Publications by authors named "S K Musharaf Ali"

8,413 Publications

A threshold approach to sustainable development: Nonlinear relationship between renewable energy consumption, natural resource rent, and ecological footprint.

J Environ Manage 2021 Jun 21;295:113073. Epub 2021 Jun 21.

Department of Business Administration, IQRA University, Karachi, 75300, Pakistan. Electronic address:

All over the world, humankind and nature are paying off economic development's opportunity cost through accelerated environmental degradation. Renewable energy is the best option to control and minimize environmental degradation for sustainable development. This study's primary motive is to examine the nonlinear relationship between renewable energy consumption, natural resource rent, and ecological footprint in the context of the world's top 15 renewable energy consumption economies to achieve sustainable development. Panel time-series data from 1996 to 2018 is focused on concluding the study. Panel Smooth Transition Model is used to explore the nonlinear relationship and transition between the low and high regimes because of the nonlinear behavior. The study's results suggest a negative association between renewable energy consumption and ecological footprint and a positive relationship between natural resource rent and ecological footprint in both low and high regimes in the case of these 15 economies. It is highly recommended that the nations must shift their energy consumption policies towards renewable energy sources by investing in renewable energy technology and research for a more sustainable development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2021.113073DOI Listing
June 2021

Trophic transfer and toxicity of heavy metals from dengue mosquito Aedes aegypti to predator dragonfly Tramea cophysa.

Ecotoxicology 2021 Jun 24. Epub 2021 Jun 24.

Department of Entomology, UCA & ES, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.

Heavy metal pollution in aquatic habitats can be detrimental to both prey and predators in a food web. To investigate the potential for bio-transfer and bioaccumulation of heavy metals between specific trophic levels, 3rd instar larvae of Aedes aegypti were exposed to mercury (Hg), lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn) for three consecutive generations and fed to dragonfly (Tramea cophysa) nymphs. Exposure to Hg caused the highest mortality in A. aegypti larvae and T. cophysa nymphs. Bioaccumulation and life-history parameters of A. aegypti, including egg hatching time, larval and pupal duration, male and female life span, and fecundity, were also evaluated after metals exposure. All life-history parameters except larval duration were significantly affected by heavy metal treatments. Bioaccumulation of metals in A. aegypti larvae and adults gradually and significantly increased from 1st to 3rd generation. To the best of our knowledge, this is the first study describing the acute toxicity of heavy metals to mosquitoes. Our study shows that heavy metals cause dietary toxicity to an aquatic predator, dragonfly, via trophic transfer, which could have considerable consequences on aquatic ecosystems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10646-021-02448-9DOI Listing
June 2021

Removal of pharmaceuticals from nitrified urine.

Chemosphere 2021 Oct 20;280:130870. Epub 2021 May 20.

School of Civil and Environmental Engineering, University of Technology Sydney (UTS), City Campus, 15 Broadway, Ultimo, NSW, 2007, Australia. Electronic address:

In this study, granular activated carbon (GAC) was examined for the removal of five of the most commonly detected pharmaceuticals (naproxen, carbamazepine, acetaminophen, ibuprofen and metronidazole) from a nitrified urine to make the urine-derived fertiliser nutrient safe for food crops. Batch experiments were conducted to investigate the adsorption kinetics that described the removal of micropollutants (equal concentrations of 0.2 mM) from the synthetic nitrified urine at different GAC dosages (10-3000 mg/L). Artificial neural network modelling was also used to predict and simulate the removal of pharmaceuticals from nitrified urine. Langmuir and Freundlich isotherm models described the equilibrium data, with the Langmuir model providing slightly higher correlations. At the highest dose of 3000 mg/L GAC, all the pharmaceuticals showed a removal rates of over 90% after 1 h of adsorption time and 99% removal rates after 6 h of adsorption time. This study concludes that GAC is able to remove the targeted xenobiotics without affecting the concentration of N and P in the urine, suggesting that nitrified urine could be safely used as a nutrient product in future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.130870DOI Listing
October 2021

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.

Cell 2021 Jun 5. Epub 2021 Jun 5.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option against COVID-19. Because rapidly emerging virus mutants are becoming the next major concern in the fight against the global pandemic, it is imperative that these therapeutic treatments provide coverage against circulating variants and do not contribute to development of treatment-induced emergent resistance. To this end, we investigated the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-COV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations, and in hamster in vivo studies using REGEN-COV or single monoclonal antibody treatments. Our study demonstrates that the combination of non-competing antibodies in REGEN-COV provides protection against all current SARS-CoV-2 variants of concern/interest and also protects against emergence of new variants and their potential seeding into the population in a clinical setting.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2021.06.002DOI Listing
June 2021

Preliminary Structural Data Revealed that the SARS-CoV-2 B.1.617 Variant's RBD binds to ACE2 receptor stronger than the Wild Type to Enhance the Infectivity.

Chembiochem 2021 Jun 23. Epub 2021 Jun 23.

Dasman Diabetes Institute, Biochemistry, Kuwait, 15462, Kuwait, Kuwait City, KUWAIT.

The evolution of new SARS-CoV-2 variants around the globe has made the COVID-19 pandemic more worrisome, further pressuring the health care system and immunity. Novel variations that are unique to the receptor-binding motif (RBM) of the receptor-binding domain (RBD) spike glycoprotein, i.e. L452R-E484Q, may play a different role in the B.1.617, also known as G/452R.V3, variant's pathogenicity and better survival compared to the wild type. Therefore, a thorough analysis was needed to understand the impact of these mutations on binding with host receptor (RBD) and to guide new therapeutics development. In this study, we used structural and biomolecular simulation techniques to explore the impact of specific mutations (L452R-E484Q) in the B.1.617 variant on the binding of RBD to the host receptor ACE2. Our analysis revealed that the B.1.617 possess different dynamic behaviour by altering the dynamic-stability, residual flexibility and structural compactness. Moreover, the new variant had also altered the bonding network and structural-dynamics properties significantly. MM/GBSA technique was used, which further established the binding differences between the wild type and B.1.617 variant. This study provides a strong impetus to develop novel drugs against the new SARS-CoV-2 variants.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.202100191DOI Listing
June 2021