Publications by authors named "S S Park"

49,638 Publications

Status of Antimicrobial Stewardship Programs in Korean hospitals including small to medium-sized hospitals with the awareness and demands by physicians: A nationwide survey in 2020.

J Glob Antimicrob Resist 2021 Jun 18. Epub 2021 Jun 18.

Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Objectives: This study aimed at identifying the status of ASPs in Korean hospitals with medium- to small-sized hospitals, as well as the awareness and demands about ASPs by physicians.

Methods: The questionnaire was designed based on a questionnaire from a previous nationwide survey in 2018 targeting large hospitals in Korea, and modified to reflect the results of in-depth interviews with non-infectious diseases physicians at secondary care hospitals. The survey targeted all hospitals with ≥ 150 beds in South Korea and performed in May-June 2020. Only one ASP-associated physician per hospital participated in the survey.

Results: The survey response rate was 31.9% (217/680). Infectious diseases specialists comprised most medical personnel participating in ASPs in tertiary care hospitals. Conversely, in secondary and primary care hospitals, there was no predominant medical personnel for ASP and the median full-time equivalent was 0 for all types of medical personnel. Tertiary care hospitals, more than secondary and primary care hospitals, tended to perform ASP activities more actively. 'Workforce for ASPs', 'establishment of healthcare fees for ASPs', and 'development of tools for ASPs' were most important required support for ASPs' improvement.

Conclusions: The level of ASP establishment was more limited in primary care hospitals than in secondary and tertiary care hospitals in Korea. To improve ASPs in Korean hospitals, a supporting workforce and the establishment of a healthcare fee for ASPs seem to be necessary.
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http://dx.doi.org/10.1016/j.jgar.2021.06.001DOI Listing
June 2021

Clinical features of advanced glaucoma with optic nerve head prelaminar schisis Prelaminar schisis in advanced glaucoma.

Am J Ophthalmol 2021 Jun 18. Epub 2021 Jun 18.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea. Electronic address:

Purpose: To investigate the clinical characteristics of optic nerve head (ONH) prelaminar schisis in eyes with advanced glaucoma.

Design: Cross-sectional study.

Methods: One hundred sixteen eyes with advanced glaucoma (30-2 MD < -12 dB) were included. ONH prelaminar schisis was identified using the spectral-domain optical coherence tomography independently by 2 evaluators and only eyes that reached to consensus for the presence of ONH prelaminar schisis were included. Bruch's membrane opening-minimum rim width (BMO-MRW), thickness and depth of lamina cribrosa (LC), peripapillary retinal nerve fiber layer (RNFL) thickness, macular thickness (total, RNFL, ganglion cell layer, inner plexiform layer), and peripapillary and subfoveal choroidal thickness were additionally obtained. Clinical characteristics were compared between the two groups based on the presence of ONH prelaminar schisis.

Results: ONH prelaminar schisis was identified in 48 of 116 eyes. Multivariate logistic regression analysis revealed that short axial length, thin and deep LC, and thick macula were associated with the presence of ONH prelaminar schisis. When the structure-function relationships were determined, macular structural parameters tended to have a better relationship with functional parameters than the BMO-MRW and peripapillary RNFL thickness parameters in eyes with ONH prelaminar schisis.

Conclusions: The ONH prelaminar schisis was associated with thin and deep LC, short axial length, and generally thick macula. In patients with this features, the macular measurements rather than peripapillary or ONH measurements, better predict the functional status of the eye. Our findings may have significant clinical implications for management of advanced glaucoma eyes with and without ONH prelaminar schisis.
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http://dx.doi.org/10.1016/j.ajo.2021.06.007DOI Listing
June 2021

Visualization of Plasmonic Couplings Using Ultrafast Electron Microscopy.

Nano Lett 2021 Jun 21. Epub 2021 Jun 21.

Center for Nanoscale Materials, Argonne National Laboratory, Lemont, Illinois 60439, United States.

Hybrids of graphene and metal plasmonic nanostructures are promising building blocks for applications in optoelectronics, surface-enhanced scattering, biosensing, and quantum information. An understanding of the coupling mechanism in these hybrid systems is of vital importance to its applications. Previous efforts in this field mainly focused on spectroscopic studies of strong coupling within the hybrids with no spatial resolution. Here we report direct imaging of the local plasmonic coupling between single Au nanocapsules and graphene step edges at the nanometer scale by photon-induced near-field electron microscopy in an ultrafast electron microscope for the first time. The proximity of a step in the graphene to the nanocapsule causes asymmetric surface charge density at the ends of the nanocapsules. Computational electromagnetic simulations confirm the experimental observations. The results reported here indicate that this hybrid system could be used to manipulate the localized electromagnetic field on the nanoscale, enabling promising future plasmonic devices.
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http://dx.doi.org/10.1021/acs.nanolett.1c01824DOI Listing
June 2021

Comparison of time and cost between conventional surgical planning and virtual surgical planning in orthognathic surgery in Korea.

Maxillofac Plast Reconstr Surg 2021 Jun 21;43(1):18. Epub 2021 Jun 21.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Busandaehak-ro, Mulgeum-eup, Yangsan, 50612, Republic of Korea.

Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost.

Material And Method: This is a retrospective study of the patients who underwent orthognathic surgery at the OOOOO University Dental Hospital from December 2017 to August 2018. All the patients were analyzed through both CSP and VSP, and all the surgical stents were fabricated through manual and 3-dimensional (3D) printing. The predictor variables were the planning method (CSP vs. VSP) and the surgery type (group I: Le Fort I osteotomy+bilateral sagittal split osteotomy [LFI+BSSO] or group II: only bilateral sagittal split osteotomy [BSSO]), and the outcomes were the time and cost. The results were analyzed using paired t test.

Results: Thirty patients (12 females, 18 males) met the inclusion criteria, and 17 patients were excluded from the study due to missing or incomplete data. There were 20 group I patients (LFI+BSSO regardless of genioplasty) and 10 group II patients (BSSO regardless of genioplasty). The average time of CSP for group I was 385±7.8 min, and that for group II was 195±8.33 min. The time reduction rate of VSP compared with CSP was 62.8% in group I and 41.5% in group II. On the other hand, there was no statistically significant cost reduction.

Conclusions: The time investment in VSP in this study was significantly smaller than that in CSP, and the difference was greater in group I than in group II.
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http://dx.doi.org/10.1186/s40902-021-00305-7DOI Listing
June 2021

Highly selective two-photon fluorescent off-on probes for imaging tyrosinase activity in living cells and tissues.

Chem Commun (Camb) 2021 Jun 21. Epub 2021 Jun 21.

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 120-750, Korea.

A coumarin-based two-photon (TP) fluorescent off-on probe has been developed for detecting tyrosinase activity. High selectivity, sensitivity and biocompatibility enable the probes to successfully image tyrosinase activity in live cells and tissues using TP microscopy.
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http://dx.doi.org/10.1039/d1cc02374hDOI Listing
June 2021