Sarah A Teichmann

Sarah A Teichmann

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Sarah A Teichmann

Publications by authors named "Sarah A Teichmann"

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Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.

J Immunol 2020 Jun 22;204(11):2949-2960. Epub 2020 Apr 22.

York Biomedical Research Institute, University of York, York, YO10 5DD Yorkshire, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1900940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231852PMC
June 2020

Prenatal development of human immunity.

Science 2020 05;368(6491):600-603

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aaz9330DOI Listing
May 2020

Putative cell type discovery from single-cell gene expression data.

Nat Methods 2020 May 18. Epub 2020 May 18.

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.

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http://dx.doi.org/10.1038/s41592-020-0825-9DOI Listing
May 2020

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.

Cell Rep 2020 May;31(7):107628

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242909PMC
May 2020

Immunology in the Era of Single-Cell Technologies.

Annu Rev Immunol 2020 Apr 19;38:727-757. Epub 2020 Feb 19.

Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-immunol-090419-020340DOI Listing
April 2020

CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.

Nat Protoc 2020 04 26;15(4):1484-1506. Epub 2020 Feb 26.

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/s41596-020-0292-xDOI Listing
April 2020

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes.

Nat Methods 2020 Apr 16;17(4):414-421. Epub 2020 Mar 16.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/s41592-020-0766-3DOI Listing
April 2020

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes.

Immunity 2020 Apr 13. Epub 2020 Apr 13.

Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, MRB2, Entrance 38, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.03.019DOI Listing
April 2020

Cell Atlas technologies and insights into tissue architecture.

Biochem J 2020 Apr;477(8):1427-1442

Wellcome Sanger Institute, Cambridge, U.K.

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http://dx.doi.org/10.1042/BCJ20190341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200628PMC
April 2020

Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.

J Exp Med 2020 Mar;217(3)

Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Oxford National Institute for Health Research Biomedical Research Centre, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1084/jem.20190811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062525PMC
March 2020

BBKNN: fast batch alignment of single cell transcriptomes.

Bioinformatics 2020 Feb;36(3):964-965

Cellular Genetics, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1093/bioinformatics/btz625DOI Listing
February 2020

Deciphering immunity at high plexity and resolution.

Nat Rev Immunol 2020 02;20(2):77-78

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/s41577-019-0254-0DOI Listing
February 2020

Computational methods for single-cell omics across modalities.

Nat Methods 2020 01;17(1):14-17

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/s41592-019-0692-4DOI Listing
January 2020

Nasal DNA methylation profiling of asthma and rhinitis.

J Allergy Clin Immunol 2020 Jan 14. Epub 2020 Jan 14.

Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Gronigen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.12.911DOI Listing
January 2020

Immunology Driven by Large-Scale Single-Cell Sequencing.

Trends Immunol 2019 11 20;40(11):1011-1021. Epub 2019 Oct 20.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1016/j.it.2019.09.004DOI Listing
November 2019

In conversation with Sarah Teichmann.

FEBS J 2019 04;286(8):1445-1450

Wellcome Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1111/febs.14806DOI Listing
April 2019

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

Cell 2019 02 10;176(4):882-896.e18. Epub 2019 Jan 10.

Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK; Theory of Condensed Matter, Cavendish Laboratory, 19 JJ Thomson Ave, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370901PMC
February 2019

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.

Immunity 2019 02 5;50(2):493-504.e7. Epub 2019 Feb 5.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382439PMC
February 2019

A test metric for assessing single-cell RNA-seq batch correction.

Nat Methods 2019 01 20;16(1):43-49. Epub 2018 Dec 20.

Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany.

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http://www.nature.com/articles/s41592-018-0254-1
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http://dx.doi.org/10.1038/s41592-018-0254-1DOI Listing
January 2019

A rapid and robust method for single cell chromatin accessibility profiling.

Nat Commun 2018 12 17;9(1):5345. Epub 2018 Dec 17.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41467-018-07771-0
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http://dx.doi.org/10.1038/s41467-018-07771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297232PMC
December 2018

Editorial overview: Sequences and topology: Dynamic sequences and topologies of proteins.

