Steffen Koschmieder

Steffen Koschmieder

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Steffen Koschmieder

Publications by authors named "Steffen Koschmieder"

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Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor.

Recent Results Cancer Res 2018;212:87-108

Department of Oncology, Hematology, Immunoncology and Rheumatology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

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http://link.springer.com/10.1007/978-3-319-91439-8_4
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http://dx.doi.org/10.1007/978-3-319-91439-8_4DOI Listing
May 2019

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha.

J Hematol Oncol 2019 Apr 2;12(1):36. Epub 2019 Apr 2.

Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany.

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http://dx.doi.org/10.1186/s13045-019-0722-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444528PMC
April 2019

Potential Technologies Review: A hybrid information retrieval framework to accelerate demand-pull innovation in biomedical engineering.

Res Synth Methods 2019 Apr 17. Epub 2019 Apr 17.

Science Management, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1002/jrsm.1350DOI Listing
April 2019

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling.

Leukemia 2019 Mar 6. Epub 2019 Mar 6.

Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

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http://www.nature.com/articles/s41375-019-0427-7
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http://dx.doi.org/10.1038/s41375-019-0427-7DOI Listing
March 2019

Mutant NRAS Q61K is responsible for MAPK pathway activation in the MARIMO cell line and renders these cells independent of the CALR-MPL-JAK2-STAT5 pathway.

Leukemia 2018 09 8;32(9):2087-2090. Epub 2018 Aug 8.

Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1038/s41375-018-0234-6DOI Listing
September 2018

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options.

Semin Cancer Biol 2018 08 2;51:180-197. Epub 2017 Aug 2.

Epigenetics Unit, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.07.006DOI Listing
August 2018

Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells.

PLoS One 2018 31;13(5):e0197233. Epub 2018 May 31.

Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197233PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979002PMC
August 2018

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.

Cancer Res 2018 05 26;78(9):2407-2418. Epub 2018 Feb 26.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3644DOI Listing
May 2018

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.

Matrix Biol 2018 04 31;67:47-62. Epub 2018 Jan 31.

Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.01.007DOI Listing
April 2018

Leukocyte Counts Based on DNA Methylation at Individual Cytosines.

Clin Chem 2018 Mar 8;64(3):566-575. Epub 2017 Nov 8.

Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2017.279
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http://dx.doi.org/10.1373/clinchem.2017.279935DOI Listing
March 2018

Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia.

Clin Cancer Res 2017 May 17;23(9):2289-2300. Epub 2016 Nov 17.

Department of Hematology and Oncology with Sections BMT and Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1930DOI Listing
May 2017

Perioperative intravenous immunoglobulin treatment in a patient with severe acquired von Willebrand syndrome: case report and review of the literature.

Clin Case Rep 2017 05 30;5(5):664-670. Epub 2017 Mar 30.

Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation Medical Faculty RWTH Aachen University Aachen Germany.

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http://dx.doi.org/10.1002/ccr3.890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412814PMC
May 2017

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.

Stem Cells 2017 04 1;35(4):898-908. Epub 2017 Feb 1.

Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany.

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http://dx.doi.org/10.1002/stem.2565DOI Listing
April 2017

Cancer Screening in Patients with Idiopathic Venous Thromboembolism--a Position Paper of the German Society of Hematology and Oncology Working Group on Hemostasis.

Oncol Res Treat 2015 5;38(9):454-8. Epub 2015 Aug 5.

Clinic for Internal Medicine II, Dept. of Hematology, Oncology, Asklepios Clinic Uckermark, Schwedt/Oder, Germany.

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http://dx.doi.org/10.1159/000437451DOI Listing
July 2016

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion.

J Hematol Oncol 2016 05 13;9(1):45. Epub 2016 May 13.

Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

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http://jhoonline.biomedcentral.com/articles/10.1186/s13045-0
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http://dx.doi.org/10.1186/s13045-016-0275-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894373PMC
May 2016

γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm.

Medicine (Baltimore) 2016 May;95(20):e3355

From the Department of Internal Medicine I (GJ, HLM, PM, JC, LJ, SC, TJ); Department of Medical Clinic III, University of Bonn, Bonn (VM, HA, BP, WD); Department of Hematology, Oncology, Hemostaseology, and SCT, Faculty of Medicine, University Hospital of the RWTH Aachen University, Aachen (KA, BTH, KS); Department of Biometrics, Informatics and Epidemiology, University of Bonn, Bonn (FR); Department for Hematology, University Hospital Essen, Essen (GJ); Department for Hematology, Oncology and Clinical Immunology, University Hospital Duesseldorf, Duesseldorf (GN); Practice for Hematology-Oncology Eppendorf, Hamburg (GE); and Department for Hematology, University Hospital Dresden, Dresden, Germany (PU).

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http://dx.doi.org/10.1097/MD.0000000000003355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902387PMC
May 2016

Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia.

Sci Rep 2016 Apr 6;6:24057. Epub 2016 Apr 6.

Joint Research Center for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, 52062 Aachen, Germany.

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http://dx.doi.org/10.1038/srep24057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822142PMC
April 2016

A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis.

PLoS One 2015 16;10(6):e0129147. Epub 2015 Jun 16.

Department of Medicine A, Hematology/Oncology, University of Muenster, Muenster, Germany; Dept. of Medicine IV, Hematology and Oncology, University of Halle, Halle, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129147PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469679PMC
March 2016

[Diagnosis and treatment of polycythemia vera in 2015].

Dtsch Med Wochenschr 2015 Oct 7;140(20):1501-6. Epub 2015 Oct 7.

Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation, Medizinische Fakultät, RWTH Uniklinik Aachen.

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http://dx.doi.org/10.1055/s-0041-103336DOI Listing
October 2015

[Diagnosis and treatment of polycythemia vera in the year 2015].

Dtsch Med Wochenschr 2015 Oct 4;140(20):e256. Epub 2015 Dec 4.

Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation, Medizinische Fakultät, RWTH Uniklinik Aachen.

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http://dx.doi.org/10.1055/s-0041-110562DOI Listing
October 2015

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

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http://jem.rupress.org/content/212/10/1551.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20141661
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http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia.

Pediatr Blood Cancer 2015 Jul 8;62(7):1144-8. Epub 2015 Mar 8.

Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1002/pbc.25462DOI Listing
July 2015

Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells.

Sci Rep 2015 Mar 10;5:8973. Epub 2015 Mar 10.

1] Institute for Biomedical Engineering - Cell Biology, RWTH Aachen University Medical School, Aachen, Germany [2] Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany.

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http://dx.doi.org/10.1038/srep08973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354028PMC
March 2015

Drug target optimization in chronic myeloid leukemia using innovative computational platform.

Sci Rep 2015 Feb 3;5:8190. Epub 2015 Feb 3.

1] Microsoft Research, Cambridge CB1 2FB, UK [2] Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1038/srep08190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650822PMC
February 2015

Bosutinib: a novel second-generation tyrosine kinase inhibitor.

Recent Results Cancer Res 2014 ;201:81-97

Department of Hematology, Oncology and Stem Cell Transplantation, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

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http://dx.doi.org/10.1007/978-3-642-54490-3_4DOI Listing
September 2014

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

Oncol Rep 2013 Nov 4;30(5):2254-62. Epub 2013 Sep 4.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe University Hospital, D‑60590 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/or.2013.2716DOI Listing
November 2013

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

Int J Oncol 2013 Jul 29;43(1):246-54. Epub 2013 Apr 29.

Department of Hematology/Oncology and Infectious Diseases, J.W. Goethe-University Hospital, 60595 Frankfurt/Main, Germany.

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http://dx.doi.org/10.3892/ijo.2013.1924DOI Listing
July 2013

Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia.

Onco Targets Ther 2013 4;6:99-106. Epub 2013 Mar 4.

Department of Hematology and Oncology, University Cancer Center Hamburg, University Hospital Hamburg Eppendorf, Aachen, Germany.

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http://dx.doi.org/10.2147/OTT.S19901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594007PMC
March 2013

Mouse models as tools to understand and study BCR-ABL1 diseases.

Am J Blood Res 2011 7;1(1):65-75. Epub 2011 Jun 7.

Medizinische Klinik A, Universitätsklinikum Münster Münster, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3301413PMC
August 2012

Ruxolitinib for myelofibrosis.

N Engl J Med 2012 05;366(21):2031-2; author reply 2032-4

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http://dx.doi.org/10.1056/NEJMc1203704DOI Listing
May 2012

The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma.

Int J Oncol 2009 Jul;35(1):175-9

Department of Medicine, Hematology and Oncology, University of Münster, D-48129 Münster, Germany.

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http://dx.doi.org/10.3892/ijo_00000326DOI Listing
July 2009

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.

J Clin Oncol 2009 Feb 15;27(4):619-28. Epub 2008 Dec 15.

University of Münster, Münster, Germany.

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http://dx.doi.org/10.1200/JCO.2008.17.9812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645860PMC
February 2009

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.

Exp Hematol 2009 Feb 18;37(2):206-14. Epub 2008 Dec 18.

Section of Experimental Haematology, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/j.exphem.2008.10.013DOI Listing
February 2009

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Nat Genet 2008 Jan 11;40(1):51-60. Epub 2007 Nov 11.

Hematology/Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng.2007.7DOI Listing
January 2008

Flt3-dependent transformation by inactivating c-Cbl mutations in AML.

Blood 2007 08 19;110(3):1004-12. Epub 2007 Apr 19.

Department of Medicine, Hematology and Oncology, and Interdisciplinary Center for Clinical Research, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany.

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http://dx.doi.org/10.1182/blood-2007-01-066076DOI Listing
August 2007

The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia.

Blood 2007 May 18;109(9):3895-905. Epub 2007 Jan 18.

Department of Medicine, Hematology and Oncology, University of Münster, Domagkstrasse 3, 48129 Münster, Germany.

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http://dx.doi.org/10.1182/blood-2006-08-040147DOI Listing
May 2007

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.

Int J Oncol 2007 Feb;30(2):349-55

Department of Internal Medicine-Hematology and Oncology, University Hospital of Münster, Germany.

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February 2007

DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

Cancer Res 2007 Feb;67(3):1370-7

Department of Medicine, Hematology and Oncology, University of Münster, Domagkstrasse 3, 48129 Münster, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1681DOI Listing
February 2007

Effect of transcription-factor concentrations on leukemic stem cells.

Blood 2005 Sep 24;106(5):1519-24. Epub 2005 May 24.

Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2005-02-0717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895222PMC
September 2005

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

Int J Hematol 2005 Jun;81(5):368-77

Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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June 2005

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

Blood 2005 Jan 26;105(1):324-34. Epub 2004 Aug 26.

Department of Hematology/Oncology, Harvard Institutes of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2003-12-4369DOI Listing
January 2005

Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report.

Blood Coagul Fibrinolysis 2003 Jun;14(4):395-9

Zentrum für Innere Medizin, Universitätsklinikum, Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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June 2003