversion efficiency, and light utilization efficiency rates as high as 25.2, 12.7, and 3.21%, respectively.
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http://dx.doi.org/10.1021/acsami.1c14953DOI Listing
December 2021
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