Curr Opin Struct Biol 2018 06;50:vii-viii

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2018.07.005DOI Listing
June 2018

SpatialDE: identification of spatially variable genes.

Nat Methods 2018 05 19;15(5):343-346. Epub 2018 Mar 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nmeth.4636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350895PMC
May 2018

Exponential scaling of single-cell RNA-seq in the past decade.

Nat Protoc 2018 04 1;13(4):599-604. Epub 2018 Mar 1.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2017.149DOI Listing
April 2018

Mapping human development at single-cell resolution.

Development 2018 02 8;145(3). Epub 2018 Feb 8.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

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http://dx.doi.org/10.1242/dev.152561DOI Listing
February 2018

Circulating and Tissue-Resident CD4 T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Gastroenterology 2017 11 4;153(5):1320-1337.e16. Epub 2017 Aug 4.

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687320PMC
November 2017

Single cell transcriptomics of pluripotent stem cells: reprogramming and differentiation.

Curr Opin Genet Dev 2017 Oct 1;46:66-76. Epub 2017 Jul 1.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK; European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1016/j.gde.2017.06.003DOI Listing
October 2017

Single-cell transcriptomics to explore the immune system in health and disease.

Science 2017 10;358(6359):58-63

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aan6828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654495PMC
October 2017

Computational approaches for interpreting scRNA-seq data.

FEBS Lett 2017 08 12;591(15):2213-2225. Epub 2017 Jun 12.

The European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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http://dx.doi.org/10.1002/1873-3468.12684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575496PMC
August 2017

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications.

Genome Med 2017 08 18;9(1):75. Epub 2017 Aug 18.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520, Turku, Finland.

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http://dx.doi.org/10.1186/s13073-017-0467-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561556PMC
August 2017

Wounding induces dedifferentiation of epidermal Gata6 cells and acquisition of stem cell properties.

Nat Cell Biol 2017 Jun 15;19(6):603-613. Epub 2017 May 15.

King's College London Centre for Stem Cells and Regenerative Medicine, 28th Floor, Tower Wing, Guy's Campus, Great Maze Pond, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncb3532DOI Listing
June 2017

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.

Nat Commun 2017 06 26;8(1):36. Epub 2017 Jun 26.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1038/s41467-017-00052-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484669PMC
June 2017

Power analysis of single-cell RNA-sequencing experiments.

Nat Methods 2017 Apr 6;14(4):381-387. Epub 2017 Mar 6.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.4220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376499PMC
April 2017

Are cells from a snowman realistic? Cryopreserved tissues as a source for single-cell RNA-sequencing experiments.

Genome Biol 2017 03 24;18(1):54. Epub 2017 Mar 24.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://dx.doi.org/10.1186/s13059-017-1192-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364640PMC
March 2017

Regulation, evolution and consequences of cotranslational protein complex assembly.

Curr Opin Struct Biol 2017 02 12;42:90-97. Epub 2016 Dec 12.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.11.023DOI Listing
February 2017

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.

J Exp Med 2017 01 19;214(1):183-196. Epub 2016 Dec 19.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK

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http://dx.doi.org/10.1084/jem.20161056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206502PMC
January 2017

Single-cell analysis at the threshold.

Nat Biotechnol 2016 11;34(11):1111-1118

Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/nbt.3721DOI Listing
November 2016

Genetics and immunity in the era of single-cell genomics.

Hum Mol Genet 2016 Oct 12;25(R2):R141-R148. Epub 2016 Jul 12.

Wellcome Trust Sanger Institute

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http://dx.doi.org/10.1093/hmg/ddw192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036872PMC
October 2016

Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.

Data Brief 2016 Sep 9;8:948-57. Epub 2016 Jul 9.

The Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.dib.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961497PMC
September 2016

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

Cell Rep 2016 09;17(1):179-192

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055476PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.087DOI Listing
September 2016

Single-cell genomics: coming of age.

Genome Biol 2016 May 10;17:97. Epub 2016 May 10.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-016-0960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862185PMC
May 2016

T cell fate and clonality inference from single-cell transcriptomes.

Nat Methods 2016 Apr 7;13(4):329-332. Epub 2016 Mar 7.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.3800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835021PMC
April 2016

AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators.

J Mol Biol 2016 Feb 25;428(4):671-678. Epub 2015 Sep 25.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783282PMC
February 2016

Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells.

Cell Rep 2016 Feb 21;14(4):966-977. Epub 2016 Jan 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742565PMC
February 2016

Classification of low quality cells from single-cell RNA-seq data.

Genome Biol 2016 Feb 17;17:29. Epub 2016 Feb 17.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13059-016-0888-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758103PMC
February 2016

Structure, dynamics, assembly, and evolution of protein complexes.

Annu Rev Biochem 2015 8;84:551-75. Epub 2014 Dec 8.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-biochem-060614-034142DOI Listing
December 2015

Principles of assembly reveal a periodic table of protein complexes.

Science 2015 Dec;350(6266):aaa2245

Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/science.aaa2245DOI Listing
December 2015

Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

Cell Stem Cell 2015 Oct;17(4):471-85

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595712PMC
October 2015

Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression.

Nat Commun 2015 Oct 22;6:8687. Epub 2015 Oct 22.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1038/ncomms9687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627577PMC
October 2015

Computational assignment of cell-cycle stage from single-cell transcriptome data.

Methods 2015 Sep 2;85:54-61. Epub 2015 Jul 2.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10462023153000
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http://dx.doi.org/10.1016/j.ymeth.2015.06.021DOI Listing
September 2015

The technology and biology of single-cell RNA sequencing.

Mol Cell 2015 May;58(4):610-20

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00261-0
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http://dx.doi.org/10.1016/j.molcel.2015.04.005DOI Listing
May 2015

An atlas of mouse CD4(+) T cell transcriptomes.

Biol Direct 2015 Apr 3;10:14. Epub 2015 Apr 3.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1186/s13062-015-0045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384382PMC
April 2015

Computational and analytical challenges in single-cell transcriptomics.

Nat Rev Genet 2015 Mar 28;16(3):133-45. Epub 2015 Jan 28.

1] European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. [2] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

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http://sv.epfl.ch/files/content/sites/svnew2/files/shared/LS
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http://www.nature.com/doifinder/10.1038/nrg3833
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http://dx.doi.org/10.1038/nrg3833DOI Listing
March 2015

Structural and evolutionary versatility in protein complexes with uneven stoichiometry.

Nat Commun 2015 Mar 16;6:6394. Epub 2015 Mar 16.

1] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK [2] Theory of Condensed Matter, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/ncomms7394DOI Listing
March 2015

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.

Nat Biotechnol 2015 Feb 19;33(2):155-60. Epub 2015 Jan 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nbt.3102DOI Listing
February 2015

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.

Cell Rep 2014 May 10;7(4):1130-42. Epub 2014 May 10.

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039991PMC
May 2014

Protein flexibility facilitates quaternary structure assembly and evolution.

PLoS Biol 2014 May 27;12(5):e1001870. Epub 2014 May 27.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1001870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035275PMC
May 2014

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.

Bioessays 2014 Feb 25;36(2):209-18. Epub 2013 Nov 25.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1002/bies.201300134DOI Listing
February 2014

Evolution of protein structures and interactions from the perspective of residue contact networks.

Curr Opin Struct Biol 2013 Dec 25;23(6):954-63. Epub 2013 Jul 25.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2013.07.004DOI Listing
December 2013

Immunology meets genomics.

Brief Funct Genomics 2013 Nov;12(6):469-70

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http://dx.doi.org/10.1093/bfgp/elt037DOI Listing
November 2013

Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes.

Mol Biosyst 2013 Jul 30;9(7):1620-6. Epub 2013 Jan 30.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665713PMC
July 2013

Protein complexes are under evolutionary selection to assemble via ordered pathways.

Cell 2013 Apr;153(2):461-70

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1016/j.cell.2013.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009401PMC
April 2013

Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.

Proc Natl Acad Sci U S A 2012 Dec 26;109(50):20461-6. Epub 2012 Nov 26.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1209312109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528536PMC
December 2012